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Stanley Perlman, Email: Stanley-Perlman@uiowa.edu
Kathryn V. Holmes, Email: Kathryn.Holmes@ucHSC.edu
References
- 1.Fabry Z, Raine CS, Hart MN. Nervous tissue as an immune compartment: the dialect of the immune response in the CNS. Immunol. Today. 1994;15:218–224. doi: 10.1016/0167-5699(94)90247-X. [DOI] [PubMed] [Google Scholar]
- 2.Hickey WF. Basic principles of immunological surveillance of the normal central nervous system. Glia. 2001;36:118–124. doi: 10.1002/glia.1101. [DOI] [PubMed] [Google Scholar]
- 3.Dorries R. The role of T-cell-mediated mechanisms in virus infections of the nervous system. Curr. Top. Microbiol. Immunol. 2001;253:219–245. doi: 10.1007/978-3-662-10356-2_11. [DOI] [PubMed] [Google Scholar]
- 4.Griffin DE. Immune responses to RNA-virus infections of the CNS. Nat. Rev. Immunol. 2003;3:493–502. doi: 10.1038/nri1105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Ransohoff RM, Kivisakk P, Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 2003;3:569–581. doi: 10.1038/nri1130. [DOI] [PubMed] [Google Scholar]
- 6.Stohlman S, Bergmann C, Perlman S. In: Persistent Viral Infection. Ahmed R, Chen I, editors. New York: John Wiley; 1999. pp. 537–558. [Google Scholar]
- 7.Marten NW, Stohlman SA, Bergmann CC. MHV infection of the CNS: mechanisms of immune-mediated control. Viral Immunol. 2001;14:1–18. doi: 10.1089/08828240151061329. [DOI] [PubMed] [Google Scholar]
- 8.Buchmeier MJ, Lane TE. Viral-induced neurodegenerative disease. Curr. Opin. Microbiol. 1999;2:398–402. doi: 10.1016/S1369-5274(99)80070-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Lin MT, Hinton DR, Marten NW, Bergmann CC, Stohlman SA. Antibody prevents virus reactivation within the central nervous system. J. Immunol. 1999;162:7358–7368. [PubMed] [Google Scholar]
- 10.Ramakrishna C, Stohlman SA, Atkinson R, Schlomchik M, Bergmann CC. Mechanisms of central nervous system viral persistence: critical role of antibody and B cells. J. Immunol. 2002;168:1204–1211. doi: 10.4049/jimmunol.168.3.1204. [DOI] [PubMed] [Google Scholar]
- 11.Fleming JO, Trousdale M, El-Zaatari F, Stohlman SA, Weiner LP. Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies. J. Virol. 1986;58:869–875. doi: 10.1128/jvi.58.3.869-875.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.Lane TE, Asensio VC, Yu N, Paoletti AD, Campbell IL, Buchmeier MJ. Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease. J. Immunol. 1998;160:970–978. [PubMed] [Google Scholar]
- 13.Parra B, Hinton DR, Lin MT, Cua DJ, Stohlman SA. Kinetics of cytokine mRNA expression in the CNS following lethal and sublethal coronavirus-induced encephalomyelitis. Virology. 1997;233:260–270. doi: 10.1006/viro.1997.8613. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Pearce BD, Hobbs MV, McGraw TS, Buchmeier MJ. Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo. J. Virol. 1994;68:5483–5495. doi: 10.1128/jvi.68.9.5483-5495.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Rempel JD, Murray SJ, Meisner J, Buchmeier MJ. Differential regulation of innate and adaptive immune responses in viral encephalitis. Virology. 2004;318:381–392. doi: 10.1016/j.virol.2003.09.023. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Rempel JD, Quina LA, Blakelu-Gonzales PK, Buchmeier MJ, Gruol DL. Viral induction of central nervous system innate immune responses. J. Virol. 2005;79:4369–4381. doi: 10.1128/JVI.79.7.4369-4381.2005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.Lane TE, Buchmeier MJ. In: Universes in Delicate Balance: Chemokines and the Nervous System. Ransohoff R, editor. New York: Elsevier Press; 2002. pp. 191–202. [Google Scholar]
- 18.Zhou J, Stohlman S, Atkinson R, Hinton D, Marten N. Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection. J. Virol. 2002;76:7373–7384. doi: 10.1128/JVI.76.15.7374-7384.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 19.Yong VW, Power C, Forsyth P, Edwards DR. Metalloproteinases in biology and pathology of the nervous system. Nature. 2001;2:502–511. doi: 10.1038/35081571. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 20.Zhou J, Stohlman S, Hinton DR, Marten N. Neutrophils modulate inflammation during viral induced encephalitis. J. Immunol. 2003;170:3331–3336. doi: 10.4049/jimmunol.170.6.3331. [DOI] [PubMed] [Google Scholar]
- 21.Bergmann CC, Parra B, Hinton D, Ramakrishna C, Morrison M, Stohlman SA. Perforin mediated effector function within the CNS requires IFN-γ mediated MHC upregulation. J. Immunol. 2003;170:3204–3213. doi: 10.4049/jimmunol.170.6.3204. [DOI] [PubMed] [Google Scholar]
- 22.Zhou J, Marten NW, Bergmann CC, Macklin WB, Hinton DR, Stohlman SA. Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis. J. Virol. 2005;79:4764–4773. doi: 10.1128/JVI.79.8.4764-4773.2005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 23.Trifilo MJ, Bergmann CC, Kuziel WA, Lane TE. CC chemokine ligand 3 (CCL3) regulates CD8+-T-cell effector function and migration following viral infection. J. Virol. 2003;77:4004–4014. doi: 10.1128/JVI.77.7.4004-4014.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24.Trifilo MJ, Montalto-Morrison C, Stiles LN, Hurst KR, Hardison JL, Manning JE, Masters PS, Lane TE. CXC chemokine ligand 10 controls viral infection in the central nervous system: Evidence for a role in innate immune response through recruitment and activation of natural killer cells. J. Virol. 2004;78:585–594. doi: 10.1128/JVI.78.2.585-594.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 25.Trifilo MJ, Lane TE. The CC chemokine ligand 3 regulates CD11c+CD11b+CD8alpha-dendritic cell maturation and activation following viral infection of the central nervous system: implications or a role in T cell activation. Virology. 2004;327:8–15. doi: 10.1016/j.virol.2004.06.027. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 26.Lane TE, Liu MT, Chen BP, Asensio VC, Samawi RM, Paoletti AD, Campbell IL, Kunkel SL, Fox HS, Buchmeier MJ. A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination. J. Virol. 2000;74:1415–1424. doi: 10.1128/JVI.74.3.1415-1424.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 27.Glass WG, Hickey MJ, Hardison JL, Liu MT, Manning JE, Lane TE. Antibody targeting of the CC chemokine ligand 5 (CCL5) results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis. J. Immunol. 2004;172:4018–4025. doi: 10.4049/jimmunol.172.7.4018. [DOI] [PubMed] [Google Scholar]
- 28.Stohlman SA, Hinton DR, Cua D, Dimacali E, Sensintaffar J, Tahara S, Hofman F, Yao Q. Tumor necrosis factor expression during mouse hepatitis virus induced demyelination. J. Virol. 1995;69:5898–5903. doi: 10.1128/jvi.69.9.5898-5903.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 29.Pewe L, Perlman S. Cutting edge: CD8 T cell-mediated demyelination is IFN-gamma dependent in mice infected with a neurotropic coronavirus. J. Immunol. 2002;168:1547–1551. doi: 10.4049/jimmunol.168.4.1547. [DOI] [PubMed] [Google Scholar]
- 30.Bergmann CC, Altman J, Hinton D, Stohlman SA. Inverted immunodominance and Impaired cytolytic function of CD8+ T cells during viral persistence in the CNS. J. Immunol. 1999;163:3379–3387. [PubMed] [Google Scholar]
- 31.Marten N, Stohlman SA, Zhou Z, Bergmann CC. Kinetics of virus specific CD8+ T cell expansion and trafficking following central nervous system infection. J. Virol. 2003;77:2775–2778. doi: 10.1128/JVI.77.4.2775-2778.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 32.Wang FI, Hinton DR, Gilmore W, Trousdale MD, Fleming JO. Sequential infection of glial cells by the murine hepatitis virus JHM strain (MHV-4) leads to a characteristic distribution of demyelination. Lab. Invest. 1992;66:744–754. [PubMed] [Google Scholar]
- 33.Liu MT, Chen BP, Oertel P, Buchmeier MJ, Armstrong D, Hamilton TA, Lane TE. The T cell chemoattractant IFN-inducible protein 10 (IP-10) is essential in host defense against viral-induced neurologic disease. J. Immunol. 2000;165:2327–2330. doi: 10.4049/jimmunol.165.5.2327. [DOI] [PubMed] [Google Scholar]
- 34.Liu MT, Keirstead HS, Lane TE. Naturalization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis. J. Immunol. 2001;167:4091–4097. doi: 10.4049/jimmunol.167.7.4091. [DOI] [PubMed] [Google Scholar]
- 35.Hauser AE, Debes GF, Arce S, Cassese G, Hamann A, Radbruch A, Manz RA. Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response. J. Immunol. 2002;169:1277–1282. doi: 10.4049/jimmunol.169.3.1277. [DOI] [PubMed] [Google Scholar]
- 36.Bergmann CC, Parra B, Hinton DR, Ramakrishna C, Dowdell KC, Stohlman S. Perforin and interferon gamma mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells. J. Virol. 2004;78:1739–1750. doi: 10.1128/JVI.78.4.1739-1750.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 37.Stohlman SA, Bergmann CC, Lin MT, Cua DJ, Hinton DR. CTL effector function within the CNS requires CD4+ T cells. J. Immunol. 1998;160:2896–2904. [PubMed] [Google Scholar]
- 38.Zhou J, Hinton DR, Stohlman SA, Marten N. Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2. Virol. Immunol. 2005;18:162–169. doi: 10.1089/vim.2005.18.162. [DOI] [PubMed] [Google Scholar]
- 39.Chen AM, Khanna N, Stohlman SA, Bergmann CC. Virus-specific and bystander CD8 T cells recruited during virus-induced encephalomyelitis. J. Virol. 2005;79:4700–4708. doi: 10.1128/JVI.79.8.4700-4708.2005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 40.Marten N, Stohlman S, Bergmann CC. Role of Viral Persistence in Retaining CD8+ T cells within the central nervous system. J. Virol. 2000;74:7903–7910. doi: 10.1128/JVI.74.17.7903-7910.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 41.Marten NW, Stohlman SA, Atkinson R, Hinton DA, Bergmann CC. Contributions of CD8+ T cells and viral spread to demyelinating disease. J. Immunol. 2000;164:4080–4088. doi: 10.4049/jimmunol.164.8.4080. [DOI] [PubMed] [Google Scholar]
- 42.Lin M, Stohlman S, Hinton D. Mouse hepatitis virus is cleared from the central nervous system of mice lacking perforin-mediated cytolysis. J. Virol. 1997;71:383–391. doi: 10.1128/jvi.71.1.383-391.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 43.Parra B, Hinton DR, Marten N, Bergmann CC, Lin M, Yang C, Stohlman SA. Gamma interferon is required for viral clearance from central nervous system oligodendroglia. J. Immunol. 1999;162:1641–1647. [PubMed] [Google Scholar]
- 44.Parra B, Lin M, Stohlman S, Bergmann C, Atkinson R, Hinton D. Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system. J. Virol. 2000;74:2447–2450. doi: 10.1128/JVI.74.5.2447-2450.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 45.Gonzalez JM, Bergmann CC, Fuss B, Hinton DR, Macklin WB, Stohlman SA. Expression of a dominant negative IFN-γ receptor on mouse oligodendrocytes. Glia. 2005;51:22–34. doi: 10.1002/glia.20182. [DOI] [PubMed] [Google Scholar]
- 46.Redwine JM, Buchmeier MJ, Evans CF. In vivo expression of major histocompatibility complex molecules on oligodendrocytes and neurons during viral infection. Am. J. Pathol. 2001;159:1219–1224. doi: 10.1016/S0002-9440(10)62507-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 47.Ramakrishna C, Stohlman S, Atkinson R, Hinton DH, Bergmann CC. Differential regulation of primary and secondary CD8+ T cells in the CNS. J. Immunol. 2004;173:6265–6273. doi: 10.4049/jimmunol.173.10.6265. [DOI] [PubMed] [Google Scholar]
- 48.Hawke S, Stevenson PG, Freeman S, Bangham CRM. Long term persistence of activated cytotoxic T lymphocytes after viral infection of the central nervous system. J. Exp. Med. 1998;187:1575–1582. doi: 10.1084/jem.187.10.1575. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 49.Marten N, Stohlman S, Smith-Begolka W, Miller S, Dimicali M, Yao Q, Stohl S, Goverman J, Bergmann C. Selection of CD8+ T cells with highly focused specificity during viral persistence in the central nervous system. J. Immunol. 1999;162:3905–3914. [PubMed] [Google Scholar]
- 50.Masopust D, Ahmed R. Reflections on CD8 T-cell activation and memory. Immunol. Res. 2004;29:151–160. doi: 10.1385/IR:29:1-3:151. [DOI] [PubMed] [Google Scholar]
- 51.Lefrancois L, Masopust D. T cell immunity in lymphoid and non-lymphoid tissues. Curr. Opin. Immunol. 2002;14:503–508. doi: 10.1016/S0952-7915(02)00360-6. [DOI] [PubMed] [Google Scholar]
- 52.Matthews AE, Weiss SR, Shlomchik MJ, Hannum LG, Gombold JL, Paterson JY. Antibody is required for clearance of infectious murine hepatitis virus A59 from the central nervous system, but not the liver. J. Immunol. 2001;167:5254–5263. doi: 10.4049/jimmunol.167.9.5254. [DOI] [PubMed] [Google Scholar]
- 53.Ramakrishna C, Bergmann C, Atkinson R, Stohlman S. Control of central nervous system viral persistence by neutralizing antibody. J. Virol. 2003;77:4670–4678. doi: 10.1128/JVI.77.8.4670-4678.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 54.Tschen SI, Bergmann C, Ramakrishna C, Atkinson R, Stohlman S. Recruitment kinetics of antibody secreting cells within the CNS following viral encephalomyelitis. J. Immunol. 2002;168:2922–2929. doi: 10.4049/jimmunol.168.6.2922. [DOI] [PubMed] [Google Scholar]
- 55.Wu GF, Dandekar AA, Pewe L, Perlman S. CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination. J. Immunol. 2000;165:2278–2286. doi: 10.4049/jimmunol.165.4.2278. [DOI] [PubMed] [Google Scholar]
- 56.Wu GF, Pewe L, Perlman S. Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase. J. Virol. 2000;74:7683–7686. doi: 10.1128/JVI.74.16.7683-7686.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 57.Pewe L, Haring J, Perlman S. CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus. J. Virol. 2002;76:7329–7333. doi: 10.1128/JVI.76.14.7329-7333.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 58.Dandekar AA, O'Malley K, Perlman S. Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus. J. Virol. 2005;79:9388–9396. doi: 10.1128/JVI.79.15.9388-9396.2005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 59.Kim TS, Perlman S. Viral expression of CCL2 is sufficient to induce demyelination in RAG1-/- mice infected with a neurotropic coronavirus. J. Virol. 2005;79:7113–7120. doi: 10.1128/JVI.79.11.7113-7120.2005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 60.Haring JS, Pewe LL, Perlman S. Bystander CD8+ T cell-mediated demyelination after viral infection of the central nervous system. J. Immunol. 2002;169:1550–1555. doi: 10.4049/jimmunol.169.3.1550. [DOI] [PubMed] [Google Scholar]
- 61.Cabarrocas J, Bauer J, Piaggio E, Liblau R, Lassman H. Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes. Eur. J. Immunol. 2003;33:1174–1182. doi: 10.1002/eji.200323492. [DOI] [PubMed] [Google Scholar]
- 62.McGavern DB, Truong P. Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells. J. Immunol. 2004;173:4779–4790. doi: 10.4049/jimmunol.173.8.4779. [DOI] [PMC free article] [PubMed] [Google Scholar]