Table 2.
Antiproliferative activities of 1–3 on MV4–11 AML and NB4 APL cell lines.
| Compd | IC50 (μM)[a] | |
|---|---|---|
| MV4–11 | NB4 | |
| 1a | >100 | >100 |
| 1b | 22.4 ± 3.8 | 25 ± 3.2 |
| 1c | 8.7 ± 1.9 | 14.4 ± 2.2 |
| 1d | 6.5 ± 0.7 | 9.4 ± 0.9 |
| 1e | 2.3 ± 0.04 | 7.5 ± 0.8 |
| 1f | 49.8 ± 7.7 | 42.4 ± 6.2 |
| 1g | 21.8 ± 3.1 | 17.8 ± 2.0 |
| 1h | 7.8 ± 1.0 | 16.4 ± 3.3 |
| 2a[b] | 10.2 ± 1.2 | 17.4 ± 2.9 |
| 2b | 24.2 ± 3.1 | 42.7 ± 5.8 |
| 2c | 52.3 ± 8.9 | 62.2 ± 9.2 |
| 2d | 4.6 ± 0.5 | 5.8 ± 0.8 |
| 2e | 5.3 ± 0.4 | 7.3 ± 0.6 |
| 2f | 5.0 ± 0.7 | 6.2 ± 0.5 |
| 2g | 8.7 ± 0.9 | 16.5 ± 2.6 |
| 2h | 5.0 ± 0.8 | 8.7 ± 1.0 |
| 2i | 7.6 ± 0.9 | 7.8 ± 0.8 |
| 2j | 15.4 ± 2.7 | 23.2 ± 4.2 |
| 2k | 16.0 ± 3.3 | 24.4 ± 3.9 |
| 2l | 6.8 ± 0.8 | 3.8 ± 0.04 |
| 2m | >100 | 70.4 ± 9.8 |
| 2n | 16.9 ± 2.5 | 46.7 ± 6.2 |
| 2o | 13.2 ± 2.2 | 30.3 ± 3.9 |
| 3a | 0.4 ± 0.01 | 0.6 ± 0.02 |
| 3b | 4.4 ± 0.3 | 7.4 ± 0.6 |
| 3c | 2.5 ± 0.1 | 0.9 ± 0.06 |
| 3d | 1.7 ± 0.02 | 1.3 ± 0.01 |
| 3e | 4.3 ± 0.3 | 5.2 ± 0.4 |
| 3f | 1.9 ± 0.08 | 1.5 ± 0.09 |
| 3g | 1.4 ± 0.06 | 3.2 ± 0.2 |
| 3h | 3.3 ± 0.3 | 5.4 ± 0.6 |
| 3i | 21.4 ± 3.3 | 23.2 ± 3.8 |
| 3j | 8.2 ± 1.2 | 8.1 ± 0.9 |
| 3k | 6.2 ± 0.7 | 9.3 ± 1.0 |
| 3l | 8.1 ± 1.0 | 7.6 ± 0.8 |
| 3m | 5.6 ± 1.1 | 5.5 ± 1.4 |
| 3n | 3.3 ± 0.6 | 3.8 ± 0.8 |
| TCP | >100 | >100 |
[a]
Data represent mean values of at least two separate experiments in duplicate.
[b]
Ref. [19], added for comparison.