Skip to main content
NCBI home page
Elsevier - PMC COVID-19 Collection logoLink to Elsevier - PMC COVID-19 Collection
. 2018 Nov 13;38(1):99–103. doi: 10.1016/S0034-5288(18)31855-1

Plasma enteroglucagon and neurotensin levels in gnotobiotic calves infected with enteropathogenic and non-enteropathogenic viruses

GA Hall *, KR Parsons *, JC Bridger *, MA Ghatei **, YC Ying **, SR Bloom **
PMCID: PMC7127511  PMID: 3919434

Abstract

Five gnotobiotic calves were each infected with five viruses. Each calf was inoculated with Coronavirus at seven days old, followed by astrovirus, Newbury agent, Parainfluenzavirus type 3 and rotavirus at intervals of two weeks. Three of the viruses were enteropathogenic (bovine Coronavirus, bovine calici-like virus and bovine rotavirus) and two were not (bovine astrovirus and Parainfluenzavirus type 3). Plasma levels of the peptide hormones enteroglucagon and neurotensin and faecal output were measured daily and xylose absorption was studied before and after each infection. A close correlation was found between a rise in plasma enteroglucagon and neurotensin and infection with enteropathogenic viruses. The three enteropathogenic viruses caused increased daily faecal output, and elevated plasma levels of enteroglucagon and neurotensin, while the non-enteropathogens did not. The calici-like virus and rotavirus but not the Coronavirus caused xylose malabsorption.

References

  • 1.Alvarado F. Experienlio. 1964;20:302–303. [Google Scholar]
  • 2.Blackburn A.M., Bloom S.R. Journal of Endocrinology. 1979;83:175–181. doi: 10.1677/joe.0.0830175. [DOI] [PubMed] [Google Scholar]
  • 3.Bloom S.R. In: Surgical Management of Obesity. Maxwell J.D., Gazet J.C., Pilkington T.R., editors. Academic Press; London: 1980. pp. 115–123. [Google Scholar]
  • 4.Bloom S.R. In: Hormones in Blood. Gray C.H., James V.H.T., editors. Academic Press; London: 1983. pp. 68–188. [Google Scholar]
  • 5.Bloom S.R., Besterman H.S., Welsby P.D., Chris-Tofides N.D., Sarson D.L. Gastroenterology. 1979;76:1102. [Google Scholar]
  • 6.Bloom S.R., Polak J.M. Scandinavia, Journal of Gastroenterology. 1982;Supplement 17, 74:93–103. [PubMed] [Google Scholar]
  • 7.Bridger J.C., Hall G.A., Brown J.F. Infection and Immunity. 1984;43:133–138. doi: 10.1128/iai.43.1.133-138.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Bridger J.C., Woode G.N., Meyling A. Veterinary Microbiology. 1978;3:101–113. [Google Scholar]
  • 9.Calam J., Unwin R., Peart W.S. Lancet. 1983;1:737–738. doi: 10.1016/s0140-6736(83)92028-7. [DOI] [PubMed] [Google Scholar]
  • 10.Dennis M.J., Davies D.C., Hoare M.N. British Veterinary Journal. 1976;132:642–646. doi: 10.1016/s0007-1935(17)34542-6. [DOI] [PubMed] [Google Scholar]
  • 11.Ferguson A., Snodgrass D.R. Acta Paediatrica. 1978;31:109. [Google Scholar]
  • 12.Ghatei M.A., Uttenthal L.O., Bryant M.G., Christofides N.D., Moody A.J., Bloom S.R. Endocrinology. 1983;112:917–923. doi: 10.1210/endo-112-3-917. [DOI] [PubMed] [Google Scholar]
  • 13.Ghatei M.A., Uttenthal L.O., Christofides N.D., Bryant M.G., Bloom S.R. Journal of Clinical Endocrinology and Metabolism. 1983;57:488–495. doi: 10.1210/jcem-57-3-488. [DOI] [PubMed] [Google Scholar]
  • 14.Hall G.A., Bridger J.C., Brooker B.E., Parsons K.R., Ormerod E. Veterinary Pathology. 1984;21:208–215. doi: 10.1177/030098588402100213. [DOI] [PubMed] [Google Scholar]
  • 15.Hall G.A., Parsons K.R., Batt R.M., Bunch K.J. Research in Veterinary Science. 1983;34:167–172. [PubMed] [Google Scholar]
  • 16.Hoare M.N., Davies D.C., Dennis M.J. British Veterinary Journal. 1976;132:369–373. doi: 10.1016/s0007-1935(17)34635-3. [DOI] [PubMed] [Google Scholar]
  • 17.Hunter W.M., Greenwood F.C. Nature. 1962;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
  • 18.Jorgensen K.H., Larsen U.D. Hormone and Metabolism Research. 1972;4:223–224. doi: 10.1055/s-0028-1097092. [DOI] [PubMed] [Google Scholar]
  • 19.Mebus C.A., Stair E.L., Rhodes M.B., Twiehaus M.J. Veterinary Pathology. 1973;10:45–64. doi: 10.1177/030098587301000105. [DOI] [PubMed] [Google Scholar]
  • 20.Probert M., Russell S.M. Journal of Clinical Microbiology. 1975;2:157–161. doi: 10.1128/jcm.2.3.157-161.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Roe J.H., Rice E.W. Journal of Biological Chemistry. 1948;173:507–512. [PubMed] [Google Scholar]
  • 22.Woode G.N., Bridger J.C. Journal of Medical Microbiology. 1978;11:441–452. doi: 10.1099/00222615-11-4-441. [DOI] [PubMed] [Google Scholar]
  • 23.Woode G.N., Bridger J.C., Hall G.A., Dennis M.J. Research in Veterinary Science. 1974;16:102–105. [PubMed] [Google Scholar]

Articles from Research in Veterinary Science are provided here courtesy of Elsevier

RESOURCES