Summary
In 1987, Pedersen et al. (1987) reported the isolation of a T-lymphotropic virus possessing thecharacteristics of a lentivirus from pet cats in Davis, California. From the first report onwards, it was evident that in causing an acquired immunodeficiency syndrome in cats, the virus was of substantial veterinary importance. It shares many physical and biochemical properties with human immunodeficiency virus (HIV), and was therefore named feline immunodeficiency virus (FIV). This article reviews recent knowledge of the aetiology, epidemiology, pathogenesis, clinical signs, diagnosis, prevention, and treatment options of FIV infection.
Keywords: FIV, feline immunodeficiency virus, feline acquired immunodeficiency syndrome
References
- Ackley C.D., Yamamoto J.K., Levy N., Pedersen N.C., Cooper M.D. Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus. Journal of Virology. 1990;64:5652–5655. doi: 10.1128/jvi.64.11.5652-5655.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ameisen J.C. Programmed cell death (apoptosis) and AIDS pathogenesis. Acquired Immune Deficiency Syndrome Research and Human Retrovinuses. 1994;10:3–5. [PubMed] [Google Scholar]
- Bandecchi P., Matteucci D., Baldinotti F. Prevalence of feline immunodeficiency virus and other retroviral infections in sick cats in Italy. Veterinary Immunology and Immunopathology. 1992;31:337–345. doi: 10.1016/0165-2427(92)90020-q. [DOI] [PubMed] [Google Scholar]
- Barlough J.E., Ackley C.D., George J.w. Acquired immune dysfunction in cats with experimentally induced feline immunodeficiency virus infection: comparison of short-term and long terminfections. Journal of the Acquired Immune Deficiency Syndrome. 1991;4:219–227. [PubMed] [Google Scholar]
- Beebe A.M., Dun N., Faith T.G., Moore P.F., Pedersen N.C., Dandekar S. Primary stage of feline immunodeficiency virus infection: viral dissemination and cellular targets. Journal of Virology. 1994;68:3080–3091. doi: 10.1128/jvi.68.5.3080-3091.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bishop S.A. Functional abnormalities in the human immune system of FIV- infected cats. In: Willett B.J., Jarrett O., editors. Feline Immunology and Immunodeficiency. Oxford University Press; New York: 1995. pp. 150–169. [Google Scholar]
- Bishop S.A., Gruffydd-Jones T.J., Harbour D.A., Stokes C.R. Programmed cell death (apoptosis) as a mechanism of cell death in peripheral blood mononuclear cells from cats infected with felineimmunodeficiency virus (FIV) Clinical Experimental Immunology. 1993;93:65–71. doi: 10.1111/j.1365-2249.1993.tb06498.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Braley J. FeLV and FIV. survey shows prevalence in the United States and Europe. Feline Practice. 1994;22:25–28. [Google Scholar]
- Brown E.W., Yuhki N., Packer C., O'Brien S.J. Lion lentivirus related to feline immunodeficiency virus: epidemiologic and phylogenetic aspects. Journal of Virology. 1994;68:5953–5968. doi: 10.1128/jvi.68.9.5953-5968.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown W.C., Bissey L., Logan K.S., Pedersen N.C., Elder J.H., Collisson E.W. Feline immunodeficiencv virus infects both CD4+ and CD8+ T lymphocytes. Journal of Virology. 1991;65:3359–3364. doi: 10.1128/jvi.65.6.3359-3364.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown W.C., Olmsted R.A., Martenson J.S., O'Brien S.J. Exposure to FIV and FIPV in wild and captive cheetahs. Zoology and Biolgoy. 1993;12:135–142. [Google Scholar]
- Brown P.J., Hopper C.D., Harbour D.A. Pathological features of lymphoid tissues in cats with natural feline immunodeficiencv virus infection. Journal of Comparative Pathology. 1991;104:345–355. doi: 10.1016/S0021-9975(08)80145-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brunner D., Pederse N.C. Infection of peritoneal macrophages in vitro and in vivo with feline immunodeficiency virus. Journal of Virology. 1989;63:5483–5488. doi: 10.1128/jvi.63.12.5483-5488.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burraco P., Guglielmino R., Abate O. Large granular lymphoma in FIV-positive and FIV-negative cats. Journal of Small Animal Practice. 1992;33:279–284. [Google Scholar]
- Gallanan J.J. Feline immunodeficiencv virus infection: a clinical and pathological perspective. In: Willett B.J., Jarrett O., editors. Feline Immunology and Immunodeficiency. University Press; Oxford New York: 1995. pp. 111–130. [Google Scholar]
- Callanan J.J., Hosie M.J., Jarrett O. Transmission of feline immunodeficiency virus from mother to kitten. Veterinary Record. 1991;128:332–333. doi: 10.1136/vr.128.14.332. [DOI] [PubMed] [Google Scholar]
- Callalan J.J., McGandlish I.A.P., O'Neil B. Lymphosarkoma in experimetnally induced feline immunodeficiency virus infection. Veterinary Record. 1992;130:293–295. doi: 10.1136/vr.130.14.293. [DOI] [PubMed] [Google Scholar]
- Callanan J.J., Racz P., Thompson H., Jarrett O. Animal models of HIV and other retroviral infections. Karger; Basel: 1993. Morphologic characterization of lymph node changes in feline immunodeficiency virus infection as an animal model of AIDS; pp. 115–136. [Google Scholar]
- Chalmers S., Schick R.O., Jeffers J. Demodicosis in two cats seropositive for feline immunodeficiency virus. Journal of the American Veterinary Medical Association. 1989;194:256–257. [PubMed] [Google Scholar]
- Clements J.E., Zink M.C. Molecular biology and pathogenesis of animal lentivirus infections. Clinical Microbiology Reviews. 1996;9:100–117. doi: 10.1128/cmr.9.1.100. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clerici M., Stocks N., Zajac R. Detection of three distinct patterns of T helper- cell dysfunction in asymptomatic, human immunodeficiencv viruspositive patients. Journal of Clinical Investigation. 1989;84:1892–1899. doi: 10.1172/JCI114376. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cohen N.D., Carter C.N., Thomas M.A., Lester T.L., Eugster A.K. Epizootiologic association between feline immunodeficiency virus infection and feline leukemia virus seropositivity. Journal of the American Veterinary Association. 1990;197:220–225. [PubMed] [Google Scholar]
- Courchamp F., Pontier D. Feline immunodeficiency virus: an epidemiological review. Comples rendus de l'Academie de Sciences Paris, Serie III. Sciences de la vie. 1994;317:1123–1134. [PubMed] [Google Scholar]
- Courchamp F., Pontier D., Langlais M., Artois M. Population dynamics of feline immunodeficiency virus within cat populations. Journal of Theoretical Biology. 1995;175:553–560. doi: 10.1006/jtbi.1995.0163. [DOI] [PubMed] [Google Scholar]
- Danave I.R., Tiffany-Castiglioni E., Zenger E., Barhoumi R., Burghardt R.C., Collisson E.W. Feline immunodeficiency virus decreases cell-communication and mitochondrial membrane potential. Journal of Virology. 1994;68:6745–6750. doi: 10.1128/jvi.68.10.6745-6750.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dandekar S., Beebe A.M., Barlough J. Detection Of feline immunodeficiency virus (FIV) nucleic acids in FIV-seronegative cats. Journal of Virology. 1992;66:4040–4049. doi: 10.1128/jvi.66.7.4040-4049.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dawson S., Smith N.R., Bennett M. Effect of primary-stage feline immunodeficiency virus on subsequent feline calicivirus vaccination and challenge in cats. AIDS. 1991;5:747–750. doi: 10.1097/00002030-199106000-00016. [DOI] [PubMed] [Google Scholar]
- Dean C.A., Reubel G.H., Moore P.F., Pedersen N.C. Proviral burden and inflection kinetics of feline immunodeficiency virus in lymphocyte subsets of blood end lymph-node. Journal of Virology. 1996;70:5165–5169. doi: 10.1128/jvi.70.8.5165-5169.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Delfierro G.M., Meers J., Thomas J., Chadwick B., Park H.S., Robinson W.F. Quantification of Iymphadenopathy in experimentally induced feline immunodeficiency virus infection in domestic cats. Veterinary Immunology and Immunopathology. 1995;46:3–12. doi: 10.1016/0165-2427(94)07001-n. [DOI] [PubMed] [Google Scholar]
- Diehl L.J., Mathiason-Dubard C.K., O'Neil L.L., Hoover E.A. Longitudinal assessment of feline immunodeficiency virus kinetics in plasma by use of a quantitative competitive reverse transcriptase PCR. Journal of Virology. 1995;69:2328–2332. doi: 10.1128/jvi.69.4.2328-2332.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dieth V., Lutz H., Hauser B., Ossent P. Pathologische Befunde bei mit Lentiviren infizierten Katzen. Schweizer Archiv für Tierheilkunde. 1989;131:19–25. [PubMed] [Google Scholar]
- Dow S.W., Poss M.L., Hoover E.A. Feline immunodeficiency virus: a neurotropic lentivirus. Journal of the Acquired Immune Deficiency Syndrome. 1990;3:658–668. [PubMed] [Google Scholar]
- Dua N., Reubel G., Higgins J., Pedersen N.C. The primary stage of experimentally-induced feline immunodeficiencv virus infection: clinical, hematologic, and virologic features. Veterinary Immunology and Immunopathology. 1994;43:337–355. doi: 10.1016/0165-2427(94)90156-2. [DOI] [PubMed] [Google Scholar]
- Egberink H.F. Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit to Utrecht. 1991. FIV infection: an animal model for AIDS. [Google Scholar]
- Egberink H.F., Borst M., Niphuis H. Vol. 87. 1990. Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl) adenine; pp. 3087–3091. (Proceedings of the National Academy of Science USA). [DOI] [PMC free article] [PubMed] [Google Scholar]
- Egberink H.F., Ederveen J., Montelaro R.C., Pedersen N.C., Horzinek M.C., Koolen M.J.M. Intracellular proteins of feline immunodeficiency virus and their antigenic relationship with equine infectious anaemia virus proteins. Journal of General Virology. 1990;71:739–743. doi: 10.1099/0022-1317-71-3-739. [DOI] [PubMed] [Google Scholar]
- Egberink H.F., Hartmann K., Horzinek M.C. Chemotherapy of feline immunodeficiency virus infection. Journal of the American Veterinary Medical Association. 1991;199:1485–1487. [PubMed] [Google Scholar]
- Egberink H.F., Lutz H., Horzinek M.C. Use of western blot and radioimmunoprecipitation for diagnosis of feline leukemia and feline immunodeficiency virus infections. Journal of the American Veterinary Medical Association. 1991;199:1839–1842. [PubMed] [Google Scholar]
- Egberink H.F., Keldermans C.E.J.M., Koolen M.J.M., Horzinek M.C. Humoral immune response to feline immunodeficiency virus in cats with experimentally induced and naturally acquired infections. American Journal of Veterinary Research. 1992;53:1133–1138. [PubMed] [Google Scholar]
- Elder J.H., Schölzer M., Hasselkus-Light C.S. Identification of proteolytic processing sites within the gag and pol polyproteins of feline immunodeficiency virus. Journal of Virology. 1993;67:1869–1876. doi: 10.1128/jvi.67.4.1869-1876.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
- English R.V., Tompkins M.B. Effect of FIV infection on the peripheral immune system. In: Willett B.J., Jarrett O., editors. Feline Immunology and Immunodeficiency. Oxford University Press; New York: 1995. pp. 131–149. [Google Scholar]
- English R.V., Davidson M.G., Nassise M.P., Tomkins W.A., Tomkins M.B. Intraocular disease associated with feline immunodeficiency vints infection in cats. Journal of the American Veterinary Medical Association. 1990;196:1116–1119. [PubMed] [Google Scholar]
- Ferrer L., Ramos J.A., Bonavia P., Cabanes J., Pumarola M. Cyrptococcosis in two cats seropositive for feline immunodeficiency virus. Veterinary Record. 1992;131:393–394. doi: 10.1136/vr.131.17.393. [DOI] [PubMed] [Google Scholar]
- Flynn J.N., Cannon C.A., Lawrence C.E., Jarrett O. Polyclonal B-cell activation in cats infected with feline immunodeficiency virus. Immunology. 1994;81:626–630. [PMC free article] [PubMed] [Google Scholar]
- Fraternale M., Rossi L., Silvotti L., Piedimonte G., Magnani M. Encapsulation of ddCTP in feline erythrocytes and inhibition of FIV infection. Advances in Bioscience. 1994;92:59–66. [Google Scholar]
- Friend S.C., Birch C.J., Lording P.M., Marshall J.A., Studdert M.J. Feline immunodeficiency virus: prevalence, disease associations and isolation. Australian Veterinary Journal. 1990;67:237–243. doi: 10.1111/j.1751-0813.1990.tb07776.x. [DOI] [PubMed] [Google Scholar]
- Furuya T., Kawaguchi Y., Miyazawa T. Existence of feline immunodeficiency virus infection in Japanese cat population since 1968. Japanese Journal of Veterinary Science. 1990;52:891–893. doi: 10.1292/jvms1939.52.891. [DOI] [PubMed] [Google Scholar]
- Geier S.A., Kuffer M., Hartmann K., Goebel F.D. FIV-related retinal microangiopathy in cats infected with the feline immunodeficiency virus?. Joint European Researcher Meetings in Ophthalmology and Vision; Montpellier Frankreich, 15–19 October 1994; 1994. p. 71. [Abstr.] [Google Scholar]
- George J.W., Pedersen N.C. Hematologic and lymphocyte subset changes during the first 11 months of infection with FIV: a study of 61 cats. First International Conference of Feline Immunodeficiencv Virus Researchers; Davis, USA. 4–7 September 1991; 1991. p. 21. [Abstr.] [Google Scholar]
- George J.W., Pedersen N.C., Higgins J. The effect of age on the course of experimental feline immunodeficiency virus infection in cats. Acquired Immunodeficiency Syndrome Research and Human Retroviruses. 1993;9:897–905. doi: 10.1089/aid.1993.9.897. [DOI] [PubMed] [Google Scholar]
- Goff S.P. Retroviral reverse transcriptase: synthesis, structure, and function. Journal of the Acquired Immune Deficiency Syndrome. 1990;3:817–831. [PubMed] [Google Scholar]
- Gothe R., Beelitz P., Schöl H., Beer B. Trichomonaden-Infektionen der Mundhöhle bei Katzen in Süddeutschland. Tierarzliche Praxis. 1992;20:195–198. [PubMed] [Google Scholar]
- Grant C.K. Immunoglobulin changes associated with feline immunodeficiency virus infection. In: Willett B.J., Jarrett O., editors. Feline Immunology and Immunodeficiency. Oxford University Press; New York: 1995. pp. 170–189. [Google Scholar]
- Grindem C.B., Corbett W.T., Ammerman B.E., Tompkins M.T. Seroepidemiologic survey of feline immunodeficiency virus infection in cats of Wake County, North Carolina. Journal of the American Veterinary Medical Association. 1989;194:226–228. [PubMed] [Google Scholar]
- Gruffydd-Jones T.J., Hopper C.D., Harbour D.A., Lutz H. Serological evidence of feline immunodeficiency virus infection in UK cats from 1975–76. Veterinary Record. 1989;123:569–570. doi: 10.1136/vr.123.22.569. [DOI] [PubMed] [Google Scholar]
- Gustina A. Molecular modeling of the structure of FIV protease. In: Takahashi K., editor. Asparlic porteinases: Structure, Function, Biology, and Biomedical Implications. Plenum Press; New York: 1995. pp. 479–484. [Google Scholar]
- Haase A.T. Pathogenesis of lentivirus infections. Nature. 1986;322:30–36. doi: 10.1038/322130a0. [DOI] [PubMed] [Google Scholar]
- Harbour D.A., Williams P.D., Gruffydd-Jones T.J., Burbridge J., Pearson G.R. Isolation of a T lymphotropic lentivirus from a persistently leukopenic domestic cat. Veterinary Record. 1988;122:84–86. doi: 10.1136/vr.122.4.84. [DOI] [PubMed] [Google Scholar]
- Hardy W.D., Jr, Zuckermann E.E. Comparison of Elisa, IFA and immunoblot tests for detection of feline immunodeficiency virus infection. First World Congress of Feline Immunodeficiency Researchers; Davis, USA, 4–7 September 1991; 1991. p. 56. [Abstr.] [Google Scholar]
- Hart S., Nolte I. Ergebnisse der Langzeitbehandlung spontan FIV- infizierter, kranker Katzen mit Zidovudin (Azidothymidin, AZT) Monatshefte-Veterinännedizin. 1993;48:223–231. [Google Scholar]
- Hart S., Nolte I. Hemostatic disorders in feline immunodeficiency virus-seropositive cats. Journal of Veterinary Internal Medicine. 1994;8:355–362. doi: 10.1111/j.1939-1676.1994.tb03250.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hartmann K. Habilitation med. vet.; 1995. Entwicklung eines Testsystems zur Erprobung neuer Medikamente gegen die FIV-Infektion der Katze als Modell für die Behandlung envorbener Immunschwächesyndrome. [Google Scholar]
- Hartmann K., Hinze K. Epidemiologie und Klinik der FIV-Infektion in Bayern. Tirrantliche Praxis. 1991;19:545–551. [PubMed] [Google Scholar]
- Hartmann K., Lutz H. Vorkommen von FIV-Infektionen im Einzugsbereich der Münchener Tierklinik. Tieräzlliche Praxis. 1989;5:81–83. [Google Scholar]
- Hartmann K., Donath A., Beer B. Use of two virustatica (AZT, PMEA) in the treatment of FIV and of FeLV seropositive cats with clinical symptoms. Veterinary Immunology and Immunopathology. 1992;35:167–175. doi: 10.1016/0165-2427(92)90129-e. [DOI] [PubMed] [Google Scholar]
- Hartmann K., Balzarini J., Higgins J., Deçlecq E., Pedersen N.C. In vitro activity of acyclic nucleoside phosphonate derivatives against feline , immunodeficiency virus in Crandell Feline Kidney cells andfeline blood lymphocytes. Antiviral Chemistry and Chemotherapy. 1994;5:13–19. [Google Scholar]
- Hartmann K., Kuffer M., Egberink H.F., Lutz H., Kraft W. Diagnostik der FIV-Infektion. Tieräzlliche Praxis. 1994;22:268–272. [PubMed] [Google Scholar]
- Hartmann K., Donath A., Kraft W. AZT in the treatment of feline immunodeficiency virus infection. part 1. Feline Practice. 1995;5:16–21. [Google Scholar]
- Hartmann K., Donath A., Kraft W. AZT in the treatment of feline immunodeficiency virus infection. part 2. Feline Practice. 1995;6:13–20. [Google Scholar]
- Hartmann K., Ferk G., North T.W., Pedersen N.C. Attempts to cure early feline immunodeficiency virus infection with mega dose 9-[2R,5 R2,5-dihydro 5- phosphonomethoxy) 2-furanyl] adenine therapy: toxicity and efficacy. Antiviral Research. 1997 doi: 10.1016/s0166-3542(97)00030-2. (in press) [DOI] [PubMed] [Google Scholar]
- Haseltine W.A. Molecular biology of the human immunodeficiency virus type 1. FASEB Journal. 1991;5:2349–2360. doi: 10.1096/fasebj.5.10.1829694. [DOI] [PubMed] [Google Scholar]
- Hayes K.A., Lafrado L.J., Erickson J.G., Marr J.M., Mathes L.E. Prophylactic ZDV therapy prevents early viremia and lymphocyte decline bitt not primary infection in feline immunodeficiency virus-inoculated cats. Journal of the Acquired Immunodeficiency Syndrome. 1993;6:127–134. [PubMed] [Google Scholar]
- Heidel J.R., Dubey J.P., Blythe L.L., Walker L.L., Duimstra J.R., Jordan J.S. Myelitis in a cat infected with Toxoplasma gondii and feline immunodeficiency virus. Journal of the American Veterinary Medical Association. 1990;196:316–318. [PubMed] [Google Scholar]
- Heider J. FIV-assoziierte Augenveränderungen der Katze [Abstr.]. 40. Jahrestagung Fachgruppe Kleintierkrankheiten der Deutschen Veterinärmediz-inischen Gesellschaft; Dresden, Deutschland, 15–18 September 1994; 1994. p. 26. [Google Scholar]
- Holznagel E., Hofmann-Lehmann R., Allenspach K., Hüttner S., Lutz H. Die Bedeutung der in vitro-induzierten Lymphozyten-Apoptose bei Katzen mit einer experimentellen Felinen Immunschäche Virus (FIV)-Infektion.. Jahrestagung der DVG, Fachgruppe Innere Medizin und Klinische Labordiagnostik; 2–5 March 1995; 1995. [Google Scholar]
- Hopper C.D., Sparkes A.H., Gruffydd-Jones T.J. Clinical and laboratory findings in cats infected with feline immunodeficiency virus. Veterinary Record. 1989;125:341–346. doi: 10.1136/vr.125.13.341. [DOI] [PubMed] [Google Scholar]
- Hopper C.D., Harbour D., Gruffydd-Jones T.J. Evidence of vertical transmission of FIV in experimentally and naturally infected cats. European Commission Concerted Action on Feline AIDS Workshop; Lucca, Italy, 18–21 June 1992; 1992. p. 17. [Abstr.] [Google Scholar]
- Hosie M.J. The development of a vaccine against feline immunodeficiency virus. British Veterinary Journal. 1995;150:25–39. doi: 10.1016/S0007-1935(05)80094-6. [DOI] [PubMed] [Google Scholar]
- Hosie M.J., Jarrett O. Serological responses of cats to feline immunodeficiency virus. AIDS. 1990;4:263–278. doi: 10.1097/00002030-199003000-00006. [DOI] [PubMed] [Google Scholar]
- Hosie M.J., Robertson C., Jarrett O. Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus in cats in the United Kingdom. Veterinary Record. 1989;128:293–297. doi: 10.1136/vr.125.11.293. [DOI] [PubMed] [Google Scholar]
- Hosie M.J., Sparres A., Hopper C. Feline immunodeficiency virus. Practice. 1989;11:87–95. [Google Scholar]
- Hurtrel M., Ganiere J.P., Guelfl J.F. Comparison of early and late feline immunodeficiency virus encephalopathies. AIDS. 1992;6:399–406. doi: 10.1097/00002030-199204000-00007. [DOI] [PubMed] [Google Scholar]
- Hutson C.A., Rideout B.A., Pedersen N.C. Neoplasia associated with feline immunodeficiency virus infection in cats of Southern California. Journal of the American Veterinary Medical Association. 1991;199:1357–1362. [PubMed] [Google Scholar]
- Ishida T., WashizU T., Toriyabe K., Motoyoshi S., Tomodo I., Pedersen N.C. Feline immunodeficiency virus infection in cats of Japan. Journal of the American Veterinary Merkreal Association. 1989;194:221–225. [PubMed] [Google Scholar]
- Ishida T., Taniguchi A., Konno A., Washizu T., Tomodo I. Clinical and immunolgical staging of feline immunodeficiency virus (FIV) infection. In: Schellekens H., Horzinek M.C., editors. Animal Models in AIDS. Elsevier; Amsterdam: 1990. pp. 189–199. [Google Scholar]
- Jarrett O., Pacitti A.M., Hosie M.J., Reid G. Comparison of diagnostic methods for feline leukemia virus and feline immunodeficiency virus. Journal of the American Veterinary Medical Association. 1991;199:1362–1364. [PubMed] [Google Scholar]
- Jordan H.L., Howard J., Tompkins W.A., Kennedy-Stoskopf S. Detection of feline immunodefi-ciency virus in semen from seropositive domestic cats (Felis ralus) Journal of Virology. 1995;69:7328–7333. doi: 10.1128/jvi.69.11.7328-7333.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kawaguchi Y., Miyazawa T., Tohya Y., Takahashi E., Mikami T. Quantification of feline immunodeficiency virus in a newly established feline T-lympphoblastoid cell line (MYA-1 cells) Archiv Virology. 1990;111:269–273. doi: 10.1007/BF01311061. [DOI] [PubMed] [Google Scholar]
- Kirstensen A.T., Petersen S.F., Hoff-Jorgsen R. Feline AIDS (FAIDS) og feline immunodeficiency virus (FIV) Dansk Veterinar Tidsskript. 1989;72:447–452. [Google Scholar]
- Knowles J.O., Gaskell R.M., Gaskell C.J., Harvey G.E., Lutz H. Prevalence of feline calicivinus, feline leukaemia virus and antibodies to FTV in cats with chronic stomatitis. Veterinary Record. 1989;124:336–338. doi: 10.1136/vr.124.13.336. [DOI] [PubMed] [Google Scholar]
- Kölbl S., Lutz H. Die Infektion mit felinern Spumavirus (FeSFV): Häufigkeit bei Katzen in Öster-reich und Beziehung zur Infektion mit dem felinenImmunschwächevirus (FIV) Kleintierpraxis. 1992;37:307–318. [Google Scholar]
- Kölbl S., Schuller W. Serologische Untersuchungen zum Vorkommen des Felinen Immundefizienzvirus (FIV) bei Katzen in tërreich. Wiener Tierärzlliche Monalsschrift. 1989;76:185–189. [Google Scholar]
- Koolen M., Egberink H.F. Feline immunodeficiency virus (FIV): a model for antiviral chemo-therapy. In: Schellekens H., Horizinek M.C., editors. Animal models in AIDS. Elsevier; Amsterdam: 1990. pp. 185–188. [Google Scholar]
- Kuffer M. Vergleichende Untersuchung über die Wirksamkeit der Medikamente 9-(2-Phosphonylmethoxyethyl)adenin (PMEA) und 9-(3-Fluoro -2-phosphonylmethoxypropyl) adenin (FPMPA) bei natürlich FIV infizierten Katzen. Dissertatio medicinae veterinariae. 1996 München. [Google Scholar]
- Lappin M.R., Marks A., Green C.E. Effect of feline immunodeficiency virus infection on toxoplasma gondii-specific humoral and cell-mediated immune responses of cats with serologicevidence of toxoplasmosis. Journal of Veterinary Internal Medicine. 1993;7:95–100. doi: 10.1111/j.1939-1676.1993.tb03176.x. [DOI] [PubMed] [Google Scholar]
- Lawrence C.E., Callanan B.J., Willett B.J., Jarrett O. Cytokine production by cats infected with feline immunodeficiency virus: a longitudinal study. Immunology. 1995;85:568–574. [PMC free article] [PubMed] [Google Scholar]
- Lehmann R., Vonbeusr B., Niederer E. Immunization-induced decrease of the CD4+ CD8+ ratio in cats experimentally infected with feline immunodeficiency virus. Veterinary Immunology and Immunopathology. 1992;35:199–214. doi: 10.1016/0165-2427(92)90132-a. [DOI] [PubMed] [Google Scholar]
- Lin D.S., Bowmann D.D., Jacobson R.H. Immunological changes in cats with concurrent toxoplasma gondii and feline immunodefiency virus infections. Journal of Clinical Microbiology. 1992;30:17–24. doi: 10.1128/jcm.30.1.17-24.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lombardi S., Garzselij C., Pistello M. A neutralizing antibody-induced peptide of the V3 domaine og feline immunodeficiency vines envelope glycoprotein does not induce protectiveimmunity. Journal of Virology. 1994;68:8374–8379. doi: 10.1128/jvi.68.12.8374-8379.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lutz H., Egberink H., Arnold P. Felines T-lymphotropes Lentivirus (FTLV): Experimentelle Infektion und Vorkommen in einigen Ländern Europas. Kleintierpraxis. 1988;33:445–492. [Google Scholar]
- Lutz H., Isenbügel E., Lehmann R., Sabapara R.H., Wolfensberger C. Retrovirus infections in non-domestic felides: serological studies and attempts to isolate a lentvirus. Veterinary Immunology and Immunopathology. 1992;35:215–224. doi: 10.1016/0165-2427(92)90133-b. [DOI] [PubMed] [Google Scholar]
- Magnani M., Rossi L., Fraternale A. Feline immunodeficiency virus infection of macrophages: in vitro and in vitro inhibition by dideoxycytidine-5′-triphosphate-loaded erythrocytes. AIDS Research and Human Retroviruses. 1994;19:1179–1186. doi: 10.1089/aid.1994.10.1179. [DOI] [PubMed] [Google Scholar]
- Maki N., Miyazawa T., Fukasawa M. Molecular characterization and heterogenity of feline immunodeficiency virus isolates. Archiv Virology. 1992;123:29–45. doi: 10.1007/BF01317136. [DOI] [PubMed] [Google Scholar]
- Mangianti N., Giannelli G., Bendinelli M., Poli A. Mycological findings in feline immunodeficiency virus-infected cats. Journal of Medical Veterinary Mycology. 1992;30:257–259. doi: 10.1080/02681219280000321. [DOI] [PubMed] [Google Scholar]
- Matsumara S., Ishida T., Washizu T., Tomoda I. Histopathology and viral antigen distribution in lymph nodes of cats naturally infected with feline immunodeficiency virus. Journal of Veterinary Medical Science USA. 1994;56:52–58. doi: 10.1292/jvms.56.523. [DOI] [PubMed] [Google Scholar]
- Medleau L. Recently described feline dermatoses. Veterinary Clinic of North America. Small Animal Practice. 1990;20:1615–1632. doi: 10.1016/s0195-5616(90)50164-3. [DOI] [PubMed] [Google Scholar]
- Meers J., Delfierro G.M., Cope R.B., Park H.S., Greene W.K., Robinson W.F. Feline immunodeficiency virus infection: plasma but not peripheral blood mononuclear cell virus titer is influenced by zidovudine and cyclosporine. Archiv Virology. 1993;132:67–81. doi: 10.1007/BF01309844. [DOI] [PubMed] [Google Scholar]
- Miyazawa T., Fukusawa M., Hasegawa A. Molecular cloning of a novel isolate of feline immunodeficiency virus biologically and genetically different from the original US isolate. Journal of Virology. 1991;65:1572–1577. doi: 10.1128/jvi.65.3.1572-1577.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moench T.R., Whaley K.J., Mandrell T.D., Bishop B.D., Witt C.J. The cat/feline immunodeficiency virus model for transmucosal transmission of AIDS: nonoxynol-9 contraceptive jelly blocks transmission by an infected cell inoculum. AIDS. 1993;7:797–802. doi: 10.1097/00002030-199306000-00006. [DOI] [PubMed] [Google Scholar]
- Moraillon A. Feline immunodepressive retrovirus infections in France. Veterinary Record. 1990;126:68–69. [PubMed] [Google Scholar]
- North T.W., Cronn R.C., Reinington K.M., Tandberg R.T., Judd R.C. Characterization of reverse transcriptase from feline immunodeficiency virus. Journal of Biological Chemistry. 1990;265:5121–5128. [PubMed] [Google Scholar]
- Neu H., Moennig V., Leidinger K., Bussian E. Erste Ergebnisse über die Verbreitung FIV (FTLV-) seropositiver Katzen in Deutschland and Interpretation der Ergebnisse. Der praktische Tierarzt. 1989;3:38–40. [Google Scholar]
- O'Connor T.P., Jr, Tanguay S., Steinman R. Development and evaluation of immunoassay for detection of antibodies to the feline T-lymphotropic lentivirus (feline immunodeficiency virus) Journal of Clinical Microbiology. 1989;27:474–479. doi: 10.1128/jcm.27.3.474-479.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Dair H.A., Hopper C.D., Gruffydd-Jones T.J., Harbour D.A., Waters L. Clinical aspects of Chlamydia psittari infection in cats infected with feline immunodeficiency virus. Veterinary Record. 1994;134:365–368. doi: 10.1136/vr.134.15.365. [DOI] [PubMed] [Google Scholar]
- O'Neil S.A., Burkhard M.J., Hoover E.A. Frequent perinatal transmission of feline immunodeficiency virus by chronically infected cats. Journal of Virology. 1996;70:2894–2901. doi: 10.1128/jvi.70.5.2894-2901.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Neil S.A., Lappin M.R., Reif J.S., Marks A., Greene G.E. Clinical and epidemiological aspects of feline immunodeficiency virus and Toxoplasma gondii coinfections in cats. Journal of the American Animal Hospital Assocation. 1991;27:211–220. [Google Scholar]
- Ohno K., Okamoto Y., Miyazawa T. Induction of apoptosis in a T lymphoblastoid cell line infected with feline immunodeficiency virus. Archiv Virology. 1994;135:153–158. doi: 10.1007/BF01309772. [DOI] [PubMed] [Google Scholar]
- Olmsted R.A., Barnes A.K., Yamamoto J.K., Hirsch V.M., Purchell R.H., Johnson P.R. Vol. 86. 1989. Molecular cloning of feline immunodeficiency virus; pp. 2448–2452. (Proceedings of the National Academy of Science USA). [DOI] [PMC free article] [PubMed] [Google Scholar]
- Olmsted R.A., Hirsch V.M., Purcell R.H., Johnson P.R. Vol. 86. 1989. Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses; pp. 8088–8092. (Proceedings of the National Academy of Science USA). [DOI] [PMC free article] [PubMed] [Google Scholar]
- Olmsted R.A., Langley R., Roelke M.E. Worldwide prevalence of lentivirus infection in wild feline species: epidemiologic and phylogenetic aspects. Journal of Virology. 1992;66:6008–6018. doi: 10.1128/jvi.66.10.6008-6018.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parodi A.L., Femenia F., Moraillon A., Crespeau F., Fontane J.J. Histopathological changes in lymph nodes of cats experimentally infected with the feline immunodeficiency virus. Journal of Comparative Pathology. 1994;111:165–174. doi: 10.1016/s0021-9975(05)80048-9. [DOI] [PubMed] [Google Scholar]
- Pedersen N.C., Barlough J.E. Clinical overview of feline immunodeficiency virus. Journal of the American Veterinary Medical Association. 1991;199:1298–1305. [PubMed] [Google Scholar]
- Pedersen N.C., Ho E.W., Brown M.L., Yamamoto J.K. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science. 1987;235:790–793. doi: 10.1126/science.3643650. [DOI] [PubMed] [Google Scholar]
- Pedersen N.C., Yamamoto J.K., Ishida T., Hansen H. Feline immunodeficiency virus infection. Veterinary Immunology and Immunopathology. 1989;21:111–129. doi: 10.1016/0165-2427(89)90134-7. [DOI] [PubMed] [Google Scholar]
- Pedersen N.C., Torten M. A review of feline immunodeficiency virus infection. Israel Journal of Veterinary Medicine. 1995;50:5–13. [Google Scholar]
- Pedersen N.C., Torten M., Rideout B. Feline leukemia virus infection as a potentiating cofactor for the primary and secondary stages of experimentally induced feline immunodeficiencyvirus infection. Journal of Virology. 1990;64:598–606. doi: 10.1128/jvi.64.2.598-606.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Phillips T.R., Prospero-Garcia O., Puaoi D.L. Neurological abnormalities associated with feline immunodeficiency virus infection. Journal of General Virology. 1994;75:979–987. doi: 10.1099/0022-1317-75-5-979. [DOI] [PubMed] [Google Scholar]
- Philpott M.S., Ebner J.P., Hoover E.A. Evaluation of 9-(2-phosphonylmethoxyethyl) adenine therapy for feline immunodeficiency virus using quantitative polymerase chain reaction. Veterinary Immunology and Immunopathology. 1992;35:155–166. doi: 10.1016/0165-2427(92)90128-d. [DOI] [PubMed] [Google Scholar]
- Podell M., Oglesbee M., Mathes L., Krakowka S., Olmsted R.A., Lafrado L. AIDS-associated encephalopathy with experimental feline immunodeficiency virus infection. Journal of Acquired Immune Deficiency Syndrome. 1993;6:758–771. [PubMed] [Google Scholar]
- Poli A., Abramo F., Taccini E. Renal involvement in feline immunodeficiency virus infection: a clinicopathological study. Nephron. 1993;64:282–288. doi: 10.1159/000187327. [DOI] [PubMed] [Google Scholar]
- Ramos-Vara J.A., Ferrer L., Visa J. Pathological findings in a cat with cryptococcosis and feline immunodeficiency virus infection. Histology and Histopathology. 1994;9:305–308. [PubMed] [Google Scholar]
- Reid G., Rigby M.A., McDonald M., Hosie M.J., Neil J.C., Jarrett O. Immunodiagnosis of feline immunodeficiency virus infection using recombinant viral p17 and p24. AIDS. 1991;5:1477–1483. doi: 10.1097/00002030-199112000-00010. [DOI] [PubMed] [Google Scholar]
- Reid R.W., Barr M.C., Scott F.W. Retrospective serological survey for the presence of feline immunodeficiency virus antibody: a comparison of ELSA and IFA techniques. Cornell Veterinary. 1992;82:359–369. [PubMed] [Google Scholar]
- Reinacher M. Pathology of FIV infection. Schweizer Archiv für Tierheilkunde. 1990;132:461–462. [Google Scholar]
- Reinacher M., Frese K. Untersuchungen zur Glomerulonephritis bei Hund und Katze. Tïerärztliche Praxis. 1991;19:175–180. [PubMed] [Google Scholar]
- Reinacher M., Holznagel E. Post mortem diagnosis of spontaneous FIV infection [Abstr.]. First World Congress of Feline Immunodeficiency Researchers; Davis, USA, 4–7 September 1991; 1991. p. 2. [Google Scholar]
- Remington K.M., Chesebro B., Wehrly K., Pedersen N.C., North T.W. Mutant of feline immunodeficiency virus resistant to 3′-Azido-3′-Deoxythymidine. Journal of Virology. 1991;65:308–312. doi: 10.1128/jvi.65.1.308-312.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reubel G.H., Dean G.A., George J.W., Barlough J.E., Pedersen N.C. Effects of incidental infections and immune activation on disease progression in experimentally feline immunodeficiency virus-infected cats. Journal of the Acquired Immune Deficiency Syndrome. 1994;7:1013–1015. [PubMed] [Google Scholar]
- Rideout B.A., Lowenstein L.J., Hutson C.A., Moore P.F., Pedersen N.C. Characterization of morphologic changes and lymphocyte subset distribution in lymph nodes from cats with naturally acquired feline immunodeficiencyvirus infection. Veterinary Pathology. 1992;29:391–399. doi: 10.1177/030098589202900504. [DOI] [PubMed] [Google Scholar]
- Rimmelzwaan G.F., Siebelink K.H.J., Broos H. Gag- and env-specific antibodies in cats after natural and experimental infection with feline immunodeficiency virus. Veterinary Microbiology. 1994;39:153–165. doi: 10.1016/0378-1135(94)90096-5. [DOI] [PubMed] [Google Scholar]
- Robinson W.F., Shaw S.E., Alexander R., Robertson J. Feline immunodeficiency virus. Australian Veterinary Journal. 1990;67:278–280. doi: 10.1111/j.1751-0813.1990.tb07796.x. [DOI] [PubMed] [Google Scholar]
- Rodgers S.J., Baldwin C.A. A serologic survey of Oklahoma cats for antibodies to feline immunodeficiency virus, coronavirus, toxoplasma gondii and for antigen to felineleukemia virus. Journal of Veterniary Diagnostic Investigation. 1990;2:180–188. doi: 10.1177/104063879000200305. [DOI] [PubMed] [Google Scholar]
- Sabine M., Michelsen J., Thomas F., Zheng M. Feline AIDS. Australian Veterinary Practice. 1988;18:105–107. [Google Scholar]
- Sellon R.K., Jordan H.L., Kennedy-Stoskopf S., Tompkins M.B., Tompkins W.F. Feline immunodeficiency virus can be experimentally transmitted via milk during acute maternal infection. Journal of Virology. 1994;68:3380–3385. doi: 10.1128/jvi.68.5.3380-3385.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shelton G.H., McKim K.D., Cooley P.L., Dice P.F., Russel R.G., Grant C.K. Feline leukemia virus and feline immunodeficiency virus infection in a cat with lymphoma. Journal of the American Veterinary Aledinal Association. 1989;194:249–252. [PubMed] [Google Scholar]
- Shelton G.H., Waltzer R.M., Gotter S.C., Grant C.K. Prevalence of feline immunodeficiency virus and feline leukemia virus infections in pet cats. Journal of the American Veterinary Medical Association. 1989;25:7–12. [Google Scholar]
- Shelton G.H., Grant C.K., Cotter S.M., Gardner M.B., Hardy W.D., Jr, Giacomo R.F.D.L. Feline immunodeficiency virus and feline leukemia virus infections and their relationships to lymphoid malignancies in cats: a retrospective study (1968–1988) Journal of the Acquired Immune Deficiency Syndrome. 1990;3:623–630. [PubMed] [Google Scholar]
- Shelton G.H., Linenberger M.L., Abrokwitz J.L. Hematologic abnormalities in cats seropositive for feline immunodeficiency virus. Journal of the American Veterinary Medical Association. 1991;199:1353–1357. [PubMed] [Google Scholar]
- Siebelink K.H.J., Huisman W., Karlas J.A., Rimmel zwaan G.F., Bosch M.L., Osterhaus A.D.M.E. Neutralization of feline immunodeficiency virus by polyclonal feline antibody: simultaneous involvement of hypervariable regions 4 and 5 of thesurface glycoprotein. Journal of Virology. 1995;69:5124–5127. doi: 10.1128/jvi.69.8.5124-5127.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith J.L., Allen S.J.W., Cherrington J.M. A rapid antiviral in situ enzyme-linked immunosorbent assay for feline immunodeficiency virus. Journal of Virological Methods. 1995;54:29–38. doi: 10.1016/0166-0934(95)00023-n. [DOI] [PubMed] [Google Scholar]
- Smyth N.R., Bennet M., Gaskell R.M., McCracken C.M., Hart C.A., Howe J.L. Effect of 3′acido-2′,3−dideoxythy midine (AZT) on experimental feline immunodeficiency virus infection 08789opuip-4in domestic cats. Research in Veterinary Science. 1994;57:220–224. doi: 10.1016/0034-5288(94)90061-2. [DOI] [PubMed] [Google Scholar]
- Smyth N.R., McCracken C., Gaskell R.M., Cameron J.M., Coates J.A.V., Gaskell C.J., Hart C.A., Bennett M. Susceptibility to cell culture of feline immunodeficiency virus to eighteen antiviral agents. Journal of Antimicrobial Chemotherapy. 1994;34:589–594. doi: 10.1093/jac/34.4.589. [DOI] [PubMed] [Google Scholar]
- Sparkes A.H., Hopper C.D., Miliard W.G., Gruffydd-Jones T.J., Harbour D.A. Feline immunodeficiency virus infection clinicopathologic findings in 90 naturally occuring cases. Journal of Veterinary Internal Medicine. 1993;7:85–90. doi: 10.1111/j.1939-1676.1993.tb03174.x. [DOI] [PubMed] [Google Scholar]
- Steinman R., Dombrowski J., O'Connor T. Biochemical and immunological characterization of the major structural proteins of feline immunodeficiency virus. Journal of General Virology. 1990;71:701–706. doi: 10.1099/0022-1317-71-3-701. [DOI] [PubMed] [Google Scholar]
- Swinney G.R., Pauli J.V., Jones B.R., Wilks C.R. Feline T-lymphotropic virus (FTLV) (feline immunodeficiency virus) in cats in New Zealand. New Zealand Velerinary Journal. 1989;37:41–43. doi: 10.1080/00480169.1989.35552. [DOI] [PubMed] [Google Scholar]
- Talbott R.L., Sparger E.E., Lovelace K.M. Vol. 86. 1989. Nucleotide sequence and genomic organization of feline immunodeficiency virus; pp. 5743–5747. (Proceedings of the National Academy of Science USA). [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tanabe-Tochikura A., Tochikura T.S., Blakeslee J.R., Olsen R.G., Mathes L.E. Anti-human immunodeficiency virus (HIV) agents are also potent and selective inhibitors of feline immunodeficiency virus (FIV)-induced cytopathiceffects: development of a new method for screening of anti-FIV substances in vitro. Antiviral Research. 1992;19:161–172. doi: 10.1016/0166-3542(92)90075-g. [DOI] [PubMed] [Google Scholar]
- Tenorio A.P., Franti C.E., Madewell B.R., Pedersen N.C. Chronic oral infections of cats and their relationship to persistent oral carriage of feline calici-, immunodeficiency, or leukemia viruses. Veterinary Immunology and Immunopathology. 1991;29:1–14. doi: 10.1016/0165-2427(91)90048-h. [DOI] [PubMed] [Google Scholar]
- Terry A., Callanan J.J., Fulton R., Jarrett O., Neil J. Molecular analysis of tumours from feline immunodeficiency (FIV)-infected cats: an indirect role for FIV? International Journal of Cancer. 1995;61:227–232. doi: 10.1002/ijc.2910610215. [DOI] [PubMed] [Google Scholar]
- Thomas J.B., Robinson W.F., Chadwick B.J., Robertson I.D., Jones P.S. Leukogram and biochemical abnormalities in naturally occurring feline immunodeficiency virus infection. Journal of the American Animal Hospital Association. 1993;29:272–278. [Google Scholar]
- Torten M., Franchini M., Barlough J.E. Progressive immune dysfunction in cats experimentally infected with feline immunodeficiency virus. Journal of Virology. 1991;65:2225–2230. doi: 10.1128/jvi.65.5.2225-2230.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ueland K.L., Lutz H. Prevalence of feline leukemia virus and antibodies to feline immunodeficiency virus in cats in Norway. Zentralblatt Veterinärinedizin (B) 1992;39:53–58. doi: 10.1111/j.1439-0450.1992.tb01137.x. [DOI] [PubMed] [Google Scholar]
- Vahlenkamp T., DeRonde A., Balzarini J. (R) -9- (2-Phosphonylmethoxypropyl) -2,6-diaminopurine is a potent inhibitor of feline immuno deficiency virus infection. Antimicrobial Agents and Chemotherapy. 1995;39:746–749. doi: 10.1128/AAC.39.3.746. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vahlenkamp T., Timmermans I., DeRonde A., Horzinek M.C., Egberink H.F. Macrophage tropism of FIV: sequences of the surface envelope protein involved [Abstr.]. 3. International Symposium Feline Retrovirus Research; Fort Collins, Colorado, USA, 6–9 March 1996; 1996. p. 11. [Google Scholar]
- Verschoor E.J., Boven L.A., Blaak H., VanVilet A.L.W., Horzinek M.C., DeRonde A. A single mutation within the V3 envelope neutralization domain of feline immunodeficiency virus determines its tropism for CrFK cells. Journal of Virology. 1995;69:4752–4757. doi: 10.1128/jvi.69.8.4752-4757.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Walker C., Malik R., Canfield P.J. Analysis of leucocytes and lymphocyte subsets in cats with naturally-occurring cryptococcosis but differing feline immunodeficiency virus status. Australian Veterinary Journal. 1995;72:93–97. doi: 10.1111/j.1751-0813.1995.tb15017.x. [DOI] [PubMed] [Google Scholar]
- Wasmoen T., Armiger-Luhman S., Egan C. Transmission of feline immunodeficiency virus from infected queens to kittens. Veterinary Immunology and Immunopathology. 1992;35:83–93. doi: 10.1016/0165-2427(92)90123-8. [DOI] [PubMed] [Google Scholar]
- Waters L., Hopper C.D., Gruffydd-Jones T.J., Harbour D.A. Chronic gingivitis in a colony of cats infected with feline immunodeficiency virus and feline calicivirus. Veterinary Record. 1993;132:340–342. doi: 10.1136/vr.132.14.340. [DOI] [PubMed] [Google Scholar]
- Weimer R., Schweighoffer T., Schmipf K., Opelz G. Helper and suppressor T-cell function in HIV infected hemophilia patients. Blood. 1989;74:298–302. [PubMed] [Google Scholar]
- Wheeler D.W., Mitchell T.W., Gasper P.W., Barr M.C., Whalen L.R. FIV infection associated with neurologic abnormalities [Abstr.]. First International Conference of Feline Immunodeficiency Virus Researchers; Davis, USA, 4–7 September 1991; 1991. p. 31. [Google Scholar]
- Whilhem N. Vergleichende Untersuchung zum therapeutischen Einsatz won (R)A-(2-Phosphonylmethoxypropyl)-2,6-diaminopurin (PMPDAP) and Melittin bei natürlich FIV-infizierten Katzen. Dissertatio medicinae veterinariae. 1996 München. [Google Scholar]
- Willett B.J., Hosie M.J., Jarrett O., Neil J.N. Identification of a putative cellular receptor for feline immunodeficiency virus as the feline homolgue of CD9. Immunology. 1994;81:228–233. [PMC free article] [PubMed] [Google Scholar]
- Willett B.J., Flynn N., Hosie J.M. FIV infection of the domestic cat: an animal model for AIDS. Immunology Today. 1997;18:182–189. doi: 10.1016/s0167-5699(97)84665-8. [DOI] [PubMed] [Google Scholar]
- Witt C.J., Moench T.R., Gittelsohn A.M., Bishop B.D., Chid J.E. Epidemiologic observations on feline immunodeficiency virus and toxoplasma gondii coinfection in cats in Baltimore, MD. Journal of the American Veterinary Medical Association. 1989;194:229–233. [PubMed] [Google Scholar]
- Yamamoto J.K., Sparger E., Ho E.W. Pathogenesis of experimentally induced feline immunodeficiency virus infection in cats. American Journal of Veterinary Research. 1988;49:1246–1258. [PubMed] [Google Scholar]
- Yamamoto J.K., Hansen H., Ho E.W. Epidemiologic and clinical aspects of feline immunodeficiency virus infection in cats from the continental United States and Canada and possible mode of transmission. Journal of the American Veterinary Medical Association. 1989;194:213–220. [PubMed] [Google Scholar]
- Zenger E., Brown W.C., Song W. Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection. American Journal of Veterinary Research. 1993;54:713–718. [PubMed] [Google Scholar]
- Zetner K., Kampfer P., Lutz H., Harvey C. Vergleichende immunologische und virologische Untersuchungen von Katzen mit chronischen oralen Erkrankungen. Wiener Tierärztliche Monatschrift. 1989;76:303–308. [Google Scholar]