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. 1999 Sep 22;2(4):398–402. doi: 10.1016/S1369-5274(99)80070-8

Viral-induced neurodegenerative disease

Michael J Buchmeier *, Thomas E Lane †
PMCID: PMC7128805  PMID: 10458992

Abstract

Viral etiology has been postulated in a variety of neurological diseases in humans, including multiple sclerosis. Several experimental animal models of viral-induced neurodegenerative disease provide insight into potential host- and pathogen-dependent mechanisms involved in the disease process. Two such mouse models are the Theiler's murine encephalomyelitis virus (TMEV) infection and mouse hepatitis virus (MHV) infection.

Abbreviations: AG, aminoguanidine; CNS, central nervous system; EAE, experimental allergic encephalomyelitis; IFN, interferon; IL, interleukin; MCP-1, monocyte chemoattractant protein-1; MHV, mouse hepatitis virus; MS, multiple sclerosis; NO, nitric oxide; NOS, NO synthase; TMEV, Theiler's murine encephalomyelitis virus; TNF, tumor necrosis factor

Contributor Information

Michael J Buchmeier, Email: buchm@scripps.edu.

Thomas E Lane, Email: tlane@uci.edu.

References and recommended reading

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