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. 2014 Oct 27;12(5):401–408. doi: 10.1016/S2095-4964(14)60039-X

Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities

Chang-qing Zhao a,b,c,d,e, Yang Zhou a,b,c,d,e, Jian Ping b,c,d,e, Lie-ming Xu a,b,c,d,e,*
PMCID: PMC7128864  PMID: 25292339

Abstract

Traditional Chinese medicine (TCM) is commonly used in treating liver diseases worldwide, especially in China. The advantages of using TCM for treatment of liver diseases include: protecting hepatocytes, inhibiting hepatic inflammation and antifibrosis in the liver. In this article, we introduce TCM herbal preparations from the Chinese materia medica (such as Fuzheng Huayu) that are typically used for the treatment of liver diseases. Literature surrounding the mechanisms of TCM therapy for treatment of liver diseases is presented and discussed. We propose that side effects of herbal compounds are often under-appreciated, and that more care should be taken in the prescription of potentially hepatotoxic medicines. Further, to deepen the understanding of TCM mechanisms, new techniques and methodologies must be developed. Future studies will lead to the enhancement of clinical outcomes of TCM. As complementary and alternative therapies, TCMs will play an expanding role in the future of liver disease treatment.

Keywords: medicine, Chinese traditional; drugs, Chinese herbal; liver diseases (TCM); liver cirrhosis; hepatoprotective drugs; hepatotoxicity; reviews

Zhao CQ, Zhou Y, Ping J, Xu LM. Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities

References

  • 1.Liu BY, He LY, Liang ZW, Tong XY, Hu JQ, Jiao Q, Ni Q, Liu XM, Xie YM, Li P, Gao FZ, Wen TC, Liu WM. Effect of glucocorticoid with traditional Chinese medicine in severe acute aespiratory syndrome (SARS) Zhongguo Zhong Yao Za Zhi. 2005;30(23):1874–1877. Chinese with abstract in English. [PubMed] [Google Scholar]
  • 2.Wang E, Bussom S, Chen JG, Quinn C, Bedognetti D, Lam W, Guan F, Jiang ZL, Mark Y, Zhao YD, Stroncek DF, White J, Marincola FM, Cheng YC. Interaction of a traditional Chinese medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment. BMC Med Genomics. 2011;4:38. doi: 10.1186/1755-8794-4-38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Miller LH, Su XZ. Artemisinin: discovery from the Chinese herbal garden. Cell. 2011;146(6):855–858. doi: 10.1016/j.cell.2011.08.024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Ashour ML, El-Readi MZ, Hamoud R, Eid SY, El Ahmady SH, Nibret E, Herrmann F, Youns M, Tahrani A, Kaufmann D, Wink M. Anti-infective and cytotoxic properties of Bupleurum marginatum. Chin Med. 2014;9(1):4. doi: 10.1186/1749-8546-9-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Zhang W, Gao K, Liu J, Zhao H, Wang J, Li Y, Murtaza G, Chen J, Wang W. A review of the pharmacological mechanism of traditional Chinese medicine in the intervention of coronary heart disease and stroke. Afr J Tradit Complement Altern Med. 2013;10(6):532–537. doi: 10.4314/ajtcam.v10i6.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Zhou YX, Zhang H, Peng C. Puerarin: a review of pharmacological effects. Phytother Res. 2014;28(7):961–975. doi: 10.1002/ptr.5083. [DOI] [PubMed] [Google Scholar]
  • 7.Luo J, Xu H, Chen KJ. Potential benefits of Chinese herbal medicine for elderly patients with cardiovascular diseases. J Geriatr Cardiol. 2013;10(4):305–309. doi: 10.3969/j.issn.1671-5411.2013.04.001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Wang Y, Li C, Liu Z, Shi T, Wang Q, Li D, Wu Y, Han J, Guo S, Tang B, Wang W. Danqi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4. BMC Complement Altern Med. 2014;14:67. doi: 10.1186/1472-6882-14-67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Liu YF, Li N, Jia ZH, Lu F, Pu JL. Chinese medicine Shensongyangxin is effective for patients with bradycardia: results of a randomized, double-blind, placebo-controlled multicenter trial. Evid Based Complement Alternat Med. 2014;2014:605714. doi: 10.1155/2014/605714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Chen Y, Fu DY, Chen Y, He YM, Fu XD, Xu YQ, Liu Y, Feng XT, Zhang T, Wang WJ. Effects of Chinese herbal medicine Yiqi Huaju Formula on hypertensive patients with metabolic syndrome: a randomized, placebo-controlled trial. J Integr Med. 2013;11(3):184–194. doi: 10.3736/jintegrmed2013031. [DOI] [PubMed] [Google Scholar]
  • 11.Chiu HE, Hong YC, Chang KC, Shih CC, Hung JW, Liu CW, Tan TY, Huang CC. Favorable circulatory system outcomes as adjuvant traditional Chinese medicine (TCM) treatment for cerebrovascular diseases in Taiwan. PLoS One. 2014;9(1):e86351. doi: 10.1371/journal.pone.0086351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Li J, Yu X, Li S, Wang H, Bai Y, Wang M, Sun Z, Zhang W, Zhou Z, Jia X, Zhou Q. Randomized controlled multicenter clinical trial for integrated treatment of community-acquired pneumonia based on traditional Chinese medicine syndrome differentiation. J Tradit Chin Med. 2012;32(4):554–560. doi: 10.1016/s0254-6272(13)60070-9. [DOI] [PubMed] [Google Scholar]
  • 13.Xu S, Tian BP, Zhang LH, Hua W, Xia LX, Chen ZH, Li W, Shen HH. Prevention of allergic airway hyperresponsiveness and remodeling in mice by Astragaliradix antiasthmatic decoction. BMC Complement Altern Med. 2013;13:369. doi: 10.1186/1472-6882-13-369. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Srivastava K, Sampson HA, Emala CW, Sr, Li XM. The anti-asthma herbal medicine ASHMI acutely inhibits airway smooth muscle contraction via prostaglandin E2 activation of EP2/EP4 receptors. Am J Physiol Lung Cell Mol Physiol. 2013;305(12):1002–1010. doi: 10.1152/ajplung.00423.2012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Hu LJ, Hu XM, Yang M, Xie HM, Xiang YH. Clinical effects of the method for warming the middle-jiao and strengthening the spleen on gastric mucosa repair in chronic gastritis patients. J Tradit Chin Med. 2008;28(3):189–192. doi: 10.1016/s0254-6272(08)60044-8. [DOI] [PubMed] [Google Scholar]
  • 16.Wan MH, Li J, Huang W, Mukherjee R, Gong HL, Xia Q, Zhu L, Cheng GL, Tang WF. Modified Da-Cheng-Qi Decoction reduces intra-abdominal hypertension in severe acute pancreatitis: a pilot study. Chin Med J (Engl) 2012;125(11):1941–1944. [PubMed] [Google Scholar]
  • 17.Wang YJ, He LQ, Sun W, Lu Y, Wang XQ, Zhang PQ, Wei LB, Cao SL, Yang NZ, Ma HZ, Gao J, Li P, Tao XJ, Yuan FH, Li J, Yao C, Liu X. Optimized project of traditional Chinese medicine in treating chronic kidney disease stage 3: a multicenter double-blinded randomized controlled trial. J Ethnopharmacol. 2012;139(3):757–764. doi: 10.1016/j.jep.2011.12.009. [DOI] [PubMed] [Google Scholar]
  • 18.Chen YP, Deng YY, Ni ZH, Chen N, Chen XM, Shi W, Zhan YL, Yuan FH, Deng W, Zhong YF. Efficacy and safety of traditional Chinese medicine (Shenqi particle) for patients with idiopathic membranous nephropathy: a multicenter randomized controlled clinical trial. Am J Kidney Dis. 2013;62(6):1068–1076. doi: 10.1053/j.ajkd.2013.05.005. [DOI] [PubMed] [Google Scholar]
  • 19.Chen YZ, Gong ZX, Chen XM, Tang L, Zhao XZ, Yuan Q, Cai GY. Tripterygium wilfordii Hook F (a traditional Chinese medicine) for primary nephrotic syndrome. Cochrane Database Syst Rev. 2013;11:8. doi: 10.1002/14651858.CD008568.pub2. [DOI] [PubMed] [Google Scholar]
  • 20.Pang BZ, Pang QQ, Pang HQ, Song GH. Clinical effect of Jiutengzhuyu tablets on promoting blood circulation in women with oviducal obstruction. J Tradit Chin Med. 2012;32(4):549–553. doi: 10.1016/s0254-6272(13)60069-2. [DOI] [PubMed] [Google Scholar]
  • 21.Liu SX, Jiang L, Liu YG, He YQ, Liang X, Kong WW, Chen J. Study on the efficacy and safety of Xueyou Mixture in treating hemophilia. Chin J Integr Med. 2007;13(2):141–144. doi: 10.1007/s11655-007-0141-6. [DOI] [PubMed] [Google Scholar]
  • 22.Rufus P, Mohamed N, Shuid AN. Beneficial effects of traditional Chinese medicine on the treatment of osteoporosis on ovariectomised rat models. Curr Drug Targets. 2013;14(14):1689–1693. doi: 10.2174/1389450114666131220160357. [DOI] [PubMed] [Google Scholar]
  • 23.Zheng ZX, Wang J, Hou JS, Ma L, Jiang CB. A traditional Chinese medicine therapy warming meridians to nourish blood in treating chronic pain due to soft tissue injury of the neck and shoulder: a randomized controlled trial. J Chin Integr Med. 2011;9(2):153–157. doi: 10.3736/jcim20110207. Chinese with abstract in English. [DOI] [PubMed] [Google Scholar]
  • 24.Okada K, Ishimoto S, Fujimaki Y, Yamasoba T. Trial of Chinese medicine Wu-Ling-San for acute low-tone hearing loss. ORL J Otorhinolaryngol Relat Spec. 2012;74(3):158–163. doi: 10.1159/000337819. [DOI] [PubMed] [Google Scholar]
  • 25.Guo H, Liu MP. Mechanism of traditional Chinese medicine in the treatment of allergic rhinitis. Chin Med J (Engl) 2013;26(4):756–760. [PubMed] [Google Scholar]
  • 26.Lin YH, Chen YC, Hu S, Chen HY, Chen JL, Yang SH. Identifying core herbal treatments for urticaria using Taiwan's nationwide prescription database. J Ethnopharmacol. 2013;48(2):556–562. doi: 10.1016/j.jep.2013.04.052. [DOI] [PubMed] [Google Scholar]
  • 27.Shinno H, Inami Y, Inagaki T, Nakamura Y, Horiguchi J. Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(3):881–885. doi: 10.1016/j.pnpbp.2007.12.027. [DOI] [PubMed] [Google Scholar]
  • 28.Zhai XF, Chen Z, Li B, Shen F, Fan J, Zhou WP, Yang YK, Xu J, Qin X, Li LQ, Ling CQ. Traditional herbal medicine in preventing recurrence after resection of small hepatocellular carcinoma: a multicenter randomized controlled trial. J Integr Med. 2013;11(2):90–100. doi: 10.3736/jintegrmed2013021. [DOI] [PubMed] [Google Scholar]
  • 29.Tian HQ, Li HL, Wang B, Liang GW, Huang XQ, Huang ZQ, Lang JM, Zhang YP, Chen XZ, Chen YS. Treatment of middle/late stage primary hepatic carcinoma by Chinese medicine comprehensive therapy: a prospective randomized controlled study. Chin J Integr Med. 2010;16(2):102–108. doi: 10.1007/s11655-010-0102-3. [DOI] [PubMed] [Google Scholar]
  • 30.Ren H, Cheng L. Clinical observation on the treatment of middle-late stage liver carcinoma by combined therapy of hepato-arterial chemo-embolising and Chinese drugs for strengthening pi and regulating qi. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004;24(9):838–840. Chinese with abstract in English. [PubMed] [Google Scholar]
  • 31.Xu LM, Hu YY. Studies on treatment of fatty liver with traditional Chinese medicine. J Chin Integr Med. 2003;1(2):138–141. doi: 10.3736/jcim20030216. Chinese with abstract in English. [DOI] [PubMed] [Google Scholar]
  • 32.Ge XQ. Experience of treatment for posthepatitic cirrhosis based on TCM syndrome differentiation. Zhongguo Shi Yong Yi Yao. 2008;3(26):160–161. Chinese. [Google Scholar]
  • 33.Mi YQ, Cao WK, Xu L, Zhen SW, Pan ZH, Ping L, Zhang H, Dong HJ, Shi G. Clinical study on effect of Jiangan Jiangzhi Pill in treating nonalcoholic fatty liver diseases. Liaoning Zhong Yi Za Zhi. 2010;37(1):97–100. Chinese. [Google Scholar]
  • 34.Niu LX. Effects of Baogan Lishui decoction on patients with ascites due to cirrhosis: a report of 84 cases. Guang Ming Zhong Yi. 2010;25(5):808–809. Chinese. [Google Scholar]
  • 35.Jiang CY, Wang BE, Chen D, Wang JC. Protective effect of compound Tongfu Granule on intestinal barrier in patients with cirrhosis of decompensation stage. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008;28(9):784–787. Chinese with abstract in English. [PubMed] [Google Scholar]
  • 36.Shi ZL, Chen ZY, Yan MX, He BH, Hong Y. Effects of method of regulating qi to dissipate blood stasis and phlegm with Chinese herbs on expression of SREBP-1c/FAS in rats liver tissue with non-alcoholic steatohepatitis. Zhonghua Zhong Yi Yao Xue Kan. 2013;31(5):1062–1065. Chinese with abstract in English. [Google Scholar]
  • 37.Hu XY, Zhang Y, Chen S, Fan XJ. A prospective cohort study on the influence of high doses of herbs for clearing heat and resolving stasis on survival rates in patients with hepatitis B-related acute-on-chronic liver failure. J Chin Integr Med. 2012;10(2):176–185. doi: 10.3736/jcim20120208. Chinese with abstract in English. [DOI] [PubMed] [Google Scholar]
  • 38.Wang XJ, Shen Y, Yang L, Liu L, Li B, Zhang LY, Zhou GQ, Yang YY, Sun FX. Clinical observation of clearing heat and removing dampness, cooling blood and detoxicating therapy for acute on chronic liver failure in hepatitis B. Beijing Zhong Yi Yao. 2013;32(3):204–207. Chinese with abstract in English. [Google Scholar]
  • 39.Zhang L, Wang G, Hou W, Li P, Dulin A, Bonkovsky HL. Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review. Hepatology. 2010;51(2):690–698. doi: 10.1002/hep.23384. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 40.Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet. 2014;383(9930):1749–1761. doi: 10.1016/S0140-6736(14)60121-5. [DOI] [PubMed] [Google Scholar]
  • 41.Brunner H. Procollagen III levels in serum: do they provide additional information in liver disease? In: Brunner H, Thalar H, editors. Hepatology: a festschrift for Hans Popper. Falk Symposium. Raven Press; New York: 1984. p. 251. [Google Scholar]
  • 42.Friedman SL, Bansal MB. Reversal of hepatic fibrosis — fact or fantasy? Hepatology. 2006;43(2 Suppl 1):S82–S88. doi: 10.1002/hep.20974. [DOI] [PubMed] [Google Scholar]
  • 43.Liu P, Liu C, Chen GC, Hu YY, Xu LM, Lü P, Yang JL, Yan RM, Ji Q, Chu F. Effect of Fuzheng Huayu 319 Recipe on serological parameters of fibrosis in treating chronic hepatitis B. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996;16(10):588–592. Chinese with abstract in English. [Google Scholar]
  • 44.Liu P, Hu YY, Liu C, Xu LM, Liu CH, Sun KW, Hu DC, Yin YK, Zhou XQ, Wan MB, Cai X, Zhang ZQ, Ye J, Tang BZ, He J. Multicenter clinical study about the action of Fuzheng Huayu Capsule against liver fibrosis with chronic hepatitis B. J Chin Integr Med. 2003;1(2):89–98. doi: 10.3736/jcim20030204. 102. Chinese with abstract in English. [DOI] [PubMed] [Google Scholar]
  • 45.Zhu JL, Huang YY, Liu P, Liu C, Xu LM, Hu YY. Effect of Ganping Capsule on posthepatitic cirrhosis in adjusting abnormal immune function. Zhongguo Zhong Yi Yao Ke Ji. 1994;1(2):23–25. Chinese. [Google Scholar]
  • 46.Huang YK, Zhao CQ, Hu YY, Xue HM, Liu C, Liu P. Influence of Fuzheng Huayu Capsules on abnormal amino acids spectrum in chronic liver diseases. Zhonghua Gan Zang Bing Za Zhi. 2005;13(3):230–231. Chinese. [PubMed] [Google Scholar]
  • 47.Hu YY, Liu C, Liu P, Shen SF, Xu LM, Zhu JL, Xue HM. Effect of Fuzhenhuayu recipe in adjusting endocrine disorders in cirrhotic patient. Zhongguo Yi Yao Xue Bao. 1992;7(5):27–29. Chinese. [Google Scholar]
  • 48.She WM, Hu DC, Zhou CH, Gu WG, Wang JY. Clinical research of Ganping Capsule against liver fibrosis in patients with chronic hepatitis B. Gan Zang. 2002;7(4):254–255. Chinese. [Google Scholar]
  • 49.Liu P, Hu YY, Liu C, Xu LM, Cheng HL, Hu DC, Yin YK, Zhou XQ, Wan MB, Cai X, Zhang Zhang ZQ, Ye J, Zhou RX, He J, Tang BZ. Multicenter clinical study on Fuzhenghuayu Capsule against liver fibrosis due to chronic hepatitis B. World J Gastroenterol. 2005;11(19):2892–2899. doi: 10.3748/wjg.v11.i19.2892. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 50.Mao YM, Zeng MD, Lu LG, Li JQ, Wan MB, Li CZ, Chen CW, Fu QC, Wang JY, She WM, Cai X, Ye J, Zhou XQ, Wang H, Wu SM, Tang MF, Zhu JS, Chen WX, Zhang HQ. Capsule oxymatrine in the treatment of liver fibrosis in patients with chronic virus hepatitis: a randomized, double blind, placebo-controlled, multicenter clinical study (II) Gan Zang. 2002;7(4):222–225. Chinese with abstract in English. [Google Scholar]
  • 51.Ji G, Wang YQ, Cao CL. Clinical study on treatment of alcoholic liver disease by Qinggan Huoxue Recipe. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004;24(1):13–16. Chinese with abstract in English. [PubMed] [Google Scholar]
  • 52.Li ZJ, Zhang XE, Su GQ, Peng YQ. Results set of traditional Chinese medicine basic theory research in 973 Program (2005-2006) China Press of Traditional Chinese Medicine; Beijing: 2011. p. 179. Chinese. [Google Scholar]
  • 53.Gu J, Zhang Q, Xue D, Cai H, Xu L. A randomized controlled study of Fuzheng Huayu Capsule for prevention of esophageal variceal bleeding in patients with liver cirrhosis. Evid Based Complement Alternat Med. 2013;2013:534960. doi: 10.1155/2013/534960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 54.Yu YQ, Zhou Q, Feng DY. Meta-analysis on Fuzhenghuayu Capsule combined with nucleoside antiviral drug for chronic hepatitis B. Ju Jie Shou Shu Xue Za Zhi. 2012;21(1):24–28. Chinese with abstract in English. [Google Scholar]
  • 55.Dong MH, Wang J, Zhang HQ, Su YH. Clinical frequently used Chinese crude drugs with hepatoprotective effect. Zhong Yi Yao Dao Bao. 2010;16(4):108–110. Chinese with abstract in English. [Google Scholar]
  • 56.Huang GY, Ni RZ. Research progress on mechanism of clinical hepatoprotective drugs. Lin Chuang Gan Dan Bing Za Zhi. 2005;21(3):187–189. Chinese. [Google Scholar]
  • 57.Liu C, Hu Y, Xu L, Liu C, Liu P. Effect of Fuzheng Huayu Formula and its actions against liver fibrosis. Chin Med. 2009;4:12. doi: 10.1186/1749-8546-4-12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 58.Wu BR, Zheng YL, Sang XL, Jin M, Wang WZ, Zhang QS, Zhao SX, Kong L. Role of the IGF-1/PI3K pathway and the molecular mechanism of Fuzhenghuayu therapy in a spontaneous recovery rat model of liver fibrosis. Zhonghua Gan Zang Bing Za Zhi. 2013;21(9):674–678. doi: 10.3760/cma.j.issn.1007-3418.2013.09.007. Chinese with abstract in English. [DOI] [PubMed] [Google Scholar]
  • 59.Liu C, Liu P, Liu CH, Zhu XQ, Ji G. Effects of Fuzhenghuayu decoction on collagen synthesis of cultured hepatic stellate cells, hepatocytes and fibroblasts in rats. World J Gastroenterol. 1998;4(6):548–549. doi: 10.3748/wjg.v4.i6.548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 60.Cheung KF, Ye DW, Yang ZF, Lu L, Liu CH, Wang XL, Poon RT, Tong Y, Liu P, Chen YC, Lau GK. Therapeutic efficacy of Traditional Chinese Medicine 319 Recipe on hepatic fibrosis induced by carbon tetrachloride in rats. J Ethnopharmacol. 2009;124(1):142–150. doi: 10.1016/j.jep.2009.03.005. [DOI] [PubMed] [Google Scholar]
  • 61.Zhao CQ, Wu YQ, Xu LM. Curative effects of Fuzheng Huayu Capsules on hepatic fibrosis and the functional mechanisms: a review. J Chin Integr Med. 2006;4(5):467–472. doi: 10.3736/jcim20060505. Chinese with abstract in English. [DOI] [PubMed] [Google Scholar]
  • 62.Wang WZ, Meng MH, Kong L, Zhang QS, Zhao SX, Nan YM. Role of Jak/Stat pathway in CCl4-induced rat liver fibrosis model and molecular action mechanism of Fuzheng Huayu Recipe in treatment of liver fibrosis. Lin Chuang Gan Dan Bing Za Zhi. 2014;30(4):344–348. Chinese with abstract in English. [Google Scholar]
  • 63.Lv Z, Xu L. Salvianolic acid B inhibits ERK and p38 MAPK signaling in TGF-β1-stimulated human hepatic stellate cell line (LX-2) via distinct pathways. Evid Based Complement Alternat Med. 2012;2012:960128. doi: 10.1155/2012/960128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 64.Xu H, Zhou Y, Lu C, Ping J, Xu LM. Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting RhoA signaling pathway. Lab Invest. 2012;92(12):1738–1748. doi: 10.1038/labinvest.2012.113. [DOI] [PubMed] [Google Scholar]
  • 65.Li S, Wang L, Yan XC, Wang QL, Tao YY, Li JX, Peng Y, Liu P, Liu CH. Salvianolic acid B attenuates rat hepatic fibrosis via downregulating angiotensin II signaling. Evid Based Complement Alternat Med. 2012;2012:160726. doi: 10.1155/2012/160726. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 66.Herath CB, Grace JA, Angus PW. Therapeutic potential of targeting the renin angiotensin system in portal hypertension. World J Gastrointest Pathophysiol. 2013;4(1):1–11. doi: 10.4291/wjgp.v4.i1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 67.Xu LM, Gu J, Lu X, Zhou Y, Tian T, Zhang J, Xu H. Traditional Chinese medicine can improve liver microcirculation and reduce portal hypertension in liver cirrhosis. In: Garbuzenko DV, editor. Portal hypertension: causes and complications. InTech; 2012. pp. 98–120.http://cdn.intechopen.com/pdfs/32251.pdf (2012-03-14) [2013-11-14]. [Google Scholar]
  • 68.Tao YY, Wang QL, Shen L, Fu WW, Liu CH. Salvianolic acid B inhibits hepatic stellate cell activation through transforming growth factor β-1 signal transduction pathway in vivo and in vitro. Exp Biol Med (Maywood) 2013;238(11):1284–1296. doi: 10.1177/1535370213498979. [DOI] [PubMed] [Google Scholar]
  • 69.Lü Z, Song Y, Xue D, Zhang W, Cheng Y, Xu L. Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells. J Ethnopharmacol. 2010;132(2):384–392. doi: 10.1016/j.jep.2010.05.026. [DOI] [PubMed] [Google Scholar]
  • 70.Lin QX, Xu LM. Facing the hepatotoxicity of Chinese herbal medicine. Ya Tai Chuan Tong Yi Yao. 2008;4(6):88–89. Chinese. [Google Scholar]
  • 71.Lin QX, Xu LM. Observation of treatment effect and hepatic toxicity of Gardenia in mouse with acute liver injury. Liaoning Zhong Yi Yao Da Xue Xue Bao. 2010;12(6):65–67. Chinese with abstract in English. [Google Scholar]
  • 72.Fang HM, Zhu YY. Effective components, toxic effects and research advances of Radix Polygoni Multiflori. Guo Ji Yao Xue Yan Jiu Za Zhi. 2010;37(4):283–286. Chinese with abstract in English. [Google Scholar]
  • 73.Fan Y. Present situation of modernization on compound prescriptions. Zhongguo Shi Yan Fang Ji Xue Za Zhi. 2007;13(6):63–65. Chinese with abstract in English. [Google Scholar]
  • 74.Miao JX, Miao MS. Research status, problems and thinking of multi-component of Chinese medicine. Zhong Yi Xue Bao. 2012;27(9):1116–1119. Chinese with abstract in English. [Google Scholar]
  • 75.Chen XP, Pei LX, Wang YT. Discussion on research and development models in innovative Chinese material medica. Zhong Cao Yao. 2011;42(7):1255–1260. Chinese with abstract in English. [Google Scholar]

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