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. 2013 Nov 23;5(4):245–255. doi: 10.1016/S1674-6384(13)60036-2

Traditional Use, Pharmacology, Toxicology, and Quality Control of Species in Genus Bupleurum L.

Ru-yu YAO a,b, Yuan-feng ZOU c, Xing-fu CHEN a,b,*
PMCID: PMC7129159  PMID: 32288759

Abstract

Many species of genus Bupleurum L. have been pharmaceutically used mainly in Asia and Europe for thousand years. Their roots are the most popular ingredients in Chinese materia medica prescriptions for the treatment of inflammatory diseases and auto-immune diseases. A plenty of chemical constituents have been isolated and identified from the species in Bupleurum L., such as saikosaponins, polysaccharides, volatile oils, flavonoids, polyacetylenes, lignins, and coumarins, most of which possess a variety of biological activities, especially for the hepatoprotective effect, antitumor activity, immunoregulation, and febrifuge efficacy. Therefore, the species in genus Bupleurum L. could be potential herbs of immunomodulator, antineoplastic, anti-oxidant, etc. Meanwhile, as potential toxicities have been discovered in some constituents, it is urgent to establish a comprehensive quality evaluation system to ensure the safety and efficiency of herbs. This paper reviews on the phytochemical and pharmacological studies, especially for the toxicology and quality control of the species in Bupleurum L., which is a reference for the species in this genus for safe usage and further development.

Key words: biological activity, Bupleurum L., phytochemistry, quality control, toxicology

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