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. 2013 Apr 3;61(3):213–218. [Article in Spanish] doi: 10.1016/S1695-4033(04)78799-8

Infecciones respiratorias por metapneumovirus en lactantes hospitalizados

Respiratory infections due to metapneumovirus in hospitalized infants

MaL García García a,*, C Calvo Rey a, F Martín del Valle a, MR López Huertas b, I Casas Flecha b, R Díaz-Delgado a, P Pérez-Breña b
PMCID: PMC7129515  PMID: 15469804

Abstract

Background

Human metapneumovirus (hPMV) is a recently identified virus that is recognized as a cause of respiratory tract illness in the pediatric population.

Objectives

To determine the incidence of respiratory tract infections caused by hPMV in hospitalized infants and to describe the clinical characteristics and possible presence of coinfection with other viral agents.

Patients and methods

We performed a prospective study from September to June 2003 in all children aged less than 24 months who were admitted to the Severo Ochoa Hospital (Leganés, Madrid) with a respiratory tract infection. Virological diagnosis was made with a direct immunofluorescent assay and/or reverse transcriptase-polymerase chain reaction on specimens obtained from nasopharyngeal washing. Demographic and clinical data from patients with an hPMV respiratory tract infection were analyzed.

Results

During the study period, 200 infants were admitted with a respiratory tract infection, of which 18 (9 %) had an hPMV infection. HPMV was the viral agent isolated in 13.8% of positive nasopharyngeal washings. All patients were admitted between March and April. The mean age was 6.7 ± 6.1 months. The most common diagnoses were recurrent wheezing (55.5 %) and bronchiolitis (38.8%). Oxygen therapy was required by 55.5 % of infants during hospitalization. Coinfection with other respiratory viruses was confirmed in 33.3% of the patients.

Conclusions

Human metapneumovirus is a major cause of respiratory tract illness in hospitalized infants. This virus causes mainly bronchiolitis and recurrent wheezing and is more frequent in spring. Coinfection with other respiratory viruses is frequent.

Key words: Respiratory tract infection, Infants, Human metapneumovirus

Bibliografía

  • 1.Van den Hoogen B.G., De Jong J.C., Groen J., Kuiken T., De Groot R., Fouchier R.A.M. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7:719–724. doi: 10.1038/89098. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Nissen M.D., Siebert D.J., Mackay I.M., Sloots T.P., Withers S.J. Evidence of human metapneumovirus in Australian children. Med J Aust. 2002:176–188. doi: 10.5694/j.1326-5377.2002.tb04354.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Falsey A.R., Erdman D., Anderson L.J., Walsh E.E. Human metapneumovirus infections in young and elderly adults. J Infect Des. 2003;187:785–790. doi: 10.1086/367901. [DOI] [PubMed] [Google Scholar]
  • 4.Jartti T., Van den Hoogen B., Garofalo R.P., Osterhaus A.D.M.E., Ruuskanen O. Metapneumovirus and acute wheezing in children. Lancet. 2002;360:1393–1394. doi: 10.1016/S0140-6736(02)11391-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Boivin G., Abed Y., Pelletier G., Ruel L., Moisan D., Cóte S. Virological features and clinical manifestations associated with human metapneumovirus: A new paramyxovirus responsible for acute respiratoy-tract infections in all age groups. J Infect Dis. 2002;186:1330–1334. doi: 10.1086/344319. [DOI] [PubMed] [Google Scholar]
  • 6.Stockton J., Stephenson I., Fleming D., Zambon M. Human metapneumovirus as a cause of community-acquired respiratory illness. Emerg Infect Dis. 2002;8:897–901. doi: 10.3201/eid0809.020084. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Stocton J., Stephenson I., Fleming D. Human metapneumovirus as a cause of community-acquired respiratory illnes. Emerg Infect Dis. 2002;8:897–901. doi: 10.3201/eid0809.020084. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Rawlinson W., Waliuzzaman Z., Carter I.W., Belessis Y.C., Gilbert K.M., Morton J.R. Asthma exacerbations in children with rhinovirus but not human metapneumovirus infection. J Infect Dis. 2003;187:11314–11318. doi: 10.1086/368411. [DOI] [PubMed] [Google Scholar]
  • 9.Greensill J., McNamara P.S., Dove W., Flanagn B., Smyth R.L., Hart C.A. Human metapneumovirus in severe syncitial virus bronchiolitis. Emerg Infect Dis. 2003;9:372–375. doi: 10.3201/eid0903.020289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Peret T., Boivin G., Li Y., Couillard M., Humphrey C., Osterhaus A.D. Characterization of human metapneumovirus isolated from patients in North America. J Infect Dis. 2002;185(11):1660–1663. doi: 10.1086/340518. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Freymouh F., Vabret A., Legrand L., Eterradossi N., Lafay-Delaire F., Brouard J. Presence of the new human metapneumovirus in French children with bronchiolitis. Pediatr Infect Dis J. 2003;22:92–94. doi: 10.1097/00006454-200301000-00024. [DOI] [PubMed] [Google Scholar]
  • 12.McConnochie K. Bronchiolitis. What’s in the name? Am J Dis Child. 1983;137:11–13. [PubMed] [Google Scholar]
  • 13.Casas I., Powell L., Klapper P.E., Cleator G.M. New method for the extraction of viral RNA and DNA from cerebrospinal fluid for use in the polymerase chain reaction assay. J Virol Methods. 1995;53:25–36. doi: 10.1016/0166-0934(94)00173-e. [DOI] [PubMed] [Google Scholar]
  • 14.Van Den Hoogen B.G., Van Doornum G.J., Fockens J.C., Cornelissen J.J., Beyer W.E., Groot Rd R. Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients. J Infect Dis. 2003;188:1571–1577. doi: 10.1086/379200. [DOI] [PubMed] [Google Scholar]
  • 15.Vicente D., Cilla G., Montes M., Pérez-Trallero E. Human metapneumovirus and community-acquired respiratory illness in children. Emerg Infect Dis. 2003;9:602–603. doi: 10.3201/eid0905.020615. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Maggi F., Pifferi M., Vatteroni M., Fornai C., Tempestini E., Anzilotti S. Human metapneumovirus associated with respiratory tract infections in a 3-year study of nasal swabs from infants in Italy. J Clin Microbiol. 2003;41:2987–2991. doi: 10.1128/JCM.41.7.2987-2991.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Jartti T., Van der Hoogen B., Garofalo R.P., Osterhaus A.D., Ruuskanen O. Metapneumovirus and acute wheezing in children. Lancet. 2002;360:1393–1394. doi: 10.1016/S0140-6736(02)11391-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Takao S., Shimozono H., Kashiwa H., Shimazu Y., Fukuda S., Kuwayama M. Clinical study of pediatric cases of acute respiratoy disease associated with human metapneumovirus in Japan. Jpn J Infect Dis. 2003;56:127–129. [PubMed] [Google Scholar]
  • 19.Chan P.K. Human metapneumovirus detection in patients with severe acute respiratory syndrome. Emerg Infect Dis. 2003;9:1058–1063. doi: 10.3201/eid0909.030304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Peiris J.S., Tang W.H., Chan K.H., Khong P.L., Guan Y., Lau Y.L. Children with respiratory disease associated with metapneumovirus in Hong Kong. Emerg Infect Dis. 2003;9:628–633. doi: 10.3201/eid0906.030009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Falsey A.R., Erdman D., Anderson L.J., Walsh E.E. Human metapneumovirus infections in young and elderly adults. J Infect Dis. 2003;187:785–790. doi: 10.1086/367901. [DOI] [PubMed] [Google Scholar]
  • 22.Esper F. BD, Weibel C., Martinello R.A., Khan J.S. Human metapneumovirus infection in the United States: Clinical manifestations associated with a newly emergening respiratory infection in children. Pediatrics. 2003;187:1407–1410. doi: 10.1542/peds.111.6.1407. [DOI] [PubMed] [Google Scholar]
  • 23.García ML García, Ordobás Gabin M., Calvo Rey C., González Álvarez M.I., Aguilar Ruiz J., Arregui Sierra A. Infecciones virales de vías respiratorias inferiores en lactantes hospitalizados: etiología, características clínicas y factores de riesgo. An Esp Pediatr. 2001;55:101–107. [PubMed] [Google Scholar]
  • 24.Ebihara T., Endo R., Kikuta H., Ishiguro N., Yoshioka M., Ma X. Seroprevalence of human metapneumovirus in Japan. J Med Virol. 2003:281–283. doi: 10.1002/jmv.10391. [DOI] [PubMed] [Google Scholar]
  • 25.Boivin G., De Serres G., Cote S., Ruel L., Moisan D., Cote S. Human metapneumovirus infections in hospitalized children. Emerg Infect Dis. 2003;9:634–640. doi: 10.3201/eid0906.030017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Viazov S., Ratjen F., Scheidhauer R., Fiedler M., Roggendorf M. High prevalence of human metapneumovirus infecction in young children and genetic heterogeneity of the viral isolates. J Clin Microbiol. 2003;41:3043–3045. doi: 10.1128/JCM.41.7.3043-3045.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Ulloa-Gutiérrez R. Metapneumovirus humano: un nuevo agente en el diagnóstico diferencial de la infección respiratoria. An Pediatr (Barc) 2003;59:129–130. doi: 10.1016/s1695-4033(03)78735-9. [DOI] [PubMed] [Google Scholar]

Articles from Anales De Pediatria (Barcelona, Spain : 2003) are provided here courtesy of Elsevier

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