Abstract
Aim
To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata.
Methods
The chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1–10 were evaluated using flu virus A.
Results
One new homolycorine-type alkaloid 2α-methoxy-6-O-ethyloduline (1), together with nine known alkaloids 2α-methoxy-6-O-methyloduline (2), trispherine (3), 8-O-demethylhomolycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), oduline (7), lycorenine (8), 6α-O-methyllycorenine (9) and O-ethyllycorenine (10) were obtained.
Conclusion
Alkaloid 1 is a new compound, and 1–3 were major alkaloids in this plant. Alkaloids 1–3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 μg·mL-1 and CC50 values of 14.37, 4.79, and 80.12 μg·mL-1, respectively.
Key Words: Lycoris radiata, Amaryllidaceae alkaloids, Homolycorine-type, 2α-Methoxy-6-O-methyloduline, 2α-Methoxy-6-O-ethyloduline
Footnotes
Available online 20 July 2013
[Research funding] This project was supported by the National Natural Science Foundation of China(No. 30830114), and Young Academic and Technical Leader Raising Foundation of Yunnan Province to Y.-T. Di (No. 2009CI072)
These authors have no conflict of interest to declare.
Contributor Information
Ying-Tong DI, Email: diyt@mail.kib.ac.cn.
Xiao-Jiang HAO, Email: haoxj@mail.kib.ac.cn.
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