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. 2002 May 25;5(1):39–49. doi: 10.1006/smvy.1994.1005

cis-acting genomic elements and trans-acting proteins involved in the assembly of RNA viruses

Sondra Schlesinger 1, Shinji Makino 1, Maxine L Linial 1
PMCID: PMC7129795  PMID: 32288439

Abstract

There is now considerable evidence that a specific site (or sites) in the genome of an RNA virus interacts with a viral protein to initiate the assembly of the virus ribonucleoprotein or nucleocapsid. We describe the progress that has been made in defining these elements for a number of different viruses: the togavirus, Sindbis virus; the coronavirus, mouse hepatitis virus; influenza A virus; several retroviruses; and the hepadnavirus, hepatitis B virus. The importance of cis-acting elements in packaging has been established for all of these viruses. For Sindbis virus, specificity in the binding of the RNA element to a region of the viral capsid protein in vitro has also been demonstrated.

Keywords: packaging signals/RNA-protein binding/RNA structures


Articles from Seminars in Virology are provided here courtesy of Elsevier

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