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. 2009 Jan 6;25(3):204–212. [Article in Spanish] doi: 10.1016/S0213-005X(07)74262-3

Infecciones transmitidas por el donante

Donor-transmitted infections

Óscar Len 1,⁎, Albert Pahissa 1
PMCID: PMC7130243  PMID: 17335701

Abstract

El tratamiento inmunosupresor que recibe el receptor de un trasplante de órgano sólido dificulta la respuesta defensiva frente a la infección. La transmisión de la misma desde un donante puede provocar la disfunción o pérdida del injerto e, incluso, la muerte del receptor si no se establecen las medidas preventivas oportunas. Este riesgo potencial debe ser evaluado minuciosamente con la intención de optimizar el uso de órganos, especialmente en aquellos casos procedentes de donantes infectados, sin aumentar la disfunción del injerto y la morbimortalidad en el receptor. Este artículo pretende revisar los conocimientos actuales sobre el cribado de las infecciones en los donantes potenciales y discutir la relaciónriesgo-beneficio para usar órganos de donantes infectados.

Palabras clave: Infección del donante, Trasplante de órgano sólido, Transmisión de donante-receptor

Bibliografía

  • 1.Delmonico F.L. Cadaver donor screening for infectious agents in solid organ transplantation. Clin Infect Dis. 2000;31:781–786. doi: 10.1086/314000. [DOI] [PubMed] [Google Scholar]
  • 2.Avery R.K., Ljungman P. Prophylactic measures in the solid-organ recipient before transplantation. Clin infect Dis. 2001;33(Suppl 1):15–21. doi: 10.1086/320899. [DOI] [PubMed] [Google Scholar]
  • 3.Schaffner A. Pretransplant evaluation for infections in donors and recipients of solid organs. Clin Infect Dis. 2001;33(Suppl 1):9–14. doi: 10.1086/320898. [DOI] [PubMed] [Google Scholar]
  • 4.Criterios de selección del donante de órganos respecto a la transmisión de infecciones. Documento de consenso ONT-GESITRA. 2.ª ed. Noviembre 2004. Disponible en: http://www.seimc.org/gesitra/dyc205.doc
  • 5.Screening of donor and recipient prior to solid organ transplantation. Am J Transplant 4 Suppl 10 2004 10-20. [DOI] [PMC free article] [PubMed]
  • 6.Simonds R.J., Holmberg S.D., Hurwitz R.L., Coleman T.R., Bottenfield S., Conley L.J. Transmission of human immunodeficiency virus type 1 from a seronegative organ and tissue donor. N Engl J Med. 1992;326:726–732. doi: 10.1056/NEJM199203123261102. [DOI] [PubMed] [Google Scholar]
  • 7.Lumbreras C., Sanz F., González A., Pérez G., Ramos M.J., Aguado J.M. Clinical significance of donor-unrecognized bacteremia in the outcome of solid-organ transplant recipients. Clin Infect Dis. 2001;33:722–726. doi: 10.1086/322599. [DOI] [PubMed] [Google Scholar]
  • 8.Caballero F., Domingo P., Rabella N., López-Navidad A. Succesful transplantation of organs retrieved from a donor with syphilis. Transplantation. 1998;65:598–599. doi: 10.1097/00007890-199802270-00029. [DOI] [PubMed] [Google Scholar]
  • 9.Freeman R.B., Giatras I., Falagas M.E., Supran S., O’Connor K., Bradley J. Outcome of transplantation of organs procured from bacteremic donors. Transplantation. 1999;68:1107–1111. doi: 10.1097/00007890-199910270-00008. [DOI] [PubMed] [Google Scholar]
  • 10.Nelson P.W., Delmonico F.L., Tolkoff-Rubin N.E., Cosimi A.B., Fang L.S., Russell P.S. Unsuspected donor Pseudomonas infection causing arterial disruption after renal transplantation. Transplantation. 1984;37:313–314. doi: 10.1097/00007890-198403000-00020. [DOI] [PubMed] [Google Scholar]
  • 11.López-Navidad A., Domingo P., Caballero F., González C., Santiago C. Succesful transplantation of organs retrieved from donors with bacterial meningitis. Transplantation. 1997;64:365–368. doi: 10.1097/00007890-199707270-00033. [DOI] [PubMed] [Google Scholar]
  • 12.Ruiz I., Gavalda J., Monforte V., León O., Román A., Bravo C. Donorto- host transmission of bacterial and fungal infections in lung transplantation. Am J Transplant. 2006;6:178–182. doi: 10.1111/j.1600-6143.2005.01145.x. [DOI] [PubMed] [Google Scholar]
  • 13.Mossad S.B., Avery R.K., Goormastic M., Hobbs R.E., Stewart R.W. Significance of positive cultures from donor left atrium and postpreservation fluid in heart transplantation. Transplantation. 1997:1209–1210. doi: 10.1097/00007890-199710270-00024. [DOI] [PubMed] [Google Scholar]
  • 14.León O., Gavaldà J., Puigfel Y., Álvarez M., Álvarez M., Gentil M. Donor infection and transmission to the recipient of a solid allograft. A prospective study from RESITRA. 45th Interscience Conference on Antimicrobial Agents and Chemotherapy; Washington. December 16-19; 2005. p. 359. Abstract k-1805. [Google Scholar]
  • 15.Singh N., Paterson D.L. Mycobacterium tuberculosis infection in solid-organ transplant recipients: impact and implications for management. Clin Infect Dis. 1998;27:1266–1277. doi: 10.1086/514993. [DOI] [PubMed] [Google Scholar]
  • 16.Limaye A.P., Connolly P.A., Sagar M., Fritsche T.R., Cookson B.T., Wheat L.J. Transmission of Histoplasma capsulatum by organ transplantation. N Engl J Med. 2000;343:1163–1166. doi: 10.1056/NEJM200010193431605. [DOI] [PubMed] [Google Scholar]
  • 17.Miller M.B., Hendren R., Gilligan P.H. Posttransplantation disseminated coccidioidomycosis acquired from donor lungs. J Clin Microbiol. 2004;42:2347–2349. doi: 10.1128/JCM.42.5.2347-2349.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.McGregor C.G., Fleck D.G., Nagington J., Stovin P.G., Cory-Pearce R., English T.A. Disseminated toxoplasmosis in cardiac transplantation. J Clin Pathol. 1984;37:74–77. doi: 10.1136/jcp.37.1.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Mayes J.T., O’Connor B.J., Avery R., Casellani W., Carey W. Transmission of Toxoplasma gondii infection by liver transplantation. Clin Infect Dis. 1995;21:511–515. doi: 10.1093/clinids/21.3.511. [DOI] [PubMed] [Google Scholar]
  • 20.Patel R. Disseminated toxoplasmosis after liver transplantation. Clin Infect Dis. 1999;29:705–706. doi: 10.1086/598673. [DOI] [PubMed] [Google Scholar]
  • 21.Centers for Disease Control and Prevention (CDC) Chagas disease after organ transplantation-Los Ángeles, California, 2006. MMWR Morb Mortal Wkly Rep. 2006;55:798–800. [PubMed] [Google Scholar]
  • 22.Barcan L., Luna C., Clara L., Sianagra A., Valledor A., De Rissio A.M. Transmission of Toxoplasma cruzi infection via liver transplantation to a nonreactive recipient for Chagas’ disease. Liver Transpl. 2005;11:1112–1116. doi: 10.1002/lt.20522. [DOI] [PubMed] [Google Scholar]
  • 23.Fischer L., Sterneck M., Claus M., Costard-Jackle A., Fleischer B., Herbst H. Transmission of malaria tertiana by multi-organ donation. Clin Transplant. 1999;13:491–495. doi: 10.1034/j.1399-0012.1999.130609.x. [DOI] [PubMed] [Google Scholar]
  • 24.Torre-Cisneros J., Fortún J., Aguado J.M., De la Cámara R., Cisneros J.M., Gavalda J. Consensus document from GESITRA-SEIMC on the prevention and treatment of cytomegalovirus infection in transplanted patients. Enferm Infecc Microbiol Clin. 2005;23:424–437. doi: 10.1157/13078802. [DOI] [PubMed] [Google Scholar]
  • 25.Preiksaitis J.K., Keay S. Diagnosis and management of postransplant lymphoproliferative disorder in solid-organ transplant recipients. Clin Infect Dis. 2001;33(Suppl 1):38–46. doi: 10.1086/320903. [DOI] [PubMed] [Google Scholar]
  • 26.McDiarmid S.V., Jordan S., Kim G.S., Toyoda M., Goss J.A., Vargas J.H. Prevention and preemptive therapy of postransplant lymphoproliferative disease in pediatric liver recipients. Transplantation. 1998;66:1604–1611. doi: 10.1097/00007890-199812270-00006. [DOI] [PubMed] [Google Scholar]
  • 27.Green M. Management of Epstein-Barr virus-induced posttransplant ymphoproliferative disease in recipients of solid organ transplantation. Am J Transpl. 2001;1:103–108. [PubMed] [Google Scholar]
  • 28.Lynfield R., Herrin J.T., Rubin R.H. Varicella in pediatric renal transplant recipients. Pediatrics. 1992;90:216–220. [PubMed] [Google Scholar]
  • 29.Benito N., Moreno A., Pumarola T., Marcos M.A. Human herpesvirus type 6 and type 7 in transplant recipients. Enferm Infecc Microbiol Clin. 2003;21:424–432. doi: 10.1016/s0213-005x(03)72980-2. [DOI] [PubMed] [Google Scholar]
  • 30.Regamey N., Tamm M., Binet I., Thiel G., Erb P., Cathomas G. Transplantation- associated Kaposi's sarcoma: herpesvirus 8 transmission through renal allografts. Transplant Proc. 1999;31:922–923. doi: 10.1016/s0041-1345(98)01837-5. [DOI] [PubMed] [Google Scholar]
  • 31.Chan P., Lok A., Cheng I., Chan M. The impact of donor and recipient hepatitis B surface antigen status on liver disease and survival in renal transplant recipients. Transplantation. 1992;53:128–131. doi: 10.1097/00007890-199201000-00025. [DOI] [PubMed] [Google Scholar]
  • 32.Prieto M., Gómez M.D., Berenguer M., Córdoba J., Rayón J.M., Pastor M. De novo hepatitis B after liver transplantation from hepatitis B core antibody- positive donors in an area with high prevalence of anti-HBc positivity in the donor population. Liver Transpl. 2001;7:51–58. doi: 10.1053/jlts.2001.20786. [DOI] [PubMed] [Google Scholar]
  • 33.Wachs M., Amend W., Ascher N., Bretan P., Emond J., Lake J. The risk of transmission of hepatitis B from HBsAg(−), HBcAb(+), HBIgM(−) organ donors. Transplantation. 1995;59:230–234. [PubMed] [Google Scholar]
  • 34.Chung R.T., Feng S., Delmonico F.L. Approach to the management of allograftrecipients following the detection of hepatitis B virus in the prostpective organ donor. Am J Transplant. 2001;1:185–191. [PubMed] [Google Scholar]
  • 35.Fishman J.A., Rubin R.H., Koziel M.J., Pereira B.J. Hepatitis C virus and organ transplantation. Transplantation. 1996;62:147–154. doi: 10.1097/00007890-199607270-00001. [DOI] [PubMed] [Google Scholar]
  • 36.Rosengard B.R., Feng S., Alfrey E.J., Zaroff J.G., Emond J.C., Henry M.L. Report of the Crystal City Meeting to maximize the use of organs recovered from the cadaver donor. Am J Transplant. 2002;2:701–711. doi: 10.1034/j.1600-6143.2002.20804.x. [DOI] [PubMed] [Google Scholar]
  • 37.Guidelines for counseling persons infected with human T-lymphotropic virus type I (HTLV-I) and type II (HTLV-II) Centers for Disease Control and Prevention and the USPHS Working Group. Ann Intern Med. 1993;118:448–454. doi: 10.7326/0003-4819-118-6-199303150-00009. [DOI] [PubMed] [Google Scholar]
  • 38.Goedert J., Fung M., Felton S., Battjes R., Engels E.A. Cause-specific mortality associated with HIV and HTLV-II infections among injecting drug users in the USA. AIDS. 2001;15:1295–1302. doi: 10.1097/00002030-200107060-00012. [DOI] [PubMed] [Google Scholar]
  • 39.Toro C., Rodes B., Poveda E., Soriano V. Rapid development of subacute myelopathy in three organ transplant recipients after transmission of human T-cell lymphotropic virus type I from a single donor. Transplantation. 2003;75:102–104. doi: 10.1097/00007890-200301150-00019. [DOI] [PubMed] [Google Scholar]
  • 40.Tanabe K., Kitani R., Takahashi K., Tokumoto T., Ishikawa N., Oshima T. Long-term results in human T-cell leukemia virus type 1-positive renal transplant recipients. Transplant Proc. 1998;30:3168–3170. doi: 10.1016/s0041-1345(98)00980-4. [DOI] [PubMed] [Google Scholar]
  • 41.Update: investigations of West Nile virus infections in recipients of organ transplantation and blood trnsfusion. MMWR Morb Mortal Wkly Report. 2002;51:833-6. [PubMed]
  • 42.Fischer S.A., Graham M.B., Kuehnert M.J., Kotton C.N., Srinivasan A., Marty F.M. Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med. 2006;354:2235–2249. doi: 10.1056/NEJMoa053240. [DOI] [PubMed] [Google Scholar]
  • 43.Burroughs M., Moscona A. Immunization of pediatric solid organ transplant candidates and recipients. Clin Infect Dis. 2000;30:857–869. doi: 10.1086/313823. [DOI] [PubMed] [Google Scholar]

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