Skip to main content
NCBI home page
Elsevier - PMC COVID-19 Collection logoLink to Elsevier - PMC COVID-19 Collection
. 2008 Feb 4;105(4):439–444. doi: 10.1016/S0021-9975(08)80113-2

Pathogenesis of Aujeszky's disease virus infection in swine tracheal organ culture

M Narita 1, T Imada 1, M Kobayashi 1
PMCID: PMC7130398  PMID: 1663139

Summary

Two different strains of Aujeszky's disease virus (ADV) were inoculated into swine tracheal organ culture. Both viruses replicated in and destroyed the tracheal epithelium and epithelial cells. ADV antigen was first localized in ciliated epithelial cells by fluorescent antibody and immunoperoxidase examinations. Corresponding to the distribution of ADV antigen, many ADV particles were observed in ciliated epithelial cells. Results demonstrated that the tracheal epithelium infected with ADV is reduced in its ciliary activity.

References

  1. Baskerville A. Ultrastructural changes in the pulmonary airways of pigs infected with a strain of Aujeszky's disease virus. Research in Veterinary Science. 1972;13:127–132. [PubMed] [Google Scholar]
  2. Becker C.-H. Zur Bedeutung der Lunge fur die Pathologische-anatomische Diagnose der Aujeszkyschen Krankheit des Schweines. Monatshefte für Veterinär Medizin. 1964;19:5–11. [Google Scholar]
  3. Becker C.-H. Electronenoptische Beobachtungen zur Bedeutung der Lung fur die Vermehrung des Virus der Aujeszkyschen Krankheit. Archly für Experimentelle Veterinärmedizin. 1966;20:339–350. [PubMed] [Google Scholar]
  4. Bridget J.C., Caul E.O., Egglestone S.I. Replication of an enteric bovine coronavirus in intestinal organ cultures. Archives of Virology. 1978;57:43–51. doi: 10.1007/BF01315636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chia W.K., Savan M. Pathogenesis of infectious bovine rhinotracheitis (IBR) virus infection in bovine fetal tracheal organ cultures. Canadian Journal of Microbiology. 1974;20:839–845. doi: 10.1139/m74-129. [DOI] [PubMed] [Google Scholar]
  6. Hoshino Y., Scott W.S. Immunofluorescent and electron microscopic studies of feline small intestinal organ cultures infected with feline infectious peritonitis virus. American Journal of Veterinary Research. 1980;41:672–681. [PubMed] [Google Scholar]
  7. McCracken R.M., Clarke J.K. A thin-section study of the morphogenesis of Aujeszky's disease virus in synchronously infected cell cultures. Archiv für die gesamte Virusforschung. 1971;34:189–201. doi: 10.1007/BF01242992. [DOI] [PubMed] [Google Scholar]
  8. McFerran J.B., Dow C. The distribution of the virus of Aujeszky's disease (pseudorabies virus) in experimentally infected swine. American Journal of Veterinary Research. 1965;26:631–635. [PubMed] [Google Scholar]
  9. Narita M., Imada T., Haritani M. Comparative pathology of HPCD pigs infected with wild-type and ara-T-resistant strains of Aujeszky's disease virus. Journal of Comparative Pathology. 1990;102:63–69. doi: 10.1016/s0021-9975(08)80008-4. [DOI] [PubMed] [Google Scholar]
  10. Narita M., Imada T., Haritani M., Kawamura H. Immunohistologic study of pulmonary and lymphatic tissues from gnotobiotic pigs inoculated with ara-T-resistant strain of pseudorabies virus. American Journal of Veterinary Research. 1989;50:1940–1945. [PubMed] [Google Scholar]
  11. Narita M., Inui S., Shimizu Y. Tonsillar changes in pigs given pseudorabies (Aujeszky's disease) virus. American Journal of Veterinary Research. 1984;45:247–251. [PubMed] [Google Scholar]
  12. Percy D.H., Creighton M.O., Hatch L.A., Clercq E.De. Experimental herpetic keratitis in rabbit corneal organ cultures. British Journal of Experimental Pathology. 1984;65:41–49. [PMC free article] [PubMed] [Google Scholar]
  13. Reed S.E. Persistent respiratory virus infection in tracheal organ cultures. British Journal of Experimental Pathology. 1969;50:378–388. [PMC free article] [PubMed] [Google Scholar]
  14. Rubenstein D., Tyrrell D.A.J. Growth of viruses in organ cultures of intestine. British Journal of Experimental Pathology. 1970;51:210–216. [PMC free article] [PubMed] [Google Scholar]
  15. Sabo A., Rajcani J., Blaskovic D. Studies on the pathogenesis of Aujeszky's disease I. Distribution of the virulent virus in piglets after peroral infection. Acta Virologica, Prague. 1968;12:214–221. [PubMed] [Google Scholar]
  16. Sabo A., Rajcani J., Blaskovic D. Studies on the pathogenesis of Aujeszky's disease III. The distribution of virulent virus in piglets after intranasal infection. Acta Virologica, Prague. 1969;13:407–414. [PubMed] [Google Scholar]
  17. Shroyer E.L., Easterday B.C. Growth of infectious bovine rhinotracheitis virus in organ cultures. American Journal of Veterinary Research. 1968;29:1355–1362. [PubMed] [Google Scholar]
  18. Tyrrell D.A.J., Bynoe M.L., Hoorn B. Studies on the antiviral activity of 1-adamantanamine. British Journal of Experimental Pathology. 1965;46:370–375. [PMC free article] [PubMed] [Google Scholar]
  19. Westerberg S.C., Smith C.B., Wiley B.B., Jensen C.G. Pathogenesis of influenza virus infection in mouse tracheal organ cultures. Proceedings of the Society for Experimental Biology and Medicine. 1972;140:846–851. doi: 10.3181/00379727-140-36565. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Comparative Pathology are provided here courtesy of Elsevier

RESOURCES