Skip to main content
PMC home page
Elsevier - PMC COVID-19 Collection logoLink to Elsevier - PMC COVID-19 Collection
. 2008 Jan 30;104(4):345–355. doi: 10.1016/S0021-9975(08)80145-4

Pathological features of lymphoid tissues in cats with natural feline immunodeficiency virus infection

PJ Brown 1, Cherida D Hopper 1, DA Harbour 1
PMCID: PMC7130401  PMID: 1651959

Abstract

A range of tissues from a total of 17 cats naturally infected with the feline immunodeficiency virus was examined histologically. In 11 cases, chronic inflammatory lesions were present in various tissues including, most commonly, the intestine, brain and lung. Extensive inflammation in the intestinal wall was present in seven of the cats. No particular bacterial organisms were demonstrated in these inflammatory lesions. A range of changes was present in the lymph nodes, including hyperplasia, atrophy or a mixed pattern. Erythrophagocytosis was a consistent feature. The changes resembled those reported in human acquired immunodeficiency syndrome as a result of infection with human immunodeficiency virus.

References

  1. Antony M.A., Brandt L.J., Klein R.S., Bernstein L.H. Infectious diarrhoea in patients with AIDS. Digestive Diseases and Science. 1988;33:1141–1146. doi: 10.1007/BF01535791. [DOI] [PubMed] [Google Scholar]
  2. Boylston A.W., Francis N.D. Editorial. Does it matter which cells are infected by the HIV virus? Journal of Pathology. 1988;156:93–96. doi: 10.1002/path.1711560202. [DOI] [PubMed] [Google Scholar]
  3. Chalifoux L.V., Ringler D.J., King N.W., Dehgal P.K., Desrosiers R.C., Daniel M.D., Letvin N.L. Lymphadenopathy in Macaques experimentally infected with the Simian immunodeficiency virus (SIV) American Journal of Pathology. 1987;120:104–110. [PMC free article] [PubMed] [Google Scholar]
  4. Diebold J., Audouin J., Le Tonneau A. Lymphoid tissue changes in HIV-infected patients. Lymphology. 1988;21:22–27. [PubMed] [Google Scholar]
  5. Gray F., Gherardi R., Scaravalli F. The neuropathology of the acquired immune deficiency syndrome (AIDS) Brain. 1988;111:245–266. doi: 10.1093/brain/111.2.245. [DOI] [PubMed] [Google Scholar]
  6. Gonda M.A., Braun M.J., Carter S.G., Kost T.A., Bess J.W., Arthur L.O., van der Maaten M.J. Characterisation and molecular cloning of a bovine lentivirus related to human immunodeficiency virus. Nature (London) 1987;330:388–391. doi: 10.1038/330388a0. [DOI] [PubMed] [Google Scholar]
  7. Harbour D.A., Williams P.D., Gruffydd-Jones T.J., Burbridge J., Pearson G.R. Isolation of a T-lymphotropic lentivirus from a persistently leucopenic domestic cat. Veterinary Record. 1988;122:84–86. doi: 10.1136/vr.122.4.84. [DOI] [PubMed] [Google Scholar]
  8. Hardy W.D. Immunopathology induced by the feline leukaemia virus. Springer Seminars in Immunopathology. 1988;5:75–106. doi: 10.1007/BF00201958. [DOI] [PubMed] [Google Scholar]
  9. Hopper C.D., Sparkes A.H., Gruffydd-Jones T.J., Crispin S.M., Muir P., Harbour D.A., Stokes C.R. Clinical and laboratory findings in cats infected with feline immunodeficiency virus. Veterinary Record. 1989;125:341–346. doi: 10.1136/vr.125.13.341. [DOI] [PubMed] [Google Scholar]
  10. Hosie M.J., Robertson D., Jarrett O. Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus in cats in the United Kingdom. Veterinary Record. 1989;125:293–297. doi: 10.1136/vr.125.11.293. [DOI] [PubMed] [Google Scholar]
  11. Ishida T., Washizu T., Toriyabe K., Motoyoshi S. Detection of feline T lymphotropic lentivirus (FTLV) infection in Japanese domestic cats. Japanese Journal of Veterinary Science. 1988;50:39–44. doi: 10.1292/jvms1939.50.39. [DOI] [PubMed] [Google Scholar]
  12. Letvin N.L., Daniel M.D., Sehgal P.K., Desrosiers R.C., Hunt R.D., Waldron L.M., MacKay J.J., Smidt D.K., Challfoux L.N., King N.W. Induction of AIDS-like disease in Macaque monkeys with T-cell tropic retrovirus STLV-III. Science. 1985;230:71–73. doi: 10.1126/science.2412295. [DOI] [PubMed] [Google Scholar]
  13. Millard P.R. AIDS: Histopathological aspects. Journal of Pathology. 1984;143:223–239. doi: 10.1002/path.1711430402. [DOI] [PubMed] [Google Scholar]
  14. Mooney S.C., Patnaik A.K., Hayes A.A., MacEwen E.G. Generalised lymphadenopathy resembling lymphoma in cats: six cases (1972-1976) Journal of the American Veterinary Medical Association. 1987;190:897–900. [PubMed] [Google Scholar]
  15. Moore F.M., Emerson W.E., Cotter S.M., DeLellis R.A. Distinctive peripheral lymph node hyperplasia of young cats. Veterinary Pathology. 1986;23:386–391. doi: 10.1177/030098588602300407. [DOI] [PubMed] [Google Scholar]
  16. Pedersen N.C. Feline Infectious Diseases, Chapter 15. American Veterinary Publications Inc.; Goleta: 1988. Feline Immunodeficiency Virus Infection. [Google Scholar]
  17. Pedersen N.C., Ho E.W., Brown M.L., Yamamoto J.K. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science. 1987;235:790–793. doi: 10.1126/science.3643650. [DOI] [PubMed] [Google Scholar]
  18. Racz P., Tenner-Racz K., Kahl C., Feller A.C., Kern P., Dietric M. Spectrum of morphologic changes of lymph nodes from patients with AIDS or AIDS-related complex. Progress in Allergy. 1986;37:81–181. doi: 10.1159/000318442. [DOI] [PubMed] [Google Scholar]
  19. Reiner A.P., Spivak J.L. Haematophagic histiocytosis. Medicine. 1988;67:369–388. [PubMed] [Google Scholar]
  20. Sheton G.H., Abkowitz J.L., Linenberger M.L., Russell R.G., Grant C.K. Chronic leukopenia associated with immunodeficiency virus in a cat. Journal of the American Veterinary Medical Association. 1989;194:253–255. [PubMed] [Google Scholar]
  21. Waisman J., Rotterdam H., Niedt G.N., Lewin K., Racz P. AIDS: An overview of the pathology. Pathology Research and Practice. 1987;182:729–754. doi: 10.1016/S0344-0338(87)80039-0. [DOI] [PubMed] [Google Scholar]
  22. Yamamoto J.K., Sparger E., Ho E.W., Andersen P.R., O'Connor T.P., Mandell C.P., Lowenstine L., Munn R., Pedersen N.C. Pathogenesis of experimentally induced feline immunodeficiency virus infection in cats. American Journal of Veterinary Research. 1988;49:1246–1258. [PubMed] [Google Scholar]

Articles from Journal of Comparative Pathology are provided here courtesy of Elsevier

RESOURCES