Skip to main content
PMC home page
Elsevier - PMC COVID-19 Collection logoLink to Elsevier - PMC COVID-19 Collection
. 2007 Sep 2;118(4):329–336. doi: 10.1016/S0021-9975(07)80008-9

Immunohistochemical demonstration of spread of Aujeszky's disease virus to the porcine central nervous system after intestinal inoculation

M Narita 1, K Kimura 1, N Tanimura 1, S Arai 1, A Uchimura 1
PMCID: PMC7130404  PMID: 9651809

Abstract

Aujeszky's disease virus (ADV) was injected into the duodenal lumen of eight specific pathogen-free pigs aged 5 weeks. The infected pigs did not show any diarrhoea or nervous symptoms, but they developed characteristic necrotizing enteritis and myenteric plexitis, accompanied by follicular necrosis in the Peyer's patches. ADV antigen was detected in the submucosa of the dome area of Peyer's patches, lymphatic follicles, Meissner's and Auerbach's plexuses, solar ganglia and thoracic spinal ganglia. These findings suggest that ADV spreads from the intestinal mucosa to the central nervous system via the autonomic nerves.

References

  1. Bergmann V., Becker C.-H. Untersuchungen zur pathomorphologie und pathogenese der Aujeszkyschen krankheit. Pathologica Veterinaria. 1967;4:97–119. doi: 10.1177/030098586700400201. [DOI] [PubMed] [Google Scholar]
  2. Collins J.E., Benfield D.A., Duimstra J.R. Comparative virulence of two porcine group-A rotavirus isolates in gnotobiotic pigs. American Journal of Veterinary Research. 1989;50:827–835. [PubMed] [Google Scholar]
  3. Corner A.H. Pathology of experimental Aujeszky's disease in piglets. Research in Veterinary Science. 1965;6:337–343. [PubMed] [Google Scholar]
  4. Ducatelle R., Coussement W., DeBouck P., Hoorens J. Pathology of experimental CV777 coronavirus enteritis in piglets. I. Histological and histochemical study. Veterinary Pathology. 1982;19:46–56. doi: 10.1177/030098588201900108. [DOI] [PubMed] [Google Scholar]
  5. Ezura K., Usami Y., Tajima K., Komaniwa H., Nagai S., Narita M., Kawashima K. Gastrointestinal and skin lesions in piglets naturally infected with pseudorabies virus. Journal of Veterinary Diagnostic Investigation. 1995;7:451–455. doi: 10.1177/104063879500700405. [DOI] [PubMed] [Google Scholar]
  6. Fukusho A., Shimizu M., Kubo M., Nanba K., Shimizu Y., Konno S., Suzuki K., Otaki T. The first outbreak of Aujeszky's disease in swine in Japan. II. Virus isolation. Bulletin of the National Institute of Animal Health. 1981;82:5–11. [Google Scholar]
  7. Hooper B.E., Haelterman E.O. Lesions of the gastrointestinal tract of pigs infected with transmissible gastroenteritis. Canadian Journal of Comparative Medicine. 1969;33:29–36. [PMC free article] [PubMed] [Google Scholar]
  8. Irie H., Harada Y., Yoshihashi H., Kitamura T., Kojima M., Kataota M., Saito M., Sugawara Y., Mori W. Spread of herpes virus type 1 (Miyama+GC strain) to the central nervous system after intraperitoneal inoculation: the role of the myenteric plexus of the gut. Archives of Virology. 1989;105:247–257. doi: 10.1007/BF01311361. [DOI] [PubMed] [Google Scholar]
  9. Kluge J.P., Beran G.W., Hill H.T., Platt K.B. Pseudorabies (Aujeszky's disease) In: D'Allaire S., Taylor D.J., editors. Disease of Swine. 7th Edit. Iowa State University Press; Ames: 1982. pp. 312–323. [Google Scholar]
  10. McFerran J.B., Dow C. The distribution of the virus of Aujeszky's disease (pseudorabies virus) in experimentally infected swine. American Journal of Veterinary Research. 1965;26:631–635. [PubMed] [Google Scholar]
  11. Narita M., Fukusho A., Shimizu Y. Electron microscopy of the intestine of gnotobiotic piglets infected with porcine rotavirus. Journal of Comparative Pathology. 1982;92:589–597. doi: 10.1016/0021-9975(82)90011-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Narita M., Imada T., Haritani M. Immunohistological demonstration of spread of Aujeszky' disease virus via the olfactory pathway in HPCD pigs. Journal of Comparative Pathology. 1991;105:141–145. doi: 10.1016/s0021-9975(08)80069-2. [DOI] [PubMed] [Google Scholar]
  13. Narita M., Kubo M., Fukusho A., Haritani M., Moriwaki M. Necrotizing enteritis in piglets associated with Aujeszky's disease virus infection. Veterinary Pathology. 1984;21:450–452. doi: 10.1177/030098588402100414. [DOI] [PubMed] [Google Scholar]
  14. Narita M., Zhao Y.M., Kawashima K., Arai S., Hirose H., Yamada S., Ezura K. Enteric lesions induced by different pseudorabies (Aujeszky's disease) virus strains inoculated into closed intestinal loops of pigs. Journal of Veterinary Diagnostic Investigation. 1998 doi: 10.1177/104063879801000107. in press. [DOI] [PubMed] [Google Scholar]
  15. Olander H.J., Saunders J.R., Gustafson D.P., Jones R.K. Pathologic findings in swine affected with a virulent strain of Aujeszky's virus. Pathologica Veterinaria. 1966;3:64–82. doi: 10.1177/030098586600300104. [DOI] [PubMed] [Google Scholar]
  16. Pospischil A., Hess R.G., Bachmann P.A. Light microscopy and ultrahistology of intestinal changes in pigs infected with enzootic diarrhea virus (PED): comparison with transmissible gastroenteritis (TGE) virus and porcine rotavirus infections. Zentralblatt für Veterinaermedizin B. 1981;28:564–577. doi: 10.1111/j.1439-0450.1981.tb01774.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Pearson G.R., McNulty M.S. Pathological changes in the small intestine of neonatal pigs inoculated with a pig reovirus-like agent (rotavirus) Journal of Comparative Pathology. 1977;87:363–375. doi: 10.1016/0021-9975(77)90026-3. [DOI] [PubMed] [Google Scholar]
  18. Rajcani J., Sabo A., Blaskovic D. Studies on the pathogenesis of Aujeszky's disease. II. The distribution of virus after subcutaneous inoculation. Acta Virologica. 1969;13:52–59. [PubMed] [Google Scholar]
  19. Sabo A., Rajcani J., Blaskovic D. Studies on the pathogenesis of Aujeszky's disease. III. The distribution of virulent virus in piglets after intranasal infection. Acta Virologica. 1969;13:407–414. [PubMed] [Google Scholar]
  20. Shepherd R.W., Gall D.G., Butler D.G., Hamilton J.R. Determinates of diarrhea in viral enteritis. The role of ion transport and epithelial changes in the ileum in transmissible gastroenteritis in piglets. Gastroenterology. 1979;76:20–24. doi: 10.1016/S0016-5085(79)80122-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Zhao Y.M., Narita M., Kawashima K. Pathologic changes in closed porcine intestinal loops inoculated with Aujeszky's disease virus. Journal of Veterinary Medical Science. 1996;58:809–810. doi: 10.1292/jvms.58.809. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Comparative Pathology are provided here courtesy of Elsevier

RESOURCES