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. 2004 Jul 19;58(3):282–283. doi: 10.1016/0034-5288(95)90118-3

Interferon induction in swine lymphocyte antigen-defined miniature pigs

LT Jordan 1, JB Derbyshire 1, BA Mallard 1
PMCID: PMC7130876  PMID: 7544905

Abstract

Interferon was induced in two groups of swine lymphocyte antigen (SLA)-defined miniature pigs with polyinosinic: polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose. The group 1 pigs were low antibody-response phenotypes (SLAa/a, SLAa/c, SLAc/c), and the group 2 pigs were high antibody-response phenotypes (SLAd/d, SLAd/g, SLAg/g). Six hours after induction the antiviral titres were not influenced by the SLA group, but higher titres were observed in females. Higher antiviral titres were found in group 2 pigs before treatment and 24 hours after treatment, and higher titres were found in female pigs. The antiviral titres before and after treatment were also influenced by the sire. Group 2 pigs had lower total leucocyte counts before treatment, and there was a significant reduction in leucocyte numbers in both groups six hours after induction, due mainly to a large reduction in lymphocyte counts.

References

  1. Abb J, Abb H, Deinhardt F. Age-related decline of human interferon alpha and gamma production. Blut. 1984;48:285–289. doi: 10.1007/BF00320399. [DOI] [PubMed] [Google Scholar]
  2. Appleyard G, Mallard B.A, Kennedy B.W, Wilkie B.N. Antibody avidity in swine lymphocyte antigen-defined miniature pigs. Canadian Journal of Veterinary Research. 1992;56:303–307. [PMC free article] [PubMed] [Google Scholar]
  3. Bever C.T, McFarlin D.E, Levy H.B. A comparison of responses to poly-ICLC in males and females. Journal oflnterferon Research. 1985;5:423–428. doi: 10.1089/jir.1985.5.423. [DOI] [PubMed] [Google Scholar]
  4. Bocci V. Roles of interferon produced in physiological conditions. A speculative review. Immunology. 1988;64:1–9. [PMC free article] [PubMed] [Google Scholar]
  5. Charley B, Lavenant L. Characterization of blood mononuclear cells producing IFN-alpha following induction by coronavirus-infected cells (porcine transmissible gastroenteritis virus) Research in Immunology. 1990;141:141–151. doi: 10.1016/0923-2494(90)90133-J. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Geffrotin C, Popescu C.P, Cribiu E.P, Boscher J, Renard C, Chardon P, Vaiman M. Assignment of MHC of swine to chromosome 7 by in situ hybridization and serological typing. Annales de Génétique. 1984;27:213–219. [PubMed] [Google Scholar]
  7. Greenberg P.L, Mosny S.A. Cytotoxic effects of interferon in vitro on granulocytic progenitor cells. Cancer Research. 1977;37:1794–1799. [PubMed] [Google Scholar]
  8. Gresser L, Guy-Grand D, Maury C, Manoury M.T. Interferon induces peripheral lymphadenopathy in mice. Journal of Immunology. 1981;127:1569–1575. [PubMed] [Google Scholar]
  9. Helwig T.T, Council K.A. SAS Institute; Raleigh: 1982. SAS Users Guide; pp. 768–770. [Google Scholar]
  10. Lefèvre S, Mege D, L'Haridon R, Bernard S, Devaureix C, La Bonnardière C. Contribution of molecular biology to the study of the porcine interferon system. Veterinary Microbiology. 1990;23:245–257. doi: 10.1016/0378-1135(90)90155-O. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Loewen K.G, Derbyshire J.B. Interferon induction with polyinosinic:polycytidylic acid in the newborn piglet. Canadian Journal of Veterinary Research. 1986;50:232–237. [PMC free article] [PubMed] [Google Scholar]
  12. Loewen K.G, Derbyshire J.B. Interferon induction in piglets with polyinosinic:polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose. Research in Veterinary Science. 1988;44:132–133. [PubMed] [Google Scholar]
  13. Lumsden J.F, Kennedy B.W, Mallard B.A, Wilkie B.N. The influence of swine major histocompatability genes on antibody and cellmediated immune responses to immunization with an aromatic-dependent mutant of Salmonella tymphimurium. Canadian Journal of Veterinary Research. 1993;57:14–18. [PMC free article] [PubMed] [Google Scholar]
  14. Mallard B.A. University of Guelph; 1987. The influence of the swine major histocompatibility gene complex and other genetics on immune responses in miniature swine. (PhD thesis). [Google Scholar]
  15. Mallard B.A, Wilkie B.N, Kennedy B.W. Genetic and other effects on antibody and cell-mediated immune responses in swine leucocyte antigen defined miniature pigs. Animal Genetics. 1989;20:167–178. doi: 10.1111/j.1365-2052.1989.tb00854.x. [DOI] [PubMed] [Google Scholar]
  16. Mallard B.A, Wilkie B.N, Kennedy B.W. Influence of swine major histocompatability genes (SLA) on variation in serum immuneglobulin (Ig) concentrations. Veterinary Immunology and Immunopathology. 1989;21:139–151. doi: 10.1016/0165-2427(89)90062-7. [DOI] [PubMed] [Google Scholar]
  17. Zawatzky R, Kirchner H, De Maeyer-Guignard J, De Maeyer E. An X-linked locus influences the amount of circulating interferon induced in the mouse by herpes simplex virus type 1. Journal of General Virology. 1982;63:325–332. doi: 10.1099/0022-1317-63-2-325. [DOI] [PubMed] [Google Scholar]

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