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. 2006 Sep 27;103(3):454–459. doi: 10.1016/S0022-3476(83)80427-2

An outbreak of rotavirus-associated neonatal necrotizing enterocolitis*

Harley A Rotbart a,b,c,d,1, Myron J Levin a,b,c,d, Robert H Yolken a,b,c,d, David K Manchester a,b,c,d, James Jantzen a,b,c,d
PMCID: PMC7131059  PMID: 6310072

Abstract

An outbreak of necrotizing enterocolitis and hemorrhagic gastroenteritis occurred in two nurseries during 25 days in August 1982. Eleven of the 40 patients in these nurseries during that time developed disease (attack rate 27.5%). In seven of the 10 patients with gastrointestinal disease, stool samples tested for human rotavirus were positive by ELISA, whereas in 20 unaffected infants, no stools tested demonstrated HRV (P=0.0001). Eleven staff members had serologic evidence of recent HRV infection. Comparison of risk factors traditionally associated with the development of NEC between the affected and unaffected infants revealed no significant differences. Rotavirus infection was the only finding that was highly correlated with this epidemic.

Footnotes

*

Supported by Grants BRSG-05357, Biomedical Research Program, Division of Research Resources, and R01-AI-17604 and N01-AI-23660, National Institutes of Health.

Presented in part at the Annual Meeting of the Society for Pediatric Research, Washington, D.C., May 4, 1983.

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