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. 2003 Jan 18;74(4):357–362. doi: 10.1016/0300-9084(92)90113-S

Recognition of correct reading frame by the ribosome

EN Trifonov 1
PMCID: PMC7131330  PMID: 1637861

Abstract

The translation frame-monitoring mechanism has been suggested earlier, based on transient complementary contacts, between mRNA and rRNA. Recent studies related to the frame-monitoring mechanism are reviewed. The mechanism is well supported by both new experimental and sequence analysis data. Experiments are suggested for further elucidation of the structural details of the mRNA-rRNA interaction in the ribosome.

Keywords: frame monitoring, mRNA-rRNA interaction, ribosome

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