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. 2008 Apr 10;59:369–455. doi: 10.1016/S0065-2776(08)60634-3

The Regulation of Pulmonary Immunity

Mary F Lipscomb *, David E Bice †, C Richard Lyons ‡, Mark R Schuyler ‡, David Wilkes §
PMCID: PMC7131473  PMID: 7484463

Abstract

Thechapter describes the cells and structures of the lung that participate in pulmonary immunity and how the lung responds to challenges fromforeign antigens, with particular emphasis on animal models that have been developed to explore these issues. Some ligands-receptor interactions are specific while others are not, and it is the particular pattern of surface molecules and secreted factors expressed by interacting immune cells that determines the type of immune response that develops during central processing. The cells that are the major initiators and regulators of immunity in the lung include macrophages, dendritic cells (DCs), and lymphocytes, each expressing surface molecules and secretory products that depend on perturbations in the environments. Immune cells and structures of the lung and lung immunity to noninfectious particulate and soluble antigens are discussed. Several models for regulation of pulmonary immunity such as models for immunity in lung infections, models for hypersensitivity lung disease, models for lung transplantation, and graft versus host are also presented. Demonstration that lung cells regulate both nonspecific inflammation and immunity through the expression of adhesion molecules and the secretion of cytokines offers hope for ways to design more effective vaccines, enhance microbial clearance in immune-suppressed hosts, and to suppress manifestations of immunologically mediated lung disease.

References

  1. Abraham Freitas E.A.A., Coutinho A.A. Purification and characterization of intraparenchymal lung lymphocytes. J. Immunol. 1990;144:2117–2122. [PubMed] [Google Scholar]
  2. Abraham W. The potential role of bradykinin antagonists in the treatment of asthma. Agents Actions (Suppl.) 1992;38:439–449. [PubMed] [Google Scholar]
  3. Afonso L.C.C., Scharton T.M., Vieira L.Q., Wysocka M., Trinchieri G., Scott P. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science. 1994;263:235–238. doi: 10.1126/science.7904381. [DOI] [PubMed] [Google Scholar]
  4. Agostini C., Chilosi M., Zambello R., Trentin L., Semenzato G. Pulmonary immune cells in health and disease: Lymphocytes. Eur. Respir. J. 1993;6:1378–1401. [PubMed] [Google Scholar]
  5. Allen R.D., Staley T.A., Sidman C.L. Differential cytokine expression in acute and chronic murine graft-versus-host-disease. Eur. J. Immunol. 1993;23:333–337. doi: 10.1002/eji.1830230205. [DOI] [PubMed] [Google Scholar]
  6. Allendoerfer R., Magee D.M., Deepe G.S., Jr., Graybill J.R. Transfer of protective immunity in murine histoplasmosis by a CD4+ T-cell clone. Infect. Immun. 1993;61:714–718. doi: 10.1128/iai.61.2.714-718.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Allison A.C., D'Arcy Hart P. Potentiation by silica of the growth of Mycobacterium tuberculosis in macrophage cultures. Br. J. Exp. Pathol. 1968;49:465–476. [PMC free article] [PubMed] [Google Scholar]
  8. Alspaugh J.A., Granger D.L. Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis. Infect. Immun. 1991;59:2291–2296. doi: 10.1128/iai.59.7.2291-2296.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Alwan W.H., Kozlowska W.J., Openshaw P.J.M. Distinct types of lung disease caused by functional subsets of antiviral T cells. J. Exp. Med. 1994;179:81–89. doi: 10.1084/jem.179.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. American Thoracic Society Clinical role of bronchoalveolar lavage in adults with pulmonary disease. Am. Rev. Respir. Dis. 1990;142:481–486. doi: 10.1164/ajrccm/142.2.481. [DOI] [PubMed] [Google Scholar]
  11. Amiri P., Locksley R.M., Parslow T.G., Sadick M., Rector E., Ritter D., McKerrow J.H. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature. 1992;356:604–607. doi: 10.1038/356604a0. [DOI] [PubMed] [Google Scholar]
  12. Ansfield M.J., Kaltreider H.B., Caldwell J.L., Herskowitz F.N. Hyporesponsiveness of canine bronchoalveolar lymphocytes to mitogens: Inhibition of lymphocyte proliferation by alveolar macrophages. J. Immunol. 1979;122:542–548. [PubMed] [Google Scholar]
  13. Antin J.H., Farrara J.L.M. Cytokine dysregulation and acute graft-versushost disease. Blood. 1992;80:2964–2968. [PubMed] [Google Scholar]
  14. Asano M., Inoue H., Ichinose M., Okada S., Takishima T. Possible mechanisms of airway hyperresponsiveness after late asthmatic response in guinea pigs. Int. Arch. Allergy Immunol. 1994;103:88–94. doi: 10.1159/000236610. [DOI] [PubMed] [Google Scholar]
  15. Atkinson K., Turner J., Biggs J.C., Dodds A., Concannon A. An acute pulmonary syndrome possibly representing acute graft-versus-host disease involving the lung interstitium. Bone Marrow Transplant. 1991;8:231–234. [PubMed] [Google Scholar]
  16. Au C., Eisenstein T. Evaluation of the role of the pneumococcal Forsman antigen (F-polysaccharide) in the cross-serotype protection induced by pneumococcal subcellular preparations. Infect. Immun. 1981;31:160–173. doi: 10.1128/iai.31.1.169-173.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Augustin A., Kubo R.T., Sim G.-K. Resident pulmonary lymphocytes expressing the γ/δ T-cell receptor. Nature. 1989;340:239–241. doi: 10.1038/340239a0. [DOI] [PubMed] [Google Scholar]
  18. Austrian R. Some observations on the pneumococcus and on the current status of pneumococcal disease and its prevention. Rev. Infect. Dis. 1981;3:S1–S7. doi: 10.1093/clinids/3.supplement_1.s1. [DOI] [PubMed] [Google Scholar]
  19. Baldwin F., Becker A. Bronchoalveolar eosinophilic cells in a canine model of asthma: Two distinctive populations. Vet. Pathol. 1993;30:97–103. doi: 10.1177/030098589303000201. [DOI] [PubMed] [Google Scholar]
  20. Barnes P.F., Chatterjee D., Abrams J.S., Lu S., Wang E., Yamamura M., Brennan P.J., Modlin R.L. Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. J. Immunol. 1992;149:541–547. [PubMed] [Google Scholar]
  21. Barnes P.F., Abrams J.S., Lu S., Sieling P.A., Rea T.H., Modlin R.L. Patterns of cytokine production by mycobacterium-reactive human T-cell clones. Infect. Immun. 1993;61:197–203. doi: 10.1128/iai.61.1.197-203.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Baughman R.P., Kim C.K., Vinegar A., Hendricks D.E., Schmidt D.J., Bullock W.E. The pathogenesis of experimental pulmonary histoplasmosis. Correlative studies of histopathology, bronchoalveolar lavage, and respiratory function. Am. Rev. Respir. Dis. 1986;134:771–776. doi: 10.1164/arrd.1986.134.4.771. [DOI] [PubMed] [Google Scholar]
  23. Becker A., Chung F., McDonald F., Frick O., Gold W. Cutaneous allergic response in atopic dogs: Relationship of cellular and histamine responses. J. Allergy Clin. Immunol. 1988;81:441–448. doi: 10.1016/0091-6749(88)90914-1. [DOI] [PubMed] [Google Scholar]
  24. Becker A., Hershkovich J., Simons F., Simons K., Lilley K., Kepron W. Development of chronic airway hyperresponsiveness in ragweed-sensitized dogs. J. Appl. Physiol. 1989;66:2691–2697. doi: 10.1152/jappl.1989.66.6.2691. [DOI] [PubMed] [Google Scholar]
  25. Becker S., Harris D.T., Koren H.S. Characterization of normal human lung lymphocytes and interleukin-2-induced lung T cell lines. Am. J. Respir. Cell. Mol. Biol. 1990;3:441–448. doi: 10.1165/ajrcmb/3.5.441. [DOI] [PubMed] [Google Scholar]
  26. Benfield J.R. Transplantation of the lung. In: Kirkpatrick C.H., Reynolds H.Y., editors. Vol. 1. Dekker; New York: 1976. pp. 485–518. (“Immunologic and Infectious Reactions in the Lung”). [Google Scholar]
  27. Berman J.S., Beer D.J., Theodore A.C., Kornfeld H., Bernardo J., Center D.M. Lymphocyte recruitment to the lung. Am. Rev. Respir. Dis. 1990;142:238–257. doi: 10.1164/ajrccm/142.1.238. [DOI] [PubMed] [Google Scholar]
  28. Beschorner W.E., Saral R., Hutchens G.M., Tutschka P.J., Santos G.W. Lymphocytic bronchitis associated with graft-versus-host disease in recipients of bone marrow transplants. N. Engl. J. Med. 1978;299:1030–1036. doi: 10.1056/NEJM197811092991902. [DOI] [PubMed] [Google Scholar]
  29. Bice D., McKarron K., Hoffman E., Salvaggio J. Adjuvant properties of Micropolyspora faeni. Int. Arch. Allergy Appl. Immunol. 1974;55:267–273. doi: 10.1159/000231935. [DOI] [PubMed] [Google Scholar]
  30. Bice D.E., Harris D.L., Hill J.O., Muggenburg B.A., Wolff R.K. Immune responses after localized lung immunization in the dog. Am. Rev. Respir. Dis. 1980;122:755–760. doi: 10.1164/arrd.1980.122.5.755. [DOI] [PubMed] [Google Scholar]
  31. Bice D.E., Harris D.L., Muggenburg B.A. Regional immunologic responses following localized deposition of antigen in the lung. Exp. Lung Res. 1980;1:33–41. doi: 10.3109/01902148009057511. [DOI] [PubMed] [Google Scholar]
  32. Bice D.E., Degen M.A., Harris D.L., Muggenburg B.A. Recruitment of antibody-forming cells in the lung after local immunization is nonspecific. Am. Rev. Respir. Dis. 1982;1982:635–639. doi: 10.1164/arrd.1982.126.4.635. [DOI] [PubMed] [Google Scholar]
  33. Bice D.E., Harris D.L., Muggenburg B.A., Bowen J.A. The evaluation of lung immunity in chimpanzees. Am. Rev. Respir. Dis. 1982;1982:358–359. doi: 10.1164/arrd.1982.126.2.358. [DOI] [PubMed] [Google Scholar]
  34. Bice D.E., Mauderly J.L., Jones R.K., McClellan R.O. Effects of inhaled diesel exhaust on immune responses after lung immunization. Fundam. Appl. Toxicol. 1985;5:1075–1086. doi: 10.1016/0272-0590(85)90143-5. [DOI] [PubMed] [Google Scholar]
  35. Bice D.E., Gray R.H., Evans M.J., Muggenburg B.A. Identification of plasma cells in lung alveoli and interstitial tissues after localized lung immunization. J. Leukocyte Biol. 1987;41:1–7. doi: 10.1002/jlb.41.1.1. [DOI] [PubMed] [Google Scholar]
  36. Bice D.E., Hahn F.F., Benson J., Carpenter R.L., Hobbs C.H. Comparative lung immunotoxicity of inhaled quartz and coal combustion fly ash. Environ. Res. 1987;43:374–389. doi: 10.1016/s0013-9351(87)80038-5. [DOI] [PubMed] [Google Scholar]
  37. Bice D.E., King-Herbert A.P., Morris M.J., Hanna N., Haley P.J. Inflammation and recruitment of immune cells into the lung. Region Immunol. 1989;2:376–384. [PubMed] [Google Scholar]
  38. Bice D.E., Weissman D.N., Muggenburg B.A. Long-term maintenance of localized antibody responses in the lung. Immunology. 1991;74:215–222. [PMC free article] [PubMed] [Google Scholar]
  39. Bice D.E., Jones S.E., Muggenburg B.A. Long-term antibody production after lung immunization and challenge: Role of lung and lymphoid tissues. Am. J. Respir. Cell. Mol. Biol. 1993;8:662–667. doi: 10.1165/ajrcmb/8.6.662. [DOI] [PubMed] [Google Scholar]
  40. Bice D.E. Pulmonary responses to antigen. Chest. 1993;103:95S–98S. doi: 10.1378/chest.103.2_supplement.95s. [DOI] [PubMed] [Google Scholar]
  41. Bice D.E., Muggenburg B.A. Localized immune memory in the lung. Am. Rev. Respir. Dis. 1988;138:565–571. doi: 10.1164/ajrccm/138.3.565. [DOI] [PubMed] [Google Scholar]
  42. Bice D.E., Shopp G.M. Antibody responses after lung immunization. Exp. Lung Res. 1988;14:133–155. doi: 10.3109/01902148809115121. [DOI] [PubMed] [Google Scholar]
  43. Bienenstock J., Johnston N., Perey D.Y.E. Bronchial lymphoid tissue. I. Morphologic characteristics. Lab. Invest. 1973;28(6):686–692. [PubMed] [Google Scholar]
  44. Bienenstock J., Johnson N., Perey D.Y.E. Bronchial lymphoid tissue. II. Functional characteristics. Lab. Invest. 1973;28(6):693–698. [PubMed] [Google Scholar]
  45. Bilyk N., Mackenzie J.S., Papadimitriou J.M., Holt P.G. Functional studies on macrophage populations in the airways and the lung wall of SPF mice in the steady-state and during respiratory virus infection. Immunology. 1988;65:417–425. [PMC free article] [PubMed] [Google Scholar]
  46. Bilyk N., Holt P.G. Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 1993;177:1773–1777. doi: 10.1084/jem.177.6.1773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Born W.K., Harshan K., Modlin R.L., O'Brien R.L. The role of gamma delta T lymphocytes in infection. Curr. Opin. Immunol. 1991;3:455–459. doi: 10.1016/0952-7915(91)90002-i. [DOI] [PubMed] [Google Scholar]
  48. Boussiotis V.A., Freeman G.J., Gray G., Gribben J., Nadler L.M. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J. Exp. Med. 1993;178:1753–1763. doi: 10.1084/jem.178.5.1753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Bowden D.H., Adamson I.Y.R. Role of monocytes and interstitial cells in the generation of alveolar macrophages. I. Kinetic studies of normal mice. Lab. Invest. 1980;42:511–517. [PubMed] [Google Scholar]
  50. Boylan C.J., Current W.L. Improved rat model of Pneumocystis carinni pneumonia: Induced laboratory infections in Pneumocytis-free animals. Infect. Immun. 1992;60:1589–1597. doi: 10.1128/iai.60.4.1589-1597.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Brain J.D., Golde D.W., Green G.M., Massaro D.J., Valberg P.A., Ward P.A., Werb Z. Biologic potential of pulmonary macrophages. Am. Rev. Respir. Dis. 1978;118:435–443. doi: 10.1164/arrd.1978.118.2.435. [DOI] [PubMed] [Google Scholar]
  52. Brain J.D. Mechanisms, measurement, and significance of lung macrophage function. Environ. Health Perspect. 1992;97:5–10. doi: 10.1289/ehp.92975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Breen E., Shuyll S., Burne S., Absher M., Kelley J., Phan S., Cutroneo K. Bleomycin regulation of transforming growth factor-β mRNA in rat lung fibroblasts. Am. J. Respir. Cell. Mol. Biol. 1992;6:146–152. doi: 10.1165/ajrcmb/6.2.146. [DOI] [PubMed] [Google Scholar]
  54. Brentjens J., O'Connell D., Pawlowski I., Hsu K., Andres G. Experimental immune complex disease of the lung. J. Exp. Med. 1974;140:105–125. doi: 10.1084/jem.140.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Brieland J., Jones M., Flory C., Miller G., Warren J., Phan S., Fantone J. Expression of monocyte chemoattractant protein-1 (MCP-1) by rat alveolar macrophages during chronic lung injury. Am. J. Respir. Cell. Mol. Biol. 1993;9:300–305. doi: 10.1165/ajrcmb/9.3.300. [DOI] [PubMed] [Google Scholar]
  56. Brown E., Joiner K., Cole R., Berger M. Localization of complement component 3 on Streptococcus pneumoniae: Anti-capsular antibody causes complement deposition on the pneumococcal capsule. Infect. Immun. 1983;39:403–409. doi: 10.1128/iai.39.1.403-409.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Brummer E., Restrepo A., Stevens D.A., Azzi R., Gomez A.M., Hoyos G.L., McEwen J.G., Cano L.E., De Bedout C. Murine model of paracoccidioidomycosis. Production of fatal acute pulmonary or chronic pulmonary and disseminated disease: Immunological and pathological observations. J. Exp. Pathol. 1984;1:241–255. [PubMed] [Google Scholar]
  58. Brusselle G., Kips J., Tavernier J., van der Heyden J., Cuvelier C., Pauwels R., Bluethmann H. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin. Exp. Allergy. 1994;24:73–80. doi: 10.1111/j.1365-2222.1994.tb00920.x. [DOI] [PubMed] [Google Scholar]
  59. Bruyn G., Zegers B., van Furth R. Mechanisms of host defense against infection with Streptococcus pneumoniae. Clin. Infect. Dis. 1992;14:251–262. doi: 10.1093/clinids/14.1.251. [DOI] [PubMed] [Google Scholar]
  60. Burrell R., Hill J.O. The effect of respiratory immunization on cell-mediated immune effector cells of the lung. Clin. Exp. Immunol. 1975;24:116–124. [PMC free article] [PubMed] [Google Scholar]
  61. Butcher E.C., Scollary R.G., Weissman I.L. Organ specificity of lymphocyte migration: Mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelial venules. Eur. J. Immunol. 1980;10:556–561. doi: 10.1002/eji.1830100713. [DOI] [PubMed] [Google Scholar]
  62. Butler J.E., Swanson P.A., Richerson H.G., Ratajczak H.V., Richards D.W., Suelzer M.T. The local and systemic IgA and IgG antibody responses of rabbits to a soluble inhaled antigen. Measurement of responses in a model of acute hypersensitivity pneumonitis. Am. Rev. Respir. Dis. 1982;126:80–85. doi: 10.1164/arrd.1982.126.1.80. [DOI] [PubMed] [Google Scholar]
  63. Campbell P.A. T cell involvement in resistance to facultative intracellular pathogens of the lung. Chest. 1993;103:113S–115S. doi: 10.1378/chest.103.2_supplement.113s. [DOI] [PubMed] [Google Scholar]
  64. Cárdenas L., Clements J.D. Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens. Clin. Microbiol. Rev. 1992;5:328–342. doi: 10.1128/cmr.5.3.328. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Carding S.R., Allan W., Kyes S., Hayday A., Bottomly K., Doherty P.C. Late dominance of the inflammatory process in murine influenza by γ/δ+ T cells. J. Exp. Med. 1990;172:1225–1231. doi: 10.1084/jem.172.4.1225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Carding S.R., Allan W., McMickle A., Doherty P.C. Activation of cytokine genes in T cells during primary and secondary murine influenza penumonia. J. Exp. Med. 1993;177:475–482. doi: 10.1084/jem.177.2.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Castleman W.L., Sorkness R.L., Lemanske R.F., Jr., McAllister P.K. Viral bronchiolitis, during early life induces increased numbers of bronchiolar mast cells and airway hyperresponsiveness. Am. J. Pathol. 1990;137:821–831. [PMC free article] [PubMed] [Google Scholar]
  68. Cerasoli F., Tocker J., Selig W. Airway eosinophils from actively sensitized guinea pigs exhibit enhanced superoxide anion release in response to antigen challenge. Am. J. Respir. Cell. Mol. Biol. 1991;4:355–363. doi: 10.1165/ajrcmb/4.4.355. [DOI] [PubMed] [Google Scholar]
  69. Chand N., Harrison J., Rooney S., Pillar J., Jakubicki R., Nolan K., Diamantis W., Sofia R. Anti-IL-5 monoclonal antibody inhibits allergic late phase bronchial eosinophilia in guinea pigs: A therapeutic approach. Eur. J. Pharmacol. 1992;211:121–123. doi: 10.1016/0014-2999(92)90273-7. [DOI] [PubMed] [Google Scholar]
  70. Chatterjee D., Roberts A.D., Lowell K., Brennan P.J., Orme I.M. Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor. Infect. Immun. 1992;60:1249–1253. doi: 10.1128/iai.60.3.1249-1253.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Chen C., Nabavi N. In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7–2. Immunity. 1994;1:147–154. doi: 10.1016/1074-7613(94)90108-2. [DOI] [PubMed] [Google Scholar]
  72. Chen G.-H., Curtis J.L., Mody C.H., Christensen P.J., Armstrong L.R., Toews G.B. Effect of granulocyte-macrophage colony-stimulating factor on rat alveolar macrophages anticryptococcal activity in vitro. J. Immunol. 1994;152:724–734. [PubMed] [Google Scholar]
  73. Chen K.-S., Burlington D.B., Quinnan G.V., Jr. Active synthesis of hemagglutinin-specific immunoglobulin A by lung cells of mice that were immunized intragastrically with inactivated influenza virus vaccine. J. Virol. 1987;61:2150–2154. doi: 10.1128/jvi.61.7.2150-2154.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Cockfield S.M., Ramassar V., Halloran P.F. Regulation of IFN-γ and tumor necrosis factor-α expression in vivo. J. Immunol. 1993;150:342–352. [PubMed] [Google Scholar]
  75. Coonrood J., Yoneda K. Complement and opsonins in alveolar secretions and serum of rats with pneumonia due to Streptococcus pneumoniae. Rev. Infect. Dis. 1981;3:310–322. doi: 10.1093/clinids/3.2.310. [DOI] [PubMed] [Google Scholar]
  76. Cooper A.M., Dalton D.K., Stewart T.A., Griffin J.P., Russell D.G., Orme I.A. Disseminated tuberculosis in interferon γ gene-disrupted mice. J. Exp. Med. 1993;178:2243–2247. doi: 10.1084/jem.178.6.2243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. Corddry D., Sander R., Weinmann G., Hirshman C., Mitzner W. Use of collateral airways to assess airway reactivity. J. Appl. Physiol. 1991;70:349–356. doi: 10.1152/jappl.1991.70.1.349. [DOI] [PubMed] [Google Scholar]
  78. Corry D., Kulkarni P., Lipscomb M.F. The migration of bronchoalveolar macrophages into hilar lymph nodes. Am. J. Pathol. 1984;115:321–328. [PMC free article] [PubMed] [Google Scholar]
  79. Coultas D.B., Gong H., Jr., Grad R., Handler A., McCurdy S.A., Player R., Rhoades E.R., Samet J.M., Thomas A., Westley M. Respiratory diseases in minorities of the United States. Am. J. Respir. Crit. Care Med. 1993;149:S93–S131. doi: 10.1164/ajrccm/149.3_Pt_2.S93. [DOI] [PubMed] [Google Scholar]
  80. Cox R.A., Kennell W., Boncyk L., Murphy J.W. Induction and expression of cell-mediated immune responses in inbred mice infected with Coccidioides immitis. Infect. Immun. 1988;56:13–17. doi: 10.1128/iai.56.1.13-17.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Coyle A., Page C., Atkinson L., Flanagan R., Metzger W. The requirement for platelets in allergen-induced late asthmatic airway obstruction. Eosinophil infiltration and heightened airway responsiveness in allergic rabbits. Am. Rev. Respir. Dis. 1990;142:587–593. doi: 10.1164/ajrccm/142.3.587. [DOI] [PubMed] [Google Scholar]
  82. Crawford J.M., Miller D.A. Lymphocyte subpopulations in rat lungs and Peyer's patches. Am. Rev. Respir. Dis. 1984;129:827–832. doi: 10.1164/arrd.1984.129.5.827. [DOI] [PubMed] [Google Scholar]
  83. Croft M. Activation of naive, memory and effector T cells. Curr. Opin. Immunol. 1994;6:431–437. doi: 10.1016/0952-7915(94)90123-6. [DOI] [PubMed] [Google Scholar]
  84. Crowle A.J. Intracellular killing of mycobacteria. Res. Microbiol. 1990;141:231–236. doi: 10.1016/0923-2508(90)90035-o. [DOI] [PubMed] [Google Scholar]
  85. Crowley M.K., Inaba K., Witmer-Pack M., Steinman R.M. The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus. Cell. Immunol. 1989;118:108–125. doi: 10.1016/0008-8749(89)90361-4. [DOI] [PubMed] [Google Scholar]
  86. Curtis J.L., Kaltreider H.B. Characterization of bronchoalveolar lymphocytes during a specific antibody-forming cell response in the lungs of mice. Am. Rev. Respir. Dis. 1989;139:393–400. doi: 10.1164/ajrccm/139.2.393. [DOI] [PubMed] [Google Scholar]
  87. Daniele R.P., Altose M.D., Rowlands D.T., Jr. Immunocompetent cells from the lower respiratory tract of normal human lungs. J. Clin. Invest. 1975;56:986–995. doi: 10.1172/JCI108179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Daniele R.P., Beacham C.H., Gorenberg D.J. The bronchoalveolar lymphocyte. Studies on the life history and lymphocyte traffic from blood to the lung. Cell. Immunol. 1977;31:48–54. doi: 10.1016/0008-8749(77)90005-3. [DOI] [PubMed] [Google Scholar]
  89. Darowski M., Hannon V., Hirshman C. Corticosteroids decrease airway hyperresponsiveness in the basenji-greyhound dog model of asthma. J. Appl. Physiol. 1989;66:1120–1126. doi: 10.1152/jappl.1989.66.3.1120. [DOI] [PubMed] [Google Scholar]
  90. Davidson B.L., Faust J., Pessano S., Daniele R.P., Rovera G. Differentiation and activation phenotypes of lung T lymphocytes differ from those of circulating T lymphocytes. J. Clin. Invest. 1985;76:60–65. doi: 10.1172/JCI111977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Defaveri J., Coelho K.I.R., Rezkallah-Iwasso F.M. Hypersensitivity pneumonitis to Paracoccidioides brasiliensis antigens in mice. J. Med. Vet. Mycol. 1989;27:93–104. [PubMed] [Google Scholar]
  92. Defaveri J., Graybill J.R. Immunohistopathology of murine pulmonary histoplasmosis during normal and hypersensitive conditions. Am. Rev. Respir. Dis. 1991;144:1366–1372. doi: 10.1164/ajrccm/144.6.1366. [DOI] [PubMed] [Google Scholar]
  93. DeMeester S.R., Rolfe M.W., Kunkel S.L., Swiderski D.L., Lincoln P.M., Deeb G.M., Strieter R.M. The bimodal expression of tumor necrosis factor-α in association with rat lung reimplantation and allograft rejection. J. Immunol. 1993;150:2494–2505. [PubMed] [Google Scholar]
  94. Demenkoff J.H., Ansfield M.J., Ansfield J., Kaltreider H.B., Adam E. Alveolar macrophage suppression of canine bronchoalveolar lymphocytes: The role of prostaglandin E2 in the inhibition of mitogen-responses. J. Immunol. 1980;124:1365–1370. [PubMed] [Google Scholar]
  95. Denholm E., Phan S. The effects of bleomycin on alveolar macrophage growth factor secretion. Am. J. Pathol. 1989;135:571–580. [PMC free article] [PubMed] [Google Scholar]
  96. Denis M. Killing of Mycobacterium tuberculosis within human monocytes: Activation by cytokines and calcitriol. Clin. Exp. Immunol. 1991;84:200–206. doi: 10.1111/j.1365-2249.1991.tb08149.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  97. Denis M. Involvement of cytokines in determining resistance and acquired immunity in murine tuberculosis. J. Leukocyte Biol. 1991;50:495–501. doi: 10.1002/jlb.50.5.495. [DOI] [PubMed] [Google Scholar]
  98. Denis M., Cormier Y., Fournier M., Tardif J., Laviolette M. Tumor necrosis factor plays an essential role in determining hypersensitivity pneumonitis in a mouse model. Am. J. Respir. Cell. Mol. Biol. 1991;5:477–483. doi: 10.1165/ajrcmb/5.5.477. [DOI] [PubMed] [Google Scholar]
  99. Denis M., Cormier Y., Laviolette M. Murine hypersensitivity pneumonitis: A study of cellular infiltrates and cytokine production and its modulation by cyclosporin A. Am. J. Respir. Cell. Mol. Biol. 1992;6:68–74. doi: 10.1165/ajrcmb/6.1.68. [DOI] [PubMed] [Google Scholar]
  100. Denis M., Cormier Y., Laviolette M., Ghadirian E. T cells in hypersensitivity pneumonitis: Effects of in vivo depletion in a mouse model. Am. J. Respir. Cell. Mol. Biol. 1992;6:183–189. doi: 10.1165/ajrcmb/6.2.183. [DOI] [PubMed] [Google Scholar]
  101. Denis M., Ghadirian E. Transforming growth factor-β is generated in the course of hypersensitivity pneumonitis: Contribution to collagen synthesis. Am. J. Respir. Cell. Mol. Biol. 1992;7:156–160. doi: 10.1165/ajrcmb/7.2.156. [DOI] [PubMed] [Google Scholar]
  102. Denis M., Ghadirian E. Murine hypersensitivity pneumonitis: Production and importance of colony-stimulating factors in the course of a lung inflammatory reaction. Am. J. Respir. Cell. Mol. Biol. 1992;7:441–446. doi: 10.1165/ajrcmb/7.4.441. [DOI] [PubMed] [Google Scholar]
  103. Denis M., Bisson D. Blockade of leukocyte function-associated antigen (LFA-1) in a murine model of lung inflammation. Am. J. Respir. Cell. Mol. Biol. 1994;10:481–496. doi: 10.1165/ajrcmb.10.5.8179910. [DOI] [PubMed] [Google Scholar]
  104. Djukanović R., Roche W.R., Wilson J.W., Beasley C.R.W., Twentyman O.P., Howarth P.H., Holgate S.T. Mucosal inflammation in asthma. Am. Rev. Respir. Dis. 1990;142:434–457. doi: 10.1164/ajrccm/142.2.434. [DOI] [PubMed] [Google Scholar]
  105. Doerschuk C.M., Winn R.K., Coxson H.O., Harlan J.M. CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits. J. Immunol. 1990;144:2327–2333. [PubMed] [Google Scholar]
  106. Doerschuk C.M. The role of CD18-mediated adhesion in neutrophil sequestration induced by infusion of activated plasma in rabbits. Am. J. Respir. Cell. Mol. Biol. 1992;7:140–148. doi: 10.1165/ajrcmb/7.2.140. [DOI] [PubMed] [Google Scholar]
  107. Donnelly J.J., Ulmer J.B., Liu M.A. Immunization with polynucleotides. A novel approach to vaccination. Immunologist. 1994;1:20–26. [Google Scholar]
  108. Du T., Xu L., Lei M., Wang N., Eidelman D., Ghezzo H., Martin J. Morphometric changes during the early airway response to allergen challenge in the rat. Am. Rev. Respir. Dis. 1992;146:1037–1041. doi: 10.1164/ajrccm/146.4.1037. [DOI] [PubMed] [Google Scholar]
  109. Duff A.L., Pomeranz E.S., Gelber L.E., Price G.W., Farris H., Hayden F.G., Platts-Mills T.A., Heymann P.W. Risk factors for acute wheezing in infants and children: Viruses, passive smoke, and IgE antibodies to inhalant allergens. Pediatrics. 1993;92:535–540. [PubMed] [Google Scholar]
  110. Ehrlich R., Kattan M., Godbold J., Saltzberg D.S., Grimm K.T., Landrigan P.J., Lilienfeld D.E. Childhood asthma and passive smoking. Am. Rev. Respir. Dis. 1992;145:594–599. doi: 10.1164/ajrccm/145.3.594. [DOI] [PubMed] [Google Scholar]
  111. Eichelberger M., Allan W., Carding S.R., Bottomly K., Doherty P.C. Activation status of the CD4−8−γδ-T cells recovered from mice with influenza pneumonia. J. Immunol. 1991;147:2069–2074. [PubMed] [Google Scholar]
  112. Emala C., Black C., Curry C., Levine M., Hirshman C. Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of airway hyperresponsiveness. Am. J. Respir. Cell. Mol. Biol. 1993;8:668–675. doi: 10.1165/ajrcmb/8.6.668. [DOI] [PubMed] [Google Scholar]
  113. Emeson E.E.A., Norin J., Veith F.J. Antigen-induced recruitment of circulating lymphocytes to the lungs and hilar lymph nodes of mice challenged intratracheally with alloantigens. Am. Rev. Respir. Dis. 1982;125:453–459. doi: 10.1164/arrd.1982.125.4.453. [DOI] [PubMed] [Google Scholar]
  114. Epler G.R. Bronchiolitis obliterans and airways obstruction associated with graft-versus-host disease. Clin. Chest Med. 1988;9:551–556. [PubMed] [Google Scholar]
  115. Esposito A.L., Pennington J.E. Experimental pneumonia due to Haemophilus influenzae: Observations on pathogenesis and treatment. J. Infect. Dis. 1984;149:728–734. doi: 10.1093/infdis/149.5.728. [DOI] [PubMed] [Google Scholar]
  116. Evans R., Mullally D.I., Wilson R.W., Gergen P.J., Rosenberg H.M., Grauman J.S., Chevarley F.M., Feinleib M. National trends in the morbidity and mortality of asthma in the US. Prevalence, hospitalization and death from asthma over two decades: 1965–1984. Chest. 1987;91:65S–74S. [PubMed] [Google Scholar]
  117. Farrara J.L.M., Deeg H.J. Graft-versus-host disease. N. Engl. J. Med. 1991;324:667–674. doi: 10.1056/NEJM199103073241005. [DOI] [PubMed] [Google Scholar]
  118. Faustman D.L., Steinman R.M., Gebel H.M., Hauptfeld V., Davie J.M., Lacy P.E. Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc. Natl. Acad. Sci. USA. 1984;81:3864–3868. doi: 10.1073/pnas.81.12.3864. [DOI] [PMC free article] [PubMed] [Google Scholar]
  119. Fei R., Schuyler M., Gott K. T cell growth factors in spleen cell cultures in experimental hypersensitivity pneumonitis. Am. Rev. Respir. Dis. 1993;147:A7913. [Google Scholar]
  120. Fink J.N. Hypersensitivity pneumonitis. In: Daniele R.P., editor. “Immunology and Immunologic Disease of the Lung”. Blackwell Scientific; Boston, MA: 1988. pp. 321–333. [Google Scholar]
  121. Flesch I.E.A., Schwamberger G., Kaufmann S.H.E. Fungicidal activity of IFN-γ-activated macrophages. Extracellular killing of Cryptococcus neoformans. J. Immunol. 1989;142:3219–3224. [PubMed] [Google Scholar]
  122. Flesch I.E., Kaufmann S.H. Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor. Infect. Immun. 1990;58:2675–2677. doi: 10.1128/iai.58.8.2675-2677.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  123. Flynn J.L., Goldstein M.M., Triebold K.J., Koller B., Bloom B.R. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. USA. 1992;89:12013–12017. doi: 10.1073/pnas.89.24.12013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  124. Flynn J.L., Chan J., Triebold K.J., Dalton D.K., Stewart T.A., Bloom B.R. An essential role for interferon γ in resistance to Mycobacterium tuberculosis. J. Exp. Med. 1993;178:2249–2254. doi: 10.1084/jem.178.6.2249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  125. Fojtasek M.F., Sherman M.R., Garringer T., Blair R., Wheat L.J., Schnizlein-Bick C.T. Local immunity in lung-associated lymph nodes in a murine model of pulmonary histoplasmosis. Infect. Immun. 1993;61:4607–4614. doi: 10.1128/iai.61.11.4607-4614.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  126. Fournier M., Vai F., Derenne J.P.H., Pariente R. Bronchial lymphoepithelial nodules in the rat: Morphologic features and uptake and transport of exogenous proteins. Am. Rev. Respir. Dis. 1977;116:685–694. doi: 10.1164/arrd.1977.116.4.685. [DOI] [PubMed] [Google Scholar]
  127. Fournier M., Lebargy F., Le Roy Ladurie F., Lenormand E., Pariente R. Intraepithelial T-lymphocyte subsets in the airways of normal subjects and of patients with chronic bronchitis. Am. Rev. Respir. Dis. 1989;140:737–742. doi: 10.1164/ajrccm/140.3.737. [DOI] [PubMed] [Google Scholar]
  128. Frew A., Moqbel R., Azzawi M., Hartnell A., Barkans J., Jeffrey P., Kay A., Scheper R., Varley J., Church M. Lymphocytes and eosinophils in allergen-induced late-phase asthmatic reactions in the guinea pig. Am. Rev. Respir. Dis. 1990;141:407–413. doi: 10.1164/ajrccm/141.2.407. [DOI] [PubMed] [Google Scholar]
  129. Frey C.L., Demarsh P.L., Drutz D.J. Divergent patterns of pulmonary blastomycosis induced by conidia and yeasts in athymic and euthymic mice. Am. Rev. Respir. Dis. 1989;140:118–124. doi: 10.1164/ajrccm/140.1.118. [DOI] [PubMed] [Google Scholar]
  130. Fukuda T., Akutsu I., Motojima S., Makino S. Inhibition of antigen-induced late asthmatic response and bronchial hyperresponsiveness by cyclosporin and FK 506. Int. Arch. Allergy Appl. Immunol. 1991;94:259–261. doi: 10.1159/000235377. [DOI] [PubMed] [Google Scholar]
  131. Ganguly R., Waldman R.H. Respiratory tract cell-mediated immunity. Bull Eur. Physiopathol. Respir. 1977;13:95–102. [PubMed] [Google Scholar]
  132. Garcia H., Salter-Cid L., Stein-Streilein J. Persistent interleukin-2 activity and molecular evidence for expression of lymphotoxin in the hapten-immune model for pulmonary interstitial fibrosis. Am. J. Respir. Cell. Mol. Biol. 1992;6:22–28. doi: 10.1165/ajrcmb/6.1.22. [DOI] [PubMed] [Google Scholar]
  133. Garssen J., Nijkamp F., Van der vliet H., van Loveren J. T-cell-mediated induction of airway hyperreactivity in mice. Am. Rev. Respir. Dis. 1991;144:931–938. doi: 10.1164/ajrccm/144.4.931. [DOI] [PubMed] [Google Scholar]
  134. Glover R.E. Infection of mice with Mycobacterium tuberculosis (bovis) by the respiratory route. Br. J. Exp. Pathol. 1944;25:141–149. [Google Scholar]
  135. Godleski J.J., Brain J.D. The origin of alveolar macrophages in mouse radiation chimeras. J. Exp. Med. 1972;136:630–643. doi: 10.1084/jem.136.3.630. [DOI] [PMC free article] [PubMed] [Google Scholar]
  136. Gong J.L., McCarthy K.M., Telford J., Tamatani T., Miyasaka M., Schneeberger E.E. Intraepithelial airway dendritic cells: A distinct subset of pulmonary dendritic cells obtained by microdissection. J. Exp. Med. 1992;175:797–807. doi: 10.1084/jem.175.3.797. [DOI] [PMC free article] [PubMed] [Google Scholar]
  137. Gorczynski R.M., Wojcik D. A role for nonspecific (Cyclosporin A) or specific (monoclonal antibodies to ICAM-1, LFA-1, and IL-10) immunomodulation in the prolongation of skin allografts after antigen-specific pretransplant immunization or transfusion. J. Immunol. 1994;152:2011–2019. [PubMed] [Google Scholar]
  138. Gorter A., Hiemstra P., Leijh P., van der Sluys M.E., van der Barselaar M.T., van Es L.A., Daha M.R. Complement mediated enhancement of IgA induced H2O2 release by human polymorphonuclear leukocytes. Immunology. 1989;67:120–125. [PMC free article] [PubMed] [Google Scholar]
  139. Graeme-Cook F., Bhan A.K., Harris N.L. Immunohistochemical characterization of intraepithelial and subepithelial mononuclear cells of the upper airways. Am. J. Pathol. 1993;143:1416–1422. [PMC free article] [PubMed] [Google Scholar]
  140. Graham B.S., Bunton L.A., Wright P.F., Karzon D.T. Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice. J. Clin. Invest. 1991;88:1026–1033. doi: 10.1172/JCI115362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  141. Graham B.S., Henderson G.S., Tang Y.-W., Lu X., Neuzil K.M., Colley D.G. Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus. J. Immunol. 1993;151:2032–2040. [PubMed] [Google Scholar]
  142. Granger D.L., Perfect J.R., Durack D.T. Macrophage-mediated fungistasis in vitro: Requirements for intracellular and extracellular cytotoxicity. J. Immunol. 1986;136:672–680. [PubMed] [Google Scholar]
  143. Granger D.L., Hibbs J.B., Jr., Perfect J.R., Durack D.T. Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages. J. Clin. Invest. 1988;81:1129–1136. doi: 10.1172/JCI113427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  144. Green G.M., Jakab G.J., Low R.B., Davis G.S. Defense mechanisms of the respiratory membrane. Am. Rev. Respir. Dis. 1977;115:479–514. doi: 10.1164/arrd.1977.115.3.479. [DOI] [PubMed] [Google Scholar]
  145. Guckian J., Christiensen G., Fine D. The role of opsonins in recovery from experimental pneumococcal pneumonia. J. Infect. Dis. 1980;142:175–190. doi: 10.1093/infdis/142.2.175. [DOI] [PubMed] [Google Scholar]
  146. Gundel R., Wegner C., Letts L. Antigen-induced acute and late-phase responses in primates. Am. Rev. Respir. Dis. 1992;146:369–373. doi: 10.1164/ajrccm/146.2.369. [DOI] [PubMed] [Google Scholar]
  147. Gyetko M.R., Toews G.B. Immunology of the aging lung. Clin. Chest Med. 1993;14:379–391. [PubMed] [Google Scholar]
  148. Haley P.J., Finch G.L., Mewhinney J.A., Harmsen A.G., Hahn F.F., Hoover M.D., Muggenburg B.A., Bice D.D. A canine model of beryllium-induced granulomatous lung disease. Lab. Invest. 1989;61:219–227. [PubMed] [Google Scholar]
  149. Hance A.J. Pulmonary immune cells in health and disease: Dendritic cells and Langerhans' cells. Eur. Respir. J. 1993;6(8):1213–1220. [PubMed] [Google Scholar]
  150. Handley D., DeLeo J., Havill A. Induction by aerosol allergen of sustained and nonspecific IgE-mediated airway hyperreactivity in the guinea pig. Agents Actions. 1992;37:201–203. doi: 10.1007/BF02028109. [DOI] [PubMed] [Google Scholar]
  151. Harding F.A., McArthur J.G., Gross J.A., Raulet D.H., Allison J.P. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature. 1992;356:607–609. doi: 10.1038/356607a0. [DOI] [PubMed] [Google Scholar]
  152. Harding G., Smith D. Host-parasite relationships in experimental airborne tuberculosis. VI. Influence of vaccination with bacille Calmette-Guerin on the onset and/or extent of hematogenous dissemination of virulent Mycobacterium tuberculosis to the lungs. J. Infect. Dis. 1977;136:439–443. doi: 10.1093/infdis/136.3.439. [DOI] [PubMed] [Google Scholar]
  153. Harmsen A.G., Muggenburg B.A., Snipes M.B., Bice D.E. The role of macrophages in particle translocation from lungs to lymph nodes. Science. 1985;230:1277–1280. doi: 10.1126/science.4071052. [DOI] [PubMed] [Google Scholar]
  154. Harmsen A.G., Mason M.J., Muggenburg B.A., Gillett N.A., Jarpe M.A., Bice D.E. Migration of neutrophils from lung to tracheobronchial lymph node. J. Leukocyte Biol. 1987;41:95–103. doi: 10.1002/jlb.41.2.95. [DOI] [PubMed] [Google Scholar]
  155. Harmsen A.G., Stankiewicz M. Requirement for CD4+ cells in resistance to Pneumocystis carinii pneumonia in mice. J. Exp. Med. 1990;172:937–945. doi: 10.1084/jem.172.3.937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  156. Havenith C.E.G., Breedijk A.J., Hoefsmit E.C.M. Effect of bacillus Calmette-Guérin inocuation on numbers of dendritic cells in bronchoalveolar lavages of rats. Immunobiology. 1992;184:336–347. doi: 10.1016/S0171-2985(11)80591-7. [DOI] [PubMed] [Google Scholar]
  157. Havenith C.E.G., Breedijk A.J., van Miert P.P.M.C., Blijleven N., Calame W., Beelen R.H.J., Hoefsmit C.M. Separation of alveolar macrophages and dendritic cells via autofluorescence: Phenotypical and functional characterization. J. Leukocyte Biol. 1993;53:504–510. doi: 10.1002/jlb.53.5.504. [DOI] [PubMed] [Google Scholar]
  158. Havenith C.E.G., van Miert P.P.M.C., Breedijk A.J., Beelen R.H.J., Hoefsmit E.C.M. Migration of dendritic cells into the draining lymph nodes of the lung and intratracheal instillation. Am. J. Respir. Cell. Mol. Biol. 1993;9:484–488. doi: 10.1165/ajrcmb/9.5.484. [DOI] [PubMed] [Google Scholar]
  159. Havenith C.E., Breedijk A.J., Betjes M.G., Calame W., Beelen R.H., Hoefsmit E.C. T cell priming in situ by intratracheally instilled antigen-pulsed dendritic cells. Am. J. Respir. Cell. Mol. Biol. 1993;8:319–324. doi: 10.1165/ajrcmb/8.3.319. [DOI] [PubMed] [Google Scholar]
  160. Heidbrink P., Rehm S., Toews G., Pierce A. Granulocyte participation in early lung clearance of pneumococci from murine lung. Am. Rev. Respir. Dis. 1980;121:351. [Google Scholar]
  161. Hellewell P.G., Young S.K., Henson P.M., Worthen G.S. Disparate role of the β2-integrin CD18 in the local accumulation of neutrophils in pulmonary and cutaneous inflammation in the rabbit. Am. J. Respir. Cell. Mol. Biol. 1994;10:391–398. doi: 10.1165/ajrcmb.10.4.7510985. [DOI] [PubMed] [Google Scholar]
  162. Hennet T., Ziltener H.J., Frei K., Peterhans E. A kinetic study of immune mediators in the lungs of mice infected with influenza A virus. J. Immunol. 1992;149:932–939. [PubMed] [Google Scholar]
  163. Herold C., Brown R., Mitzner W., Links J., Hirshman C., Zerhouni E. Assessment of pulmonary airway reactivity with high-resolution computed tomography. Radiology. 1991;181:369–374. doi: 10.1148/radiology.181.2.1924774. [DOI] [PubMed] [Google Scholar]
  164. Hertz M.I., Jessurun J., King M.B., Savik S.K., Murray J.J. Reproduction of the obliterative bronchiolitis lesion after heterotopic transplantation of mouse airways. Am. J. Pathol. 1993;142:1945–1951. [PMC free article] [PubMed] [Google Scholar]
  165. Hiemstra P., Biewenga J., Gorter A., Stuurman M.E., Faber A., van Es L.A., Daha M.R. Activation of complement by human serum IgA, secretory IGA and IgA1 fragments. Mol. Immunol. 1988;25:527–533. doi: 10.1016/0161-5890(88)90074-0. [DOI] [PubMed] [Google Scholar]
  166. Hill J.O., Burrell R. Cell-mediated immunity to soluble and particulate inhaled antigens. Clin. Exp. Immunol. 1979;38:332–341. [PMC free article] [PubMed] [Google Scholar]
  167. Hill J.O., Dunn P.L. A T cell-independent protective host response against Cryptococcus neoformans expressed at the primary site of infection in the lung. Infect. Immun. 1993;61:5302–5308. doi: 10.1128/iai.61.12.5302-5308.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  168. Hill J.O., Harmsen A.G. Intrapulmonary growth and dissemination of an avirulent strain of Cryptococcus neoformans in mice depleted of Cd4+ or CD8+ T cells. J. Exp. Med. 1991;173:755–758. doi: 10.1084/jem.173.3.755. [DOI] [PMC free article] [PubMed] [Google Scholar]
  169. Hill J.O. CD4+ T cells cause multinucleated giant cells to form around Cryptococcus neoformans and confine the yeast within the primary site of infection in the respiratory tract. J. Exp. Med. 1992;175:1685–1695. doi: 10.1084/jem.175.6.1685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  170. Hill J.O., Bice D.E., Harris D.L., Muggenburg B.A. Evaluaiton of the pulmonary immune response by analysis of bronchoalveolar fluids obtained by serial lung lavage. Int. Arch. Allergy Appl. Immunol. 1983;71:173–177. doi: 10.1159/000233383. [DOI] [PubMed] [Google Scholar]
  171. Hillam R.P., Bice D.E., Muggenburg B.A. Lung localization of antibody-forming cells stimulated in distant peripheral lymph nodes. Immunology. 1985;55:257–261. [PMC free article] [PubMed] [Google Scholar]
  172. Hirshman C., Malley A., Downes H. The bensenji-greyhound dog model of asthma: Reactivity to Ascaris suum, citic acid and methacholine. J. Appl. Physiol. 1980;49:953–957. doi: 10.1152/jappl.1980.49.6.953. [DOI] [PubMed] [Google Scholar]
  173. Hirshman C., Austin D., Klein W., Hanifin J., Hulbert W. Increased metachromatic cells and lymphocytes in bronchoalveolar lavage fluid of dogs with airway hyperreactivity. Am. Rev. Respir. Dis. 1986;133:482–487. doi: 10.1164/arrd.1986.133.3.482. [DOI] [PubMed] [Google Scholar]
  174. Hirshman C., Austin D., Kettelkamp N. Enhanced bronchoalveolar lavage mast cells histmine releasability in allergic dogs with and without airway hyperresponsiveness. J. Allergy Clin. Immunol. 1988;81:829–835. doi: 10.1016/0091-6749(88)90938-4. [DOI] [PubMed] [Google Scholar]
  175. Hoag K.A., Street N.E., Lipscomb M.F. Role of cytokines in the clearance of Cryptococcus neoformans pulmonary infections in mice. FASEB J. 1994;8:A251. [Google Scholar]
  176. Holt P.G. Alveolar macrophages. II. Inhibition of lymphocyte proliferation by purified macrophages from rat lung. Immunology. 1979;37:429–436. [PMC free article] [PubMed] [Google Scholar]
  177. Holt P.G. Down-regulation of immune responses in the lower respiratory tract: The role of alveolar macrophages. Clin. Exp. Immunol. 1986;63:261–270. [PMC free article] [PubMed] [Google Scholar]
  178. Holt P.G. Regulation of antigen-presenting cell function(s) in lung and airway tissues. Eur. Respir. J. 1993;6:120–129. [PubMed] [Google Scholar]
  179. Holt P.G., Leivers S. Tolerance induction via antigen inhalation: Isotype specificity, stability, and involvement of suppressor T cells. Int. Arch. Allergy Appl. Immunol. 1982;67:155–160. doi: 10.1159/000233007. [DOI] [PubMed] [Google Scholar]
  180. Holt P.G., Schon-Hegrad M.A. Localization of T cells, macrophages and dendritic cells in rat respiratory tract tissue: Implications for immune function studies. Immunology. 1987;62:349–356. [PMC free article] [PubMed] [Google Scholar]
  181. Holt P.G., Warner L.A., Papadimitrious J.M. Alveolar macophages: Functional heterogeneity within macrophage populations from rat lung. Ajebak. 1982;60:607–618. doi: 10.1038/icb.1982.63. [DOI] [PubMed] [Google Scholar]
  182. Holt P.G., Degebrodt A., Venaille T., O'Leary C., Krska K., Flexman J., Farrell H., Shellam G., Young P., Penhale J., Robertson T., Papadimitriou J.M. Preparation of interstitial lung cells by enzymatic digestion of tissue slices: Preliminary characterization by morphology and performance in functional assays. Immunology. 1985;54:139–147. [PMC free article] [PubMed] [Google Scholar]
  183. Holt P.G., Robinson B.W.S., Reid M., Kees U.R., Warton A., Dawson V.H., Rose A., Schon-Hegrad M. Extraction of immune and inflammatory cells from human lung parenchyma: Evaluation of an enzymatic digestion procedure. Clin. Exp. Immunol. 1986;66:188–200. [PMC free article] [PubMed] [Google Scholar]
  184. Holt P.G., Schon-Hegrad M.A., Oliver J. MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophages populations. J. Exp. Med. 1988;167:262–274. doi: 10.1084/jem.167.2.262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  185. Holt P.G., McMenamin C., Schon-Hegrad M.A., Strickland D., Nelson D., Wilkes L., Bilyk N., Oliver J., Holt B.J., McMenamin P.G. Immunoregulation of asthma: Control of T-lymphocyte activation in the respiratory tract. Eur. Respir. J. 1991;13:6s–15s. [PubMed] [Google Scholar]
  186. Holt P.G., Oliver J., Bilyk N., McMenamin C., McMenamin P.G., Kraal G., Thepen T. Downregulation of the antigen-presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J. Exp. Med. 1993;177:397–407. doi: 10.1084/jem.177.2.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  187. Holt P.G., Haining S., Nelson D.J., Sedgwick J.D. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J. Immunol. 1994;153:256–261. [PubMed] [Google Scholar]
  188. Horowitz J., Volanakis J., Briles D. Blood clearance of Streptococcus pneumoniae by C-reactive protein. J. Immunol. 1987;138:2598–2603. [PubMed] [Google Scholar]
  189. Hsieh C.S., Macatonia S.E., Tripp C.S., Wolf S.F., O-Garra A., Murphy K.M. Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science. 1993;260:547–549. doi: 10.1126/science.8097338. [DOI] [PubMed] [Google Scholar]
  190. Hu H., Stein-Streilein J. Hapten-immune pulmonary interstitial fibrosis (HIPIF) in mice requires both CD4+ and CD8+ T lymphocytes. J. Leukocyte Biol. 1993;54:414–422. doi: 10.1002/jlb.54.5.414. [DOI] [PubMed] [Google Scholar]
  191. Huffnagle G.B., Lipscomb M.F. Animal model of human disease. Pulmonary cryptococcosis. Am. J. Pathol. 1992;141:1517–1520. [PMC free article] [PubMed] [Google Scholar]
  192. Huffnagle G.B., Yates J.L., Lipscomb M.F. Immunity to a pulmonary Cryptococcus neoformans infection requires both CD4+ and CD8+ T cells. J. Exp. Med. 1991;173:793–800. doi: 10.1084/jem.173.4.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  193. Huffnagle G.B., Yates J.L., Lipscomb M.F. T cell-mediated immunity in the lung: A Cryptococcus neoformans pulmonary infection model using SCID and athymic nude mice. Infect. Immun. 1991;59:1423–1433. doi: 10.1128/iai.59.4.1423-1433.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  194. Huffnagle G.B., Lipscomb M.F., Lovchik J.A., Hoag K.A., Street N.E. The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection. J. Leukocyte Biol. 1994;55:35–42. doi: 10.1002/jlb.55.1.35. [DOI] [PubMed] [Google Scholar]
  195. Inaba K., Steinman R.M., Pack M.W., Aya H., Inaba M., Sudo T., Wolpe S., Schuler G. Identification of proliferating dendritic cell precursors in mouse blood. J. Exp. Med. 1992;175:1157–1167. doi: 10.1084/jem.175.5.1157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  196. Inaba K., Inaba M., Deguchi M., Hagi K., Yasumizu R., Ikehara S., Muramatsu S., Steinman R.M. Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc. Natl. Acad. Sci. USA. 1993;90:3038–3042. doi: 10.1073/pnas.90.7.3038. [DOI] [PMC free article] [PubMed] [Google Scholar]
  197. Iwamoto I., Nakajima H., Endo H., Yoshida S. Interferon γ regulates antigen-induced eosinophil infiltration into the mouse airways by inhibiting the inflitration of CD4+ T cells. J. Exp. Med. 1993;177:573–576. doi: 10.1084/jem.177.2.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  198. Jakab G.J. Factors influencing the immune enhancement of intrapulmonary bactericidal mechanisms. Infect. Immun. 1976;14:389–398. doi: 10.1128/iai.14.2.389-398.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  199. Janis E.M., Kaufmann S.H., Schwartz R.H., Pardoll D.M. Activation of gamma delta T cells in the primary immune response to Mycobacterium tuberculosis. Science. 1989;244:713–716. doi: 10.1126/science.2524098. [DOI] [PubMed] [Google Scholar]
  200. Joel D.D., Chanana A.D. Distribution of lung-associated lymphocytes from the caudal mediastinal lymph node: Effect of antigen. Immunology. 1987;62:641–646. [PMC free article] [PubMed] [Google Scholar]
  201. Johnson K., Ward P. Acute immunologic pulmonary alveolitis. J. Clin. Invest. 1974;54:349–357. doi: 10.1172/JCI107770. [DOI] [PMC free article] [PubMed] [Google Scholar]
  202. Joiner K., Brown E., Frank M. Complement and bacteria: Chemistry and biology in host defense. Annu Rev Immunol. 1984;2:461–491. doi: 10.1146/annurev.iy.02.040184.002333. [DOI] [PubMed] [Google Scholar]
  203. Jones M., Mulligan M., Flory C., Ward P., Warren J. Potential role of monocyte chemoattractant protein 1/JE in monocyte/macrophage-dependent IgA immune complex alveolitis in the rat. J. Immunol. 1992;149:2147–2154. [PubMed] [Google Scholar]
  204. Jones P.D., Ada G.L. Influenza virus-specific antibody-secreting cells in the murine lung during primary influenza virus infection. J. Virol. 1986;60:614–619. doi: 10.1128/jvi.60.2.614-619.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  205. Jones P.D., Ada G.L. Persistence of influenza virus-specific antibody-secreting cells and B-cell memory after primary murine influenza virus infection. Cell Immunol. 1987;109:53–64. doi: 10.1016/0008-8749(87)90291-7. [DOI] [PubMed] [Google Scholar]
  206. Jordan S.C., Kondo T., Prehn J., Marchevsky A., Waters P. Cytokine gene activation in rat lung allografts: Analysis by Northern blotting. Transplant. Proc. 1991;23:604–606. [PubMed] [Google Scholar]
  207. Jordana M., Richards C., Irving L., Gauldie J. Spontaneous in vitro release of alveolar-macrophage cytokines after the intratracheal instillation of bleomycin in rats. Am. Rev. Respir. Dis. 1988;137:1135–1140. doi: 10.1164/ajrccm/137.5.1135. [DOI] [PubMed] [Google Scholar]
  208. Jordana M., Ohno I., Xing Z., Gauldie J. Cytokines in lung and airways fibrosis. Regul. Immunol. 1993;5:201–206. [PubMed] [Google Scholar]
  209. June C.H., Bluestone J.A., Nadler L.M., Thompson C.B. The B7 and CD28 receptor families. Immunol. Today. 1994;15:321–331. doi: 10.1016/0167-5699(94)90080-9. [DOI] [PubMed] [Google Scholar]
  210. Jutila M.A. Function and regulation of leukocyte homing receptors. J. Leukocyte Biol. 1994;55:133–140. doi: 10.1002/jlb.55.1.133. [DOI] [PubMed] [Google Scholar]
  211. Kaltreider H.B. Expression of immune mechanisms in the lung. Am. Rev. Respir. Dis. 1976;113:347–379. doi: 10.1164/arrd.1976.113.3.347. [DOI] [PubMed] [Google Scholar]
  212. Kaltreider H.B., Barth E., Pellegrini C. The effect of splenectomy on the appearance of specific antibody-forming cells in the lungs of dogs after intravenous immunization with sheep erythrocytes. Exp. Lung Res. 1981;2:231–238. doi: 10.3109/01902148109052318. [DOI] [PubMed] [Google Scholar]
  213. Kaltreider H.B., Byrd P.K., Daughety T.W., Shalaby M.R. The mechanism of appearance of specific antibody-forming cells in lungs of inbred mice after intratracheal immunization with sheep erythrocytes. Am. Rev. Respir. Dis. 1983;127:316–321. doi: 10.1164/arrd.1983.127.3.316. [DOI] [PubMed] [Google Scholar]
  214. Kaltreider H.B., Caldwell J.L., Byrd P.K. The capacity of normal murine alveolar macrophages to function as antigen-presenting cells for the initiation of primary antibody-forming cell responses to sheep erythrocytes in vitro. Am. Rev. Respir. Dis. 1986;133:1097–1104. doi: 10.1164/arrd.1986.133.6.1097. [DOI] [PubMed] [Google Scholar]
  215. Kanaly S.T., Hines S.A., Palmer G.H. Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T-lymphocyte-deficient transgenic mice. Infect. Immun. 1993;61:4929–4932. doi: 10.1128/iai.61.11.4929-4932.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  216. Kapikian A.Z., Mitchell R.H., Chanock R.M., Shvedoff R.A., Stewart C.E. An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am. J. Epidemiol. 1969;89:405–421. doi: 10.1093/oxfordjournals.aje.a120954. [DOI] [PubMed] [Google Scholar]
  217. Karaoui R.M., Hall N.K., Larsh H.W. Role of macrophages in immunity and pathogenesis of experimental cryptococcosis induced by the airborne route—Part I: Pathogenesis and acquired immunity of Cryptococcus neoformans. Mykosen. 1977;20:380–388. [PubMed] [Google Scholar]
  218. Karmiol S., Remick D., Kunkel S., Phan S. Regulation of rat pulmonary endothelial cell interleukin-6 production by bleomycin: Effects of cellular fatty acid composition. Am. J. Respir. Cell. Mol. Biol. 1993;9:628–636. doi: 10.1165/ajrcmb/9.6.628. [DOI] [PubMed] [Google Scholar]
  219. Kaufmann S.H.E. CD8+ T lymphocytes in intracellular microbial infections. Immunol. Today. 1988;9:168–174. doi: 10.1016/0167-5699(88)91292-3. [DOI] [PubMed] [Google Scholar]
  220. Kaufmann S.H., Kabelitz D. Gamma/delta T lymphocytes and heat shock proteins. Curr. Top. Microbiol. Immunol. 1991;167:191–207. doi: 10.1007/978-3-642-75875-1_11. [DOI] [PubMed] [Google Scholar]
  221. Kaufman S.H.E., Young D.B. Vaccination against tuberculosis and leprosy. Immunobiology. 1992;184:208–229. doi: 10.1016/S0171-2985(11)80476-6. [DOI] [PubMed] [Google Scholar]
  222. Kawamura I., Tsukada H., Yoshikawa H., Fujita M., Nomoto K., Mitsuyama M. IFN-gamma-producing ability as a possible marker for the protective T cells against Mycobacterium bovis BCG in mice. J. Immunol. 1992;148:2887–2893. [PubMed] [Google Scholar]
  223. Kazmierowski J.A., Aduan R.P., Reynolds H.Y. Pulmonary host defense: Coordinated interaction of mechanical, cellular and humoral immune systems of the lung. Bull. Eur. Physiopathol. Respir. 1977;13:103–116. [PubMed] [Google Scholar]
  224. Kepon W., James J., Kirk B., Sehon A., Tse K. A canine model for reagenic hypersensitivity and allergic broncho constriction. J. Allergy Clin. Immunol. 1977;59:64–68. doi: 10.1016/0091-6749(77)90178-6. [DOI] [PubMed] [Google Scholar]
  225. Khalil N., Bereznay O., Sporn M., Greenberg A. Macrophage production of tranforming growth factor β and fibroblast collagen synthesis in chronic pulmonary inflammation. J. Exp. Med. 1989;170:727–737. doi: 10.1084/jem.170.3.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
  226. Kikuchi R., Watabe N., Konno T., Mishina N., Sekizawa K., Sasaki H. High incidence of silent aspiration in elderly patients with community-acquired pneumonia. Am. J. Respir. Crit. Care Med. 1994;150:251–253. doi: 10.1164/ajrccm.150.1.8025758. [DOI] [PubMed] [Google Scholar]
  227. Kim H.W., Canchola J.G., Brandt C.D., Pyles G., Chanock R.M., Jensen K., Parrott R.H. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am. J. Epidemiol. 1969;89:422–434. doi: 10.1093/oxfordjournals.aje.a120955. [DOI] [PubMed] [Google Scholar]
  228. Kimura R., Hu H., Stein-Streilein J. Delayed type hypersensitivity responses regulate collagen deposition in the lung. Immunology. 1992;77:550–555. [PMC free article] [PubMed] [Google Scholar]
  229. Kimura R., Hu H., Stein-Streilein J. Tolerance to hapten prevents specific delayed type hypersensitivity and pulmonary interstitial fibrosis in the mouse model. Chest. 1993;103:122S–124S. doi: 10.1378/chest.103.2_supplement.122s. [DOI] [PubMed] [Google Scholar]
  230. Kindler V., Sappino A., Grau G.E., Piguet P., Vassalli P. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG development. Cell. 1989;56:731–740. doi: 10.1016/0092-8674(89)90676-4. [DOI] [PubMed] [Google Scholar]
  231. Kitani A., Strober W. Regulation of Cγ subclass germ-line transcripts in human peripheral blood B cells. J. Immunol. 1993;151:3478–3488. [PubMed] [Google Scholar]
  232. Knight S.C., Mertin J., Stackpoole A., Clark J. Induction of immune responses in vivo with small number of veiled (dendritic) cells. Proc. Natl. Acad. Sci. 1983;80:6032–6035. doi: 10.1073/pnas.80.19.6032. [DOI] [PMC free article] [PubMed] [Google Scholar]
  233. Kopp W., Dierks S., Butler J., Upadrashta B., Richerson H. Cyclosporine immunodulation in a rabbit model of chronic hypersensitivity pneumonitis. Am. Rev. Respir. Dis. 1985;132:1027–1033. doi: 10.1164/arrd.1985.132.5.1027. [DOI] [PubMed] [Google Scholar]
  234. Kopp W., Suelzer M., Richerson H. Alveolar macrophage immunosuppression is maintained in rabbit models of hypersensitivity pneumonitis. J. Allergy Clin. Immunol. 1988;82:204–212. doi: 10.1016/0091-6749(88)91000-7. [DOI] [PubMed] [Google Scholar]
  235. Kozel T.S., Pfrommer G.S.T. Activation of the complement system by Cryptococcus neoformans leads to binding of iC3b to the yeast. Infect. Immun. 1986;52:1–5. doi: 10.1128/iai.52.1.1-5.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  236. Kozel T.R., Pfrommer G.S.T., Guerlain A.S., Highison B.A., Highison G.J. Role of the capsule in phagocytosis of Cryptococcus neoformans. Rev. Infect. Dis. 1988;10:S436–S439. doi: 10.1093/cid/10.supplement_2.s436. [DOI] [PubMed] [Google Scholar]
  237. Kradin R.L., McCarthy K.M., Dailey C.I., Burdeshaw A., Kurnick J.T., Schneeberger E.E. The poor accessory cell function of macrophages in the rat may reflect their inability to form clusters with T cells. Clin. Immunol. Immunopathol. 1987;44:348–363. doi: 10.1016/0090-1229(87)90079-1. [DOI] [PubMed] [Google Scholar]
  238. Kradin R.L., McCarthy K.M., Xia W., Lazarus D., Schneeberger E.E. Accessory cells of the lung. I. Interferon-gamma increases Ia+ dendritic cells in the lung without augmenting their accessory activities. Am. J. Respir. Cell. Mol. Biol. 1991;4:210–218. doi: 10.1165/ajrcmb/4.3.210. [DOI] [PubMed] [Google Scholar]
  239. Kradin R.L., Xia W., McCarthy K., Schneeberger E.E. FcR± subsets of Ia+ pulmonary dendritic cells in the rat display differences in their abilities to provide accessory co-stimulation for naive (OX-22+) and sensitized (OX-22−) T cells. Am. J. Pathol. 1993;142:811–819. [PMC free article] [PubMed] [Google Scholar]
  240. Kroemer G., Cuende E., Martinez A.C. Compartmentalization of the peripheral immune system. Adv. Immunol. 1993;53:157–216. doi: 10.1016/s0065-2776(08)60500-3. [DOI] [PubMed] [Google Scholar]
  241. Kunkel S.L., Stephen W., Chensue W., Strieter R.M., Lynch J.P., Remick D.G. Cellular and molecular aspects of granulomatous inflammation. Am. J. Respir. Cell. Mol. Biol. 1989;1:439–447. doi: 10.1165/ajrcmb/1.6.439. [DOI] [PubMed] [Google Scholar]
  242. Lack G., Renz H., Saloga J., Bradley K., Loader J., Leung D., Larsen G., Gelfand E. Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airways function in a murine model of allergic sensitization. J. Immunol. 1994;152:2546–2554. [PubMed] [Google Scholar]
  243. Lambert P.H. New vaccines for the world—Needs and prospects. Immunologist. 1993;1:50–55. [Google Scholar]
  244. Larsen G., Renz H., Loader J., Bradley K., Gelfand E. Airway response to electrical field stimulation in sensitized inbred mice: Passive transfer of increased responsiveness with peribronchial lymph nodes. J. Clin. Invest. 1992;89:747–752. doi: 10.1172/JCI115651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  245. Larson C.L., Wicht W.C. Studies of resistance to experimental tuberculosis in mice vaccinated with living attenuated tubercle bacilli and challenged with virulent organisms. Am. Rev. Respir. Dis. 1962;85:833–846. doi: 10.1164/arrd.1962.85.6.833. [DOI] [PubMed] [Google Scholar]
  246. Lauweryns J.M., Baert J.H. Alveolar clearance and the role of the pulmonary lymphatics. In: Murray J.F., editor. “Lung Disease State of the Art”. American Lung Association; New York: 1976. pp. 185–243. [Google Scholar]
  247. Lechler R.I., Batchelor J.R. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J. Exp. Med. 1982;155:31–41. doi: 10.1084/jem.155.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  248. Lehnert B.E. Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung. Environ. Health Perspect. 1992;97:17–46. doi: 10.1289/ehp.929717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  249. Leveton C., Barnass S., Champion B., Lucas S., De Souza B., Nicol M., Banerjee D., Rook G. T-cell-mediated protection of mice against virulent Mycobacterium tuberculosis. Infect. Immun. 1989;57:390–395. doi: 10.1128/iai.57.2.390-395.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  250. Levitz S.M., Dupont M.P., Smail E.H. Direct activity of human T lymphocytes and natural killer cells against Cryptococcus neoformans. Infect. Immun. 1994;62:194–202. doi: 10.1128/iai.62.1.194-202.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  251. Lim T.S., Murphy J.W., Cauley L.K. Host–etiological agent interactions intranasally and intraperitoneally induced cryptococcosis in mice. Infect. Immun. 1980;29:633–641. doi: 10.1128/iai.29.2.633-641.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  252. Lim T.S., Murphy J.W. Transfer of immunity to cryptococcosis by T-enriched splenic lymphocytes from Cryptococcus neoformans sensitized mice. Infect. Immun. 1980;30:5–11. doi: 10.1128/iai.30.1.5-11.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  253. Lipscomb M.F., Lyons C.R., O'Hara R.M., Jr., Stein-Streilein J. The antigen-induced selective recruitment of specific T lymphocytes to the lung. J. Immunol. 1982;128:111–115. [PubMed] [Google Scholar]
  254. Lipscomb M.F., Yeakel-Houlihan D., Lyons C.R., Gleason R.R., Stein-Streilein J. Persistence of influenza as an immunogen in pulmonary antigen-presenting cells. Infect. Immun. 1983;42:965–972. doi: 10.1128/iai.42.3.965-972.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  255. Lipscomb M.F., Lyons C.R., Nunez G., Ball E.J., Stastny P., Vial W., Lem V., Weissler J., Miller L.M., Toews G.B. Human alveolar macrophages: HLA-DR-positive macrophages that are poor stimulators of a primary mixed leukocyte reaction. J. Immunol. 1986;136:497–504. [PubMed] [Google Scholar]
  256. Lipscomb M.F., Alvarellos T., Toews G.B., Tompkins R., Evans Z., Koo G., Kumar V. Role of natural killer cells in resistance to Cryptococcus neoformans infections in mice. Am. J. Pathol. 1987;128:354–361. [PMC free article] [PubMed] [Google Scholar]
  257. Lipscomb M.F., Huffnagle G.B., Lovchik J.A., Lyons C.R., Pollard A.M., Yates J.L. The role of T lymphocytes in pulmonary microbial defense mechanisms. Arch. Pathol. Lab. Med. 1993;117:1225–1232. [PubMed] [Google Scholar]
  258. Lipscomb M.F., Pollard A.M., Yates J.L. A role for TGF-β in the suppression by murine bronchoalveolar cells of lung dendritic cell initiated immune responses. Regul. Immunol. 1993;5:151–157. [PubMed] [Google Scholar]
  259. Lipscomb M.F. The alveolar macrophage: Role in antigen presentation and accessory cell function. In: Daniele R.P., editor. “Immunology and Immunologic Diseases of the Lung”. Blackwell Scientific; Boston, MA: 1988. pp. 79–96. [Google Scholar]
  260. Lipscomb M.F. Lung defenses against opportunistic infections. Chest. 1989;96:1393–1399. doi: 10.1378/chest.96.6.1393. [DOI] [PubMed] [Google Scholar]
  261. Locksley R.M., Heinzel F.P., Holaday B.J., Mutha S.S., Reiner S.L., Sadick M.D. Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection. Res. Immunol. 1991;142:28–32. doi: 10.1016/0923-2494(91)90007-6. [DOI] [PubMed] [Google Scholar]
  262. Loosli C. Pathogenesis and pathology of lobar pneumonia. Lancet. 1940;60:49–54. [Google Scholar]
  263. Loosli C. The histogenesis of cells in experimental pneumonia in the dog. J. Exp. Med. 1942;75:657–671. doi: 10.1084/jem.75.6.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  264. Lovchik J.A., Lipscomb M.F. Role for C5 and neutrophils in the pulmonary intravascular clearance of circulating Cryptococcus neoformans. Am. J. Respir. Cell. Mol. Biol. 1993;9:617–627. doi: 10.1165/ajrcmb/9.6.617. [DOI] [PubMed] [Google Scholar]
  265. Lovchik J.A., Lyons C.R., Lipscomb M.F. A role for gamma interferum induced nitric oxide in pulmonary clearance of crypto coccus neotormans. Am. J. Respir. Cell. Mol. Biol. 1995 doi: 10.1165/ajrcmb.13.1.7598935. in press. [DOI] [PubMed] [Google Scholar]
  266. Lue C., Tarkowski A.J., Mestecky J. Systemic immunization with pneumococcal polysaccharide vaccine induces a predominant IgA2 response of peripheral blood lymphocytes and increases of both serum and secretory anti-pneumococcal antibodies. J. Immunol. 1988;140:3793–3800. [PubMed] [Google Scholar]
  267. Lukacher A.E., Braciale V.L., Braciale T.J. In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific. J. Exp. Med. 1984;160:814–826. doi: 10.1084/jem.160.3.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  268. Lukacs N.W., Chensue S.W., Strieter R.M., Warmington K., Kunkel S.L. Inflammatory granuloma formation is mediated by TNF-α-inducible intercellular adhesion molecule-1. J. Immunol. 1994;152:5883–5889. [PubMed] [Google Scholar]
  269. Lukacs N., Strieter R., Chensue S., Kunkel S. Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma. Am. J. Respir. Cell. Mol. Biol. 1994;10:526–532. doi: 10.1165/ajrcmb.10.5.8179915. [DOI] [PubMed] [Google Scholar]
  270. Lurie M. “Resistance to Tuberculosis: Experimental Studies in Native and Acquired Defense Mechanisms”. Harvard Univ. Press; Cambridge, MA: 1964. [Google Scholar]
  271. Lyons C.R., Lipscomb M.F. Alveolar macrophages in pulmonary immune responses. I. Role in the initiation of primary immune responses and in the selective recruitment of T lymphocytes to the lung. J. Immunol. 1983;130:1113–1119. [PubMed] [Google Scholar]
  272. Lyons C.R., Ball E.J., Toews G.B., Weissler J.C., Stastny P., Lipscomb M.F. Inability of human alveolar macrophages to stimulate resting T cells correlates with decreased antigen-specific T cell macrophage binding. J. Immunol. 1986;137:1173–1180. [PubMed] [Google Scholar]
  273. Mackaness G.B. The immunological basis of acquired cellular resistance. J. Exp. Med. 1964;120:105–120. doi: 10.1084/jem.120.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  274. Mackaness G.B. The J. Burns Amberson lecture—The induction and expression of cell-mediated hypersensitivity in the lung. Am. Rev. Respir. Dis. 1971;104:813–828. doi: 10.1164/arrd.1971.104.6.813. [DOI] [PubMed] [Google Scholar]
  275. Marathias K.P., Preffer F.I., Pinto C., Kradin R.L. Most human pulmonary infiltrating lymphocytes display the surface immune phenotype and functional responses of sensitized T cells. Am. J. Respir. Cell. Mol. Biol. 1991;5:470–476. doi: 10.1165/ajrcmb/5.5.470. [DOI] [PubMed] [Google Scholar]
  276. Marck K.W., Prop J., Wildevuur C.R.H. Lung transplantation in the rat. J. Surg. Res. 1983;35:149–158. doi: 10.1016/0022-4804(83)90137-3. [DOI] [PubMed] [Google Scholar]
  277. Mason C.M., Nelson S. Normal host defenses and impairments associated with the delayed resolution of pneumonia. Semin. Respir. Infect. 1992;7:243–255. [PubMed] [Google Scholar]
  278. Mason M.J., Bice D.E., Muggenburg B.A. Local pulmonary immune responsiveness after multiple antigenic exposures in the cynomolgus monkey. Am. Rev. Respir. Dis. 1985;132:657–660. doi: 10.1164/arrd.1985.132.3.657. [DOI] [PubMed] [Google Scholar]
  279. Mauser P., Pitman A., Witt A., Fernandez X., Zurcher J., Kung T., Jones H., Watnic A., Egan R., Kreutner W. Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma. Am. Rev. Respir. Dis. 1993;148:1623–1627. doi: 10.1164/ajrccm/148.6_Pt_1.1623. [DOI] [PubMed] [Google Scholar]
  280. McCarthy D.L., Abhyankar S., Neben S., Newman G., Sieff C., Thompson R.C., Burkakoff S.J., Ferrara J.L.M. Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevent grant-versus-host disease. Blood. 1991;78:1915–1921. [PubMed] [Google Scholar]
  281. McCarthy K.M., Gong J.L., Telford J.R., Schneeberger E.E. Ontogeny of Ia+ accessory cells in fetal and newborn rat lung. Am. J. Respir. Cell. Mol. Biol. 1992;6:349–356. doi: 10.1165/ajrcmb/6.3.349. [DOI] [PubMed] [Google Scholar]
  282. McDermott M.R., Bienenstock J. Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues. J. Immunol. 1979;122:1892–1898. [PubMed] [Google Scholar]
  283. McDermott M.R., Befus A.D., Bienenstock J. The structural basis for immunity in the respiratory tract. Int. Rev. Exp. Pathol. 1982;23:47–99. [PubMed] [Google Scholar]
  284. McDermott M.R., Lukacher A.E., Braciale V.L., Braciale T.J., Bienenstock J. Characterization and in vivo distribution of influenza-virus-specific T-lymphocytes in the murine respiratory tract. Am. Rev. Respir. Dis. 1987;135:245–249. doi: 10.1164/arrd.1987.135.1.245. [DOI] [PubMed] [Google Scholar]
  285. McGhee J.R., Mestecky J., Dertzbaugh M.T., Eldridge J.H., Hirasawa M., Kiyono H. The mucosal immune system: From fundamental concepts to vaccine development. Vaccine. 1992;10:75–88. doi: 10.1016/0264-410x(92)90021-b. [DOI] [PubMed] [Google Scholar]
  286. McKinney E.C., Streilein J.W. On the extraordinary capacity of allogeneic epidermal Langerhans cells to prime cytotoxic T cells in vivo. J. Immunol. 1989;143:1560–1564. [PubMed] [Google Scholar]
  287. McNeely T., Coonrood J. Comparison of the opsonic activity of human surfactant protein A for Staphylococcus aureus and Streptococcus pneumoniae with rabbit and human macrophages. J. Infect. Dis. 1993;167:91–97. doi: 10.1093/infdis/167.1.91. [DOI] [PubMed] [Google Scholar]
  288. Mestecky J., Eldridge J.H. Targeting and controlled release of antigens for the effective induction of secretory antibody responses. Curr. Opin. Immunol. 1991;3:492–495. doi: 10.1016/0952-7915(91)90009-p. [DOI] [PubMed] [Google Scholar]
  289. Middlebrook G. An apparatus for airborne infection of mice. Proc. Soc. Exp. Biol. Med. 1952;80:105–110. doi: 10.3181/00379727-80-19538. [DOI] [PubMed] [Google Scholar]
  290. Miller M.F., Mitchell T.G., Storkus W.J., Dawson J.R. Human natural killer cells do not inhibit growth of Cryptococcus neoformans in the absence of antibody. Infect. Immun. 1990;58:639–645. doi: 10.1128/iai.58.3.639-645.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  291. Miller M.F., Mitchell T.G. Killing of Cryptococcus neoformans strains by human neutrophils and monocytes. Infect. Immun. 1991;59:24–28. doi: 10.1128/iai.59.1.24-28.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  292. Modlin R.L., Pirmez C., Hofman F.M., Torigian V., Uyemura K., Rea T.H., Bloom B.R., Brenner M.B. Lymphocytes bearing antigen-specific gamma delta T-cell receptors accumulate in human infectious disease lesions. Nature. 1989;339:544–548. doi: 10.1038/339544a0. [DOI] [PubMed] [Google Scholar]
  293. Mody C.H., Lipscomb M.F., Street N.E., Toews G.B. Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans. J. Immunol. 1990;144:1472–1477. [PubMed] [Google Scholar]
  294. Mody C.H., Tyler C.L., Sitrin R.G., Jackson C., Toews G.B. Interferon-γ activates rat alveolar macrophages for anticryptococcal activity. Am. J. Respir. Cell. Mol. Biol. 1991;5:19–26. doi: 10.1165/ajrcmb/5.1.19. [DOI] [PubMed] [Google Scholar]
  295. Mody C.H., Chen G.-H., Jackson C., Curtis J.L., Toews G.B. Depletion of murine CD8+ T cells in vivo decreases pulmonary clearance of a moderately virulent strain of Cryptococcus neoformans. J. Lab. Clin. Med. 1993;121:765–773. [PubMed] [Google Scholar]
  296. Mody C.H., Paine R., III, Jackson C., Chen G.-H., Toews G.B. CD8 cells play a critical role in delayed type hypersensitivity to intact Cryptococcus neoformans. J. Immunol. 1994;152:3970–3979. [PubMed] [Google Scholar]
  297. Morag A., Beutner K.R., Morag B., Ogra P.L. Development and characteristics of in-vitro correlates of cellular immunity to rubella virus in the systemic and mucosal sites in guinea pigs. J. Immunol. 1974;113:1703–1709. [PubMed] [Google Scholar]
  298. Morozumi P.A., Brummer E., Stevens D.A. Protection against pulmonary blastomycosis: Correlation with cellular and humoral immunity in mice after subcutaneous nonlethal infection. Infect. Immun. 1982;37:670–678. doi: 10.1128/iai.37.2.670-678.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  299. Morrow P.E. Lymphatic drainage of the lung in dust clearance. Ann. NY Acad. Sci. 1972;200:46–65. doi: 10.1111/j.1749-6632.1972.tb40177.x. [DOI] [PubMed] [Google Scholar]
  300. Moser S.A., Koker P.J., Williams J.E. Fungal-strain-dependent alterations in the time course and mortality of chronic murine pulmonary blastomycosis. Infect. Immun. 1988;56:34–39. doi: 10.1128/iai.56.1.34-39.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  301. Mosmann T.R., Coffman R.L. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989;7:145–173. doi: 10.1146/annurev.iy.07.040189.001045. [DOI] [PubMed] [Google Scholar]
  302. Mukherjee J., Scharff M.D., Casadevall A. Protective murine monoclonal antibodies to Cryptococcus neoformans. Infect. Immun. 1992;60:4534–4541. doi: 10.1128/iai.60.11.4534-4541.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  303. Mulligan M., Varani J., Dame M., Lane C., Smith C., Anderson D., Ward P. Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J. Clin. Invest. 1991;88:1396–1406. doi: 10.1172/JCI115446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  304. Mulligan M., Polley M.J., Bayer R.J., Nunn M.F., Paulson J.C., Ward P.A. Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140) J. Clin. Invest. 1992;90:1600–1607. doi: 10.1172/JCI116029. [DOI] [PMC free article] [PubMed] [Google Scholar]
  305. Mulligan M., Yeh C., Rudolph A., Ward P. Protective effects of soluble CR1 in complement- and neutrophil-mediated tissue injury. J. Immunol. 1992;148:1479–1485. [PubMed] [Google Scholar]
  306. Mulligan M., Warren J., Smith C., Anderson D., Yeh C., Rudolph A., Ward P. Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine. J. Immunol. 1992;148:3086–3092. [PubMed] [Google Scholar]
  307. Mulligan M., Vaporciyan A., Miyasaka M., Tamatani T., Ward P. Tumor necrosis factor alpha regulates in vivo intrapulmonary expression of ICAM-1. Am. J. Pathol. 1993;142:1739–1749. [PMC free article] [PubMed] [Google Scholar]
  308. Mulligan M.S., Jones M., Bolanowski M., Baganoff M., Deppeler C., Meyers D., Ryan U., Ward P.A. Inhibition of lung inflammatory reactions in rats by an anti-human IL-8 antibody. J. Immunol. 1993;150:5585–5595. [PubMed] [Google Scholar]
  309. Mulligan M., Smith C., Anderson D., Todd R., Miyasaka M., Tamatani T., Issekutz T., Ward P. Role of leukocyte adhesion molecules in complement-induced lung injury. J. Immunol. 1993;150:2401–2406. [PubMed] [Google Scholar]
  310. Mulligan M., Wilson G., Todd R., Smith C., Anderson D., Varani J., Issekutz T., Miyasaka M., Tamatani T., Miyasaka M. Role of beta 1, beta 2 integrins and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes. J. Immunol. 1993;150:2407–2417. [PubMed] [Google Scholar]
  311. Mulligan M., Jones M., Vaporciyan A., Howard M., Ward P.A. Protective effects of IL-4 and IL-10 against immune complex-induced lung injury. J. Immunol. 1993;151:5666–5674. [PubMed] [Google Scholar]
  312. Murphy M.A., Herscowitz H.B. Heterogeneity among alveolar macrophages in humoral and cell-mediated immune responses: Separation of functional subpopulations by density gradient centrifugation on Percoll. J. Leukocyte Biol. 1984;35:39–54. doi: 10.1002/jlb.35.1.39. [DOI] [PubMed] [Google Scholar]
  313. Murphy J.W., Hidore M.R., Wong S.C. Direct interactions of human lymphocytes with the yeast-like organisms Cryptococcus neoformans. J. Clin. Invest. 1993;91:1553–1566. doi: 10.1172/JCI116361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  314. Murray A., Morrison B. Passive smoking and the seasonal difference of severity of asthma in children. Chest. 1988;94:701–708. doi: 10.1378/chest.94.4.701. [DOI] [PubMed] [Google Scholar]
  315. Murray K., Eden R., England P., Dolan J., Grimsditch D., Stutchbury C., Patel B., Reeves M., Worby A., Torphy T. Potential use of selective phosphodiesterase inhibitors in the treatment of asthma. Agents Actions (Suppl.) 1991;34:27–46. [PubMed] [Google Scholar]
  316. Musher D., Johnson J.B., Watson D. Quantitative relationship between anticapsular antibody measured by enzyme-linked immunosorbent assay or radioimmunoassay and protection of mice against challenge with Streptococcus pneumonia serotype 4. Infect. Immun. 1990;58:3871–3876. doi: 10.1128/iai.58.12.3871-3876.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  317. Myrvik Q.N., Ockers J.R. Transport of horseradish peroxidase from the vascular compartment to bronchial-associated lymphoid tissue. J Reticuloendo. Soc. 1982;31:267–278. [PubMed] [Google Scholar]
  318. Nakajima H., Iwamoto I., Tomoe S., Matsumura R., Tomioka H., Takatsu K., Yoshida S. CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am. Rev. Respir. Dis. 1992;146:374–377. doi: 10.1164/ajrccm/146.2.374. [DOI] [PubMed] [Google Scholar]
  319. Nash D.R., Holle B. Local and systemic cellular immune responses in guinea-pigs given antigen parenterally or directly into the lower respiratory tract. Clin. Exp. Immunol. 1973;13:573–583. [PMC free article] [PubMed] [Google Scholar]
  320. Nelson D.J., McMenamin C., McWilliam A.S., Brenan M., Holt P.G. Development of the airway intraepithlial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: Differential regulation of Ia expression at different levels of the respiratory tract. J. Exp. Med. 1994;179:203–212. doi: 10.1084/jem.179.1.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  321. Newhouse M., Sanchis J., Bienenstock J. Lung defense mechanisms. N. Engl. J. Med. 1976;295:990–998. doi: 10.1056/NEJM197610282951805. 1045–1052. [DOI] [PubMed] [Google Scholar]
  322. Nicod L.P., Lipscomb M.F., Weissler J.C., Lyons C.R., Albertson J., Toews G.B. Mononuclear cells in human lung parenchyma. Characterization of a potent accessory cell not obtained by bronchoalveolar lavage. Am. Rev. Respir. Dis. 1987;136:818–823. doi: 10.1164/ajrccm/136.4.818. [DOI] [PubMed] [Google Scholar]
  323. Nicod L.P., Lipscomb M.F., Toews G.B., Weissler J.C. Separation of potent and poorly functional human lung accessory cells based on autofluorescence. J. Leukocyte Biol. 1989;45:458–465. doi: 10.1002/jlb.45.5.458. [DOI] [PubMed] [Google Scholar]
  324. Nicod L.P., Lipscomb M.F., Weissler J.C., Toews G.B. Mononuclear cells from human lung parenchyma support antigen-induced T lymphocyte proliferation. J. Leukocyte Biol. 1989;45:336–344. doi: 10.1002/jlb.45.4.336. [DOI] [PubMed] [Google Scholar]
  325. Nicod L.P., El Habre F. Adhesion molecules on human lung dendritic cells and their role for T-cell activation. Am. J. Respir. Cell. Mol. Biol. 1992;7:207–213. doi: 10.1165/ajrcmb/7.2.207. [DOI] [PubMed] [Google Scholar]
  326. North R.J., Izzo A.A. Granuloma formation in severe combined immunodeficient (SCID) mice in response to progressive BCG infection. Tendency not to form granulomas in the lung is associated with faster bacterial growth in this organ. Am. J. Pathol. 1993;142:1959–1966. [PMC free article] [PubMed] [Google Scholar]
  327. O'Brien R., Happ M.P., Dallas A., Palmer E., Kubo R., Born W. Stimulation of a major subset of lymphocytes expressing T cell receptors γδ by an antigen derived from Mycobacterium tuberculosis. Cell. 1989;57:667–674. doi: 10.1016/0092-8674(89)90135-9. [DOI] [PubMed] [Google Scholar]
  328. O'Connell P.J., Pacheco-Silva A., Nickerson P.W., Muggia R.A., Bastos M., Kelley V.R., Strom T.B. Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts. J. Immunol. 1993;150:1093–1104. [PubMed] [Google Scholar]
  329. O'Connor C.M., FitzGerald M.X. Speculations on sarcoidosis. Respir. Med. 1992;86:277–282. doi: 10.1016/s0954-6111(06)80024-7. [DOI] [PubMed] [Google Scholar]
  330. Oghiso Y. Morphologic and functional heterogeneity among rat alveolar macrophage fractions isolated by centrifugation on density gradients. J. Leukocyte Biol. 1987;42:188–196. doi: 10.1002/jlb.42.3.188. [DOI] [PubMed] [Google Scholar]
  331. Orme I.M., Collins F.M. Adoptive protection of the Mycobacterium tuberculosis-infected lung. Dissociation between cells that passively transfer protective immunity and those that transfer delayed-type hypersensitivity to tuberculin. Cell. Immunol. 1984;84:113–120. doi: 10.1016/0008-8749(84)90082-0. [DOI] [PubMed] [Google Scholar]
  332. Orme I.M. The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis. J. Immunol. 1987;138:293–298. [PubMed] [Google Scholar]
  333. Orme I.M., Roberts A.D., Griffin J.P., Abrams J.S. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J. Immunol. 1993;51:518–525. [PubMed] [Google Scholar]
  334. Osebold J.W., Gershwin L.J., Zee Y.C. Studies on the enhancement of allergic lung sensitization by inhalation of ozone and sulfuric acid aerosol. J. Environ. Pathol. Toxicol. 1980;3:221–234. [PubMed] [Google Scholar]
  335. Otsuki Y., Ito Y., Magari S. Lymphocyte subpopulations in high endothelial venules and lymphatic capillaries of bronchus-associated lymphoid tissue (BALT) in the rat. Am. J. Anat. 1989;184:139–146. doi: 10.1002/aja.1001840205. [DOI] [PubMed] [Google Scholar]
  336. Pabst R. Compartmentalization and kinetics of lymphoid cells in the lung. Reg. Immunol. 1990;3:62–71. [PubMed] [Google Scholar]
  337. Pabst R. Is BALT a major component of the human lung immune system? Immunol. Today. 1992;13:119–122. doi: 10.1016/0167-5699(92)90106-H. [DOI] [PubMed] [Google Scholar]
  338. Paradis I.L., Marrai M., Zeeri A. HLA phenotype of lung lavage cells following heart lung transplantation. J. Heart Transplant. 1985;4:422–425. [PubMed] [Google Scholar]
  339. Parker D., Turk J.L. Delay in the development of the allergic response to metals following intratracheal instillation. Int. Arch. Allergy Appl. Immunol. 1978;57:289–293. doi: 10.1159/000232117. [DOI] [PubMed] [Google Scholar]
  340. Patterson R., Harris K. IgE-mediated rhesus monkey asthma: Natural history and individual animal variation. Int. Arch. Allergy Immunol. 1992;97:154–159. doi: 10.1159/000236111. [DOI] [PubMed] [Google Scholar]
  341. Pedrazzini T., Louis J.A. Functional analysis in vitro and in vivo of Mycobacterium bovis strain BCG-specific T cell clones. J. Immunol. 1986;136:1828–1834. [PubMed] [Google Scholar]
  342. Pedrazzini T., Hug K., Louis J.A. Importance of L3T4+ and Lyt-2+ cells in the immunologic control of infection with Mycobacterium bovis strain Bacillus–Calmette–Guerin in mice: Assessment by elimination of T cell subsets in vivo. J. Immunol. 1987;139:2032–2037. [PubMed] [Google Scholar]
  343. Peeters S.H., Carter B.G. Regulation of the IgE antibody response in mice. II. Radioresistance of established IgE antibody production. Immunology. 1981;43:25–32. [PMC free article] [PubMed] [Google Scholar]
  344. Pepys J. Hypersensitivity diseases of the lungs due to fungi and organic dusts. Monogr. Allergy. 1969;4:1–110. [PubMed] [Google Scholar]
  345. Phan S., Gharaee-Kermani M., Wolber F., Ryan U. Stimulation of rat endothelial cell transforming growth factor-β production by bleomycin. J. Clin. Invest. 1991;87:148–154. doi: 10.1172/JCI114964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  346. Phan S., Gharaee-Kermani M., McGarry B., Kunkel S., Wolber F. Regulation of rat pulmonary artery endothelial cell transforming growth factor-β production by IL-1 β and tumor necrosis factor-α. J. Immunol. 1992;149:103–106. [PubMed] [Google Scholar]
  347. Picker L.J. Control of lymphocyte homing. Curr. Opin. Immunol. 1994;6:394–406. doi: 10.1016/0952-7915(94)90118-x. [DOI] [PubMed] [Google Scholar]
  348. Picker L.J., Martin R.J., Trumble A., Newman L.S., Collins P.A., Bergstresser P.R., Leung D.Y.M. Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites. Eur. J. Immunol. 1994;24:1269–1277. doi: 10.1002/eji.1830240605. [DOI] [PubMed] [Google Scholar]
  349. Piguet P., Collart M., Grau G., Kapanci Y., Vassalli P. Tumor necrosis factor/cachetin plays a key role in bleomycin-induced pneumopathy. J. Exp. Med. 1989;170:655–664. doi: 10.1084/jem.170.3.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  350. Piguet P.F., Grau G.E., Collart M.A., Vassalli P., Kapanci Y. Pneumopathies of the graft-versus-host reaction. Lab. Invest. 1989;61:37–45. [PubMed] [Google Scholar]
  351. Pilewski J.M., Albelda S.M. Adhesion molecules in the lung. Am. Rev. Respir. Dis. 1993;148:S31–S37. doi: 10.1164/ajrccm/148.6_Pt_2.S31. [DOI] [PubMed] [Google Scholar]
  352. Pinkett M.O., Cowdrey C.R., Nowell P.C. Mixed hematopoietic and pulmonary origin of “alveolar macrophages” as demonstrated by chromosome markers. Am. J. Pathol. 1966;48:859–866. [PMC free article] [PubMed] [Google Scholar]
  353. Platts-Mills T.A., Ward G.W., Jr., Sporik R., Gelber L.E., Chapman M.D., Heymann P.W. Epidemiologist of the relationship between exposure to indoor allergens and asthma. Int Arch. Allergy Appl. Immunol. 1991;94:339–345. doi: 10.1159/000235398. [DOI] [PubMed] [Google Scholar]
  354. Polack L. Immunologic aspects of contact sensitivity: An experimental study. Monogr. Allergy. 1980;15:1–46. [PubMed] [Google Scholar]
  355. Pollard A.M., Lipscomb M.F. Characterization of murine lung dendritic cells: Similarities to Langerhans cells and thymic dendritic cells. J. Exp. Med. 1990;172:159–167. doi: 10.1084/jem.172.1.159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  356. Pozzi G., Contorni M., Oggioni M.R., Manganelli R., Tommasino M., Cavalieri F., Fischetti V.A. Delivery and expression of a heterologous antigen on the surface of streptococci. Infect. Immun. 1992;60:1902–1907. doi: 10.1128/iai.60.5.1902-1907.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  357. Prop J., Nieuwenhuis P., Wildevuur C.R.H. Lung allograft rejection in the rat. Accelerated rejection caused by graft lymphocytes. Transplant. 1985;40:25–30. doi: 10.1097/00007890-198507000-00006. [DOI] [PubMed] [Google Scholar]
  358. Prop J., Wildevuur C.R.H., Nieuwenhuis P. Lung allograft rejection in the rat. Corresponding morphological rejection phases in various rat strain combinations. Transplant. 1985;40:132–136. doi: 10.1097/00007890-198508000-00004. [DOI] [PubMed] [Google Scholar]
  359. Prop J., Wildevuur C.R.H., Nieuwenhuis P. Acute graft-versus-host disease after lung transplantation. Transplant. Proc. 1989;21:2603–2604. [PubMed] [Google Scholar]
  360. Randhawa P., Yousem S.A. The pathology of lung transplantation. Pathol. Annu. 1992;2:247–279. [PubMed] [Google Scholar]
  361. Rastogi N. Killing intracellular mycobacteria in in vitro macrophage systems: What may be the role of known host microbicidal mechanisms? Res. Microbiol. 1990;141:217–230. doi: 10.1016/0923-2508(90)90034-n. [DOI] [PubMed] [Google Scholar]
  362. Ratajczak H.V., Richards D.W., Richerson H.B. Systemic and local lymphocyte responses in experimental hypersensitivity pneumonitis. Am. Rev. Respir. Dis. 1980;122:761–768. doi: 10.1164/arrd.1980.122.5.761. [DOI] [PubMed] [Google Scholar]
  363. Redington A.E., Bradding P., Holgate S.T. The role of cytokines in the pathogenesis of allergic asthma. Regul. Immunol. 1993;5:174–200. [PubMed] [Google Scholar]
  364. Reiss C.S., Burakoff S.J. Specificity of the helper T cells for the cytolytic T lymphocyte response to influenza viruses. J. Exp. Med. 1981;154:541–546. doi: 10.1084/jem.154.2.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  365. Renz H., Smith H., Henson J., Ray B., Irvin C., Gelfand E. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J. Allergy Clin. Immunol. 1992;89:1127–1138. doi: 10.1016/0091-6749(92)90296-e. [DOI] [PubMed] [Google Scholar]
  366. Reynolds H.Y. Bronchoalveolar lavage. Am. Rev. Respir. Dis. 1987;135:250–263. doi: 10.1164/arrd.1987.135.1.250. [DOI] [PubMed] [Google Scholar]
  367. Rich E.A., Tweady D.J., Fujiwara H., Ellner J.J. Spectrum of immunoregulatory functions and properties of human alveolar macrophages. Am. Rev. Respir. Dis. 1987;136:258–265. doi: 10.1164/ajrccm/136.2.258. [DOI] [PubMed] [Google Scholar]
  368. Richerson H., Cheng F., Bauserman S. Acute experimental hypersensitivity pneumonitis in rabbits. Am. Rev. Respir. Dis. 1971;104:568–575. doi: 10.1164/arrd.1971.104.4.568. [DOI] [PubMed] [Google Scholar]
  369. Richerson H., Seidenfeld J., Ratajczak H., Richards D. Chronic experimental hypersensitivity pneumonitis in rabbits. Am. Rev. Respir. Dis. 1978;117:5–13. doi: 10.1164/arrd.1978.117.1.5. [DOI] [PubMed] [Google Scholar]
  370. Richerson H., Richards D., Swanson P., Butler J., Suelzer M. Antigen-specific desensitization in a rabbit model of acute hypersensitivity pneumonitis. J. Allergy Clin. Immunol. 1981;68:226–234. doi: 10.1016/0091-6749(81)90188-3. [DOI] [PubMed] [Google Scholar]
  371. Richerson H., Suelzer M., Swanson P., Butler J., Kopp W., Rose R. Chronic hypersensitivity pneumonitis produced in the rabbit by the adjuvant effect of inhaled muramyl dipeptide (MDP) Am. J. Pathol. 1982;106:409–420. [PMC free article] [PubMed] [Google Scholar]
  372. Richerson H.B. Acute experimental hypersensitivity pneumonitis in the guinea pig. J. Lab. Clin. Med. 1972;79:745–757. [PubMed] [Google Scholar]
  373. Ritter R.C., Larsh H.W. The infection of white mice following an intranasal instillation of Cryptococcus neoformans. Am. J. Hyg. 1963;78:241–246. doi: 10.1093/oxfordjournals.aje.a120342. [DOI] [PubMed] [Google Scholar]
  374. Roach T.I., Barton C.H., Chatterjee D., Blackwell J.M. Macrophage activation: Lipoarabinomannan from avirulent and virulent strains of Mycobacterium tuberculosis differentially induces the early genes c-fos, KC, JE, and tumor necrosis factor-alpha. J. Immunol. 1993;150:1886–1896. [PubMed] [Google Scholar]
  375. Rochester C.L., Goodell E.M., Stoltenborg J.K., Bowers W.E. Dendritic cells from rat lung are potent accessory cells. Am. Rev. Respir. Dis. 1988;138:121–128. doi: 10.1164/ajrccm/138.1.121. [DOI] [PubMed] [Google Scholar]
  376. Rolfe M., Kunkel S., Standiford T., Orringer M., Phan S., Evanoff H., Burdick M., Streiter R. Expression and regulation of human fibroblast-derived monocyte chemtactic peptide-1. Am. J. Physiol. 1992;263:L536–L545. doi: 10.1152/ajplung.1992.263.5.L536. [DOI] [PubMed] [Google Scholar]
  377. Rolfe M.W., Kunkel S.L., DeMeester S.R., Swiderski D.L., Lincoln P.M., Deeb G.M., Strieter R.M. Expression of interleukin-6 in association with rat lung reimplantation and allograft rejection. Am. Rev. Respir. Dis. 1993;147:1010–1016. doi: 10.1164/ajrccm/147.4.1010. [DOI] [PubMed] [Google Scholar]
  378. Romani N., Koide S., Crowley M., Witmer-Pack M., Livingstone A.M., Fathman C.G., Inaba K., Steinman R.M. Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J. Exp. Med. 1989;169:1169–1178. doi: 10.1084/jem.169.3.1169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  379. Roska A., Garancis J., Moore V., Abramoff P. Immune-complex disease in guinea pig lungs. Clin. Immunol. Immunopathol. 1977;8:213–224. doi: 10.1016/0090-1229(77)90111-8. [DOI] [PubMed] [Google Scholar]
  380. Ruedl C., Frühwirth M., Wick G., Wolf H. Immune response in the lungs following oral immunization with bacterial lysates of respiratory pathogens. Clin. Diagn. Lab. Immunol. 1994;1:150–154. doi: 10.1128/cdli.1.2.150-154.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  381. Russell P.S., Chase C.M., Winn H.J., Colvin R.B. Coronary athersclerosis in transplanted mouse hearts. J. Immunol. 1994;152:5135–5141. [PubMed] [Google Scholar]
  382. Saito R., Prehn J., Zuo X.J., Marchevesky A., Castracane J., Waters P., Matloff J., Jordan S.C. The participation of tumor necrosis factor in the pathogenesis of lung allograft rejection in the rat. Transplantation. 1993;55:967–972. doi: 10.1097/00007890-199305000-00002. [DOI] [PubMed] [Google Scholar]
  383. Salk J., Salk D. Control of influenza and poliomyelitis with killed virus vaccines. Science. 1977;195:834–847. doi: 10.1126/science.320661. [DOI] [PubMed] [Google Scholar]
  384. Sallusto F., Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 1994;179:1109–1118. doi: 10.1084/jem.179.4.1109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  385. Saloga J., Renz H., Larsen G., Gelfand E. Increased airways responsiveness in mice depends on local challenge with antigen. Am. J. Respir. Crit. Care Med. 1994;149:65–70. doi: 10.1164/ajrccm.149.1.8111600. [DOI] [PubMed] [Google Scholar]
  386. Saltini C., Kirby M., Trapnell B.C., Tamura N., Crystal R.G. Biased accumulation of T lymphocytes with memory-type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung. J. Exp. Med. 1990;171:1123–1140. doi: 10.1084/jem.171.4.1123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  387. Sarawar S.R., Carding S.R., Allan W., McMickle A., Fujihashi K., Kiyono H., McGhee J.R., Doherty P.C. Cytokine profiles of bronchoalveolar lavage cells from mice with influenza pneumonia: Consequences of CD4+ and CD8+ T cell depletion. Regul. Immunol. 1993;5:142–150. [PubMed] [Google Scholar]
  388. Sarawar S.R., Sangster M., Coffman R.L., Doherty P.C. Administration of anti-IFN-γ antibody to β2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype. J. Immunol. 1994;153:1246–1253. [PubMed] [Google Scholar]
  389. Schatz M., Patterson R., Fink J. Immunopathogenesis of hypersensitivity pneumonitis. J. Allergy Clin. Immunol. 1977;60:27–37. doi: 10.1016/0091-6749(77)90079-3. [DOI] [PubMed] [Google Scholar]
  390. Schon-Hegrad M.A., Oliver J., McMenamin P.G., Holt P.G. Studies on the density, distribution and surface phenotype of intraepithelial class II MHC antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J. Exp. Med. 1991;173:1345–1356. doi: 10.1084/jem.173.6.1345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  391. Schrier D., Kunkel R., Phan S. The role of strain variation in murine bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 1983;127:63–66. doi: 10.1164/arrd.1983.127.1.63. [DOI] [PubMed] [Google Scholar]
  392. Schrier D., Phan S., McGarry B. The effects of the nude (nu/nu) mutation on bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 1983;127:614–617. doi: 10.1164/arrd.1983.127.5.614. [DOI] [PubMed] [Google Scholar]
  393. Schuyler M., Kleinerman J., Pensky J., Brandt C., Schmitt D. Pulmonary response to repeated exposure to Micropolyspora faeni. Am. Rev. Respir. Dis. 1983;128:1071–1076. doi: 10.1164/arrd.1983.128.6.1071. [DOI] [PubMed] [Google Scholar]
  394. Schuyler M., Schmitt D. Alveolar macrophage catabolism of Micropolyspora faeni. J. Allergy Clin. Immunol. 1985;76:614–622. doi: 10.1016/0091-6749(85)90784-5. [DOI] [PubMed] [Google Scholar]
  395. Schuyler M., Subramanyan S., Hassen M. Prolonged exposure to M. faeni in Strain II guinea pigs. Br. J. Exp. Pathol. 1987;68:743–747. [PMC free article] [PubMed] [Google Scholar]
  396. Schuyler M., Gott K., Haley P. Experimental murine hypersensitivity pneumonitis. Cell. Immunol. 1991;136:303–317. doi: 10.1016/0008-8749(91)90354-e. [DOI] [PubMed] [Google Scholar]
  397. Schuyler M., Gott K., Shopp G., Crooks L. CD3+, CD4+ cells adoptively transfer experimental hypersensitivity pneumonitis. Am. Rev. Respir. Dis. 1992;146:1582–1588. doi: 10.1164/ajrccm/146.6.1582. [DOI] [PubMed] [Google Scholar]
  398. Schuyler M., Gott K., Edwards B. Adoptive transfer of experimental hypersensitivity pneumonitis: CD4 cells are memory and naive cells. J. Lab. Clin. Med. 1994;123:378–386. [PubMed] [Google Scholar]
  399. Schuyler M., Gott K., Edwards B., Nikula K. Experimental hypersensitivity pneumonitis: Effect of CD4 cell depletion. Am. J. Respir. Crit. Care Med. 1994;149:1286–1294. doi: 10.1164/ajrccm.149.5.7909706. [DOI] [PubMed] [Google Scholar]
  400. Schwabacher H., Wilson G.S. The inoculation of minimal doses of tubercle bacilli into guinea pigs, rabbits, and mice. Tubercle. 1937;18:442–455. [Google Scholar]
  401. Sertl K., Takemura T., Tschachler E., Ferrans V.J., Kaliner M.A., Shevach E.M. Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura. J. Exp. Med. 1986;163:436–451. doi: 10.1084/jem.163.2.436. [DOI] [PMC free article] [PubMed] [Google Scholar]
  402. Sestini P., Nencioni L., Villa L., Boraschi D., Tagliabue A. IgA-driven antibacterial activity against Streptococcus pneumoniae by mouse lung lymphocytes. Am. Rev. Respir. Dis. 1988;137:138–143. doi: 10.1164/ajrccm/137.1.138. [DOI] [PubMed] [Google Scholar]
  403. Shellito J., Kaltreider B. Heterogeneity of immunologic function among subfractions of normal rat alveolar macrophages. II. Activation as a determinant of functional activity. Am. Rev. Respir. Dis. 1985;131:678–683. doi: 10.1164/arrd.1985.131.5.678. [DOI] [PubMed] [Google Scholar]
  404. Shellito J., Caldwell J.L., Kaltreider H.B. Immune functions of murine alveolar macrophages: Binding of lymphocytes and support of lymphocyte proliferation. Exp. Lung Res. 1983;4:93–107. doi: 10.3109/01902148309055007. [DOI] [PubMed] [Google Scholar]
  405. Shellito J., Esparza C., Armstrong C. Maintenance of the normal rat alveolar macrophage cell population. The roles of monocyte influx and alveolar macrophages proliferation in situ. Am. Rev. Respir. Dis. 1987;135:78–82. doi: 10.1164/arrd.1987.135.1.78. [DOI] [PubMed] [Google Scholar]
  406. Shellito J., Suzara V.V., Blumenfeld W., Beck J.M., Steger H.J., Ermak T.H. A new model of Pneumocystis carinii infection in mice selectively depleted of helper T lymphocytes. J. Clin. Invest. 1990;85:1683–1686. doi: 10.1172/JCI114621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  407. Shopp G.M., Bice D.E. The pulmonary antibody-forming cell response in the guinea pig after intratracheal immunization. Exp. Lung Res. 1987;13:193–203. doi: 10.3109/01902148709064318. [DOI] [PubMed] [Google Scholar]
  408. Skerrett S.J., Martin T.R. Alveolar macrophage activation in experimental legionellosis. J. Immunol. 1991;147:337–345. [PubMed] [Google Scholar]
  409. Sminia T., van der Brugge-Gamelkoorn G.J., Jeurissen S.H.M. Structure and function of bronchus-associated lymphoid tissue (BALT) Crit. Rev. Immunol. 1989;9:119–151. [PubMed] [Google Scholar]
  410. Smith C.D., Ritter R., Larsh H.W., Furcolow M.L. Infection of white Swiss mice with airborne Cryptococcus neoformans. J. Bacteriol. 1964;87:1364–1368. doi: 10.1128/jb.87.6.1364-1368.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  411. Smith D., Harding G. Animal model: Experimental airborne tuberculosis in the guinea pig. Am. J. Pathol. 1977;89:273–276. [PMC free article] [PubMed] [Google Scholar]
  412. Smith D.W., Wiegehaus E.H. What animal models can teach us about the pathogenesis of tuberculosis in humans. Rev. Infect. Dis. 1989;11(Suppl. 2):S385–S392. doi: 10.1093/clinids/11.supplement_2.s385. [DOI] [PubMed] [Google Scholar]
  413. Snider D.P., Marshall J.S., Perdue M.H., Liang H. Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin. J. Immunol. 1994;153:647–657. [PubMed] [Google Scholar]
  414. Snider G., Hayes J., Korthy A. Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin. Am. Rev. Respir. Dis. 1978;117:1099–1108. doi: 10.1164/arrd.1978.117.6.1099. [DOI] [PubMed] [Google Scholar]
  415. Snyder D. The relationship between tuberculosis and silicosis. Am. Rev. Respir. Dis. 1978;118:455–460. doi: 10.1164/arrd.1978.118.3.455. [DOI] [PubMed] [Google Scholar]
  416. Sornasse T., Flamand V., De Beceker G., Bazin H., Tielemans F., Thielemans K., Urbain J., Leo O., Moser M. Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo. J. Exp. Med. 1992;175:15–21. doi: 10.1084/jem.175.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  417. Sorokin S.P., Hoyt R.F., Grant M.M. Development of macrophages in the lungs of fetal rabbits, rats, and hamsters. Anat. Rec. 1984;208:103–121. doi: 10.1002/ar.1092080112. [DOI] [PubMed] [Google Scholar]
  418. Spencer J., Hall J.G. Studies on the lymphocytes of sheep. IV. Migration patterns of lung-associated lymphocytes efferent from the caudal mediastinal lymph node. Immunology. 1984;52:1–5. doi: 10.1016/0011-9164(84)80001-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  419. Spencer J.C., Waldman R.H., Johnson J.E., III Local and systemic cell-mediated immunity after immunization of guinea pigs with live or killed M. tuberculosis by various routes. J. Immunol. 1974;112:1322–1328. [PubMed] [Google Scholar]
  420. Sprent J. T and B memory cells. Cell. 1994;76:315–322. doi: 10.1016/0092-8674(94)90338-7. [DOI] [PubMed] [Google Scholar]
  421. Springer T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell. 1994;76:301–314. doi: 10.1016/0092-8674(94)90337-9. [DOI] [PubMed] [Google Scholar]
  422. Springmeyer S.C., Altman L.C., Kopecky K.J., Deeg J., Storb R. Alveolar macrophage kinetics and function after interruption of canine marrow function. Am. Rev. Respir. Dis. 1982;125:347–351. doi: 10.1164/arrd.1982.125.3.347. [DOI] [PubMed] [Google Scholar]
  423. Standiford T.J., Kunkel S.L., Strieter R.M. Interleukin-8: A major mediator of acute pulmonary inflammation. Regul. Immunol. 1993;5:134–141. [PubMed] [Google Scholar]
  424. Steinman R.M., Cohn Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 1973;137:1142–1162. doi: 10.1084/jem.137.5.1142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  425. Steinman R.M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 1991;9:271–296. doi: 10.1146/annurev.iy.09.040191.001415. [DOI] [PubMed] [Google Scholar]
  426. Stein-Streilein J., Gross G.N., Hart D.A. Comparison of intratracheal and intravenous inoculation of sheep erythrocytes in the induction of local and systemic immune responses. Infect. Immun. 1979;24:145–150. doi: 10.1128/iai.24.1.145-150.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  427. Stein-Streilein J., Lipscomb M.F., Hart D.A., Darden A. Graft-versus-host reaction in the lung. Transplantation. 1981;32:38–44. doi: 10.1097/00007890-198107000-00008. [DOI] [PubMed] [Google Scholar]
  428. Stein-Streilein J., Bennett M., Mann D., Kumar V. Natural killer cells in mouse lung: Surface phenotype, target preference, and response to local influenza virus infection. J. Immunol. 1983;131:2699–2704. [PubMed] [Google Scholar]
  429. Stein-Streilein J., Lipscomb M., Fisch H., Whitney P. Pulmonary interstitial fibrosis induced in hapten-immune hamsters. Am. Rev. Respir. Dis. 1987;136:119–123. doi: 10.1164/ajrccm/136.1.119. [DOI] [PubMed] [Google Scholar]
  430. Stein-Streilein J., Salter-Cid L., Roberts B., Altman N. Persistent pulmonary interstitial fibrosis, induced by the immune response to TNP, is associated with altered mRNA procollagen type I:III ratio. Regul. Immunol. 1992;4:391–400. [PubMed] [Google Scholar]
  431. Stein-Streilein J. Allergic contact dermatitis induced by intratracheal administration of hapten. J. Immunol. 1983;131:1748–1753. [PubMed] [Google Scholar]
  432. Stein-Streilein J. Immunobiology of lymphocytes in the lung. Regul. Immunol. 1988;1:128–136. [PubMed] [Google Scholar]
  433. Stein-Streilein J., Hart D.A. Effect of route of immunization on development of antibody-forming cells in hilar lymph nodes. Infect. Immun. 1980;30:391–396. doi: 10.1128/iai.30.2.391-396.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  434. Stein-Streilein J., Phipps R.P. Horses and zebras. Regul. Immunol. 1993;5:127–133. [PubMed] [Google Scholar]
  435. Stevens R.H., Macy E., Morrow C., Saxon A. Characterization of a circulating subpopulation of spontaneous antitetanus toxoid antibody producing B cells following in vivo booster immunization. J. Immunol. 1979;122:2498–2503. [PubMed] [Google Scholar]
  436. Stevens S.K., Weissman I.L., Butcher E.C. Differences in the migration of B and T lymphocytes: Organ-selective localization in vivo and the role of lymphocyte-endothelial cell recognition. J. Immunol. 1982;128:844–851. [PubMed] [Google Scholar]
  437. Suter E. Passive transfer of acquired resistance to infection with mycobacteria by means of cells. Am. Rev. Respir. Dis. 1961;83:535–543. [Google Scholar]
  438. Szu S., Clarke S., Robbins J. Protection against pneumococcal infection conferred by phosphocholine-binding antibodies: Specificity of the phosphocholine binding and relation to several types. Infect. Immun. 1983;39:993–999. doi: 10.1128/iai.39.2.993-999.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  439. Szu S., Schneerson R., Robbins J. Rabbit antibodies to the cell wall polysaccharide of Streptococcus pneumoniae fail to protect mice from lethal challenge with encapsulated pneumococci. Infect. Immun. 1986;54:448–455. doi: 10.1128/iai.54.2.448-455.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  440. Takashima T., Collins F.M. T-cell-mediated immunity in persistent Mycobacterium intracellulare infections in mice. Infect. Immun. 1988;56:2782–2787. doi: 10.1128/iai.56.11.2782-2787.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  441. Takizawa H., Suto M., Kobayashi N. Experimental hypersensitivity pneumonitis in the mouse. Histologic and immunologic features and their modulation with cyclosporin A. J. Allergy Clin. Immunol. 1988;81:391–400. doi: 10.1016/0091-6749(88)90907-4. [DOI] [PubMed] [Google Scholar]
  442. Takizawa H., Suko M., Kobayashi N., Ohta K., Shoji S., Horiuchi T., Okudaira H., Miyamoto T., Shiga J. Spontaneous regression in murine hypersensitivity pneumonitis: Lack of immunologic tolerance. Int. Arch Allergy Appl. Immunol. 1989;89:173–180. doi: 10.1159/000234942. [DOI] [PubMed] [Google Scholar]
  443. Takizawa H., Ohta K., Horiuchi T., Suzuki N., Ueda T. Hypersensitivity pneumonitis in athymic nude mice. Am. Rev. Respir. Dis. 1992;146:479–484. doi: 10.1164/ajrccm/146.2.479. [DOI] [PubMed] [Google Scholar]
  444. Tao M.-H., Levy R. Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma. Nature. 1993;362:755–758. doi: 10.1038/362755a0. [DOI] [PubMed] [Google Scholar]
  445. Tarling J.D., Lin H.-S., Hsu S. Self-renewal of pulmonary alveolar macrophages: Evidence from radiation chimera studies. J. Leukocyte Biol. 1987;42:443–446. [PubMed] [Google Scholar]
  446. Tazi A., Fajac I., Soler P., Valeyre D., Batteati J., Hance A. Gamma/delta T-lymphocytes are not increased in number in granulomatous lesions of patients with tuberculosis or sarcoidosis. Am. Rev. Respir. Dis. 1991;144:1373–1375. doi: 10.1164/ajrccm/144.6.1373. [DOI] [PubMed] [Google Scholar]
  447. Tew J.G., Phipps R.P., Mandel T.E. The maintenance and regulation of the humoral immune response: Persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells. Immunol. Rev. 1980;53:175–201. doi: 10.1111/j.1600-065x.1980.tb01044.x. [DOI] [PubMed] [Google Scholar]
  448. Thepen T., Van Rooijen N., Kraal G. Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice. J. Exp. Med. 1989;170:499–509. doi: 10.1084/jem.170.2.499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  449. Thomas R., Davis L.S., Lipsky P.E. Comparative accessory cell function of human peripheral blood dendritic cells and monocytes. J. Immunol. 1993;151:6840–6852. [PubMed] [Google Scholar]
  450. Toews G.B., Vial W.C., Dunn M.M., Guzzetta P., Nunez G., Stastny P., Lipscomb M.F. The accessory cell function of human alveolar macrophages in specific T cell proliferation. J. Immunol. 1984;132:181–186. [PubMed] [Google Scholar]
  451. Toews G., Viroslav S., Hart D., Hansen E. Pulmonary clearance of encapsulated and unencapsulated Haemophilus influenzae strains. Infect. Immun. 1984;45:437–442. doi: 10.1128/iai.45.2.437-442.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  452. Toews G., Hart D., Hansen E. Effect of systemic immunization on pulmonary clearance of Haemophilus influenzae type b. Infect. Immun. 1985;48:343–349. doi: 10.1128/iai.48.2.343-349.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  453. Toews G., Vial W. The role of C5 in polymorphonuclear leukocyte recruitment in response to Streptococcus pneumoniae. Am. Rev. Respir. Dis. 1984;129:82–86. doi: 10.1164/arrd.1984.129.1.82. [DOI] [PubMed] [Google Scholar]
  454. Truitt G.L., Mackaness G.B. Cell-mediated resistance to aerogenic infection of the lung. Am. Rev. Respir. Dis. 1971;104:829–843. doi: 10.1164/arrd.1971.104.6.829. [DOI] [PubMed] [Google Scholar]
  455. Trulock E.P. Management of lung transplant rejection. Chest. 1993;103:1566–1576. doi: 10.1378/chest.103.5.1566. [DOI] [PubMed] [Google Scholar]
  456. Upadrashta B., Croom J., Kopp W., Withers J., Richerson H. T cell localization in rabbit models of acute and chronic hypersensitivity pneumonitis. J. Allergy Clin. Immunol. 1988;81:821–828. doi: 10.1016/0091-6749(88)90937-2. [DOI] [PubMed] [Google Scholar]
  457. Uyama T., Winter J.B., Groen G., Wildevuur C.R.H., Monden Y., Prop J. Late airway changes caused by chronic rejection in rat lung allografts. Transplantation. 1992;54:809–812. doi: 10.1097/00007890-199211000-00008. [DOI] [PubMed] [Google Scholar]
  458. Uyama T., Winter J.B., Sakiyama S., Monden Y., Groen G., Prop J. Replacement of dendritic cells in the airways of rat lung allografts. Am. Rev. Respir. Dis. 1993;148:760–767. doi: 10.1164/ajrccm/148.3.760. [DOI] [PubMed] [Google Scholar]
  459. VanCott J.L., Brim T.A., Lunney J.K., Saif L.J. Contribution of antibody-secreting cells induced in mucosal lymphoid tissues of pigs inoculated with respiratory or enteric strains of coronavirus to immunity against enteric coronavirus challenge. J. Immunol. 1994;152:3980–3990. [PubMed] [Google Scholar]
  460. Vandenberghe P.H., Delabie J., de Boer M., De Wolf-Peeters C., Ceuppens J.L. In situ expression of B7/BB1 on antigen presenting cells and activated B cells; An immunohistochemical study. Int. Immunol. 1993;5:317. doi: 10.1093/intimm/5.3.317. [DOI] [PubMed] [Google Scholar]
  461. van der Brugge-Gamelkoorn G.J., van de Ende M.B., Sminia T. Uptake of antigens and inert particles by bronchus-associated lymphoid tissue (BALT) epithelium in the rat. Cell. Biol. Int. Rep. 1985;9:524–525. doi: 10.1016/0309-1651(85)90011-6. [DOI] [PubMed] [Google Scholar]
  462. van der Brugge-Gamelkoorn G.J., Kraal G. The specificity of the high endothelial venule in bronchus-associated lymphoid tissue (BALT) J. Immunol. 1985;134:3746–3750. [PubMed] [Google Scholar]
  463. van der Brugge-Gamelkoorn G.J. Ph. D. thesis. Free University; Amsterdam: 1986. Structure and function of bronchus-associated lymphoid tissue (BALT) in the rat. [PubMed] [Google Scholar]
  464. Van Gool S.W., de Boer M., Ceuppens J.L. The combination of anti-B7 monoclonal antibody and cyclosporin A induces alloantigen-specific anergy during a primary mixed lymphocyte reaction. J. Exp. Med. 1994;179:715–720. doi: 10.1084/jem.179.2.715. [DOI] [PMC free article] [PubMed] [Google Scholar]
  465. van Haarst J.M.W., de Wit H.J., Drexhage H.A., Hoogsteden H.C. Distribution and immunophenotype of mononuclear phagocytes and dendritic cells in the human lung. Am. J. Respir. Cell. Mol. Biol. 1994;10:487–492. doi: 10.1165/ajrcmb.10.5.8179911. [DOI] [PubMed] [Google Scholar]
  466. Van Oud Alblas A.B., Van Furth R. Origin, kinetics, and characteristics of pulmonary macrophages in the normal steady state. J. Exp. Med. 1979;149:1504–1518. doi: 10.1084/jem.149.6.1504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  467. Van Oud Alblas A.B., Van Der Linden-Schrever B., Van Furth R. Origin and kinetics of pulmonary macrophages during an inflammatory reaction induced by intra-alveolar administration of aerosolized heat-killed BCG. Am. Rev. Respir. Dis. 1983;128:276–281. doi: 10.1164/arrd.1983.128.2.276. [DOI] [PubMed] [Google Scholar]
  468. Vial W., Toews G., Pierce A. Early pulmonary granulocyte recruitment in response to Streptococcus pneumoniae. Am. Rev. Respir. Dis. 1984;129:87–91. doi: 10.1164/arrd.1984.129.1.87. [DOI] [PubMed] [Google Scholar]
  469. Volanakis J., Kaplan M. Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide. Proc. Soc. Exp. Biol. Med. 1971;136:612–614. doi: 10.3181/00379727-136-35323. [DOI] [PubMed] [Google Scholar]
  470. Waldman R.H., Henney C.S. Cell-mediated immunity and antibody responses in the respiratory tract after local and systemic immunizations. J. Exp. Med. 1971;134:482–494. doi: 10.1084/jem.134.2.482. [DOI] [PMC free article] [PubMed] [Google Scholar]
  471. Waldman R.H., Spencer C.S., Johnson J.E., III Respiratory and systemic cellular and humoral immune responses to influenza virus vaccine administered parenterally or by nose drops. Cell. Immunol. 1972;3:294–300. doi: 10.1016/0008-8749(72)90168-2. [DOI] [PubMed] [Google Scholar]
  472. Wallace F., Clancy R., Cripps A. An animal model demonstration of enhanced clearance of nontypable Haemophilus inflenzae from the respiratory tract after antigen stimulation of gut-associated lymphoid tissue. Am. Rev. Respir. Dis. 1989;140:311–316. doi: 10.1164/ajrccm/140.2.311. [DOI] [PubMed] [Google Scholar]
  473. Walzer P.D. Experimental models of Pneumocytis carinii infections. In: Young L.S., editor. “Pneumocystis carinii Pneumonia”. Dekker; New York: 1984. pp. 7–76. [Google Scholar]
  474. Warren J., Barton P., Mandel D., Matrosic K. Intrapulmonary tumor necrosis factor triggers local platelet-activating factor production in rat immune complex alveolitis. Lab. Invest. 1990;63:746–754. [PubMed] [Google Scholar]
  475. Warren J., Barton P., Jones M. Contrasting roles for tumor necrosis factor in the pathogenesis of IgA and IgG immune complex lung injury. Am. J. Pathol. 1991;138:581–590. [PMC free article] [PubMed] [Google Scholar]
  476. Warren J. Relationship between interleukin-1 β and platelet-activating factor in the pathogenesis of acute immune complex alveolitis in the rat. Am. J. Pathol. 1992;141:551–560. [PMC free article] [PubMed] [Google Scholar]
  477. Waserman S., Olivenstein R., Renzi P., Xu L., Martin J. The relationship between late asthmatic responses and antigen-specific immunoglobulin. J. Allergy Clin. Immunol. 1992;90:661–669. doi: 10.1016/0091-6749(92)90140-w. [DOI] [PubMed] [Google Scholar]
  478. Wegner C., Rothlein R., Gundel R. Adhesion molecules in the pathogenesis of asthma. Agents Actions (Suppl.) 1991;34:529–544. [PubMed] [Google Scholar]
  479. Weigle W. Immunological unresponsiveness. Adv. Immunol. 1973;16:61–122. doi: 10.1016/s0065-2776(08)60296-5. [DOI] [PubMed] [Google Scholar]
  480. Weissler J.C., Nicod L.P., Lipscomb M.F., Toews G.B. Natural killer cell function in human lung is compartmentalized. Am. Rev. Respir. Dis. 1987;135:941–949. doi: 10.1164/arrd.1987.135.4.941. [DOI] [PubMed] [Google Scholar]
  481. Weissman D.N., Bice D.E., Crowell R.E., Schuyler M.R. Intrapulmonary antigen deposition in the human lung: Local responses. Am. J. Respir. Cell. Mol. Biol. 1994 doi: 10.1165/ajrcmb.11.5.7946390. (in press) [DOI] [PubMed] [Google Scholar]
  482. Weisz-Carrington P., Grimes S.R., Jr., Lamm M.E. Gut-associated lymphoid tissue as source of an IgA immune response in respiratory tissues after oral immunization and intrabronchial challenge. Cell. Immunol. 1987;106:132–138. doi: 10.1016/0008-8749(87)90156-0. [DOI] [PubMed] [Google Scholar]
  483. Wilkes D.S., Weissler J.C. Alloantigen-induced immunoglobulin production in human lung: Differential effects of accessory cell populations on IgG synthesis. Am. J. Respir. Cell. Mol. Biol. 1994;10:339–346. doi: 10.1165/ajrcmb.10.3.8117452. [DOI] [PubMed] [Google Scholar]
  484. Wilkes D.S., Heidler K.M., Quinlan W.M., Doyle N.A., Doerschuk C.M. Allogeneic alveolar macrophages stimulate selective production of IgG2a in recipient murine lung. Am. J. Respir. Crit. Care Med. 1994;149:A72. [Google Scholar]
  485. Wilkes D.S., Heidler K.M., Niemeier M., Schwenk G.R., Mathur P.N., Breite W.M., Cummings O.W., Weissler J.C. Increased bronchoalveolar IgG2/IgG1 ratio is a marker for human lung allograft rejection. J. Invest. Med. 1994 (in press) [PubMed] [Google Scholar]
  486. Williams D.M., Byrne G.I., Grubbs B., Marshall T.J., Schachter J. Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice. Infect. Immun. 1988;56:3004–3006. doi: 10.1128/iai.56.11.3004-3006.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  487. Williams J.E., Moser S.A., Turner S.H., Standard P.G. Development of pulmonary infection in mice inoculated with Blastomyces dermatitidis conidia. Am. J. Respir. Crit. Care Med. 1994;149:500–509. doi: 10.1164/ajrccm.149.2.8306053. [DOI] [PubMed] [Google Scholar]
  488. Winkelstein J. The role of complement in the host's defense against Streptococcus pneumonia. Rev. Infect. Dis. 1981;3:289–298. doi: 10.1093/clinids/3.2.289. [DOI] [PubMed] [Google Scholar]
  489. Winter S.M., Paradis I.L., Dauber J.H., Griffith B.P., Hardesty R.L., Merrill W.W. Proteins of the respiratory tract after heart-lung transplantation. Transplantation. 1989;48:974–980. doi: 10.1097/00007890-198912000-00016. [DOI] [PubMed] [Google Scholar]
  490. Winthereik M., Lundberg L., Sparck J., Katzenstein T., Sompolinsky D. Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity. Allergy. 1992;47:103–109. doi: 10.1111/j.1398-9995.1992.tb05096.x. [DOI] [PubMed] [Google Scholar]
  491. Wood W., Jr. Studies on the mechanism of recovery in pneumococcal pneumonia. I. The action of type specific antibody upon the pulmonary lesion of experimental pneumonia. J. Exp. Med. 1941;73:201–222. doi: 10.1084/jem.73.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  492. Wood W., Jr., Smith M., Watson B. Studies on the mechanism of recovery in pneumococcal pneumonia. IV. The mechanism of phagocytosis in the absence of antibody. J. Exp. Med. 1946;84:387–401. doi: 10.1084/jem.84.4.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  493. Wright P.F., Belshe R.B., Kim H.W., Van Voris L.P., Chanock R.M. Administration of a highly attenuated, live respiratory syncytial virus vaccine to adults and children. Infect. Immun. 1982;37:397–400. doi: 10.1128/iai.37.1.397-400.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  494. Xia W., Schneeberger E.E., McCarthy K., Kradin R.L. Accessory cells of the lung. II. Ia+ pulmonary dendritic cells display cell surface antigen heterogeneity. Am. J. Respir. Cell. Mol. Biol. 1991;5:276–283. doi: 10.1165/ajrcmb/5.3.276. [DOI] [PubMed] [Google Scholar]
  495. Yamaya M., Zayasu K., Sekizawa K., Yamauchi K., Fukushima T., Sasaki H., Takishima T. Mechanisms of decrease in cytoplasmic motility of alveolar macrophages during immediate asthmatic response in dogs. Am. J. Physiol. 1990;258:220–226. doi: 10.1152/ajplung.1990.258.4.L220. [DOI] [PubMed] [Google Scholar]
  496. Yap K.L., Ada G.L., McKenzie I.F.C. Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature. 1978;273:238–239. doi: 10.1038/273238a0. [DOI] [PubMed] [Google Scholar]
  497. Yarbrough W.C., Jr., Wilkes D.S., Weissler J.C. Human alveolar macrophages inhibit receptor-mediated increases in intracellular calcium concentration in lymphocytes. Am. J. Respir. Cell. Mol. Biol. 1991;5:411–415. doi: 10.1165/ajrcmb/5.5.411. [DOI] [PubMed] [Google Scholar]
  498. Yoshizawa Y., Hostetter M.W., Nakazawa T., Ripani L.M., Dawson C.A., Moore V.L. Enhancement of systemic immune response by immunization into chronically inflamed lungs. J. Lab. Clin. Med. 1982;100:61–69. [PubMed] [Google Scholar]
  499. Yousem S.A., Berry G.J., Brunt E.M., Chamberlain D., Hruban R.H., Sibley R.K., Stewart S., Tazelaar H.D. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Lung rejection study group. J. Heart Transplant. 1990;9:593–601. [PubMed] [Google Scholar]
  500. Zinkernagel R.M., Althage A. Antiviral protection by virus-immune cytotoxic T cells: Infected target cells are lysed before infectious virus progeny is assembled. J. Exp. Med. 1977;145:644–651. doi: 10.1084/jem.145.3.644. [DOI] [PMC free article] [PubMed] [Google Scholar]
  501. Zinkernagel R.M. Immunity to viruses. In: Paul W.E., editor. “Fundamental Immunology”. Raven Press; New York: 1993. pp. 1211–1250. [Google Scholar]

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