Cell receptor-independent infection by a neurotropic murine coronavirus

Thomas M Gallagher; Michael J Buchmeier; Stanley Perlman

doi:10.1016/0042-6822(92)90223-C

. 2004 Feb 11;191(1):517–522. doi: 10.1016/0042-6822(92)90223-C

Cell receptor-independent infection by a neurotropic murine coronavirus

Thomas M Gallagher ^∗,¹, Michael J Buchmeier ^∗, Stanley Perlman ^†,²

PMCID: PMC7131763 PMID: 1413526

Abstract

The cellular receptors for a coronavirus, mouse hepatitis virus (MHV), have been recently identified as one or more members of the carcinoembryonic antigen (CEA) family. The neurotropic JHM strain of MHV (MHV-JHM) possesses a highly fusogenic surface (S) glycoprotein. This protein is now shown to promote the spread of MHV into cells lacking the specific CEA-related MHV receptor. Resistant cells are recruited into MHV-induced syncytium with consequent production of progeny virus. Cell-to-cell spread of virus via membrane fusion without the requirement for specific cell surface receptor offers a novel way for virus to spread within infected hosts.

References

1.Williams R.K., Jiang G.-S., Holmes K.V. Vol. 88. 1991. pp. 5533–5536. (Proc. Natl. Acad. Sci. USA). [DOI] [PMC free article] [PubMed] [Google Scholar]
2.Dveksler G.S., Pensiero M., Cardellichio C., Williams R.K., Jiang G.-S., Holmes K.V., Dieffenbach C.W. J. Virol. 1991;65:6881–6891. doi: 10.1128/jvi.65.12.6881-6891.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
3.Marsh M., Helenius A. Adv. Virus Res. 1989;36:107–151. doi: 10.1016/S0065-3527(08)60583-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
4.Lentz T.L. J. Gen. Virol. 1990;71:751–766. doi: 10.1099/0022-1317-71-4-751. [DOI] [PubMed] [Google Scholar]
5.Bergelson J., Shepley M.P., Chan B.M., Hemler M., Finberg R.W. Science. 1992;255:1718–1720. doi: 10.1126/science.1553561. [DOI] [PubMed] [Google Scholar]
6.Delmas B., Gelfi J., L'Haridon R., Vogel L., Sjostrom H., Noren O., Laude H. Nature. 1992;357:417–420. doi: 10.1038/357417a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
7.Yeager C.L., Ashmun R.A., Williams R.K., Cardellichio C.B., Shapiro L.H., Look A.T., Holmes K.V. Nature. 1992;357:420–422. doi: 10.1038/357420a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
8.White J.M. Annu. Rev. Physiol. 1990;52:675–697. doi: 10.1146/annurev.ph.52.030190.003331. [DOI] [PubMed] [Google Scholar]
9.Collins A.R., Knobler R.L., Powell H., Buchmeier M.J. Virology. 1982;119:358–371. doi: 10.1016/0042-6822(82)90095-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
10.Yoo D., Parker M., Babiuk L.A. Virology. 1991;180:395–399. doi: 10.1016/0042-6822(91)90045-D. [DOI] [PMC free article] [PubMed] [Google Scholar]
11.Taguchi F., Ikeda T., Shida H. J. Gen. Virol. 1992;73:1065–1072. doi: 10.1099/0022-1317-73-5-1065. [DOI] [PubMed] [Google Scholar]
12.Hirano N., Fujiwara K., Hind S., Matsumoto M. Arch. Gesamte Virusforsch. 1974;44:298–302. doi: 10.1007/BF01240618. [DOI] [PubMed] [Google Scholar]
13.Parker S., Gallagher T.M., Buchmeier M.J. Virology. 1989;173:664–673. doi: 10.1016/0042-6822(89)90579-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
14.Yokomori K., La Monica N., Making S., Shieh C.-K., Lai M.C.C. Virology. 1989;173:683–691. doi: 10.1016/0042-6822(89)90581-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
15.Pfleiderer M., Routledge E., Herrler G., Siddell S. J. Gen Virol. 1991;72:1309–1315. doi: 10.1099/0022-1317-72-6-1309. [DOI] [PubMed] [Google Scholar]
16.Fuerst T.R., Niles E.G., Studier F.W., Moss B. Vol. 83. 1986. pp. 8122–8126. (Proc. Natl. Acad. Sci. USA). [DOI] [PMC free article] [PubMed] [Google Scholar]
17.Gallagher T.M., Escarmis C., Buchmeier M.J. J. Virol. 1991;65:1916–1928. doi: 10.1128/jvi.65.4.1916-1928.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
18.Mobley J., Evans G., Dailey M.O., Perlman S. Virology. 1992;187:443–452. doi: 10.1016/0042-6822(92)90446-V. [DOI] [PMC free article] [PubMed] [Google Scholar]
19.Pfleiderer M., Routledge E., Siddell S.G. Adv. Exp. Med. Biol. 1990;276:21–31. doi: 10.1007/978-1-4684-5823-7_4. [DOI] [PubMed] [Google Scholar]
20.Robb J., Bond C., Leibowitz J.L. Virology. 1979;94:385–399. doi: 10.1016/0042-6822(79)90469-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
21.Luytjes W., Sturman L., Bredenbeek P., Charite J., van der Zeust B.A.M., Horzinek M.C., Spaan W.J.M. Virology. 1987;161:479–487. doi: 10.1016/0042-6822(87)90142-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
22.Frana M.F., Behnke J.N., Sturman L.S., Holmes K.V. J. Virol. 1985;56:912–920. doi: 10.1128/jvi.56.3.912-920.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
23.Daya M., Cervin M., Anderson R. Virology. 1988;163:276–283. doi: 10.1016/0042-6822(88)90267-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
24.Roos D.S., Duchala C.S., Stephenson C.B., Holmes K.V., Choppin P.W. Virology. 1990;175:345–357. doi: 10.1016/0042-6822(90)90419-R. [DOI] [PMC free article] [PubMed] [Google Scholar]
25.Wilson G.A.R., Dales S. J. Virol. 1988;62:3371–3377. doi: 10.1128/jvi.62.9.3371-3377.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
26.Flintoff W.F., van Dinter S. J. Gen Virol. 1989;70:1713–1724. doi: 10.1099/0022-1317-70-7-1713. [DOI] [PubMed] [Google Scholar]
27.Nagashima K., Wege H., Meyermann R., ter Meulen V. Acta Neuropathol. (Berlin) 1979;45:205–213. doi: 10.1007/BF00702672. [DOI] [PMC free article] [PubMed] [Google Scholar]
28.Sorensen O., Perry D., Dales S. Arch. Neurol. 1980;37:478–484. doi: 10.1001/archneur.1980.00500570026003. [DOI] [PubMed] [Google Scholar]
29.Murray R.S., Cai G.-Y., Hoel K., Zhang J.-Y., Soike K.F., Cabirac G.F. Virology. 1992;188:274–284. doi: 10.1016/0042-6822(92)90757-G. [DOI] [PMC free article] [PubMed] [Google Scholar]
30.Perez L.G., O'Donnell M.A., Stephens E.B. J. Virol. 1992;66:4134–4143. doi: 10.1128/jvi.66.7.4134-4143.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
31.Schmid A., Spielhofer P., Cattaneo R., Baczko K., ter Meulen V., Billeter M. Virology. 1992;188:910–915. doi: 10.1016/0042-6822(92)90552-z. [DOI] [PubMed] [Google Scholar]
32.Mulligan M., Yamshchikov G., Ritter D., Gao F., Jin M., Nail C., Spies C., Hahn B.H., Compans R.W. J. Virol. 1992;66:3971–3975. doi: 10.1128/jvi.66.6.3971-3975.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
33.MacGregor G.R., Mogg A.E., Burke J.F., Caskey C.T. Somatic Cell Mol. Gen. 1987;13:253–265. doi: 10.1007/BF01535207. [DOI] [PubMed] [Google Scholar]
34.Elroy-Stein C., Moss B. Vol. 87. 1990. pp. 6743–6747. (Proc. Natl. Acad. Sci. USA). [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB1] 1.Williams R.K., Jiang G.-S., Holmes K.V. Vol. 88. 1991. pp. 5533–5536. (Proc. Natl. Acad. Sci. USA). [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB2] 2.Dveksler G.S., Pensiero M., Cardellichio C., Williams R.K., Jiang G.-S., Holmes K.V., Dieffenbach C.W. J. Virol. 1991;65:6881–6891. doi: 10.1128/jvi.65.12.6881-6891.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB3] 3.Marsh M., Helenius A. Adv. Virus Res. 1989;36:107–151. doi: 10.1016/S0065-3527(08)60583-7. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB4] 4.Lentz T.L. J. Gen. Virol. 1990;71:751–766. doi: 10.1099/0022-1317-71-4-751. [DOI] [PubMed] [Google Scholar]

[BIB5] 5.Bergelson J., Shepley M.P., Chan B.M., Hemler M., Finberg R.W. Science. 1992;255:1718–1720. doi: 10.1126/science.1553561. [DOI] [PubMed] [Google Scholar]

[BIB6] 6.Delmas B., Gelfi J., L'Haridon R., Vogel L., Sjostrom H., Noren O., Laude H. Nature. 1992;357:417–420. doi: 10.1038/357417a0. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB7] 7.Yeager C.L., Ashmun R.A., Williams R.K., Cardellichio C.B., Shapiro L.H., Look A.T., Holmes K.V. Nature. 1992;357:420–422. doi: 10.1038/357420a0. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB8] 8.White J.M. Annu. Rev. Physiol. 1990;52:675–697. doi: 10.1146/annurev.ph.52.030190.003331. [DOI] [PubMed] [Google Scholar]

[BIB9] 9.Collins A.R., Knobler R.L., Powell H., Buchmeier M.J. Virology. 1982;119:358–371. doi: 10.1016/0042-6822(82)90095-2. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB10] 10.Yoo D., Parker M., Babiuk L.A. Virology. 1991;180:395–399. doi: 10.1016/0042-6822(91)90045-D. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB11] 11.Taguchi F., Ikeda T., Shida H. J. Gen. Virol. 1992;73:1065–1072. doi: 10.1099/0022-1317-73-5-1065. [DOI] [PubMed] [Google Scholar]

[BIB12] 12.Hirano N., Fujiwara K., Hind S., Matsumoto M. Arch. Gesamte Virusforsch. 1974;44:298–302. doi: 10.1007/BF01240618. [DOI] [PubMed] [Google Scholar]

[BIB13] 13.Parker S., Gallagher T.M., Buchmeier M.J. Virology. 1989;173:664–673. doi: 10.1016/0042-6822(89)90579-5. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB14] 14.Yokomori K., La Monica N., Making S., Shieh C.-K., Lai M.C.C. Virology. 1989;173:683–691. doi: 10.1016/0042-6822(89)90581-3. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB15] 15.Pfleiderer M., Routledge E., Herrler G., Siddell S. J. Gen Virol. 1991;72:1309–1315. doi: 10.1099/0022-1317-72-6-1309. [DOI] [PubMed] [Google Scholar]

[BIB16] 16.Fuerst T.R., Niles E.G., Studier F.W., Moss B. Vol. 83. 1986. pp. 8122–8126. (Proc. Natl. Acad. Sci. USA). [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB17] 17.Gallagher T.M., Escarmis C., Buchmeier M.J. J. Virol. 1991;65:1916–1928. doi: 10.1128/jvi.65.4.1916-1928.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB18] 18.Mobley J., Evans G., Dailey M.O., Perlman S. Virology. 1992;187:443–452. doi: 10.1016/0042-6822(92)90446-V. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB19] 19.Pfleiderer M., Routledge E., Siddell S.G. Adv. Exp. Med. Biol. 1990;276:21–31. doi: 10.1007/978-1-4684-5823-7_4. [DOI] [PubMed] [Google Scholar]

[BIB20] 20.Robb J., Bond C., Leibowitz J.L. Virology. 1979;94:385–399. doi: 10.1016/0042-6822(79)90469-0. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB21] 21.Luytjes W., Sturman L., Bredenbeek P., Charite J., van der Zeust B.A.M., Horzinek M.C., Spaan W.J.M. Virology. 1987;161:479–487. doi: 10.1016/0042-6822(87)90142-5. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB22] 22.Frana M.F., Behnke J.N., Sturman L.S., Holmes K.V. J. Virol. 1985;56:912–920. doi: 10.1128/jvi.56.3.912-920.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB23] 23.Daya M., Cervin M., Anderson R. Virology. 1988;163:276–283. doi: 10.1016/0042-6822(88)90267-X. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB24] 24.Roos D.S., Duchala C.S., Stephenson C.B., Holmes K.V., Choppin P.W. Virology. 1990;175:345–357. doi: 10.1016/0042-6822(90)90419-R. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB25] 25.Wilson G.A.R., Dales S. J. Virol. 1988;62:3371–3377. doi: 10.1128/jvi.62.9.3371-3377.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB26] 26.Flintoff W.F., van Dinter S. J. Gen Virol. 1989;70:1713–1724. doi: 10.1099/0022-1317-70-7-1713. [DOI] [PubMed] [Google Scholar]

[BIB27] 27.Nagashima K., Wege H., Meyermann R., ter Meulen V. Acta Neuropathol. (Berlin) 1979;45:205–213. doi: 10.1007/BF00702672. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB28] 28.Sorensen O., Perry D., Dales S. Arch. Neurol. 1980;37:478–484. doi: 10.1001/archneur.1980.00500570026003. [DOI] [PubMed] [Google Scholar]

[BIB29] 29.Murray R.S., Cai G.-Y., Hoel K., Zhang J.-Y., Soike K.F., Cabirac G.F. Virology. 1992;188:274–284. doi: 10.1016/0042-6822(92)90757-G. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB30] 30.Perez L.G., O'Donnell M.A., Stephens E.B. J. Virol. 1992;66:4134–4143. doi: 10.1128/jvi.66.7.4134-4143.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB31] 31.Schmid A., Spielhofer P., Cattaneo R., Baczko K., ter Meulen V., Billeter M. Virology. 1992;188:910–915. doi: 10.1016/0042-6822(92)90552-z. [DOI] [PubMed] [Google Scholar]

[BIB32] 32.Mulligan M., Yamshchikov G., Ritter D., Gao F., Jin M., Nail C., Spies C., Hahn B.H., Compans R.W. J. Virol. 1992;66:3971–3975. doi: 10.1128/jvi.66.6.3971-3975.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]

[BIB33] 33.MacGregor G.R., Mogg A.E., Burke J.F., Caskey C.T. Somatic Cell Mol. Gen. 1987;13:253–265. doi: 10.1007/BF01535207. [DOI] [PubMed] [Google Scholar]

[BIB34] 34.Elroy-Stein C., Moss B. Vol. 87. 1990. pp. 6743–6747. (Proc. Natl. Acad. Sci. USA). [DOI] [PMC free article] [PubMed] [Google Scholar]

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Cell receptor-independent infection by a neurotropic murine coronavirus

Thomas M Gallagher

Michael J Buchmeier

Stanley Perlman

Abstract

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PERMALINK

Cell receptor-independent infection by a neurotropic murine coronavirus

Thomas M Gallagher

Michael J Buchmeier

Stanley Perlman

Abstract

References

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