Skip to main content
NCBI home page
Elsevier - PMC COVID-19 Collection logoLink to Elsevier - PMC COVID-19 Collection
. 2005 Apr 14;57(6):595–604. doi: 10.1016/0091-6749(76)90011-7

Bronchiolitis and asthma: Possible common pathogenetic pathways☆

Kenneth McIntosh 1,∗
PMCID: PMC7133166  PMID: 180072

Abstract

A discussion of possible mechanisms for virus-induced wheezing in normal and asthmatic children is presented. Presently attractive theories for immune injury in viral bronchiolitis include those which depend on pathology induced by types 1, 3, and 4 of Gell and Coombs. The continuum of viral bronchiolitis with virus-induced wheezing in young children who are labeled “asthmatic” argues for some common mechanism of bronchiolar obstruction.

Footnotes

☆

Postgraduate Course presented at the American Academy of Allergy Meetings, February, 1975.

References

  • 1.Knight V. Lea & Febiger, Publishers; Philadelphia: 1973. Viral and mycoplasmal infections of the respiratory tract. [Google Scholar]
  • 2.Tyrrell D.A.J., Hoorn B. The growth of some myxoviruses in organ cultures. Br. J. Exp. Pathol. 1965;46:514. [PMC free article] [PubMed] [Google Scholar]
  • 3.Hoorn B., Tyrrell D.A.J. On the growth of certain “newer” respiratory viruses in organ cultures. Br. J. Exp. Pathol. 1964;46:109. [PMC free article] [PubMed] [Google Scholar]
  • 4.Reed S.E., Boyde A. Organ cultures of respiratory epithelium infected with rhinovirus or parainfluenza virus studied in a scanning electron microscope. Infect. Immun. 1972;6:68. doi: 10.1128/iai.6.1.68-76.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Beem M. Repeated infections with respiratory syncytial virus. J. Immunol. 1967;98:1115. [PubMed] [Google Scholar]
  • 6.Connolly J.H., Field C.M.B., Glasgow J.F.T., Slattery C.M., MacLynn D.M. A double-blind trial of prednisolone in epidemic bronchiolitis due to respiratory syncytial virus. Acta Paediatr. Scand. 1969;58:116. doi: 10.1111/j.1651-2227.1969.tb04693.x. [DOI] [PubMed] [Google Scholar]
  • 7.Dabbous I.S., Tkachyk J.S., Stamm S.M. A double-blind study of the effects of corticosteroids in the treatment of bronchiolitis. Pediatrics. 1966;37:477. [PubMed] [Google Scholar]
  • 8.Phelan P.D., Williams H.E. Sympathomimetic drugs in acute viral bronchiolitis. Pediatrics. 1969;44:493. [PubMed] [Google Scholar]
  • 9.Hogg J.C., Williams J., Richardson J.B., Macklem P.T., Thurlbeck W.M. Age as a factor in the distribution of lower-airway conductance and in the pathologic anatomy of obstructive lung disease. N. Engl. J. Med. 1970;282:1283. doi: 10.1056/NEJM197006042822302. [DOI] [PubMed] [Google Scholar]
  • 10.Aherne W., Bird T., Court S.D.M., Gardner P.S., McQuillin J. Pathological changes in virus infections of the lower respiratory tract in children. J. Clin. Pathol. 1970;23:7. doi: 10.1136/jcp.23.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Chanock R.M., Parrott R.H., Kapikian A.Z., Kim H.W., Brandt C.D. Possible role of immunological factors in pathogenesis of respiratory syncytial virus lower respiratory tract disease. Perspect. Virol. 1968;6:125. [Google Scholar]
  • 12.Fulginiti V.A., Eller J.J., Sieber O.F., Joyner J.W., Minamitani M., Meiklejohn G. Respiratory virus immunization, I. Am. J. Epidemiol. 1969;89:435. doi: 10.1093/oxfordjournals.aje.a120956. [DOI] [PubMed] [Google Scholar]
  • 13.Kim H.W., Canchola J.G., Brandt C.D., Pyles G., Chanock R.M., Jensen K., Parrott R.H. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am. J. Epidemiol. 1969;89:422. doi: 10.1093/oxfordjournals.aje.a120955. [DOI] [PubMed] [Google Scholar]
  • 14.Kapikian A.Z., Mitchell R.H., Chanock R.M., Shvedoff R.A., Stewart C.E. An epidemiologic study of altered clinical reactivity to respiratory syncytial virus infection in children previously vaccinated with an inactivated respiratory syncytial virus vaccine. Am. J. Epidemiol. 1969;89:405. doi: 10.1093/oxfordjournals.aje.a120954. [DOI] [PubMed] [Google Scholar]
  • 15.Chin J., Magoffin R.L., Shearer L.A., Schieble J.H., Lennette E.H. Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am. J. Epidemiol. 1969;89:449. doi: 10.1093/oxfordjournals.aje.a120957. [DOI] [PubMed] [Google Scholar]
  • 16.Gardner P.S., McQuillin J., Court S.D.M. Speculation on pathogenesis in death from respiratory syncytial virus infection. Br. Med. J. 1970;1:327. doi: 10.1136/bmj.1.5692.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.McIntosh K., Ellis E.F., Hoffman L.S., Lybass T.G., Eller J.J., Fulginiti V.A. The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J. Pediatr. 1973;82:578. doi: 10.1016/S0022-3476(73)80582-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Parrott R.H., Kim H.W., Arrobio J.O., Hodes D.S., Murphy B.R., Brandt C.D., Camargo E., Chanock R.M. Epidemiology of respiratory syncytial virus infection in Washington, D. C. II. Infection and disease with respect to age, immunologic, status, race and sex. Am. J. Epidemiol. 1973;98:289. doi: 10.1093/oxfordjournals.aje.a121558. [DOI] [PubMed] [Google Scholar]
  • 19.Jacobs J.W., Peacock D.B., Corner B.D., Caul E.O., Clarke S.K.R. Respiratory syncytial and other viruses associated with respiratory disease in infants. Lancet. 1971;1:871. doi: 10.1016/S0140-6736(71)92440-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Ana P.P., Arrobio J.O., Kim H.W., Brandt C.D., Chanock R.M., Parrott R.H. Vol. 134. 1970. Serum complement in acute bronchiolitis; p. 499. (Proc. Soc. Exp. Biol. Med). [DOI] [PubMed] [Google Scholar]
  • 21.Neligan G.A., Steiner H., Gardner P.S., McQuillin J. Respiratory syncytial virus infection in the newborn. Br. Med. J. 1970;3:146. doi: 10.1136/bmj.3.5715.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22.Scott R., Gardner P.S. The local antibody response to respiratory syncytial viral infection in the respiratory tract. J. Hyg. (Camb.) 1974;72:111. doi: 10.1017/s0022172400023275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Brandt C.D., Kim H.W., Arrobio J.O., Jeffries B.C., Wood S.C., Chanock R.M., Parrott R.H. Epidemiology of respiratory syncytial virus infection in Washington, D.C. III. Composite analysis of eleven consecutive yearly epidemics. Am. J. Epidemiol. 1973;98:355. doi: 10.1093/oxfordjournals.aje.a121565. [DOI] [PubMed] [Google Scholar]
  • 24.Polmar S.H., Robinson L.D., Jr., Minnefor A.B. Immunoglobulin E in bronchiolitis. Pediatrics. 1972;50:279. [PubMed] [Google Scholar]
  • 25.Foucard T., Berg T., Johansson S.G.O., Wahren B. Virus serology and serum IgE levels in children with asthmatoid bronchitis. Acta Paediatr. Scand. 1971;60:621. doi: 10.1111/j.1651-2227.1971.tb07001.x. [DOI] [PubMed] [Google Scholar]
  • 26.Freeman G.L., Todd R.H. The role of allergy in viral respiratory tract infections. Am. J. Dis. Child. 1962;104:330. doi: 10.1001/archpedi.1962.02080030332002. [DOI] [PubMed] [Google Scholar]
  • 27.Freeman G.L. Wheezing associated with respiratory tract infections in children. Clin. Pediatr. 1966;5:586. doi: 10.1177/000992286600501004. [DOI] [PubMed] [Google Scholar]
  • 28.Rooney J.C., Williams H.E. The relationship between proved viral bronchiolitis and subsequent wheezing. J. Pediatr. 1971;79:744. doi: 10.1016/s0022-3476(71)80385-2. [DOI] [PubMed] [Google Scholar]
  • 29.Berkovitch S., Millian S.J., Snyder R.D. The association of viral and mycoplasma infections in the recurrence of wheezing in the asthmatic child. Ann. Allergy. 1970;28:43. [PubMed] [Google Scholar]
  • 30.Minor T.E., Dick E.C., DeMeo A.N., Ouellctte J.J., Cohen M., Reed C.E. Viruses as precipitants of asthmatic attacks in children. J. A. M. A. 1974;227:292. [PubMed] [Google Scholar]
  • 31.Horn M.E.C., Gregg I. Role of viral infection and host factors in acute episodes of asthma and chronic bronchitis. Chest. 1973;63:44. doi: 10.1378/chest.63.4_supplement.44s-a. (Suppl.) [DOI] [PubMed] [Google Scholar]
  • 32.Huhti E., Mokka T., Nikoskelainen J., Halonen P. Association of viral and mycoplasma infections with exacerbations of asthma. Ann. Allergy. 1974;33:145. [PubMed] [Google Scholar]
  • 33.Disney M.E., Matthews R., Williams J.D. The role of infection in the morbidity of asthmatic children admitted to hospital. Clin. Allergy. 1971;1:399. doi: 10.1111/j.1365-2222.1971.tb00791.x. [DOI] [PubMed] [Google Scholar]
  • 34.McIntosh K., Arbeter A.M., Stahl M.K., Orr I.A., Hodes D.S., Ellis E.F. Attenuated respiratory syncytial virus vaccines in asthmatic children. Pediatr. Res. 1974;8:689. doi: 10.1203/00006450-197407000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Hampton S.F., Johnson M.C., Galakatos E. Studies of bacterial hypersensitivity in asthma. I. J. Allergy. 1963;34:63. [Google Scholar]
  • 36.Snyder R.D., Stiefel F.H. Prophylactic antibiotics in asthmatic children. Ann. Allergy. 1970;28:307. [PubMed] [Google Scholar]

Articles from The Journal of Allergy and Clinical Immunology are provided here courtesy of Elsevier

RESOURCES