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. 2004 Nov 22;80(3):348–358. doi: 10.1016/0091-6749(87)90041-8

Mucosal immunity: The immunology of breast milk

Herbert B Slade 1,∗, Stanley A Schwartz 1
PMCID: PMC7133196  PMID: 3305665

Abstract

The mammary glands represent one part of the mucosal immune system, a definable, subunit of humoral and cellular immune functions in man that appears to have developed particular qualities well suited to guard our interface with the environment. As our understanding of secretory immunoglobulins and lymphocyte migration patterns continues to develop, the immunologic components found in breast milk appear increasingly likely to play a specific immunologic role in the protection of the nursing infant. The biologic basis for the observed protective effect of breast-feeding is reviewed with an emphasis on the mechanisms involved in the development and maintenance of mucosal immunity in general.

Abbreviations: PP, Peyer's patches; BALT, Bronchus-associated lymphoid tissue; GALT, Gut-associated lymphoid tissue; SIgA, Secretory IgA; SIgM, Secretory IgM; sIgA, Surface IgA; SC, Secretory component; HEV, High endothelial venules; PLN, Peripheral lymph nodes; BM, Breast milk; PBL, Peripheral blood lymphocytes; MLN, Mesenteric lymph nodes; Mab, Monoclonal antibody; FcR, Fc receptor

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