Abstract
One hundred and three patients (90 nonatopics and 13 atopics) with respiratory infections to various viral agents were studied retrospectively with respect to IgE immunoglobulin levels during acute (1 to 7 days) and convalescent (8 to 30 days) phases of infection. It was found that 59% of patients had a decrease of 20% or more in IgE level, 27% remained the same, and only 14% showed a rise of 20% or more from the acute to the convalescent phases of infection. IgE levels decreased up to 3 to 4 wk after symptoms and the degree of decrease was more apparent for the nonatopics who had higher IgE levels in their acute phase of infection. Less dramatic decrease in IgE was observed for the 13 atopics studied. The changes in IgE levels during the viral infectious period are discussed in terms of possible cellular mechanisms that may control IgE immunoglobulin.
References
- 1.Freeman GL, Todd RH. The role of allergy in viral respiratory tract infections. Am J Dis Child. 1962;104:330. doi: 10.1001/archpedi.1962.02080030332002. [DOI] [PubMed] [Google Scholar]
- 2.Minor TE, Dick EC, DeMeo AN, Ouellette JJ, Cohen M, Reed CE. Viruses as precipitants of asthmatic attacks in children. JAMA. 1974;227:292. [PubMed] [Google Scholar]
- 3.Berkovich S, Millian SJ, Snyder RD. The association of viral and mycoplasma infections with recurrence of wheezing in the asthmatic child. Ann Allergy. 1970;28:43. [PubMed] [Google Scholar]
- 4.McIntosh K, Ellis EF, Hoffman LS, Lybass TG, Eller JJ, Fulginiti VA. The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J Pediatr. 1973;82:578. doi: 10.1016/S0022-3476(73)80582-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Ouellette JJ, Reed CE. Increased response of asthmatic subjects to methacholine after influenza vaccine. J Allergy. 1965;36:558. doi: 10.1016/0021-8707(65)90193-0. [DOI] [PubMed] [Google Scholar]
- 6.Ida S, Hooks JJ, Siraganian RP, Natkins AL. Enhancement of IgE-mediated histamine release from human basophils by viruses: Role of interferon. J Exp Med. 1977;145:892. doi: 10.1084/jem.145.4.892. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Frick OL, Ashton FA, Mills J. Virus infection association with onset of allergic sensitization in infants. Ann Allergy. 1977;38:449. [Google Scholar]
- 8.Leonardy JG, Peacock LB. An evaluation of quantitative serum immunoglobulins determinations in clinical practice. Ann Allergy. 1972;30:378. [PubMed] [Google Scholar]
- 9.Perelmutter L, Potvin L. A study on the IgE levels of military recruits and association with HLA antigens. Ann Allergy. 1978;40:319. [PubMed] [Google Scholar]
- 10.Perelmutter L, Phipps P, Potvin L. Viral infections and IgE levels. Ann Allergy. 1978;41:158. [PubMed] [Google Scholar]
- 11.Moneret-Vautrin DA, Olive D, Viniaker-Bronstein J. Signification des valeurs basses d'IgE sériques. Les Immunoglobuline E. Symposium IgE; Nancy, France; Sept. 17–18, 1976. p. 91. [Google Scholar]
- 12.Lennette EH, Schmidt NJ. American Public Health Association Inc; New York: 1977. Diagnostic procedures for viral and rickettsial infections. [Google Scholar]
- 13.Kjellman N, Johansson SGO, Roth A. Serum IgE levels in healthy children quantified by a sandwich technique (PRIST) Clin Allergy. 1976;6:51. doi: 10.1111/j.1365-2222.1976.tb01411.x. [DOI] [PubMed] [Google Scholar]
- 14.Zetterström O, Johansson SGO: (To be published.)
- 15.Bahna SL, Horwitz CA, Heiner DC. IgE in cytomegalovirus mononucleosis. J Allergy Clin Immunol. 1978;61:177. doi: 10.1016/0091-6749(78)90102-1. [DOI] [PubMed] [Google Scholar]
- 16.Bahna SL, Horwitz CA, Ficula M, Heiner DC. IgE response in heterophil-positive infectious mononucleosis. J Allergy Clin Immunol. 1978;62:167. doi: 10.1016/0091-6749(78)90102-1. [DOI] [PubMed] [Google Scholar]
- 17.Perelmutter L, Forrester J, Fyson B, Perry E: IgE responses during immunization with influenza antigens. (In preparation.)
- 18.Heiner DC, Bahna SL. Specific IgE antibodies to EBV in infectious mononucleosis. Presented at the Third International Congress of Immunology; Sydney, Australia; July 1977. [Google Scholar]
- 19.Strannegard O, Strannegard I-L. T lymphocyte numbers and function in human IgE-mediated allergy. Immunol Rev. 1978;41:149. doi: 10.1111/j.1600-065x.1978.tb01463.x. [DOI] [PubMed] [Google Scholar]