Protease-dependent virus tropism and pathogenicity

Yoshiyuki Nagai

doi:10.1016/0966-842X(93)90112-5

. 2003 Jun 18;1(3):81–87. doi: 10.1016/0966-842X(93)90112-5

Protease-dependent virus tropism and pathogenicity

Yoshiyuki Nagai ¹

PMCID: PMC7133224 PMID: 8143121

Abstract

Viral tissue tropism in a susceptible host is often determined by virus-receptor interactions. Nevertheless, closely related viruses utilizing the same receptor molecules can display striking differences in tropism, or a virus can cause a localized infection despite the widespread occurrence of the receptor. These events are now explained by another mechanism of tropism, in which host proteases play a major role by activating viral fusion glycoproteins.

References

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Protease-dependent virus tropism and pathogenicity

Yoshiyuki Nagai

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Protease-dependent virus tropism and pathogenicity

Yoshiyuki Nagai

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