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. 2004 Apr 7;3(2):295–300. doi: 10.1016/0959-437X(93)90037-P

Gene regulation: translational initiation by internal ribosome binding

Soo-Kyung Oh 1, Peter Sarnow 1
PMCID: PMC7133282  PMID: 8504255

Abstract

During the past year, several examples of cellular mRNAs have been described in which translational initiation occurs by internal ribosome binding, a mechanism hitherto thought to be restricted to picornaviral RNAs. New insights into the molecular mechanism of internal ribosome entry have been provided by the structural and functional analyses of both the internal ribosome entry sites and the protein factors that stimulate translation mediated by these elements.

Abbreviations: Antp, Antennapedia; eIF, eukaryote initiation factor; EMC, encephalomyocarditis; FMD, foot and mouth disease; HCV, hepatitis C virus; IBV, infectious bronchitis virus; IRES, internal ribosome entry site; 5′ NCR, 5′ non-coding region; Tfm, testicular feminization

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