Problems and prospects of developing effective therapy for common cold viruses

Sebastian L Johnston

doi:10.1016/S0966-842X(96)10082-2

. 2000 Mar 8;5(2):58–63. doi: 10.1016/S0966-842X(96)10082-2

Problems and prospects of developing effective therapy for common cold viruses

Sebastian L Johnston ¹

PMCID: PMC7133329 PMID: 9108931

Abstract

No effective treatment for common colds has yet been developed. Combination antiviral and anti-inflammatory therapies are the best hope for intervention after the onset of symptoms. Prophylaxis, especially in the form of vaccination, would have a major impact in disease prevention. These approaches offer new avenues for treating populations at risk and are of particular significance to those with asthma or chronic bronchitis.

References

1.Johnston S.L. J. Clin. Microbiol. 1993;31:111–117. doi: 10.1128/jcm.31.1.111-117.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
2.Dearden C. Arch. Virol. 1989;109:71–81. doi: 10.1007/BF01310519. [DOI] [PubMed] [Google Scholar]
3.Hayden F.G. New Engl. J. Med. 1989;321:1696–1702. doi: 10.1056/NEJM198912213212502. [DOI] [PubMed] [Google Scholar]
4.Johnston S.L. Br. Med. J. 1995;310:1225–1228. [Google Scholar]
5.Nicholson K.G. Br. Med. J. 1993;307:982–986. doi: 10.1136/bmj.307.6910.982. [DOI] [PMC free article] [PubMed] [Google Scholar]
6.Arola M. Ann. Otol. Rhinol. Laryngol. 1990;99:451–453. doi: 10.1177/000348949009900607. [DOI] [PubMed] [Google Scholar]
7.Gwaltney J.M., Jr New Engl. J. Med. 1994;330:25–30. doi: 10.1056/NEJM199401063300105. [DOI] [PubMed] [Google Scholar]
8.Igarashi Y. J. Allergy Clin. Immunol. 1993;92:722–731. doi: 10.1016/0091-6749(93)90016-9. [DOI] [PubMed] [Google Scholar]
9.Naclerio R.M. J. Infect. Dis. 1987;157:133–142. doi: 10.1093/infdis/157.1.133. [DOI] [PubMed] [Google Scholar]
10.Volovitz B. Pediatr. Res. 1988;24:504–507. doi: 10.1203/00006450-198810000-00018. [DOI] [PubMed] [Google Scholar]
11.Lau L.C.K. Am. J. Respir. Crit. Care Med. 1996;153:A697. [Google Scholar]
12.Teran L.M., Johnston S.L., Holgate S.T. Am. J. Respir. Crit. Care Med. 1995;151:A385. doi: 10.1164/ajrccm.155.4.9105080. [DOI] [PubMed] [Google Scholar]
13.Einarrson O. Chest. 1995;107:132–133. [Google Scholar]
14.Taylor C.E. Arch. Dis. Child. 1989;64:1656–1660. doi: 10.1136/adc.64.12.1656. [DOI] [PMC free article] [PubMed] [Google Scholar]
15.Levandowski R.A. J. Med. Virol. 1988;25:423–432. doi: 10.1002/jmv.1890250406. [DOI] [PubMed] [Google Scholar]
16.Winther B. Am. J. Rhinol. 1992;4:149. [Google Scholar]
17.Fraenkel D.J. Am. J. Respir. Crit. Care Med. 1994;150:1130–1136. doi: 10.1164/ajrccm.150.4.7921447. [DOI] [PubMed] [Google Scholar]
18.Fraenkel D.J. Am. J. Respir. Crit. Care Med. 1995;151:879–886. doi: 10.1164/ajrccm/151.3_Pt_1.879. [DOI] [PubMed] [Google Scholar]
19.Seminario M-C. Vol. 95. 1995. p. 259. (J. Allergy Clin. Immunol.). [Google Scholar]
20.Heymann P.W. Int. Arch. Allergy Immunol. 1995;107:380–382. doi: 10.1159/000237043. [DOI] [PubMed] [Google Scholar]
21.Hemila H., Herman Z.S. J. Am. Coll. Nutr. 1995;14:116–123. doi: 10.1080/07315724.1995.10718483. [DOI] [PubMed] [Google Scholar]
22.Tyrrell D. Br. Med. J. 1989;298:1280–1283. doi: 10.1136/bmj.298.6683.1280. [DOI] [PMC free article] [PubMed] [Google Scholar]
23.Godfrey J.C. J. Int. Med. Res. 1992;20:234–246. doi: 10.1177/030006059202000305. [DOI] [PubMed] [Google Scholar]
24.Sperber S.J., Hayden F.G. Antimicrob. Agents Chemother. 1988;32:409–419. doi: 10.1128/aac.32.4.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
25.Douglas R.M. New Engl. J. Med. 1986;314:65–70. doi: 10.1056/NEJM198601093140201. [DOI] [PubMed] [Google Scholar]
26.Pinto L.H., Holsinger L.J., Lamb R.A. Cell. 1992;69:517–528. doi: 10.1016/0092-8674(92)90452-i. [DOI] [PubMed] [Google Scholar]
27.Graham B.S. Trends Microbiol. 1996;4:290–294. doi: 10.1016/0966-842x(96)10032-9. [DOI] [PubMed] [Google Scholar]
28.Openshaw P.J.M. Am. J. Respir. Crit. Care Med. 1995;152:S59–S62. doi: 10.1164/ajrccm/152.4_Pt_2.S59. [DOI] [PubMed] [Google Scholar]
29.Graham B.S. Am. J. Respir. Crit. Care Med. 1995;152:S63–S66. doi: 10.1164/ajrccm/152.4_Pt_2.S63. [DOI] [PubMed] [Google Scholar]
30.Alwan W.H. J. Exp. Med. 1994;179:81–89. doi: 10.1084/jem.179.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
31.Murphy B.R. Virus Res. 1994;32:13–36. doi: 10.1016/0168-1702(94)90059-0. [DOI] [PubMed] [Google Scholar]
32.Hastings G.Z. J. Gen. Virol. 1991;72:2947–2952. doi: 10.1099/0022-1317-72-12-2947. [DOI] [PubMed] [Google Scholar]
33.Farr B. J. Infect. Dis. 1990;162:1173–1177. doi: 10.1093/infdis/162.5.1173. [DOI] [PubMed] [Google Scholar]
34.Gustafson L.M. J. Allergy Clin. Immunol. 1996;97:1009–1014. doi: 10.1016/s0091-6749(96)80077-7. [DOI] [PubMed] [Google Scholar]
35.Wilson N.W., Silverman M. Arch. Dis. Child. 1990;65:407–410. doi: 10.1136/adc.65.4.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
36.Connett G., Lenney W. Arch. Dis. Child. 1993;68:85–87. doi: 10.1136/adc.68.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
37.Wilson N. Arch. Dis. Child. 1995;72:317–320. doi: 10.1136/adc.72.4.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
38.Smith T.F., Remigio L.K. Int. Arch. Allergy Appl. Immunol. 1982;67:380–383. doi: 10.1159/000233051. [DOI] [PubMed] [Google Scholar]
39.Gaffey M.J. Am. Rev. Respir. Dis. 1987;136:556–560. doi: 10.1164/ajrccm/136.3.556. [DOI] [PubMed] [Google Scholar]
40.Vignola A.M. Allergy. 1995;50:200–203. doi: 10.1111/j.1398-9995.1995.tb01133.x. [DOI] [PubMed] [Google Scholar]
41.Naclerio R.M. Pediatr. Infect. Dis. J. 1988;7:219–222. doi: 10.1097/00006454-198803000-00031. [DOI] [PubMed] [Google Scholar]
42.Proud D. J. Infect. Dis. 1990;161:120–123. doi: 10.1093/infdis/161.1.120. [DOI] [PubMed] [Google Scholar]
43.Higgins P.G. Antiviral Res. 1990;14:339–344. doi: 10.1016/0166-3542(90)90052-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
44.Dockhorn R. J. Allergy Clin. Immunol. 1992;90:1076–1082. doi: 10.1016/0091-6749(92)90126-m. [DOI] [PubMed] [Google Scholar]
45.Hayden F.G. Ann. Intern. Med. 1996;125:89–97. doi: 10.7326/0003-4819-125-2-199607150-00002. [DOI] [PubMed] [Google Scholar]
46.Norris A.A., Alton E.W.F.W. Clin. Exp. Allergy. 1996;26:50–53. [PubMed] [Google Scholar]
47.Barrow G.I. Clin. Exp. Allergy. 1990;20:45–51. doi: 10.1111/j.1365-2222.1990.tb02774.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
48.Aberg N. Clin. Exp. Allergy. 1996;26:1045–1050. doi: 10.1111/j.1365-2222.1996.tb00642.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
49.Gwaltney J.M., Jr J. Infect. Dis. 1992;166:776–782. doi: 10.1093/infdis/166.4.776. [DOI] [PubMed] [Google Scholar]
50.Johnston S.L. Clin. Exp. Allergy. 1993;23:237–246. doi: 10.1111/j.1365-2222.1993.tb00316.x. [DOI] [PubMed] [Google Scholar]
51.Arruda E. Antimicrob. Agents Chemother. 1994;38:66–70. doi: 10.1128/aac.38.1.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
52.Panuska J.R. Am. J. Respir. Crit. Care Med. 1996;153:A17. [Google Scholar]
53.Hassel B.A. EMBO J. 1993;12:3297. doi: 10.1002/j.1460-2075.1993.tb05999.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
54.Maran A. Science. 1994;265:789–792. doi: 10.1126/science.7914032. [DOI] [PubMed] [Google Scholar]
55.Ziebuhr J. J. Virol. 1995;69:4331–4338. doi: 10.1128/jvi.69.7.4331-4338.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
56.Malcolm B.A. Protein Sci. 1995;4:1439–1445. doi: 10.1002/pro.5560040801. [DOI] [PMC free article] [PubMed] [Google Scholar]
57.Ulmer J.B. Science. 1993;259:1745–1749. doi: 10.1126/science.8456302. [DOI] [PubMed] [Google Scholar]
58.Johnston S.L. Am. J. Respir. Crit. Care Med. 1996;154:654–660. doi: 10.1164/ajrccm.154.3.8810601. [DOI] [PubMed] [Google Scholar]
59.Myint S., Taylor-Robinson D., editors. Viral and Other Infections of the Human Respiratory Tract. Chapman & Hall; 1996. [Google Scholar]
60.Diana G.D. Antiviral Chem. Chemother. 1993;4:1–10. [Google Scholar]
61.Smith T.J. Science. 1986;233:1286–1293. doi: 10.1126/science.3018924. [DOI] [PubMed] [Google Scholar]
62.Zhang A. J. Mol. Biol. 1993;230:857–867. doi: 10.1006/jmbi.1993.1206. [DOI] [PubMed] [Google Scholar]
63.Hayden F.G., Andries K., Janssen P.A.J. Antimicrob. Agents Chemother. 1993;36:727–732. doi: 10.1128/aac.36.4.727. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib1] 1.Johnston S.L. J. Clin. Microbiol. 1993;31:111–117. doi: 10.1128/jcm.31.1.111-117.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib2] 2.Dearden C. Arch. Virol. 1989;109:71–81. doi: 10.1007/BF01310519. [DOI] [PubMed] [Google Scholar]

[bib3] 3.Hayden F.G. New Engl. J. Med. 1989;321:1696–1702. doi: 10.1056/NEJM198912213212502. [DOI] [PubMed] [Google Scholar]

[bib4] 4.Johnston S.L. Br. Med. J. 1995;310:1225–1228. [Google Scholar]

[bib5] 5.Nicholson K.G. Br. Med. J. 1993;307:982–986. doi: 10.1136/bmj.307.6910.982. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib6] 6.Arola M. Ann. Otol. Rhinol. Laryngol. 1990;99:451–453. doi: 10.1177/000348949009900607. [DOI] [PubMed] [Google Scholar]

[bib7] 7.Gwaltney J.M., Jr New Engl. J. Med. 1994;330:25–30. doi: 10.1056/NEJM199401063300105. [DOI] [PubMed] [Google Scholar]

[bib8] 8.Igarashi Y. J. Allergy Clin. Immunol. 1993;92:722–731. doi: 10.1016/0091-6749(93)90016-9. [DOI] [PubMed] [Google Scholar]

[bib9] 9.Naclerio R.M. J. Infect. Dis. 1987;157:133–142. doi: 10.1093/infdis/157.1.133. [DOI] [PubMed] [Google Scholar]

[bib10] 10.Volovitz B. Pediatr. Res. 1988;24:504–507. doi: 10.1203/00006450-198810000-00018. [DOI] [PubMed] [Google Scholar]

[bib11] 11.Lau L.C.K. Am. J. Respir. Crit. Care Med. 1996;153:A697. [Google Scholar]

[bib12] 12.Teran L.M., Johnston S.L., Holgate S.T. Am. J. Respir. Crit. Care Med. 1995;151:A385. doi: 10.1164/ajrccm.155.4.9105080. [DOI] [PubMed] [Google Scholar]

[bib13] 13.Einarrson O. Chest. 1995;107:132–133. [Google Scholar]

[bib14] 14.Taylor C.E. Arch. Dis. Child. 1989;64:1656–1660. doi: 10.1136/adc.64.12.1656. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib15] 15.Levandowski R.A. J. Med. Virol. 1988;25:423–432. doi: 10.1002/jmv.1890250406. [DOI] [PubMed] [Google Scholar]

[bib16] 16.Winther B. Am. J. Rhinol. 1992;4:149. [Google Scholar]

[bib17] 17.Fraenkel D.J. Am. J. Respir. Crit. Care Med. 1994;150:1130–1136. doi: 10.1164/ajrccm.150.4.7921447. [DOI] [PubMed] [Google Scholar]

[bib18] 18.Fraenkel D.J. Am. J. Respir. Crit. Care Med. 1995;151:879–886. doi: 10.1164/ajrccm/151.3_Pt_1.879. [DOI] [PubMed] [Google Scholar]

[bib19] 19.Seminario M-C. Vol. 95. 1995. p. 259. (J. Allergy Clin. Immunol.). [Google Scholar]

[bib20] 20.Heymann P.W. Int. Arch. Allergy Immunol. 1995;107:380–382. doi: 10.1159/000237043. [DOI] [PubMed] [Google Scholar]

[bib21] 21.Hemila H., Herman Z.S. J. Am. Coll. Nutr. 1995;14:116–123. doi: 10.1080/07315724.1995.10718483. [DOI] [PubMed] [Google Scholar]

[bib22] 22.Tyrrell D. Br. Med. J. 1989;298:1280–1283. doi: 10.1136/bmj.298.6683.1280. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib23] 23.Godfrey J.C. J. Int. Med. Res. 1992;20:234–246. doi: 10.1177/030006059202000305. [DOI] [PubMed] [Google Scholar]

[bib24] 24.Sperber S.J., Hayden F.G. Antimicrob. Agents Chemother. 1988;32:409–419. doi: 10.1128/aac.32.4.409. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib25] 25.Douglas R.M. New Engl. J. Med. 1986;314:65–70. doi: 10.1056/NEJM198601093140201. [DOI] [PubMed] [Google Scholar]

[bib26] 26.Pinto L.H., Holsinger L.J., Lamb R.A. Cell. 1992;69:517–528. doi: 10.1016/0092-8674(92)90452-i. [DOI] [PubMed] [Google Scholar]

[bib27] 27.Graham B.S. Trends Microbiol. 1996;4:290–294. doi: 10.1016/0966-842x(96)10032-9. [DOI] [PubMed] [Google Scholar]

[bib28] 28.Openshaw P.J.M. Am. J. Respir. Crit. Care Med. 1995;152:S59–S62. doi: 10.1164/ajrccm/152.4_Pt_2.S59. [DOI] [PubMed] [Google Scholar]

[bib29] 29.Graham B.S. Am. J. Respir. Crit. Care Med. 1995;152:S63–S66. doi: 10.1164/ajrccm/152.4_Pt_2.S63. [DOI] [PubMed] [Google Scholar]

[bib30] 30.Alwan W.H. J. Exp. Med. 1994;179:81–89. doi: 10.1084/jem.179.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib31] 31.Murphy B.R. Virus Res. 1994;32:13–36. doi: 10.1016/0168-1702(94)90059-0. [DOI] [PubMed] [Google Scholar]

[bib32] 32.Hastings G.Z. J. Gen. Virol. 1991;72:2947–2952. doi: 10.1099/0022-1317-72-12-2947. [DOI] [PubMed] [Google Scholar]

[bib33] 33.Farr B. J. Infect. Dis. 1990;162:1173–1177. doi: 10.1093/infdis/162.5.1173. [DOI] [PubMed] [Google Scholar]

[bib34] 34.Gustafson L.M. J. Allergy Clin. Immunol. 1996;97:1009–1014. doi: 10.1016/s0091-6749(96)80077-7. [DOI] [PubMed] [Google Scholar]

[bib35] 35.Wilson N.W., Silverman M. Arch. Dis. Child. 1990;65:407–410. doi: 10.1136/adc.65.4.407. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib36] 36.Connett G., Lenney W. Arch. Dis. Child. 1993;68:85–87. doi: 10.1136/adc.68.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib37] 37.Wilson N. Arch. Dis. Child. 1995;72:317–320. doi: 10.1136/adc.72.4.317. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib38] 38.Smith T.F., Remigio L.K. Int. Arch. Allergy Appl. Immunol. 1982;67:380–383. doi: 10.1159/000233051. [DOI] [PubMed] [Google Scholar]

[bib39] 39.Gaffey M.J. Am. Rev. Respir. Dis. 1987;136:556–560. doi: 10.1164/ajrccm/136.3.556. [DOI] [PubMed] [Google Scholar]

[bib40] 40.Vignola A.M. Allergy. 1995;50:200–203. doi: 10.1111/j.1398-9995.1995.tb01133.x. [DOI] [PubMed] [Google Scholar]

[bib41] 41.Naclerio R.M. Pediatr. Infect. Dis. J. 1988;7:219–222. doi: 10.1097/00006454-198803000-00031. [DOI] [PubMed] [Google Scholar]

[bib42] 42.Proud D. J. Infect. Dis. 1990;161:120–123. doi: 10.1093/infdis/161.1.120. [DOI] [PubMed] [Google Scholar]

[bib43] 43.Higgins P.G. Antiviral Res. 1990;14:339–344. doi: 10.1016/0166-3542(90)90052-9. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib44] 44.Dockhorn R. J. Allergy Clin. Immunol. 1992;90:1076–1082. doi: 10.1016/0091-6749(92)90126-m. [DOI] [PubMed] [Google Scholar]

[bib45] 45.Hayden F.G. Ann. Intern. Med. 1996;125:89–97. doi: 10.7326/0003-4819-125-2-199607150-00002. [DOI] [PubMed] [Google Scholar]

[bib46] 46.Norris A.A., Alton E.W.F.W. Clin. Exp. Allergy. 1996;26:50–53. [PubMed] [Google Scholar]

[bib47] 47.Barrow G.I. Clin. Exp. Allergy. 1990;20:45–51. doi: 10.1111/j.1365-2222.1990.tb02774.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib48] 48.Aberg N. Clin. Exp. Allergy. 1996;26:1045–1050. doi: 10.1111/j.1365-2222.1996.tb00642.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib49] 49.Gwaltney J.M., Jr J. Infect. Dis. 1992;166:776–782. doi: 10.1093/infdis/166.4.776. [DOI] [PubMed] [Google Scholar]

[bib50] 50.Johnston S.L. Clin. Exp. Allergy. 1993;23:237–246. doi: 10.1111/j.1365-2222.1993.tb00316.x. [DOI] [PubMed] [Google Scholar]

[bib51] 51.Arruda E. Antimicrob. Agents Chemother. 1994;38:66–70. doi: 10.1128/aac.38.1.66. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib52] 52.Panuska J.R. Am. J. Respir. Crit. Care Med. 1996;153:A17. [Google Scholar]

[bib53] 53.Hassel B.A. EMBO J. 1993;12:3297. doi: 10.1002/j.1460-2075.1993.tb05999.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib54] 54.Maran A. Science. 1994;265:789–792. doi: 10.1126/science.7914032. [DOI] [PubMed] [Google Scholar]

[bib55] 55.Ziebuhr J. J. Virol. 1995;69:4331–4338. doi: 10.1128/jvi.69.7.4331-4338.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib56] 56.Malcolm B.A. Protein Sci. 1995;4:1439–1445. doi: 10.1002/pro.5560040801. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib57] 57.Ulmer J.B. Science. 1993;259:1745–1749. doi: 10.1126/science.8456302. [DOI] [PubMed] [Google Scholar]

[bib58] 58.Johnston S.L. Am. J. Respir. Crit. Care Med. 1996;154:654–660. doi: 10.1164/ajrccm.154.3.8810601. [DOI] [PubMed] [Google Scholar]

[bib59] 59.Myint S., Taylor-Robinson D., editors. Viral and Other Infections of the Human Respiratory Tract. Chapman & Hall; 1996. [Google Scholar]

[bib60] 60.Diana G.D. Antiviral Chem. Chemother. 1993;4:1–10. [Google Scholar]

[bib61] 61.Smith T.J. Science. 1986;233:1286–1293. doi: 10.1126/science.3018924. [DOI] [PubMed] [Google Scholar]

[bib62] 62.Zhang A. J. Mol. Biol. 1993;230:857–867. doi: 10.1006/jmbi.1993.1206. [DOI] [PubMed] [Google Scholar]

[bib63] 63.Hayden F.G., Andries K., Janssen P.A.J. Antimicrob. Agents Chemother. 1993;36:727–732. doi: 10.1128/aac.36.4.727. [DOI] [PMC free article] [PubMed] [Google Scholar]

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Problems and prospects of developing effective therapy for common cold viruses

Sebastian L Johnston

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Problems and prospects of developing effective therapy for common cold viruses

Sebastian L Johnston

Abstract

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