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. 2002 Nov 14;47(2):281–328. doi: 10.1016/0163-7258(90)90091-F

Hepatic circulation: Potential for therapeutic intervention

François Ballet 1,∗
PMCID: PMC7133670  PMID: 2203072

Abstract

In recent years, knowledge of the physiology and pharmacology of hepatic circulation has grown rapidly. Liver microcirculation has a unique design that allows very efficient exchange processes between plasma and liver cells, even when severe constraints are imposed upon the system, i.e. in stressful situations. Furthermore, it has been recognized recently that sinusoids and their associated cells can no longer be considered only as passive structures ensuring the dispersion of molecules in the liver, but represent a very sophisticated network that protects and regulates parenchymal cells through a variety of mediators. Finally, vascular abnormalities are a prominent feature of a number of liver pathological processes, including cirrhosis and liver cell necrosis whether induced by alcohol, ischemia, endotoxins, virus or chemicals. Although it is not clear whether vascular lesions can be the primary events that lead to hepatocyte injury, the main interest of these findings is that liver microcirculation could represent a potential target for drug action in these conditions.

References

  1. Abecassis M., Falk J.A., Makowka L., Dindzans V.J., Falk R.E., Levy G.Z. 16,16 dimethyl prostaglandin E2 prevents the development of fulminant hepatitis and blocks the induction of monocyte/macrophage procoagulant activity after murine hepatitis virus strain 3 infection. J. clin. Invest. 1987;80:881–889. doi: 10.1172/JCI113147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ahmad A.B., Bennett P.N., Rowland M. Influence of route of hepatic administration on drug availability. J. Pharmac. exp. Ther. 1984;230:718–725. [PubMed] [Google Scholar]
  3. Akerboom T., Lenzen R., Schneider I., Sies H. Cholestasis and changes in the microcirculation of perfused rat liver caused by the calcium ionophore A 23187 and type I antiarrhythmic drugs. Biochem. Pharmac. 1987;36:3037–3042. doi: 10.1016/0006-2952(87)90221-8. [DOI] [PubMed] [Google Scholar]
  4. Altin J.G., Bygrave F.L. Prostaglandin F2α and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Biochem. J. 1988;249:677–685. doi: 10.1042/bj2490677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Altin J.G., Bygrave F.L. Non-parenchymal cells as mediators of physiological responses in liver. Molec. cell. Biochem. 1988;83:3–4. doi: 10.1007/BF00223193. [DOI] [PubMed] [Google Scholar]
  6. Altin J.G., Dieter P., Bygrave F.L. Evidence that Ca2+ fluxes and respiratory, glycogenolytic and vasoconstrictive effects induced by the action of platelet-activating factor and l-α-lysophosphatidylcholine in the perfused rat liver are mediated by products of the cyclo-oxygenase pathway. Biochem. J. 1987;245:145–150. doi: 10.1042/bj2450145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Al Tuwaijri A., Akdama K., Di Luzio N. Modification of galactosamine-induced liver injury in rats by reticuloendothelial system stimulation or depression. Hepatology. 1981;1:107–113. doi: 10.1002/hep.1840010204. [DOI] [PubMed] [Google Scholar]
  8. Alvarez-Lopez A., De Hemptinne B., Hoebeke Y., Lambotte L. Prostaglandin E2 increases the tolerance of the rat liver to warm ischemia in absence of splanchnic congestion. Transp. Proc. 1987;19:4105–4109. [PubMed] [Google Scholar]
  9. Anders M.W. Biotransformation of halogenated hydrocarbons. In: Mitchell J.R., Horning M.G., editors. Drug Metabolism and Drug Toxicity. Raven Press; New York: 1984. pp. 55–70. [Google Scholar]
  10. Arai M., Okuno F., Kobayashi T., Ishii H., Tsuchiya M. Endotoxin hepatotoxicity: a possible key role of intravascular coagulation. Hepatology. 1988;8:1397. (Abstr.) [Google Scholar]
  11. Araki H., Lefer A.M. Cytoprotective action of prostacyclin during hypoxia in the isolated perfused cat liver. Am. J. Physiol. 1980;238:H176–H178. doi: 10.1152/ajpheart.1980.238.2.H176. [DOI] [PubMed] [Google Scholar]
  12. Arenson D.M., Friedman S.L., Bissel D.M. Formation of extracellular matrix in normal rat liver: lipocytes as a major source of proteoglycans. Gastroenterology. 1988;95:441–447. doi: 10.1016/0016-5085(88)90502-1. [DOI] [PubMed] [Google Scholar]
  13. Arroyo V., Planas R., Gaya J., Deulofeu R., Rimola A., Perez-Ayoso R.M., Rivera F., Rodes J. Sympathetic nervous activity renin-angiotensin system and renal excretion of prostaglandin E2 in cirrhosis. Relationship to functional renal failure and sodium and water excretion. Eur. J. clin. Invest. 1983;13:271–278. doi: 10.1111/j.1365-2362.1983.tb00100.x. [DOI] [PubMed] [Google Scholar]
  14. Arthur M.J.P., Bentley I.S., Tanner A.R., Saunders P.K., Millward-Sadler G.H., Wright R. Oxygen-derived free radicals promote hepatic injury in the rat. Gastroenterology. 1985;89:1114–1122. doi: 10.1016/0016-5085(85)90218-5. [DOI] [PubMed] [Google Scholar]
  15. Arthur M.J.P., Saunders P.K., Wright R. Effect of endotoxin on release of reactive oxygen intermediates by rat hepatic macrophages. Gastroenterology. 1988;95:1588–1594. doi: 10.1016/s0016-5085(88)80082-9. [DOI] [PubMed] [Google Scholar]
  16. Ballé C., Jungermann K. Control of urea production, glutamine release and ammonia uptake in the perfused rat liver by the sympathetic innervation. Eur. J. Biochem. 1986;158:13–18. doi: 10.1111/j.1432-1033.1986.tb09714.x. [DOI] [PubMed] [Google Scholar]
  17. Ballé C., Beuers U., Englelhardt R., Jungermann K. Intracellular mechanism of action of sympathetic hepatic nerves on glucose and lactate balance in perfused rat liver. Eur. J. Biochem. 1987;170:193–199. doi: 10.1111/j.1432-1033.1987.tb13686.x. [DOI] [PubMed] [Google Scholar]
  18. Ballet F., Chretien Y., Lhoste F., Poupon R. Hepatic clearance of norepinephrine in the isolated perfused rat liver. J. Hepatol. 1985;2:S188. (Abstr.) [Google Scholar]
  19. Ballet F., Chretien Y., Rey C., Poupon R. Norepinephrine: a potential modulator of the hepatic transport of taurocholate. A study in the isolated perfused rat liver. J. Pharmac. exp. Ther. 1987;240:303–307. [PubMed] [Google Scholar]
  20. Ballet F., Mastai R., Brault A., Huet P.M. Norepinephrine-induced alteration of taurocholate transport: a vascular or a cellular effect. Hepatology. 1987;7:1037. (Abstr.) [Google Scholar]
  21. Ballet F., Chretien Y., Rey C., Poupon R. Differential response of normal and cirrhotic liver to vasoactive agents. A study in the isolated perfused rat liver. J. Pharmac. exp. Ther. 1988;244:233–235. [PubMed] [Google Scholar]
  22. Bang S., Myren J., Naess O., Beraki K., Serck-Hanssen A., Arnesen K. Prostaglandins and CCl4-induced liver cell mortality. Scand. J. Gastroenterol. 1988;23:931–934. doi: 10.3109/00365528809090149. [DOI] [PubMed] [Google Scholar]
  23. Barbare J.C., Poupon R., Jaillon P., Bories P., Aussanaire M., Darnis F., Michel H., Cheymol G. The influence of vasoactive agents on metabolic activity of the liver in cirrhosis: a study of the effects of posterior pituitary extract, vasopressin and somatostatin. Hepatology. 1984;4:59–62. doi: 10.1002/hep.1840040110. [DOI] [PubMed] [Google Scholar]
  24. Barrowman J.A., Perry M.A., Kvietys P.R., Granger D.N. Exclusion phenomenon in the liver interstitium. Am. J. Physiol. 1982;243:G410–G414. doi: 10.1152/ajpgi.1982.243.5.G410. [DOI] [PubMed] [Google Scholar]
  25. Bass N.M., Manning J.A., Weisiger R.A. Increased sinusoidal volume and solute extraction during retrograde liver perfusion. Am. J. Physiol. 1987;256:G1041–G1048. doi: 10.1152/ajpgi.1989.256.6.G1041. [DOI] [PubMed] [Google Scholar]
  26. Beckh K., Balks H.J., Jungermann K. Activation of glycogenolysis and norepinephrine overflow in the perfused rat liver during repetitive perivascular nerve stimulation. FEBS Lett. 1982;149:261–265. doi: 10.1016/0014-5793(82)81113-7. [DOI] [PubMed] [Google Scholar]
  27. Beckh K., Hartmann H., Jungermann K., Sholz R. Regulation of oxygen consumption in perfused rat liver: decrease by α-sympathetic nerve stimulation and increase by the α-agonist phenylephrine. Pflügers Arch. 1984;401:104–106. doi: 10.1007/BF00581541. [DOI] [PubMed] [Google Scholar]
  28. Belinsky S.A., Popp J.A., Kauffman F.C., Thurman R.G. Trypan blue uptake as a new method to investigate hepatotoxicity in periportal and pericentral regions of the liver lobule: stuides with allyl alcohol in the perfused liver. J. Pharmac. exp. Ther. 1984;230:755–760. [PubMed] [Google Scholar]
  29. Belzer F.O., Southard J.H. Principles of solid-organ preservation by cold-storage. Transplantation. 1988;45:673–676. doi: 10.1097/00007890-198804000-00001. [DOI] [PubMed] [Google Scholar]
  30. Bennett T.D., Rothe C.F. Hepatic capacitance responses to changes in flow and hepatic venous pressure in dogs. Am. J. Physiol. 1981;246:H525–H531. doi: 10.1152/ajpheart.1981.240.1.H18. [DOI] [PubMed] [Google Scholar]
  31. Benoit J.N., Barrowman J.A., Harper S.L., Kvietys P.R., Granger D.N. Role of humoral factors in the intestinal hyperemia associated with chronic portal hypertension. Am. J. Physiol. 1984;247:G486–G493. doi: 10.1152/ajpgi.1984.247.5.G486. [DOI] [PubMed] [Google Scholar]
  32. Benoit J.N., Womack W.A., Hernandez L., Granger D.N. ‘Forward’ and ‘backward’ flow mechanisms of portal hypertension. Gastroenterology. 1985;89:1092–1096. [PubMed] [Google Scholar]
  33. Benoit J.N., Wormack W.A., Korthius R.J., Wilborn W.H., Granger D.N. Chronic portal hypertension: effects on gastrointestinal blood flow distribution. Am. J. Physiol. 1986;250:G535–G539. doi: 10.1152/ajpgi.1986.250.4.G535. [DOI] [PubMed] [Google Scholar]
  34. Bernardi M., Trivisani F., Santini C., Zoli G., Baraldini M., Ligabue A., Gasbarrini G. Plasma norepinephrine, weak neurotransmitters, and renin activity during active tilting in liver cirrhosis: relationship with cardiovascular homeostasis and renal function. Hepatology. 1983;3:56–64. doi: 10.1002/hep.1840030109. [DOI] [PubMed] [Google Scholar]
  35. Beuers U., Beckh K., Jungermann K. Control of ketogenesis in the perfused rat liver by the sympathetic innervation. Eur. J. Biochem. 1986;158:19–24. doi: 10.1111/j.1432-1033.1986.tb09715.x. [DOI] [PubMed] [Google Scholar]
  36. Bevan J.A. Some bases of differences in vascular response to sympathetic activity. Circ. Res. 1979;45:161–171. doi: 10.1161/01.res.45.2.161. [DOI] [PubMed] [Google Scholar]
  37. Bevan J.A. Vascular myogenic or stretch-dependent tone. J. cardiovasc. Pharmac. 1985;7:S129–S136. doi: 10.1097/00005344-198500073-00015. [DOI] [PubMed] [Google Scholar]
  38. Bhatal P.S., Grossman J.H. Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators. J. Hepatol. 1985;1:325–337. doi: 10.1016/s0168-8278(85)80770-4. [DOI] [PubMed] [Google Scholar]
  39. Bichet D.G., Vanputten V.J., Schrier R.W. Potential role of increased sympathetic activity in impaired sodium and water excretion in cirrhosis. New Engl. J. Med. 1982;307:1552–1557. doi: 10.1056/NEJM198212163072504. [DOI] [PubMed] [Google Scholar]
  40. Bioulac-Sage P., Balabaud C. La cellule périsinusoïdale (ou cellule de Ito) Gastroenterol. clin. Biol. 1985;9:312–322. [PubMed] [Google Scholar]
  41. Bioulac-Sage P., Lafon M.E., Le Bail B., Balabaud C. Perisinusoidal and pit cells in liver sinusoids. In: Bioulac-Sage P., Balabaud C., editors. Sinusoids in Human Liver: Health and Disease. Kupffer cells Foundation; Rijswijk: 1988. pp. 39–63. [Google Scholar]
  42. Bioulac-Sage P., Lafon M.E., Saric J., Balabaud C. Nerves and perisinusoidal cells in human liver. J. Hepatol. 1990;10:105–112. doi: 10.1016/0168-8278(90)90080-b. [DOI] [PubMed] [Google Scholar]
  43. Birmelin M., Decker K. Synthesis of prostanoids and cyclic nucleotides by phagocytosing rat Kupffer cells. Eur. J. Biochem. 1984;142:219–225. doi: 10.1111/j.1432-1033.1984.tb08274.x. [DOI] [PubMed] [Google Scholar]
  44. Blanchet L., Lebrec D. Changes in splanchnic blood flow in portal hypertensive rats. Eur. J. clin. Invest. 1982;12:327–330. doi: 10.1111/j.1365-2362.1982.tb02240.x. [DOI] [PubMed] [Google Scholar]
  45. Blei A.T. Vasodilator therapy of portal hypertension: focus on the liver. Hepatology. 1989;6:896–899. doi: 10.1002/hep.1840090618. [DOI] [PubMed] [Google Scholar]
  46. Blei A.T., Gottstein J. Isosorbide dinitrate in experimental portal hypertension: a study of factors that modulate the haemodynamic response. Hepatology. 1986;6:107–111. doi: 10.1002/hep.1840060120. [DOI] [PubMed] [Google Scholar]
  47. Blei A.T., Granger D., Fung H.L. Organic nitrates in portal hypertension. Eur. Heart. J. 1988;9A:205–211. doi: 10.1093/eurheartj/9.suppl_a.205. [DOI] [PubMed] [Google Scholar]
  48. Bloch E.H. The termination of hepatic arterioles and the functional unit of the liver as determined by microscopy of the living organ. Ann. N.Y. Acad. Sci. 1970;170:78–87. [Google Scholar]
  49. Bomzon A., Blendis L.M. Vascular reactivity in experimental portal hypertension. Am. J. Physiol. 1987;252:G158–G162. doi: 10.1152/ajpgi.1987.252.2.G158. [DOI] [PubMed] [Google Scholar]
  50. Bonventre J.V. Mediators of ischemic renal injury. Ann. Rev. Med. 1988;39:531–544. doi: 10.1146/annurev.me.39.020188.002531. [DOI] [PubMed] [Google Scholar]
  51. Boobis A.R., Powis G. The effects of catecholamines upon the metabolism of foreign compounds and upon the distribution of perfusate in the isolated liver of the rat. Biochem. Pharmac. 1974;23:3377–3384. doi: 10.1016/0006-2952(74)90340-2. [DOI] [PubMed] [Google Scholar]
  52. Bosch J. Effect of pharmacological agents on portal hypertension: a haemodynamic appraisal. Clin. Gastroenterol. 1985;14:169–184. [PubMed] [Google Scholar]
  53. Bosch J., Enriquez R., Groszmann R.J., Storer E.H. Chronic bile duct ligation in the dog: hemodynamic characterization of a portal hypertensive model. Hepatology. 1983;3:1002–1007. doi: 10.1002/hep.1840030618. [DOI] [PubMed] [Google Scholar]
  54. Bradford B.U., Marotto M., Lemasters J.J., Thurman R.G. New, simple models to evaluate zone-specific damage due to hypoxia in the perfused rat liver: time course and effect of nutritional state. J. Pharmac. exp. Ther. 1986;236:263–268. [PubMed] [Google Scholar]
  55. Braquet P., Touqui L., Shen T.Y., Vargaftig B.B. Perspectives in platelet-activating factor research. Pharmac. Rev. 1987;39:97–133. [PubMed] [Google Scholar]
  56. Brauer R.W. Blood flow distribution in the liver and the circulatory control of liver function. In: Brauer R.W., editor. Liver Function. Am. Inst. Biol. Sci. Monograph; 1958. pp. 113–127. [Google Scholar]
  57. Brauer R.W. Liver circulation and function. Physiol. Rev. 1963;43:116–192. doi: 10.1152/physrev.1963.43.1.115. [DOI] [PubMed] [Google Scholar]
  58. Brauer R.W., McElroy R.F., Holloway R.J. Hemodynamics of the vascular tree of the isolated rat liver preparation. Am. J. Physiol. 1956;535–542 doi: 10.1152/ajplegacy.1956.186.3.537. [DOI] [PubMed] [Google Scholar]
  59. Braunwald E., Kloner R.A. Myocardial reperfusion: a double-edged sword. J. clin. Invest. 1985;76:1713–1719. doi: 10.1172/JCI112160. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Bray M.A. Prostaglandins and leukotrienes: fine tuning of the immune response. ISI Atlas Sci.: Pharmac. 1987;1:101–106. [Google Scholar]
  61. Bredfeldt J.E., Riley E.M., Groszmann R.J. Compensatory mechanisms in response to an elevated hepatic oxygen consumption in chronically ethanol-fed rats. Am. J. Physiol. 1985;248:G507–G511. doi: 10.1152/ajpgi.1985.248.5.G507. [DOI] [PubMed] [Google Scholar]
  62. Brouwer A., Barelds R.J., De Leeuw A.M., Blauw E., Plas A., Yap S.H., Van den Broek A.M.W.C., Knook D.L. Isolation and culture of Kupffer cells from human liver. Ultrastructure, endocytosis and prostaglandin synthesis. J. Hepatol. 1988;6:36–49. doi: 10.1016/s0168-8278(88)80460-4. [DOI] [PubMed] [Google Scholar]
  63. Burnstock G. Neurohumoral control of blood vessels: some future directions. J. cardiovasc. Pharmac. 1985;7:S137–S146. doi: 10.1097/00005344-198500073-00016. [DOI] [PubMed] [Google Scholar]
  64. Burnstock G. Sympathetic purinergic transmission in small blood vessels. TIPS. 1988;9:116–117. doi: 10.1016/0165-6147(88)90185-x. [DOI] [PubMed] [Google Scholar]
  65. Burridge R. Are stress fibres contractile? Nature. 1981;294:691–692. doi: 10.1038/294691a0. [DOI] [PubMed] [Google Scholar]
  66. Burroughs A.K. Pitfalls in studies of prophylactic therapy for variceal bleeding in cirrhotics. Hepatology. 1986;6:1407–1413. doi: 10.1002/hep.1840060631. [DOI] [PubMed] [Google Scholar]
  67. Burton K.P., McCord J.M., Ghai G. Myocardial alterations due to free-radical generation. Am. J. Physiol. 1984;15:H776–H783. doi: 10.1152/ajpheart.1984.246.6.H776. [DOI] [PubMed] [Google Scholar]
  68. Buxton D.B. Potentiation of the glycogenolytic and haemodynamic actions of adenosine in the perfused rat liver by verapamil. Eur. J. Pharmac. 1988;146:121–127. doi: 10.1016/0014-2999(88)90493-1. [DOI] [PubMed] [Google Scholar]
  69. Buxton D.B., Hanahan D.J., Olson M.S. Stimulation of glycogenolysis and platelet-activating factor production by heat-aggregated immunoglobin G in the perfused rat liver. J. biol. Chem. 1984;259:13758–13761. [PubMed] [Google Scholar]
  70. Buxton D.B., Shkla S.D., Hanahan D.J., Olson M.S. Stimulation of hepatic glycogenolysis by acetylglyceryl ether phosphorylcholine. J. biol. Chem. 1984;259:1468–1471. [PubMed] [Google Scholar]
  71. Buxton D.B., Fisher R.A., Hanahan D.J., Olson M.S. Platelet-activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. J. biol. Chem. 1986;261:644–649. [PubMed] [Google Scholar]
  72. Buxton D.B., Hanahan D.J., Olson M.D. Specific antagonists of platelet activating factor-mediated vaosconstriction and glycogenolysis in the perfused rat liver. Biochem. Pharmac. 1986;35:893–897. doi: 10.1016/0006-2952(86)90073-0. [DOI] [PubMed] [Google Scholar]
  73. Buxton D.B., Robertson S.M., Olson M.S. Stimulation of glycogenolysis by adenine nucleotides in the perfused rat liver. Biochem. J. 1986;237:773–780. doi: 10.1042/bj2370773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Buxton D.B., Fisher R.A., Briseno D.L., Hanahan D.J., Olson M.D. Glycogenolysis and haemodynamic responses to heat-aggregated immunoglobulin G and prostaglandin E2 in the perfused rat liver. Biochem. J. 1987;243:493–498. doi: 10.1042/bj2430493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Buxton D.B., Fisher R.A., Robertson S.M., Olson M.D. Stimulation of glycogenolysis and vasoconstriction by adenosine and adenosine analogues in the perfused rat liver. Biochem. J. 1987;248:35–41. doi: 10.1042/bj2480035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Caldwell-Kenkel J.C., Thurman R.G., Lemasters J.J. Selective loss of nonparenchymal cell viability after cold ischemic storage of rat livers. Transplantation. 1987;45:834–837. [PubMed] [Google Scholar]
  77. Caldwell-Kenkel J.C., Currin R.T., Tanaka Y., Thurman R.G. Morphological evidence for activation of Kupffer cells after reperfusion of rat livers stored in Euro-Collins solution. Hepatology. 1988;8:1291. (Abstr.) [Google Scholar]
  78. Calès P., Pascal J.P. Histoire naturelle des varices oesophagiennes au cours de la cirrhose (de la naissance à la rupture. Gastroenterol. clin. Biol. 1988;12:245–254. [PubMed] [Google Scholar]
  79. Carmichael F.J., Saldivia V., Israel Y., McKaigney J.P., Orrego H. Ethanol-induced increase in portal hepatic blood flow: interference by anesthetic agents. Hepatology. 1987;7:89–94. doi: 10.1002/hep.1840070119. [DOI] [PubMed] [Google Scholar]
  80. Casteleijn E., Kuiper J., Van Rooij H.C.J., Kamps J.A.A.M., Koster J.F., Van Berkel T.J.C. Endotoxin stimulated glycogenolysis in the liver by means of intercellular communication. J. biol. Chem. 1988;263:6953–6955. [PubMed] [Google Scholar]
  81. Casteleijn E., Kuiper J., Van Rooij H.C.J., Kamps J.A.A.M., Koster J.F., Van Berkel T.J.C. Hormonal control of glycogenolysis in parenchymal liver cells by Kupffer and endothelial liver cells. J. biol. Chem. 1988;263:2699–2703. [PubMed] [Google Scholar]
  82. Casteleijn E., Kuiper J., Van Rooij H.C.J., Kamps J.A.A.M., Koster J.F., Van Berkel T.J.C. Prostaglandin D2 mediates the stimulation of glycogenolysis in the liver by phorbol ester. Biochem. J. 1988;250:77–80. doi: 10.1042/bj2500077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Caujolle B., Ballet F., Poupon R. Relationship among beta-adrenergic blockade, propranolol concentration and liver function in patients with cirrhosis. Scan.. J. Gastroenterol. 1988;23:925–928. doi: 10.3109/00365528809090148. [DOI] [PubMed] [Google Scholar]
  84. Cauvin V.A., Van Breeman C. Vascular effects of organic calcium antagonists. ISI Atlas Sci. 1987;1:13–19. [Google Scholar]
  85. Cauvin C., Tejerina M., Hwang O., Kai-Yamamoto M., Van Breeman C. The effects of Ca++ antagonists on isolated rat and rabbit mesenteric resistance vessels. Ann. N.Y. Acad. Sci. 1988;522:338–350. doi: 10.1111/j.1749-6632.1988.tb33375.x. [DOI] [PubMed] [Google Scholar]
  86. Chazouillères O., Ballet F., Chrétien Y., Marteau P., Rey C., Maillard D., Poupon R. Protective effect of vasodilators on liver function after long hypothermic preservation: a study on the isolated perfused rat liver. Hepatology. 1989;9:824–829. doi: 10.1002/hep.1840090606. [DOI] [PubMed] [Google Scholar]
  87. Chiandussi L., Vaccarino A., Greco F., Muratori F., Cesano L., Indovina D. Vol. 112. 1962. Effect of drug infusion on the splanchnic circulation I. Angiotensin infusion in normal and cirrhotic subjects; pp. 324–326. (Proc. Soc. exp. Biol. Med.). [DOI] [PubMed] [Google Scholar]
  88. Chojkier M., Fierer J. D-Galactosamine hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice. Gastroenterology. 1985;88:115–121. doi: 10.1016/s0016-5085(85)80142-6. [DOI] [PubMed] [Google Scholar]
  89. Colman J.C., Britton R.S., Orrego H., Saldivia V., Medline A., Israel Y. Relation between osmotically induced hepatocyte enlargement and portal hypertension. Am. J. Physiol. 1983;245:G382–G387. doi: 10.1152/ajpgi.1983.245.3.G382. [DOI] [PubMed] [Google Scholar]
  90. Condon R.E., Chapman N.D., Nyhus L.M., Harkins H.N. Hepatic arterial and portal venous pressure-flow relationship in isolated, perfused liver. Am. J. Physiol. 1962;202:1090–1094. doi: 10.1152/ajplegacy.1962.202.6.1090. [DOI] [PubMed] [Google Scholar]
  91. Conn H.O. Prophylactic propranolol: the first big step? Hepatology. 1988;8:167–170. doi: 10.1002/hep.1840080130. [DOI] [PubMed] [Google Scholar]
  92. Conn H.O., Groszmann R.J. The pathophysiology of portal hypertension. In: Arias I.M., Popper H., Schachter D., Shafritz D.A., editors. The Liver: Biology and Pathobiology. Raven Press; New York: 1982. pp. 821–848. [Google Scholar]
  93. Cousineau D., Goresky C.A., Rose C.P. Blood flow and norepinephrine effects on liver vascular and extravascular volumes. Am. J. Physiol. 1983;244:H495–H504. doi: 10.1152/ajpheart.1983.244.4.H495. [DOI] [PubMed] [Google Scholar]
  94. Cousineau D., Goresky C.A., Rose C.P., Lee S. Reflex sympathetic effects on liver vascular space and liver perfusion in dogs. Am. J. Physiol. 1985;248:H186–H192. doi: 10.1152/ajpheart.1985.248.2.H186. [DOI] [PubMed] [Google Scholar]
  95. Crone C. Vol. 45. 1986. Modulation of solute permeability in microvascular endothelium; pp. 77–83. (Fedn Proc.). [PubMed] [Google Scholar]
  96. Cryer P.E. Physiology and pathophysiology of the human sympathoadrenal neuroendocrine system. New Engl. J. Med. 1980;303:436–444. doi: 10.1056/NEJM198008213030806. [DOI] [PubMed] [Google Scholar]
  97. Cybulsky M.I., Chan M.K.W., Movat H.Z. Acute inflammation and microthrombosis induced by endotoxin, interleukin-1 and tumor necrosis factor and their implication in Gram-negative infection. Lab. Invest. 1988;58:365–378. [PubMed] [Google Scholar]
  98. Dan C., Wake K. Modes of endocytosis of latex particles in sinusoidal endothelial and Kupffer cells of normal and perfused rat liver. Expl Cell Res. 1985;158:75–85. doi: 10.1016/0014-4827(85)90432-x. [DOI] [PubMed] [Google Scholar]
  99. Daniel P.M., Pritchard M.M.L. Effects of stimulation of the hepatic nerves and of adrenaline upon the circulation of the portal venous blood within the liver. J. Physiol. 1951;114:538–548. doi: 10.1113/jphysiol.1951.sp004644. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Darlington D.N., Shin Sako J., Dallman M.F. Responses of ACTH, epinephrine, norepinephrine and cardiovascular system to hemorrhage. Am. J. Physiol. 1986;251:H612–H618. doi: 10.1152/ajpheart.1986.251.3.H612. [DOI] [PubMed] [Google Scholar]
  101. Decker K., Keppler D. Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev. Physiol. Biochem. Pharmac. 1974;71:78–106. doi: 10.1007/BFb0027661. [DOI] [PubMed] [Google Scholar]
  102. Decker T., Lohmann-Matthes M.L., Karck U., Peters T., Decker K. Comparative study of cytotoxicity, tumor necrosis factor, and prostaglandin release after stimulation of rat Kupffer cells, murine Kupffer cells and murine inflammatory liver macrophages. J. Leuk. Biol. 1989;45:139–146. doi: 10.1002/jlb.45.2.139. [DOI] [PubMed] [Google Scholar]
  103. Denzlinger C., Rapp S., Hagmann W., Keppler D. Leukotrienes as mediators in tissue trauma. Science. 1985;230:330–332. doi: 10.1126/science.4048937. [DOI] [PubMed] [Google Scholar]
  104. Dieter P., Schulze-Specking A., Decker K. Differential inhibition of prostaglandin and superoxide production by dexamethasone in primary cultures of rat Kupffer cells. Eur. J. Biochem. 1986;159:451–457. doi: 10.1111/j.1432-1033.1986.tb09907.x. [DOI] [PubMed] [Google Scholar]
  105. Dieter P., Altin J.G., Bygrave F.L. Possible involvement of prostaglandins in vasoconstriction induced by zymosan and arachidonic acid in the perfused rat liver. FEBS Lett. 1987;213:174–178. doi: 10.1016/0014-5793(87)81486-2. [DOI] [PubMed] [Google Scholar]
  106. Dieter P., Altin J.G., Decker K., Bygrave F.L. Possible involvement of eicosanoids in the zymosan and arachidonic acid-induced oxygen uptake, glycogenolysis and Ca++ mobilization in the perfused rat liver. Eur. J. Biochem. 1987;165:455–460. doi: 10.1111/j.1432-1033.1987.tb11460.x. [DOI] [PubMed] [Google Scholar]
  107. Dieter P., Schulze-Specking A., Decker K. Release of lysosomal enzymes is not correlated with superoxide and prostaglandin production by stimulated rat Kupffer cells in primary culture. J. Hepatol. 1988;6:167–174. doi: 10.1016/s0168-8278(88)80028-x. [DOI] [PubMed] [Google Scholar]
  108. Donald D.E. Mobilization of blood from the splanchnic circulation. In: Lautt W.W., editor. Hepatic Circulation in Health and Disease. Raven Press; New York: 1981. pp. 193–201. [Google Scholar]
  109. Dumont A.E. Liver lymph. In: Lautt W.W., editor. Hepatic Circulation in Health and Disease. Raven Press; New York: 1981. pp. 55–67. [Google Scholar]
  110. Esler M., Jennings G., Korner P., Blombery P., Sacharias N., Leonard P. Measurements of total and organ-specific norepinephrine kinetics in humans. Am. J. Physiol. 1984;247:E21–E28. doi: 10.1152/ajpendo.1984.247.1.E21. [DOI] [PubMed] [Google Scholar]
  111. Exton J.H. Mechanisms involved in α-adrenergic phenomena. Am. J. Physiol. 1985;248:E633–E647. doi: 10.1152/ajpendo.1985.248.6.E633. [DOI] [PubMed] [Google Scholar]
  112. Exton J.H. Mechanisms involved in calcium-mobilizing agonist responses. Adv. Cycl. Nucleot. Res. 1986;20:211–262. [PubMed] [Google Scholar]
  113. Exton J.H. Role of phosphoinositide in the regulation of liver function. Hepatology. 1988;8:152–166. doi: 10.1002/hep.1840080129. [DOI] [PubMed] [Google Scholar]
  114. Eyhorn S., Schlayer H.J., Dieter P., Hermann R., Woort-Menker Becker H., Schaeffer H.E.N., Decker K. Rat hepatic sinusoidal endothelial cells in monolayer culture. Biochemical and ultrastructural characteristics. J. Hepatol. 1988;6:23–35. doi: 10.1016/s0168-8278(88)80459-8. [DOI] [PubMed] [Google Scholar]
  115. Ezzat W.R., Lautt W.W. Hepatic arterial pressure-flow autoregulation is adenosine mediated. Am. J. Physiol. 1987;252:H836–H845. doi: 10.1152/ajpheart.1987.252.4.H836. [DOI] [PubMed] [Google Scholar]
  116. Fahimi H.D. Sinusoidal endothelial cells and perisinusoidal fat-storing cells. Structure and function. In: Arias I., Popper H., Schachter D., Shafritz D.A., editors. The Liver: Biology and Pathology. Raven Press; New York: 1982. pp. 495–506. [Google Scholar]
  117. Fernandez-Munoz D., Caramelo C., Santos H.C., Blanchat A., Hernando L., Lopez-Novoa J.M. Systemic and splanchnic hemodynamic disturbances in conscious rats with experimental liver cirrhosis without ascites. Am. J. Physiol. 1985;249:G316–G320. doi: 10.1152/ajpgi.1985.249.3.G316. [DOI] [PubMed] [Google Scholar]
  118. Filkins J.P. Vol. 131. 1969. Hepatic vascular response to endotoxin; pp. 1235–1238. (Proc. Soc. exp. Biol. Med.). [DOI] [PubMed] [Google Scholar]
  119. Fisher R.A., Shukla S.D., Debuysere M.S., Hanahan D.J., Olson M.S. The effect of acetylglyceryl ether phosphorylcholine on glycogenolysis and phosphatidylinositol 4,5-biphosphate metabolism in rat hepatocytes. J. biol. Chem. 1984;259:8685–8688. [PubMed] [Google Scholar]
  120. Fisher R.A., Kumar R., Hanahan D.J., Olson M.S. Effects of β-adrenergic stimulation on 1-O-hexadecyl-2-acetyl-Sn-glycero-3-phosphocholinemediated vasoconstriction and glycogenolysis in the perfused rat liver. J. biol. Chem. 1986;261:8817–8823. [PubMed] [Google Scholar]
  121. Fisher R.A., Robertson S.M., Olson M.S. Stimulation of glycogenolysis and vasoconstriction in the perfused rat liver by the thromboxane A2 analogue U-46619. J. biol. Chem. 1987;261:8817–8823. [PubMed] [Google Scholar]
  122. Fisher R.A., Robertson S.M., Olson M.S. Stimulation of glycogenolysis and vasoconstriction in the perfused rat liver by the thromboxane A2 analogues U-46619. J. biol. Chem. 1987;262:4631–4638. [PubMed] [Google Scholar]
  123. Ford-Hutchinson A.W. Leukotrienes as mediators of inflammation. ISI Atlas Sci.: Pharmac. 1987;1:25–27. [Google Scholar]
  124. Fraker D.L., Stovroff M.C., Merino M.J., Norton J.A. Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity. J. exp. Med. 1988;168:95–105. doi: 10.1084/jem.168.1.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  125. French S.W., Miyamoto K., Ohta Y., Geoffrion Y. Pathogenesis of experimental alcoholic liver disease in the rat. In: Jasmin G., editor. Kinetics and Patterns of Necrosis. Karger; Basel: 1988. pp. 181–207. [PubMed] [Google Scholar]
  126. Friedman M.I. Hepatic nerve function. In: Arias H., Schachter D., Shafritz D.A., editors. The Liver: Biology and Pathobiology. Raven Press; New York: 1982. pp. 663–673. [Google Scholar]
  127. Fujiwara K., Ogata I., Hirata K., Ohta Y., Oka H. Factors contributing to fibrin formation in the hepatic sinusoids in acute liver failure. Hepatology. 1988;8:1401. [Google Scholar]
  128. Fujiwara K., Ogata I., Ohta Y., Hirata K., Oka Y., Yamada S., Sato Y., Masaki N., Oka H. Intravascular coagulation in acute liver failure in rats and its treatment with antithrombin III. Gut. 1988;29:1103–1108. doi: 10.1136/gut.29.8.1103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  129. Gaeta G.B., Adinolfi I.E., Utili R., Tripodi M.F., Albernathy C.O. Prevention of the toxicity of erythromycin estolate in the perfused rat liver by endotoxin. Life Sci. 1986;39:453–460. doi: 10.1016/0024-3205(86)90525-4. [DOI] [PubMed] [Google Scholar]
  130. Galanos C., Freudenberg M.A., Reutter W. Vol. 76. 1979. Galactosamine-induced sensitization of the lethal effects of endotoxin; pp. 5939–5943. (Proc. natn. Acad. Sci. U.S.A.). [DOI] [PMC free article] [PubMed] [Google Scholar]
  131. Garceau D., Yamaguchi N., Goyer R., Guitard F. Correlation between endogenous noradrenaline and glucose released from the liver upon hepatic sympathetic nerve stimulation in anesthetized dogs. Can. J. Physiol. Pharmac. 1984;62:1086–1091. doi: 10.1139/y84-181. [DOI] [PubMed] [Google Scholar]
  132. Garceau D., Yamaguchi N., Goyer R. Hepatic adrenoreceptors involved in the glycogenolytic response to exogenous-norepinephrine in the dog liver in vivo. Life Sci. 1985;37:1963–1970. doi: 10.1016/0024-3205(85)90027-x. [DOI] [PubMed] [Google Scholar]
  133. Garcia-Sainz J.A. Intercellular communication within the liver has clinical applications. TIPS. 1989;10:10–11. doi: 10.1016/0165-6147(89)90093-x. [DOI] [PubMed] [Google Scholar]
  134. Garcia-Sainz J.A., Hernandez-Sotomayor S.M.T. Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cycloxygenase products. Biochem. biophys. Res. Commun. 1985;132:204–209. doi: 10.1016/0006-291x(85)91008-3. [DOI] [PubMed] [Google Scholar]
  135. Garcia-Tsao G., Groszmann R.J., Fisher R.L., Conn H.O., Atterbury C.E., Glickman M. Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology. 1985;5:419–424. doi: 10.1002/hep.1840050313. [DOI] [PubMed] [Google Scholar]
  136. Gardemann A., Jungermann K. Control of glucose balance in the perfused rat liver by the parasympathetic innervation. Biol. Chem. Hoppe-Seyler. 1986;367:559–566. doi: 10.1515/bchm3.1986.367.2.559. [DOI] [PubMed] [Google Scholar]
  137. Gardemann A., Strulik H., Jungermann K. Nervous control of glycogenolysis and blood flow in arterially and portally perfused liver. Am. J. Physiol. 1987;253:E238–E245. doi: 10.1152/ajpendo.1987.253.3.E238. [DOI] [PubMed] [Google Scholar]
  138. Gendrault J.L., Steffan A.M., Bingen A., Kirn A. Kupffer and endothelial cells. In: Bioulac-Sage P., Balabaud C., editors. Sinusoids in Human Liver: Health and Disease. Kupffer Cell Foundation; Rijswitk: 1988. pp. 17–39. [Google Scholar]
  139. Gerbes A.L., Remien J., Jungst D., SauerBruch T., Paumgartner G. Evidence for down regulation of β2-adrenoreceptor stimulation in cirrhotic patients with ascites and diuretic treatment. Lancet. 1986;1:1409–1411. doi: 10.1016/s0140-6736(86)91556-4. [DOI] [PubMed] [Google Scholar]
  140. Gerbes A.L., Degenhardt F., Paumgartner G., Remien J. cAMP response to β2-adrenoreceptor stimulation is reduced in cirrhotic patients with ascites and diuretic treatment. Gastroenterology. 1987;92:1735. (Abstr.) [Google Scholar]
  141. Godfrind T. Calcium channels in smooth muscle. Ann. N.Y. Acad. Sci. 1988;522:312–327. doi: 10.1111/j.1749-6632.1988.tb33373.x. [DOI] [PubMed] [Google Scholar]
  142. Goresky C.A. A linear method for determining liver sinusoidal and extravascular volumes. Am. J. Physiol. 1963;204:626–640. doi: 10.1152/ajplegacy.1963.204.4.626. [DOI] [PubMed] [Google Scholar]
  143. Goresky C.A., Bach G.C. Membrane transport and the hepatic circulation. Ann. N.Y. Acad. Sci. 1970;170:18–47. [Google Scholar]
  144. Goresky C.A., Zieggler W.H., Bach G.C. Capillary exchange modeling. Barrier-limited and flow-limited distribution. Circ. Res. 1970;27:739–763. doi: 10.1161/01.res.27.5.739. [DOI] [PubMed] [Google Scholar]
  145. Goresky C.A., Cousineau D., Rose C.P., Lee S. Lack of liver vascular response to carotid occlusion in mildly acidotic dogs. Am. J. Physiol. 1986;251:H991–H999. doi: 10.1152/ajpheart.1986.251.5.H991. [DOI] [PubMed] [Google Scholar]
  146. Goresky C.A., Bach G.G., Cousineau D., Schwab A.J., Rose C., Lee S., Goresky S. Handling of tracer norepinephrine by the dog liver. Am. J. Physiol. 1989;256:G107–G123. doi: 10.1152/ajpgi.1989.256.1.G107. [DOI] [PubMed] [Google Scholar]
  147. Granger D.N. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am. J. Physiol. 1988;225:H1269–H1275. doi: 10.1152/ajpheart.1988.255.6.H1269. [DOI] [PubMed] [Google Scholar]
  148. Granger D.N., Barrowman J.A. Micro-circulation of the alimentary tract. I. Physiology of transcapillary fluid and solute exchange. Gastroenterology. 1983;84:846–868. [PubMed] [Google Scholar]
  149. Granger D.N., Miller T., Allen R., Parker R.E., Parker J.C., Taylor A.E. Permselectivity of cat liver blood-lymph barrier to endogenous macromolecules. Gastroenterology. 1979;77:103–109. [PubMed] [Google Scholar]
  150. Granger D.N., Perry M.A., Kvietys P.R. Vol. 42. 1983. The microcirculation and fluid transport in digestive organs; pp. 1667–1672. (Fedn Proc.). [PubMed] [Google Scholar]
  151. Greenway C.V. Hepatic plethysmography. In: Lautt W.W., editor. Hepatic Circulation in Health and Disease. Raven Press; New York: 1979. pp. 41–56. [Google Scholar]
  152. Greenway C.V. Hepatic fluid exchange. In: Lautt W.W., editor. Hepatic Circulation in Health and Disease. Raven Press; New York: 1981. pp. 153–170. [Google Scholar]
  153. Greenway C.V. Vol. 42. 1983. Role of splanchnic venous system in overall cardiovascular homeostasis; pp. 1678–1684. (Fedn Proc.). [PubMed] [Google Scholar]
  154. Greenway C.V. Effects of hemorrhage and hepatic nerve stimulation on venous compliance and unstressed volume in cat liver. Can. J. Physiol. Pharmac. 1987;65:2168–2174. doi: 10.1139/y87-342. [DOI] [PubMed] [Google Scholar]
  155. Greenway C.V., Stark R.D. Hepatic vascular bed. Physiol. Rev. 1971;51:23–65. doi: 10.1152/physrev.1971.51.1.23. [DOI] [PubMed] [Google Scholar]
  156. Greenway C.V., Oshiro G. Comparison of the effects of hepatic nerve stimulation on arterial flow, distribution of arterial and portal flows and blood contingent in the livers of anaesthetized cats and dogs. J. Physiol. 1972;227:487–501. doi: 10.1113/jphysiol.1972.sp010044. [DOI] [PMC free article] [PubMed] [Google Scholar]
  157. Greenway C.V., Lawson A.E., Mellander S. The effects of stimulation of the hepatic nerves, infusions of noradrenaline and occlusion of the carotid arteries in liver blood flow in the anaesthetized cat. J. Physiol. 1967;192:21–41. doi: 10.1113/jphysiol.1967.sp008285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  158. Greenway C.V., Seaman K.L., Innes I.R. Norepinephrine on venous compliance and unstressed volume in cat liver. Am. J. Physiol. 1985;248:H468–H475. doi: 10.1152/ajpheart.1985.248.4.H468. [DOI] [PubMed] [Google Scholar]
  159. Greenway C.V., Burczynski F., Innes I.R. Effects of bromocryptine on hepatic blood volume responses to hepatic nerve stimulation in cats. Can. J. Physiol. Pharmac. 1986;64:621–624. doi: 10.1139/y86-103. [DOI] [PubMed] [Google Scholar]
  160. Greenway C.V., Dettman R., Burczynski F., Sitar D.S. Effects of circulating catecholamines on hepatic blood volume in anesthetized cats. Am. J. Physiol. 1986;250:H992–H997. doi: 10.1152/ajpheart.1986.250.6.H992. [DOI] [PubMed] [Google Scholar]
  161. Grega C.J. Role of the endothelial cell in the regulation of microvascular permeability to molecules. Fedn Proc. 1986;45:75–76. [PubMed] [Google Scholar]
  162. Grega C.J. Contractile elements in endothelial cells as potential targets for drug actions. TIPS. 1986;452–457 [Google Scholar]
  163. Grega C.J., Adamski S.W., Dobbins D.E. Vol. 45. 1986. Physiological and pharmacological evidence for the regulation of permeability; pp. 96–100. (Fedn Proc.). [PubMed] [Google Scholar]
  164. Gressner A.M., Haarman R. Regulation of hyaluronate synthesis in rat liver fat storing cel cultures by Kupffer cells. J. Hepatol. 1988;7:310–318. doi: 10.1016/s0168-8278(88)80003-5. [DOI] [PubMed] [Google Scholar]
  165. Grishan J.N., Nopanitay A. Scanning electron microscopy of casts of hepatic microvessels: review of method and results. In: Lautt W.W., editor. Hepatic Circulation in Health and Disease. Raven Press; New York: 1979. pp. 87–105. [Google Scholar]
  166. Gross J.B., Reichen J., Zeltner T.B., Zimmermann A. The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: correlation with morphometric measurement of hepatocyte mass. Hepatology. 1987;7:457–463. doi: 10.1002/hep.1840070308. [DOI] [PubMed] [Google Scholar]
  167. Grossman H.J., Bhathal P.S. Application of the isolated perfused rat liver preparation to pharmacological studies of the intrahepatic portal vascular bed. Meth. Find. exp. clin. Pharmac. 1984;6:33–40. [PubMed] [Google Scholar]
  168. Grossman H.J., Bhatal P.S. Analysis of pressure-flow curve in the isolated perfused rat liver. Critical closing pressure and viscous resistance of the normal liver. Hepatology. 1989;8:1244. (Abstr.) [Google Scholar]
  169. Groszmann R.J., Atterbury C.E. The pharmacologic treatment of portal hypertension. Ann. Rev. Med. 1985;36:81–91. doi: 10.1146/annurev.me.36.020185.000501. [DOI] [PubMed] [Google Scholar]
  170. Groszmann R.J., Vorobioff J., Riley E. Splanchnic hemodynamics in portal-hypertensive rats: measurement with γ-labeled microspheres. Am. J. Physiol. 1982;242:G156–G160. doi: 10.1152/ajpgi.1982.242.2.G156. [DOI] [PubMed] [Google Scholar]
  171. Groszmann R.J., Blei A.T., Atterbury C.E. Portal hypertension. In: Arias I.M., Jakobi W.B., Popper H., Schachter D., Shafritz D.A., editors. Liver—Biology and Pathobiology. Raven Press; New York: 1988. pp. 1147–1161. [Google Scholar]
  172. Grygelwski R.J., Szczeklik A., Wandzilak M. The effect of six prostaglandins, prostacyclin and iloprost on generation of superoxide anions by human polymorphonuclear leucocytes stimulated by zymosan or formylmethionyl-leucyl-phenylalanine. Biochem. Pharmac. 1987;36:4209–4213. doi: 10.1016/0006-2952(87)90660-5. [DOI] [PubMed] [Google Scholar]
  173. Guarner F., Fremont-Smith M.W., Corzo J., Quiroga J., Rodriguez J.L., Prieto J. In vivo and in vitro effects of arachidonic acid products on liver cell integrity following carbon tetrachloride poisoning. In: Samuelsson B., Paoletti R., Ramwell P., editors. Advances in Prostaglandin, Thromboxane and Leukotriene Research. Raven Press; New York: 1983. pp. 75–82. [PubMed] [Google Scholar]
  174. Gumucio J.J., Miller D.L. Functional implications of liver cells heterogeneity. Gastroenterology. 1981;80:393–403. [PubMed] [Google Scholar]
  175. Hagmann W., Keppler D. Leukotrienes and other eicosanoids in liver pathophysiology. In: Arias I.M., Jakoby W.B., Popper H., Schachter D., Shafritz D.A., editors. The Liver: Biology and Pathobiology. Raven Press; New York: 1988. pp. 793–806. [Google Scholar]
  176. Hagmann W., Denzlinger C., Keppler D. Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action. Circ. Shock. 1984;14:223–235. [PubMed] [Google Scholar]
  177. Hagmann W., Steffan A.M., Kirn A., Keppler D. Leukotrienes as mediators in Frog Virus 3-induced hepatitis in rats. Hepatology. 1987;7:732–736. doi: 10.1002/hep.1840070419. [DOI] [PubMed] [Google Scholar]
  178. Harper S.L., Bohlen H.G., Granger D.N. Vasoactive agents and the mesenteric microcirculation. Am. J. Physiol. 1985;249:G309–G315. doi: 10.1152/ajpgi.1985.249.3.G309. [DOI] [PubMed] [Google Scholar]
  179. Hartmann H., Beckh K., Jungermann K. Direct control of glycogen metabolism in the perfused rat liver by the sympathetic innervation. Eur. J. Biochem. 1982;123:521–526. doi: 10.1111/j.1432-1033.1982.tb06562.x. [DOI] [PubMed] [Google Scholar]
  180. Haussinger D. Regulation of hepatic metabolism by extracellular nucleotides and eicosanoids. J. Hepatol. 1989;8:259–266. doi: 10.1016/0168-8278(89)90017-2. [DOI] [PubMed] [Google Scholar]
  181. Haussinger D., Stehle T. Hepatocyte heterogeneity in response to icosanoids. Eur. J. Biochem. 1988;175:395–403. doi: 10.1111/j.1432-1033.1988.tb14209.x. [DOI] [PubMed] [Google Scholar]
  182. Haussinger D., Stehle T., Gerok W. Actions of extracellular UTP and ATP in perfused rat liver. Eur. J. Biochem. 1987;167:65–71. doi: 10.1111/j.1432-1033.1987.tb13304.x. [DOI] [PubMed] [Google Scholar]
  183. Haussinger D., Stehle T., Gerok W., Sies H. Perivascular nerve stimulation and phenylephrine responses in rat liver. Eur. J. Biochem. 1987;163:197–203. doi: 10.1111/j.1432-1033.1987.tb10755.x. [DOI] [PubMed] [Google Scholar]
  184. Haussinger D., Stehle T., Tran-Thi T.A., Decker K., Gerok W. Prostaglandin responses in isolated perfused rat liver: Ca++ and K+ fluxes, hemodynamic and metabolic effects. Biol. Chem. Hoppe-Seyler. 1987;368:1509–1513. doi: 10.1515/bchm3.1987.368.2.1509. [DOI] [PubMed] [Google Scholar]
  185. Haussinger D., Busshart E., Stehle T., Stoll B., Wettstein M., Gerok W. Stimulation of thromboxane release by extracellular UTP and ATP from perfused rat liver. Eur. J. Biochem. 1988;178:249–256. doi: 10.1111/j.1432-1033.1988.tb14450.x. [DOI] [PubMed] [Google Scholar]
  186. Haussinger D., Stehle T., Gerok W. Effects of leukotrienes and the thromboxane A2 analogue U-46619 in isolated perfused rat liver. Biol. Chem. Hoppe-Seyler. 1988;369:97–107. doi: 10.1515/bchm3.1988.369.1.97. [DOI] [PubMed] [Google Scholar]
  187. Hems D.A., Whitton P.D. Control of hepatic glycogenolysis. Physiol. Rev. 1980;60:2–38. doi: 10.1152/physrev.1980.60.1.1. [DOI] [PubMed] [Google Scholar]
  188. Hems D.A., Rodrigues L.M., Whitton P.D. Glycogen phosphorylase, glucose output and vasoconstriction in the perfused rat liver. Biochem. J. 1976;160:367–374. doi: 10.1042/bj1600367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  189. Hendriks H.F.J., Brouwer A., Knook D.L. The role of hepatic fat-storing (stellate) cells in retinoid metabolism. Hepatology. 1987;7:1368–1371. doi: 10.1002/hep.1840070630. [DOI] [PubMed] [Google Scholar]
  190. Henriksen J.H., Ring-Larsen H., Christensen N.J. Sympathetic nervous activity in cirrhosis. A survey of plasma cathecholamine studies. J. Hepatol. 1984;1:55–65. doi: 10.1016/s0168-8278(85)80068-4. [DOI] [PubMed] [Google Scholar]
  191. Henriksen J.H., Ring-Larsen H., Christensen N.J. Circulating nonadrenaline and central hemodynamics in patients with cirrhosis. Scand. J. Gastroent. 1985;20:1185–1190. doi: 10.3109/00365528509089274. [DOI] [PubMed] [Google Scholar]
  192. Hernandez L.A., Grisham M.B., Twohig B., Arfors K.E., Harlan J.M., Granger D.N. Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am. J. Physiol. 1987;253:H699–H703. doi: 10.1152/ajpheart.1987.253.3.H699. [DOI] [PubMed] [Google Scholar]
  193. Hill E.C., Oslon M.S. Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. Biochem. J. 1987;247:207–214. doi: 10.1042/bj2470207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  194. Hill E.C., Pryor J.S., Olson M.S., Dawson A.P. Potassium-mediated stimulation of hepatic glycogenolysis. J. biol. Chem. 1987;262:6623–6627. [PubMed] [Google Scholar]
  195. Hirooka N., Iwasaki I., Horie H., Ide G. Hepatic microcirculation of liver cirrhosis studied by corrosion cast/scanning electron microscope examination. Acta Path. Jap. 1986;36:375–387. doi: 10.1111/j.1440-1827.1986.tb01027.x. [DOI] [PubMed] [Google Scholar]
  196. Hjemdahl P., Belfrage E., Daleskog M. Vascular and metabolic effects of circulating epinephrine and norepinephrine. Concentration-effect study in dogs. J. clin. Invest. 1979;64:1221–1228. doi: 10.1172/JCI109576. [DOI] [PMC free article] [PubMed] [Google Scholar]
  197. Housset B., Hurbain I., Derrene J.Ph. Xanthine derivatives inhibit H2O2 release by human alveolar macrophages. Eur. Res. J. 1988;1(Suppl. 1):335. (Abstr.) [Google Scholar]
  198. Huet P.M., Goreski C.A., Villeneuve J.P., Marleau D. Assessment of liver microcirculation in human cirrhosis. J. clin. Invest. 1982;70:1234–1244. doi: 10.1172/JCI110722. [DOI] [PMC free article] [PubMed] [Google Scholar]
  199. Huet P.M., Villeneuve J.P., Pomier-Layrargues G., Marleau D. Hepatic circulation in cirrhosis. Clin. Gastroent. 1985;14:155–184. [PubMed] [Google Scholar]
  200. Huet P.M., Pomier-Layrarges G., Villeneuve J.P., Varin F., Vialet A. Intrahepatic circulation in liver diseases. Semin. Liver Dis. 1986;6:277–286. doi: 10.1055/s-2008-1040610. [DOI] [PubMed] [Google Scholar]
  201. Huet P.M., Mastai R., Brault A. The rat liver microcirculation in alcohol induced hepatomegaly. Hepatology. 1987;7:1032. doi: 10.1002/hep.1840100608. (Abstr.) [DOI] [PubMed] [Google Scholar]
  202. Israel Y., Orrego H. Hypermetabolic state, hepatocyte expansion and liver blood flow: an interaction triad in alcoholic liver injury. Ann. N.Y. Acad. Sci. 1987;492:303–323. doi: 10.1111/j.1749-6632.1987.tb48683.x. [DOI] [PubMed] [Google Scholar]
  203. Israel Y.H., Kalant H., Orrego H., Khanna J.M., Videla L., Phillips M.J. Vol. 72. 1975. Experimental alcohol-induced hepatic necrosis: suppression by propylthiouracil; pp. 1137–1141. (Proc. natn. Acad. Sci. U.S.A.). [DOI] [PMC free article] [PubMed] [Google Scholar]
  204. Israel Y., Walfish P.G., orrego H., Blake J., Kaland H. Thyroid hormones in alcoholic liver disease. Effect of treatment with 6-n-propylthiouracil. Gastroenterology. 1978;76:116–121. [PubMed] [Google Scholar]
  205. Iu S., Harvey P.R.C., Makowka L., Petrunka C.N., Ilson R.G., Strasberg S.M. Markers of allograft viability in the rat. Transplantation. 1987;44:562–569. doi: 10.1097/00007890-198710000-00021. [DOI] [PubMed] [Google Scholar]
  206. Iwai M., Jungermann K. Possible involvement of eicosanoids in the actions of sympathetic hepatic nerves on carbohydrate metabolism and hemodynamics in perfused rat liver. FEBS Lett. 1987;221:155–160. doi: 10.1016/0014-5793(87)80371-x. [DOI] [PubMed] [Google Scholar]
  207. Iwai M., Jungermann K. Leukotrienes increase glucose and lactate output and decrease flow in perfused rat liver. Biochem. biophys. Res. Commun. 1988;151:283–290. doi: 10.1016/0006-291x(88)90591-8. [DOI] [PubMed] [Google Scholar]
  208. Iwai M., Jungermann K. Mechanism of action of cysteinyl-leukotrienes on glucose and lactate balance and on flow in perfused rat liver. Comparison with the effects of sympathetic nerve stimulation and noradrenaline. Eur. J. Biochem. 1989;180:273–281. doi: 10.1111/j.1432-1033.1989.tb14644.x. [DOI] [PubMed] [Google Scholar]
  209. Iwai M., Gardemann A., Puschel G., Jungermann K. Potential role for prostaglandin F2α; D2, E2 and thromboxane A2 in mediating the metabolic and hemodynamic actions of sympathetic nerves in perfused rat liver. Eur. J. Biochem. 1988;175:45–50. doi: 10.1111/j.1432-1033.1988.tb14164.x. [DOI] [PubMed] [Google Scholar]
  210. Iwai M., Hagmann W., Keppler D., Jungermann K. Leukotriene C4 metabolism during its action on glucose and lactate balance and flow in perfused rat liver. Biol. Chem. Hoppe-Seyler. 1988;369:1131–1136. doi: 10.1515/bchm3.1988.369.2.1131. [DOI] [PubMed] [Google Scholar]
  211. Jaeschke H., Mitchell J.R. Neutrophil accumulation exacerbates acetaminophen-induced liver injury. FASEB J. 1989 in press. [Google Scholar]
  212. Jetley M., Weston A.H. Some effects of sodium nitroprusside, methoxyverapamil and nifedipine on rat portal vein. Br. J. Pharmac. 1990;68:311–319. doi: 10.1111/j.1476-5381.1980.tb10420.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  213. Ji S., Beckh K., Jungerman K. Regulation of oxygen consumption and microcirculation by α-sympathetic nerves in isolated perfused rat liver. FEBS Lett. 1984;167:117–122. doi: 10.1016/0014-5793(84)80844-3. [DOI] [PubMed] [Google Scholar]
  214. Johansson B., Ljung B. Spread of excitation in the smooth muscle of the rat portal vein. Acta physiol. scand. 1967;70:312–322. doi: 10.1111/j.1748-1716.1967.tb03631.x. [DOI] [PubMed] [Google Scholar]
  215. Johansson B., Mellander S. Static and dynamic components in the vascular myogenic response to passive changes in length as revealed by electrical and mechanical recordings from the rat portal vein. Circ. Res. 1975;36:76–83. doi: 10.1161/01.res.36.1.76. [DOI] [PubMed] [Google Scholar]
  216. Kamp T.J., Miller R.J. Voltage sensitive calcium channels and calcium antagonists. ISI Atlas Sci.: Pharmac. 1987;1:87–176. [Google Scholar]
  217. Karck U., Peters T., Decker K. The release of tumor necrosis factor from endotoxin-stimulated rat Kupffer cells is regulated by prostaglandin E2 and dexamethasone. J. Hepatol. 1988;7:352–361. doi: 10.1016/s0168-8278(88)80008-4. [DOI] [PubMed] [Google Scholar]
  218. Kardon R.H., Kessel R.G. Three dimensional organization of the hepatic microcirculation in the rodent as observed by scanning electron microscopy of corrosion casts. Gastroenterology. 1980;79:72–81. [PubMed] [Google Scholar]
  219. Keppler D., Hagmann W., Rapp S., Denzlinger C., Koch H.K. The relation of leukotrienes to liver injury. Hepatology. 1985;5:883–891. doi: 10.1002/hep.1840050530. [DOI] [PubMed] [Google Scholar]
  220. Keppler D., Huber M., Hagmann W., Ball H.A., Guhlmann A., Kastner S. Metabolism and analysis of endogenous cysteinyl-leukotrienes. In: Levi R., Krell R.D., editors. Biology of Leukotrienes. 1988. pp. 68–74. (Ann. N.Y. Acad. Sci.). [DOI] [PubMed] [Google Scholar]
  221. Kessler M., Hoper J., Ji S. Action of norepinephrine on microcirculation and PO2 distribution in the isolated perfused rat liver. Gerontology. 1978;24:55–65. doi: 10.1159/000212298. [DOI] [PubMed] [Google Scholar]
  222. Kessler M., Harrison D.K., Hoper J. Tissue oxygen measurement techniques. In: Baker Ch., Nastuk W.L., editors. Microcirculatory Technology. Academic Press; New York: 1986. pp. 391–425. [Google Scholar]
  223. Kiel J.W., Pitts V., Benoit J.N., Gringer D.N., Shepherd A.P. Reduced vascular sensitivity to norepinephrine in portal-hypersensitive rats. Am. J. Physiol. 1985;248:G192–G195. doi: 10.1152/ajpgi.1985.248.2.G192. [DOI] [PubMed] [Google Scholar]
  224. Kirn A., Gut J.P., Bingen A., Steffan A.M. Murine hepatitis induced by Frog Virus 3: a model for studying the effect of sinisoidal cell damage on the liver. Hepatology. 1983;3:105–111. doi: 10.1002/hep.1840030117. [DOI] [PubMed] [Google Scholar]
  225. Kolb-Bachofen V., Schlepper-Schaefer J., Kolb H. Receptor-mediated particle uptake by liver macrophages. Expl Cell Res. 1983;148:173–182. doi: 10.1016/0014-4827(83)90197-0. [DOI] [PubMed] [Google Scholar]
  226. Komatsu H., Koo A., Chan E., Inoue M., Kaplowitz N., Guth P.H. Hepatic microvascular “noreflow” induced by ischemia-reperfusion in the rat: role of superoxide free radicals. Gastroenterology. 1989;96:A266. (Abstr.) [Google Scholar]
  227. Koo A., Liang Y.S., Cheng K.K. The terminal hepatic microcirculation in the rat. Q. Jl exp. Physiol. 1975;60:261–266. doi: 10.1113/expphysiol.1975.sp002320. [DOI] [PubMed] [Google Scholar]
  228. Koo A., Liang I.Y.S., Cheng K.K. Adrenergic mechanisms in the hepatic microcirculation in the rat. Q. Jl exp. Physiol. 1977;62(1):199–208. doi: 10.1113/expphysiol.1977.sp002392. [DOI] [PubMed] [Google Scholar]
  229. Koo A., Komatsu H., Chan E., Guth P.H., Inoue M., Kaplowitz N. Long-acting superoxide dismutase decreases the incidence of leukocyte-endothelium adhesion in ischemic, reperfused rat liver. Gastroenterology. 1989;96:A615. (Abstr.) [Google Scholar]
  230. Korthuis R.J., Benoit J.N., Kvietys P.R., Townsley M.I., Taylor A.E., Granger D.N. Humoral factors may mediate increased rat hindquarter blood flow in portal hypertension. Am. J. Physiol. 1985;249:H827–H833. doi: 10.1152/ajpheart.1985.249.4.H827. [DOI] [PubMed] [Google Scholar]
  231. Korthuis R.J., Grisham M.B., Zimmerman B.J., Granger D.N., Taylor A.E. Vascular injury in dogs during ischemia-reperfusion: improvement with ATP-MgCl2 pretreatment. Am. J. Physiol. 1988;254:H702–H708. doi: 10.1152/ajpheart.1988.254.4.H702. [DOI] [PubMed] [Google Scholar]
  232. Kroeger R.J., Groszmann R.J. Increased portal venous resistance hinders portal pressure reduction during the administration of β-adrenergic blocking agents in a portal hypertensive model. Hepatology. 1985;5:97–101. doi: 10.1002/hep.1840050120. [DOI] [PubMed] [Google Scholar]
  233. Kroeger R.J., Groszmann R.J. Effect of selective blockade of β2-adrenergic receptors on portal and systemic hemodynamics in a portal hypertensive rat model. Gastroenterology. 1985;88:896–900. doi: 10.1016/s0016-5085(85)80005-6. [DOI] [PubMed] [Google Scholar]
  234. Kuiper J., Zijlstra F.J., Kamps J.A.A.M., Van Berkel T.J.C. Identification of prostaglandin D2 as the major eicosanoid from liver endothelial and Kupffer cells. Biochem. biophys. Acta. 1988;959:143–152. doi: 10.1016/0005-2760(88)90025-2. [DOI] [PubMed] [Google Scholar]
  235. Langer S.Z., Armstrong J.M. Prejunctional receptors and the cardiovascular system: pharmacological and therapeutic relevance. In: Antonaccio M., editor. Cardiovascular Pharmacology. Raven Press; New York: 1984. pp. 197–213. [Google Scholar]
  236. Langer S.Z., Hicks P.E. α-Adrenoreceptor subtypes in blood vessels: physiology and pharmacology. J. cardiovasc. Pharmac. 1984;6:S547–S558. doi: 10.1097/00005344-198406004-00001. [DOI] [PubMed] [Google Scholar]
  237. Lapointe D.S., Olson M.S. Alteration of hepatic tissue spaces by platelet-activating factor and phenylephrine. Hepatology. 1989;9:278–284. doi: 10.1002/hep.1840090220. [DOI] [PubMed] [Google Scholar]
  238. Laragh J.H., Cannon P.J., Bentzel C.J., Sicinski A.M., Meltzer J.I. Angiotensin II, norepinephrine and renal transport of electrolytes and water in normal rats and cirrhosis with ascites. J. clin. Invest. 1963;42:1179–1192. doi: 10.1172/JCI104803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  239. Lauterburg B.H., Bilzer M. Mechanisms of acetaldehyde hepatotoxicity. J. Hepatol. 1988;7:384–390. doi: 10.1016/s0168-8278(88)80012-6. [DOI] [PubMed] [Google Scholar]
  240. Lautt W.W. Hepatic vasculature: a conceptual review. Gastroenterology. 1977;73:1163–1169. [PubMed] [Google Scholar]
  241. Lautt W.W. Hepatic nerves: a review of their functions and effects. Can. J. Physiol. Pharmac. 1980;58:105–123. doi: 10.1139/y80-019. [DOI] [PubMed] [Google Scholar]
  242. Lautt W.W. Role and control of the hepatic artery. In: Lautt W.W., editor. Hepatic Circulation in Health and Disease. Raven Press; New York: 1981. pp. 203–226. [Google Scholar]
  243. Lautt W.W. Vol. 42. 1983. Relationship between hepatic blood flow and overall metabolism: the hepatic arterial buffer response; pp. 1662–1666. (Fedn Proc.). [PubMed] [Google Scholar]
  244. Lautt W.W. Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Am. J. Physiol. 1985;249:G549–G556. doi: 10.1152/ajpgi.1985.249.5.G549. [DOI] [PubMed] [Google Scholar]
  245. Lautt W.W., Greenway C.V. Conceptural review of the hepatic vascular bed. Hepatology. 1987;7:952–963. doi: 10.1002/hep.1840070527. [DOI] [PubMed] [Google Scholar]
  246. Lautt W.W., Legare D.J. Effect of histamine, norepinephrine and nerves on vascular pressures in dog liver. Am. J. Physiol. 1987;252:G472–G478. doi: 10.1152/ajpgi.1987.252.4.G472. [DOI] [PubMed] [Google Scholar]
  247. Lautt W.W., Legare D.J., D'Almeida M.S. Adenosine as putative regulator of hepatic arterial flow (the buffer response) Am. J. Physiol. 1985;248:H331–H338. doi: 10.1152/ajpheart.1985.248.3.H331. [DOI] [PubMed] [Google Scholar]
  248. Lautt W.W., Greenway C.V., Legare D.J., Weisman H. Localization of antrahepatic portal vascular resistance. Am. J. Physiol. 1986;251:G375–G381. doi: 10.1152/ajpgi.1986.251.3.G375. [DOI] [PubMed] [Google Scholar]
  249. Lautt W.W., Greenway C.V., Legare D.J. Effect of hepatic nerves, norepinephrine, angiotensin and elevated central venous pressure on postsinusoidal resistance sites and intrahepatic pressures in cats. Microvasc. Res. 1987;33:50–61. doi: 10.1016/0026-2862(87)90006-9. [DOI] [PubMed] [Google Scholar]
  250. Leaf A., Macknight A.D.C., Cheung J.Y., Bonventre J.V. The cellular basis of ischemic acute renal failure. In: Andreoli T.E., Hoffmann J.F., Fanestil D.D., Schultz S.G., editors. Physiology of Membrane Disorders. Plenum; New York: 1986. [Google Scholar]
  251. Lebrec D. Beta-bloquants et hémorragies digestives. Gastroent. clin. Biol. 1987;11:37–40. [PubMed] [Google Scholar]
  252. Lebrec D., Blanchet L. Effect of two models of portal hypertension on splanchnic organ blood flow in the rat. Clin. Sci. 1985;68:23–28. doi: 10.1042/cs0680023. [DOI] [PubMed] [Google Scholar]
  253. Lebrec D., Hadengue A. Traitements pharamcologiques de l'hypertension portale. In: Benhamou J.P., Lebrec D., editors. Hypertension Portale. Doin; Paris: 1989. pp. 165–188. [Google Scholar]
  254. Lebrec D., Poynard T., Hillon P., Benhamou J.P. Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis of the liver and esophageal varices. New Engl. J. Med. 1981;305:1371–1374. doi: 10.1056/NEJM198112033052302. [DOI] [PubMed] [Google Scholar]
  255. Lee S.S., Girod C., Valla D., Goeffroy P., Lebrec D. Effects of pentobarbital sodium anesthesia on splanchnic hemodynamics of normal and portal-hypertensive rats. Am. J. Physiol. 1985;249:G528–G532. doi: 10.1152/ajpgi.1985.249.4.G528. [DOI] [PubMed] [Google Scholar]
  256. Lefer A.M., Papanicolaou G. Benificial actions of two novel calcium entry blockers in the isolated perfused hypoxic cat liver. Meth. Find. exp. clin. Pharmac. 1985;7:59–63. [PubMed] [Google Scholar]
  257. Lefer A.M., Stahl G.L. Mechanisms of the hepatoprotective effect of nitrendipine in the isolated perfused cat liver. J. cardiovasc. Pharmac. 1987;9:S66–S70. [Google Scholar]
  258. Lefkowitch J.H., Mendez L. Morphologic features of hepatic injury in cardiac disease and shock. J. Hepatol. 1986;2:313–327. doi: 10.1016/s0168-8278(86)80043-5. [DOI] [PubMed] [Google Scholar]
  259. Legare D.J., Lautt W.W. Hepatic venous resistance site in the dog: localization and validation of intrahepatic pressure measurements. Can. J. Physiol. Pharmac. 1986;65:352–359. doi: 10.1139/y87-061. [DOI] [PubMed] [Google Scholar]
  260. Lehmann V., Freudenberg M.A., Galanos C. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice. J. exp. Med. 1987;165:657–663. doi: 10.1084/jem.165.3.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  261. Lemaster J.J., Thurman R.G. Centrilobular injury following hypoxia in isolated, perfused rat liver. Science. 1981;313:661–662. doi: 10.1126/science.7256265. [DOI] [PubMed] [Google Scholar]
  262. Lemasters J.J., Stemkowski C.J., Ji S., Thurman R.G. Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated, perfused rat liver. J. cell. Biol. 1983;97:778–786. doi: 10.1083/jcb.97.3.778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  263. Lemasters J.J., DiGuiseppi J., Nieminen A.L., Herman B. Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes. Nature. 1987;325:78–81. doi: 10.1038/325078a0. [DOI] [PubMed] [Google Scholar]
  264. Lenz K., Hortnagel H., Magometschnigg D., Kleinberger G., Druml W., Laggner A. Function of the autonomic nervous system in patients with hepatic encephalopathy. Hepatology. 1985;5:831–836. doi: 10.1002/hep.1840050521. [DOI] [PubMed] [Google Scholar]
  265. Lewis R.A., Austen K.F. The biologically active leukotrienes. J. clin. Invest. 1984;73:889–897. doi: 10.1172/JCI111312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  266. Lieber C.S. Biochemical and molecular basis of alcohol induced injury to liver and other tissues. New Engl. J. Med. 1988;319:1639–1650. doi: 10.1056/NEJM198812223192505. [DOI] [PubMed] [Google Scholar]
  267. Loutsenhiser R., Epstein M. Effects of calcium antagonists on renal hemodynamics. Am. J. Physiol. 1985;249:F619–F629. doi: 10.1152/ajprenal.1985.249.5.F619. [DOI] [PubMed] [Google Scholar]
  268. Loutsenhiser R., Epstein M. Calcium antagonists and the renal hemodynamic response to vasocontrictors. Ann. N.Y. Acad. Sci. 1988;522:771–784. doi: 10.1111/j.1749-6632.1988.tb33428.x. [DOI] [PubMed] [Google Scholar]
  269. Majno G., Shea S.M., Leventhal M. Endothelial contraction induced by histamine-type mediators. J. cell. Biol. 1969;42:647–672. doi: 10.1083/jcb.42.3.647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  270. Marotto M.E., Thurman R.G., Lemasters J.J. Early midzonal cell death during low-flow hypoxia in the isolated perfused rat liver: protection by allopurinol. Hepatology. 1988;8:585–590. doi: 10.1002/hep.1840080325. [DOI] [PubMed] [Google Scholar]
  271. Marteau P., Ballet F., Chrétien Y., Rey C., Jailion P., Poupon R. Effect of vasodilators on hepatic microcirculation: a study of the inhibition of norepinephrine-induced vasoconstriction in the isolated perfused rat liver. Hepatology. 1988;8:228–231. doi: 10.1002/hep.1840080206. [DOI] [PubMed] [Google Scholar]
  272. Marteau P., Ballet F., Chrétien Y., Rey C., Poupon R. Evidence for α2-adrenergic receptors in hepatic microcirculation: a study in the isolated perfused rat liver. Hepatology. 1988;9:1344. doi: 10.1002/hep.1840080206. (Abstr.) [DOI] [PubMed] [Google Scholar]
  273. Marteau P., Ballet F., Chrétien Y., Rey C., Petit D., Poupon R. Effect of vasodilators on hepatic microcirculation in cirrhosis: a study in the isolated perfused rat liver. Hepatology. 1989;9:820–823. doi: 10.1002/hep.1840090605. [DOI] [PubMed] [Google Scholar]
  274. Martinez-Hernandez A. The hepatic extracellular matrix I. Electron immunohistochemical studies in normal rat liver. Lab. Invest. 1984;51:57–74. [PubMed] [Google Scholar]
  275. Martinez-Hernandez A. The hepatic extracellular matrix II. Electron immunohistochemical studies in rats with CCl4-induced cirrhosis. Lab. Invest. 1985;53:166–168. [PubMed] [Google Scholar]
  276. Mastaï R., Laganière S., Rocheleau B., Giroux L., Huet P.M. Hemodynamic characterization of a new model of cirrhosis and portal hypertension in conscious rabbits. Gastroenterology. 1988;94:A569. [Google Scholar]
  277. Mastaï R., Rocheleau B., Giroux L., Brault A., Huet P.M. A new model of sinusoidal capillarization in the rabbit: influence of protein bound drug extraction. Hepatology. 1988;8:1384. (Abstr.) [Google Scholar]
  278. Mastaï R., Huet P.M., Brault A., Belgiorno J. The rat liver microcirculation in alcohol-induced hepatomegaly. Hepatology. 1989;10:941–946. doi: 10.1002/hep.1840100608. [DOI] [PubMed] [Google Scholar]
  279. Mauger J.P., Claret M. Calcium channels in hepatocytes. J. Hepatol. 1988;7:278–282. doi: 10.1016/s0168-8278(88)80492-6. [DOI] [PubMed] [Google Scholar]
  280. McCord J.M. Oxygen-derived free radicals in postischemic tissue injury. New Engl. J. Med. 1983;312:159–163. doi: 10.1056/NEJM198501173120305. [DOI] [PubMed] [Google Scholar]
  281. McCuskey R.S. A dynamic and static study of hepatic arterioles and hepatic sphincters. Am. J. Anat. 1965;119:455–478. doi: 10.1002/aja.1001190307. [DOI] [PubMed] [Google Scholar]
  282. McCuskey R.S. Microscopic methods for studying the microvasculature of internal organs. In: Backer Ch., Nastuk W.L., editors. Microcirculatory Technology. Academic Press; New York: 1986. pp. 247–261. [Google Scholar]
  283. McCuskey R.S. Hepatic microcirculation. In: Bioulac-Sage P., Balabaud C., editors. Sinusoids in Human Liver: Health and Disease. Kupffer Cell Foundation; Rjswitjk: 1988. pp. 151–165. [Google Scholar]
  284. McCuskey R.S. Hepatic microcirculation in disease. In: Bioulac-Sage P., Balabaud C., editors. Sinusoids in Human Liver: Health and Disease. Kupffer Cell Foundation; Rjswitjk: 1988. pp. 299–315. [Google Scholar]
  285. McCuskey R.S., Reilly F.D., McCuskey P.A., Dimlich R.V.W. In vivo microscopy of the hepatic microvascular system. Bibl. Anat. 1979;18:73–76. [PubMed] [Google Scholar]
  286. McKaigney J.P., Carmichael F.J., Saldivia V., Israel Y., Orrego H. Role of ethanol metabolism in the ethanol-induced increase in splanchnic circulation. Am. J. Physiol. 1986;13:G518–G523. doi: 10.1152/ajpgi.1986.250.4.G518. [DOI] [PubMed] [Google Scholar]
  287. McKelvey T.G., Hollwarth M.E., Granger D.N., Engerson T.D., Landler U., Jones H.P. Mechanisms of conversion of xanthine dehydrogenase to xanthine oxidase in ischemic rat liver and kidney. Am. J. Physiol. 1988;17:G753–G760. doi: 10.1152/ajpgi.1988.254.5.G753. [DOI] [PubMed] [Google Scholar]
  288. McKeown C.M.B., Edwards V., Phillips M.J., Harvey P.R.C., Petrunka C.N., Strasberg S.M. Sinusoidal lining cell damage: the critical injury in cold preservation of liver allografts in the rat. Transplantation. 1988;46:178–191. [PubMed] [Google Scholar]
  289. McPhee P.J., Dindzans V.J., Fung L.S., Levy G.A. Acute and chronic changes in the microciirculation of the liver in inbred strains of mice following infection with mouse hepatitis virus type 3. Hepatology. 1985;5:649–660. doi: 10.1002/hep.1840050422. [DOI] [PMC free article] [PubMed] [Google Scholar]
  290. McPhee P.J., Schmidt E.E., Keown P.A., Groom A.C. Microcirculatory changes in livers of mice infected with murine hepatitis virus. Evidence from microcorrosion casts and measurements of red cell velocity. Microvasc. Res. 1988;36:140–149. doi: 10.1016/0026-2862(88)90014-3. [DOI] [PubMed] [Google Scholar]
  291. Mendlovic F., Corvera S., Garcia-Sainz J.A. Possible involvement of cyclooxygenase products is the actions of platelet-activating factor and of lipooxygenase products in the vascular effects of epinephrine in perfused rat liver. Biochem. biophys. Res. Commun. 1984;123:507–514. doi: 10.1016/0006-291x(84)90259-6. [DOI] [PubMed] [Google Scholar]
  292. Meren H., Varin F., Ruwart M., Thurman R.G. Effect of 16,16-dimethyl prostaglandin E2 an oxygen uptake and microcirculation in the perfused rat liver. Hepatology. 1986;6:917–921. doi: 10.1002/hep.1840060518. [DOI] [PubMed] [Google Scholar]
  293. Mitzner W. Hepatic outflow resistance, sinusoid pressure, and the vascular waterfall. Am. J. Physiol. 1974;227:513–519. doi: 10.1152/ajplegacy.1974.227.3.513. [DOI] [PubMed] [Google Scholar]
  294. Mizoguchi Y., Tustsui H., Miyajima K., Sakagami Y., Seki S., Kobayashi K., Yamamoto S., Morisawa S. The protective effects of prostaglandin E1 in an experimental massive hepatic cell necrosis model. Hepatology. 1987;7:1184–1188. doi: 10.1002/hep.1840070603. [DOI] [PubMed] [Google Scholar]
  295. Mora N.P., Cienfuegos J.A., Bernaldo de Quiros L., Tendillo F., Pereira F., Fores R., Alvarez I., Navidad R., Castillo-Olivares J.L. Vol. 19. 1987. Successful liver allograft function after 24-hour preservation: cumulative effects of prostacyclin plus verapamil; pp. 3932–3936. (Transpl. Proc.). [PubMed] [Google Scholar]
  296. Morgan J.J., Groszmann R.J. Somatostatin in portal hypertension. Dig. Dis. Sci. 1989;34:405–475. doi: 10.1007/BF01536044. [DOI] [PubMed] [Google Scholar]
  297. Mullane K.M., Westlin W., Kraemer R. Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. In: Levi R., Krell R.D., editors. Biology of the Leukotrienes. 1988. pp. 103–121. (Ann. N.Y. Acad. Sci.). New York. [DOI] [PubMed] [Google Scholar]
  298. Muller-Berghaus G., Reuter C., Bleyl U. Experimental galactosamine-induced hepatitis. Am. J. Path. 1975;82:393–406. [PMC free article] [PubMed] [Google Scholar]
  299. Murray B.M., Paller M.S. Decreased pressor reactivity to angiotensin II in cirrhotic rats. Evidence for a post-receptor defect in angiotensin action. Circ. Res. 1985;57:424–431. doi: 10.1161/01.res.57.3.424. [DOI] [PubMed] [Google Scholar]
  300. Myagkaya G.L., Van Heen H., James J. Ultrastructural changes in the rat liver during Eurocollins storage, compared with hypothermic in vitro ischemia. Virch. Arch. B. 1987;53:176–182. doi: 10.1007/BF02890241. [DOI] [PubMed] [Google Scholar]
  301. Nakata K., Leong G.F., Brauer R.W. Direct measurement of blood pressures in minute vessels of the liver. Am. J. Physiol. 1960;199:1181–1188. doi: 10.1152/ajplegacy.1960.199.6.1181. [DOI] [PubMed] [Google Scholar]
  302. Nakano M., Wormer T.M., Lieber C.S. Perivenular fibrosis in alcoholic liver injury: ultrastructure and histologic progression. Gastroenterology. 1982;83:777–785. [PubMed] [Google Scholar]
  303. Navasa M., Bosch J., Reichen J., Mastai R., Zysset T., Bru C., Silva G., Chesta J., Rodés J. Effects of verapamil on hepatic and systemic hemodynamics and liver function in patients with cirrhosis and portal hypertension. Hepatology. 1988;8:850–854. doi: 10.1002/hep.1840080425. [DOI] [PubMed] [Google Scholar]
  304. Nicholis K.M., Shapiro M.D., Van Putten V.J., Kluge R., Chung H.M., Bichet D.G., Schrier R.W. Elevated plasma norepinephrine concentrations in decompensated cirrhosis. Circ. Res. 1985;56:457–461. doi: 10.1161/01.res.56.3.457. [DOI] [PubMed] [Google Scholar]
  305. Noda Y., Hughes R.D., Williams R. Effect of prostacyclin (PGI2) and a prostaglandin analogue BW 245 C on galactosamine-induced hepatic necrosis. J. Hepatol. 1986;2:53–64. doi: 10.1016/s0168-8278(86)80008-3. [DOI] [PubMed] [Google Scholar]
  306. Noguchi Y., Plaa G.L. Effect of adrenergic drugs on the hemodynamics of the isolated perfused rat liver. Archs int. Pharmacodyn. 1970;187:336–348. [PubMed] [Google Scholar]
  307. Noguchi Y., Plaa G.L. Effect of nucleotides and nitroglycerine on the hemodynamics of the isolated perfused rat liver. Archs int. Pharmacodyn. 1970;188:305–311. [PubMed] [Google Scholar]
  308. Nolan J.P., Cohen S.A. Interaction of endotoxin with sinusoidal cells of the liver. In: Bioulac-Sage P., Balabaud C., editors. Sinusodis in Human Liver: Health and Disease. Kupffer Cell Foundation; 1988. pp. 341–358. [Google Scholar]
  309. Nolan J.P., O'Connell C.J. Vascular response in the isolated rat liver. I. Endoxotin, direct effects. J. exp. Med. 1965;122:1063–1073. doi: 10.1084/jem.122.6.1063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  310. Ogawa M., Mori T., Mori Y., Ueda S., Yoshida H., Kato I., Iesato K., Wakashin Y., Waskashin M., Okuda K. Inhibitory effects of prostaglandin E1 on T-cell mediated cytotoxicity against isolated mouse liver cells. Gastroenterology. 1988;94:1024–1030. doi: 10.1016/0016-5085(88)90562-8. [DOI] [PubMed] [Google Scholar]
  311. Orrego H., Kalant H., Israel Y., Blake J., Medline A., Rankin J.G., Armstrong A., Kapur B. Effect of short-term therapy with propylthiouracil in patients with alcoholic liver disease. Gastroenterology. 1979;76:105–115. [PubMed] [Google Scholar]
  312. Orrego H., Blendis L.M., Crossley I.R., Medline A., MacDonald A., Ritchie S., Israel Y. Correlation of intrahepatic pressure with collagen in the Disse space and heaptomegaly in humans and in the rat. Gastroenterology. 1981;80:5546–5567. [PubMed] [Google Scholar]
  313. Orrego H., Blake J.E., Blendis L.M., Compton K.V., Israel Y. Long-term treatment of alcoholic liver disease with propylthiouracil. New Engl. J. Med. 1987;317:1421–1427. doi: 10.1056/NEJM198712033172301. [DOI] [PubMed] [Google Scholar]
  314. Orrenius S., Bellomo G. Toxicological implications of perturbation of Ca2+ homeostasis in hepatocytes. In: Cheung W.Y., editor. Calcium and Cell Function. Academic Press; New York: 1986. pp. 185–208. [Google Scholar]
  315. Otto G., Wolff H., Uerlins I., Gellert K. Preservation damage in liver transplantation. Transplantation. 1986;42:122–124. doi: 10.1097/00007890-198608000-00003. [DOI] [PubMed] [Google Scholar]
  316. Ouwendijk R.J., Zijistra F.J., Van den Broek A.M.W.C., Brouwer A., Wilson J.H.P., Vincent J.E. Comparison of the production of eicosanoids by human and rat peritoneal macrophages and rat Kuppfer cells. Prostaglandins. 1988;35:437–446. doi: 10.1016/0090-6980(88)90134-7. [DOI] [PubMed] [Google Scholar]
  317. Parks D.A., Granger D.N. Ischemia-reperfusion injury: a radical view. Hepatology. 1988;8:680–682. doi: 10.1002/hep.1840080341. [DOI] [PubMed] [Google Scholar]
  318. Patel T.B. Stimulation of hepatic glycogenolysis by phorbol 12-myristate 13-acetate. Biochem. J. 1987;241:549–554. doi: 10.1042/bj2410549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  319. Peck R.C., Lefer A.M. Protective effect of nofedipine in the hypoxic perfused cat liver. Agents Actions. 1981;11:421–424. doi: 10.1007/BF01982481. [DOI] [PubMed] [Google Scholar]
  320. Pignon J.P., Poynard T., Naveau S., Chaput J.C. Meta-analyse des essais randomisés des betabloquants dan la prévention des hémorragies digestives des sujets atteints de cirrhose. Gastroent. clin. Biol. 1988;12:A175. (Abstr.) [Google Scholar]
  321. Popper H. Alcoholic hepatitis. An experimental approach to a conceptual and clinical problem. New Engl. J. Med. 1974;290:159–160. doi: 10.1056/NEJM197401172900311. [DOI] [PubMed] [Google Scholar]
  322. Popper H. Regulatory modulation in hepatology. Hepatology. 1987;7:590–596. doi: 10.1002/hep.1840070329. [DOI] [PubMed] [Google Scholar]
  323. Popper H. Hepatocellular degeneration and death. In: Arias I.M., Jakoby W.B., Popper H., Schachter D., editors. The Liver: Biology and Pathobiology. Raven Press; New York: 1988. pp. 1087–1105. [Google Scholar]
  324. Pounds J.G., Rosen J.F. Cellular Ca2+ homeostasis and Ca2+-mediated cell processes as critical targets for toxicant action: conceptual and methodological pitfalls. Toxic. appl. Pharmac. 1988;94:331–341. doi: 10.1016/0041-008x(88)90275-x. [DOI] [PubMed] [Google Scholar]
  325. Poynard T., Chaput J.C. Facteurs de risque des hémorragies digestives par rupture de varices oesophagiennes. In: Benhamou J.P., Lebrec D., editors. Hypertension Portale. Doin; Paris: 1989. pp. 131–142. [Google Scholar]
  326. Praaning-Van Dalen D.P., Brouwer A., Knook D.L. Clearance capacity of rat liver Kupffer endothelial and parenchymal cells. Gastroenterology. 1981;81:1036–1044. [PubMed] [Google Scholar]
  327. Praaning-Van Dalen D.P., De Leeuw A.M., Brouwer A., Knook D.L. Rat liver endothelial cells have a greater capacity than Kupffer cells to endocytose N-acetylglucosamine and mannose-terminated glycoproteins. Hepatology. 1987;7:672–679. doi: 10.1002/hep.1840070410. [DOI] [PubMed] [Google Scholar]
  328. Pritchard M.M.L., Daniel P.M. Some features of the vascular arrangements of the kidney and the liver and their relevance to changes in the circulation in these organs. In: Volstenholme G.E.W., editor. Visceral Circulation. Churchill; London: 1952. pp. 60–69. [Google Scholar]
  329. Puschel G.P., Nath A., Jungermann K. Increase of urate formation by stimulation of sympathetic hepatic nerves, circulating noradrenaline and glucagon in the perfused rat liver. FEBS Lett. 1987;219:145–150. doi: 10.1016/0014-5793(87)81207-3. [DOI] [PubMed] [Google Scholar]
  330. Puschel G.P., Oppermann M., Muschol W., Gotze O., Jungermann K. Increase of glucose and lactate output and decrease of flow by human anaphylatoxin C3a but not C5a in perfused rat liver. FEBS Lett. 1989;243:83–87. doi: 10.1016/0014-5793(89)81222-0. [DOI] [PubMed] [Google Scholar]
  331. Ramond M.J., Comoy E., Lebrec D. Alterations in isoprenaline sensitivity in patients with cirrhosis: evidence for abnormality of the sympathetic nervous activity. Br. J. clin. Pharmac. 1986;21:191–196. doi: 10.1111/j.1365-2125.1986.tb05174.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  332. Rappaport A.M. The acinus-microvascular unit of the liver. In: Lautt W.W., editor. Hepatic Circulation in Health and Disease. Raven Press; New York: 1981. pp. 175–192. [Google Scholar]
  333. Rappaport A.M. Microvascular methods—the transilluminated liver. In: Lautt W.W., editor. Hepatic Circulation in Health and Disease. Raven Press; New York: 1981. pp. 1–13. [Google Scholar]
  334. Rasio E.A., Bendayan M., Goresky C.A. Effect of reduced energy metabolism and reperfusion on the permeability and morphology of the capillaries of an isolated rete mirabile. Circ. Res. 1987;64:243–254. doi: 10.1161/01.res.64.2.243. [DOI] [PubMed] [Google Scholar]
  335. Rasmunsen H. The calcium messenger system. New Engl. J. Med. 1986;314:1094–1101. doi: 10.1056/NEJM198604243141707. [DOI] [PubMed] [Google Scholar]
  336. Rasmunsen H. The calcium messenger system. New Engl. J. Med. 1986;314:1164–1170. doi: 10.1056/NEJM198605013141807. [DOI] [PubMed] [Google Scholar]
  337. Ratych R.E., Chuknyiska R.S., Bulkley G.B. The primary localization of free radical generation after anoxia/reoxygenation in isolated endothelial cells. Surgery. 1987;102:122–131. [PubMed] [Google Scholar]
  338. Reichen J. Role of the hepatic artery in canalicular bile formation by the perfused rat liver. A multiple indicator dilution study. J. clin. Invest. 1987;81:1462–1469. doi: 10.1172/JCI113477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  339. Reichen J., Le M. Verapamil favorably influences hepatic microvascular exchange and function in rats with cirrhosis of the liver. J. clin. Invest. 1986;78:448–455. doi: 10.1172/JCI112596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  340. Reichen J., Hirlinger A., Ha H.R., Sagesser S. Chronic verapamil administration lowers portal pressure and improves hepatic function in rats with liver cirrhosis. J. Hepatol. 1986;3:49–58. doi: 10.1016/s0168-8278(86)80145-3. [DOI] [PubMed] [Google Scholar]
  341. Reichen J., Arts B., Schafroth V., Zimmermann A., Zeitner T.B., Zysset T. Aminopyrin N-dimethylation by rats with liver cirrhosis. Evidence for the intact cell hypothesis. A morphometric functional study. Gastroenterology. 1987;93:719–726. doi: 10.1016/0016-5085(87)90433-1. [DOI] [PubMed] [Google Scholar]
  342. Reichen J., Hoilien C., Le M., Jones R.H. Decreased uptake of taurocholate and ouabain by hepatocytes isolated from cirrhotic rat liver. Hepatology. 1987;7:67–70. doi: 10.1002/hep.1840070115. [DOI] [PubMed] [Google Scholar]
  343. Reichen J., Sagesser H., Stuber R., Zysset T. Resistance of cirrhotic rat liver to the microvascular and functional effects of norepinephrine: down regulation of hepatic adrenoreceptors? Hepatology. 1987;7:1032. (Abstr.) [Google Scholar]
  344. Reichen J., Egger B., Zeltner T.B., Zysset T., Zimmermann A. Determinants of hepatic function in liver cirrhosis in the rat. J. clin. Invest. 1988;82:2069–2076. doi: 10.1172/JCI113828. [DOI] [PMC free article] [PubMed] [Google Scholar]
  345. Reilly F.D., McCuskey P.A., McCuskey R.S. Intrahepatic distribution of nerves in the rat. Anat. Rec. 1978;191:55–68. doi: 10.1002/ar.1091910106. [DOI] [PubMed] [Google Scholar]
  346. Reilly F.D., McCuskey R.S., Cilento E.V. Hepatic microvascular regulatory mechanisms. I. Adrenergic mechanisms. Microvasc. Res. 1981;21:103–116. doi: 10.1016/0026-2862(81)90008-x. [DOI] [PubMed] [Google Scholar]
  347. Reilly F.D., Dimlich R.V.W., Cilento E.V., McCuskey R.S. Hepatic microvascular regulatory mechanisms. II. Cholinergic mechanisms. Hepatology. 1982;2:230–235. doi: 10.1002/hep.1840020207. [DOI] [PubMed] [Google Scholar]
  348. Richardson P.D.I. Pharmacology of intestinal blood flow and oxygen uptake. In: Shepherd A.P., Granger D.N., editors. Physiology of the Intestinal Circulation. Raven Press; New York: 1984. pp. 393–402. [Google Scholar]
  349. Richardson P.D.I., Withrington P.G. The effects of intraportal injections of noradrenaline, adrenaline, vasopressin and angiotensin on the hepatic portal vascular bed of the dog: marked tachyphylaxis to angiotensin. Br. J. Pharmac. 1977;59:293–301. doi: 10.1111/j.1476-5381.1977.tb07492.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  350. Richardson P.D.I., Withrington P.G. The role of β-adrenoreceptors in the responses of the hepatic arterial vascular bed of the dog to phenylephrine, isoprenaline, noradrenaline and adrenaline. Br. J. Pharmac. 1977;60:239–249. [PMC free article] [PubMed] [Google Scholar]
  351. Richardson P.D.I., Withrington P.G. Pressure-flow relationships and effects of noradrenaline and isoprenaline on the hepatic arterial and portal venous vascular beds of the dog. J. Physiol. 1978;282:451–470. doi: 10.1113/jphysiol.1978.sp012475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  352. Richardson P.D.I., Withrington P.G. Liver blood flow. I. Intrinsic and nervous controls of liver blood flow. Gastroenterology. 1981;81:159–173. [PubMed] [Google Scholar]
  353. Richardson P.D.I., Withrington P.G. Liver blood flow. II. Effects of drugs and hormones on liver blood flow. Gastroenterology. 1981;81:356–375. [PubMed] [Google Scholar]
  354. Richardson P.D.I., Withrington P.G. Physiological regulation of the hepatic circulation. Ann. Rev. Physiol. 1982;44:57–69. doi: 10.1146/annurev.ph.44.030182.000421. [DOI] [PubMed] [Google Scholar]
  355. Rieder H., Ramadori G., Meyer Zumbüschenfelde K.H. Guinea pig Kupffer cells can be activated in vitro to an enhanced superoxide response. I. Comparison with peritoneal macrophages. J. Hepatol. 1988;7:338–344. doi: 10.1016/s0168-8278(88)80006-0. [DOI] [PubMed] [Google Scholar]
  356. Ring-Larsen H., Hesse B., Henriksen J.H., Christensen N.J. Sympathetic nervous activity and renal and systemic hemodynamics in cirrhosis: plasma norepinephrine concentration, hepatic extraction, and renal release. Hepatology. 1982;2:304–310. doi: 10.1002/hep.1840020303. [DOI] [PubMed] [Google Scholar]
  357. Rosen G.M., Freeman B.A. Vol. 81. 1984. Detection of superoxide generated by endothelial cells; pp. 7269–7273. (Proc. natn. Acad. Sci. U.S.A.). [DOI] [PMC free article] [PubMed] [Google Scholar]
  358. Rothe C.F. Reflex control of veins and vascular capacitance. Physiol. Rev. 1983;63:1281–1342. doi: 10.1152/physrev.1983.63.4.1281. [DOI] [PubMed] [Google Scholar]
  359. Rothe C.F. Control of capacitance vessels. In: Shepherd A.P., Granger D.N., editors. Physiology of the Intestinal Circulation. Raven Press; New York: 1984. pp. 73–81. [Google Scholar]
  360. Rudolph R., McClure W.J., Woodward M. Contractile fibroblasts in chronic alcoholic cirrhosis. Gastroenterology. 1979;76:704–709. [PubMed] [Google Scholar]
  361. Rush B., Merritt M.V., Kaluzny M., Vanschoick T., Brunden M.N., Ruwart M. Studies on the mechanism of the protective action of 16,16-dimethyl prostaglandin E2 in carbon tetrachloride induced acute hepatic injury in the rat. Prostaglandins. 1986;32:439–455. doi: 10.1016/0090-6980(86)90011-0. [DOI] [PubMed] [Google Scholar]
  362. Sakagami Y., Mizoguchi Y., Seki S., Kobayashi K., Mirosawa S., Yamamoto S. Release of peptide leukotrienes for rat Kupffer cells. Biochem. biophys. Res. Commun. 1988;156:217–221. doi: 10.1016/s0006-291x(88)80827-1. [DOI] [PubMed] [Google Scholar]
  363. Samuelsson B., Dahlen S.R., Lindgren J.A., Rouzer C.A., Serhan C.N. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science. 1987;237:1171–1176. doi: 10.1126/science.2820055. [DOI] [PubMed] [Google Scholar]
  364. Sannemann J., Beckh K., Jungermann K. Control of glycogenolysis and hemodynamics in perfused rat liver by the sympathetic innervation. Biol. Chem. Hoppe-Seyler. 1986;367:401–409. doi: 10.1515/bchm3.1986.367.1.401. [DOI] [PubMed] [Google Scholar]
  365. Sasse D. Liver structure and innervation. In: Thurman R.G., Kauffman F.C., Jungermann K., editors. Regulation of Hepatic Metabolism. Plenum; New York: 1986. pp. 3–25. [Google Scholar]
  366. Sawchenko P.E., Friedmann M.I. Sensory functions of the liver—a review. Am. J. Physiol. 1979;236:R5–R20. doi: 10.1152/ajpregu.1979.236.1.R5. [DOI] [PubMed] [Google Scholar]
  367. Schafer J.A., Andreoli T.E. Principles of water and nonelectrolyte transport across membranes. In: Andreoli T.E., Hoffman J.F., Fanestil D.D., Schutz S.G., editors. Physiology of Membrane Disorders. Plenum; New York: 1986. pp. 177–190. [Google Scholar]
  368. Schlayer H.J., Karck U., Ganter U., Hermann R., Decker K. Enhancement of neutrophil adherence to isolated rat liver sinusoidal endothelial cells by supernatants of lipopolysaccharide-activated monocytes. J. Hepatol. 1987;5:311–321. doi: 10.1016/s0168-8278(87)80037-5. [DOI] [PubMed] [Google Scholar]
  369. Schlayer H.J., Laaff H., Peters T., Woort-Menker M., Estler H.C., Karck U., Schaefer H.E., Decker K. Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal endothelial cells of mouse liver and its modulation in acute phase. J. Hepatol. 1988;7:239–249. doi: 10.1016/s0168-8278(88)80488-4. [DOI] [PubMed] [Google Scholar]
  370. Schrier R.W., Caramelo C. Hemodyanmics and hormonal alteration in hepatic cirrhosis. In: Epstein M., editor. The Kidney in Liver Disease. Williams and Wilkins; Baltimore: 1987. [Google Scholar]
  371. Seaman K.L., Greenway C.V. Hepatic venoconstrictor effects of isoproterenol and nifedipine in anesthetized cats. Can. J. Physiol. Pharmac. 1984;62:665–672. doi: 10.1139/y84-109. [DOI] [PubMed] [Google Scholar]
  372. Segstro R., Greenway C.V. Alpha adrenoceptor subtype mediating sympathetic mobilization of blood from the hepatic venous system in anesthetized cats. J. Pharmac. exp. Ther. 1986;236:224–229. [PubMed] [Google Scholar]
  373. Sharma R.J., Rodrigues L.M., Whitton P.D., Hems D.A. Control mechanisms in the acceleration of hepatic glycogen degradation during hypoxia. Biochem. biophys. Acta. 1980;630:414–424. doi: 10.1016/0304-4165(80)90290-1. [DOI] [PubMed] [Google Scholar]
  374. Shibayama Y. On the pathogenesis of portal hypertension in cirrhosis of the liver. Liver. 1988;8:95–99. doi: 10.1111/j.1600-0676.1988.tb00974.x. [DOI] [PubMed] [Google Scholar]
  375. Shibayama Y., Nakata K. Localization of increased hepatic vascular resistance in liver cirrhosis. Hepatology. 1985;5:643–648. doi: 10.1002/hep.1840050421. [DOI] [PubMed] [Google Scholar]
  376. Shibayama Y., Nakata K. Relation of sinusoidal stenoses following hepatocyte swelling to hepatic vascular resistance in experimental liver cirrhosis. Liver. 1989;9:36–42. doi: 10.1111/j.1600-0676.1989.tb00376.x. [DOI] [PubMed] [Google Scholar]
  377. Shibayama Y., Nakata K. The role of sinusoidal stenoses in portal hypertension of liver cirrhosis. J. Hepatol. 1989;8:60–66. doi: 10.1016/0168-8278(89)90162-1. [DOI] [PubMed] [Google Scholar]
  378. Shiratori Y., Kawase T., Shina S., Okano K., Sugimoto T., Teraoka H., Matano S., Matsumoto K., Kamii K. Modulation of hepatotoxicity by macrophages in the liver. Hepatology. 1988;4:815–821. doi: 10.1002/hep.1840080420. [DOI] [PubMed] [Google Scholar]
  379. Shukla S.D., Buxton D.B., Olson M.S., Hanahan D.J. Acetylglyceryl ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis. J. biol. Chem. 1983;258:10212–10214. [PubMed] [Google Scholar]
  380. Sies H., Graf P. Hepatic thiol and glutathione efflux under the influence of vasopressin, phenylephrine and adrenaline. Biochem. J. 1985;226:545–549. doi: 10.1042/bj2260545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  381. Sikugara O., Monden M., Toyoshima K., Okamura J., Kosaki G. Cytoprotective effect of prostaglandin I2 on ischemia-induced hepatic cell injury. Transplantation. 1983;36:238–242. doi: 10.1097/00007890-198309000-00002. [DOI] [PubMed] [Google Scholar]
  382. Sikuler E., Groszmann R.J. Interaction of flow and resistance in maintenance of portal hypertension in a rat model. Am. J. Physiol. 1986;250:G205–G212. doi: 10.1152/ajpgi.1986.250.2.G205. [DOI] [PubMed] [Google Scholar]
  383. Sikuler E., Groszmann R.J. Hemodynamic studies in long- and short-term portal hypertensive rats: the relation to systemic glucagon levels. Hepatology. 1986;6:414–418. doi: 10.1002/hep.1840060315. [DOI] [PubMed] [Google Scholar]
  384. Sikuler E., Kravetz D., Groszmann R.J. Evolution of portal hypertension and mechanisms involved in its maintenance in a rat model. Am. J. Physiol. 1985;248:G618–G625. doi: 10.1152/ajpgi.1985.248.6.G618. [DOI] [PubMed] [Google Scholar]
  385. Singal P.K., Kapur N., Dhillon K.S., Beamish R.E., Dhalla N.S. Role of free radicals in catecholamine-induced cardiomyopathy. Can. J. Physiol. Pharmac. 1981;60:1390–1397. doi: 10.1139/y82-207. [DOI] [PubMed] [Google Scholar]
  386. Skaaring P., Bierring F. On the intrinsic innervation of normal rat liver. Histochemical and scanning electron microscopical studies. Cell Tissue Res. 1976;171:141–155. doi: 10.1007/BF00219403. [DOI] [PubMed] [Google Scholar]
  387. Stachura J., Tarnawski A., Szczudrawa J., Bogdal J., Mach T., Klimczyk B., Kirchmayer S. Cytoprotective effect of 16,16-dimethyl prostaglandin E2 and some drugs on an acute galactosamine induced liver damage in rat. Folia Histochem. Cytochem. 1980;18:311–318. [PubMed] [Google Scholar]
  388. Stachura J., Tarnawski A., Ivey K.J., Mach T., Bogdal J., Szczudrawa J., Klimiczyk B. Prostaglandin protection of carbon tetrachloride-induced liver cell necrosis in the rat. Gastroenterology. 1981;81:211–217. [PubMed] [Google Scholar]
  389. Steffan A.M., Gendrault J.L., McCuskey R.S., McCuskey P.A., Kirn A. Phagocytosis an unrecognized property of murine endothelial liver cells. Hepatology. 1986;6:830–836. doi: 10.1002/hep.1840060505. [DOI] [PubMed] [Google Scholar]
  390. Steffan A.M., Gendrault J.L., Kirn A. Increase in the number of fenestrae in mouse endothelial liver cells by altering the cytoskeleton with cytochalasin B. Hepatology. 1987;7:1230–1238. doi: 10.1002/hep.1840070610. [DOI] [PubMed] [Google Scholar]
  391. Steinhelper M.E., Olson M.S. Regulation of immune-aggregate-stimulated hepatic glycogenolysis and vasoconstriction by vicinal dithiols. Biochem. J. 1988;249:631–637. doi: 10.1042/bj2490631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  392. Steinhelper M.E., Olson M.S. Effects of phenylarsine oxide on agonist-induced hepatic vasoconstriction and glycogenolysis. Biochem. Pharmac. 1988;37:1167–1169. doi: 10.1016/0006-2952(88)90526-6. [DOI] [PubMed] [Google Scholar]
  393. Stenger R.J. Hepatic sinusoids in carbon tetrachloride-induced cirrhosis. Archs. Path. 1966;81:439–447. [PubMed] [Google Scholar]
  394. Summerfield J.A., Jones E.A. Further progress towards understanding hepatic sinusoidal cells. J. Hepatol. 1986;3:413–418. doi: 10.1016/s0168-8278(86)80497-4. [DOI] [PubMed] [Google Scholar]
  395. Svensjo E., Grega G.J. Vol. 45. 1986. Evidence for endothelial cell-mediated regulation of macromolecular permeability by postcapillary venules; pp. 89–95. (Fedn Proc.). [PubMed] [Google Scholar]
  396. Tage-Jensen V., Henriksen J.H., Christensen E., Widding A., Ring-Larsen H., Christensen N.J. Plasma catecholamine level and portal venous pressure as guides to prognosis in patients with cirrhosis. J. Hepatol. 1988;6:350–358. doi: 10.1016/s0168-8278(88)80053-9. [DOI] [PubMed] [Google Scholar]
  397. Tanner A., Keyhani A., Reiner R., Holdstock G., Wright R. Proteolytic enzymes released by liver macrophages may promote hepatic injury in a rat model of hepatic damage. Gastroenterology. 1981;80:647–654. [PubMed] [Google Scholar]
  398. Taylor W.M., Van de Pol E., Van Helden D.F., Reinhart P.H., Bygrave F.L. Effect of depolarizing concentrations of potassium on calcium uptake and metabolism in rat liver. FEBS Lett. 1985;183:70–74. doi: 10.1016/0014-5793(85)80956-x. [DOI] [PubMed] [Google Scholar]
  399. Taylor F.B., Chang A., Esmon C.T., D'Angelo A., Vigano-D'Angelo S., Blick K.E. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J. clin. Invest. 1987;79:918–925. doi: 10.1172/JCI112902. [DOI] [PMC free article] [PubMed] [Google Scholar]
  400. Terada T., Ishida F., Nakanuma Y. Vascular plexus around intrahepatic bile ducts in normal livers and portal hypertension. J. Hepatol. 1989;8:139–149. doi: 10.1016/0168-8278(89)90001-9. [DOI] [PubMed] [Google Scholar]
  401. Thurman R.G., Ji S., Lemasters J.J. Lobular oxygen gradients: possible role in alcohol-induced hepatotoxicity. In: Thurman R.G., Kauffman F.C., Jungermann K., editors. Regulation of Hepatic Metabolism. Plenum; New York: 1986. pp. 293–320. [Google Scholar]
  402. Thurman R.G., King J.N., Lemasters J.J. Nitrendipine protects the liver against hypoxia-induced damage at submicromolar concentrations in the perfused rat liver. J. cardiovasc. Pharmac. 1987;9:S71–S76. [Google Scholar]
  403. Thurman R.G., Apel E., Badr M., Lemasters J.L. Protection of liver by calcium entry blockers. In: Vanheutte P.M., Paoletti R., Govoni S., editors. Calcium Antagonists. 1988. pp. 755–770. (Ann. N.Y. Acad. Sci.). New York. [DOI] [PubMed] [Google Scholar]
  404. Thurman R.G., Cowper K.B., Marzi I., Currin R., Lemasters J.J. Functional activation of Kupffer cells by cold ischemic storage of the liver in Eurocollins solution. Hepatology. 1988;8:1284. (Abstr.) [Google Scholar]
  405. Thurman R.G., Marzi I., Seitz G., Thies J., Lemasters J.J., Zimmermann F. Hepatic reperfusion injury following orthotopic liver transplantation in the rat. Transplantation. 1988;46:502–506. doi: 10.1097/00007890-198810000-00006. [DOI] [PubMed] [Google Scholar]
  406. Tiegs G., Wendel A. Leukotriene-mediated liver injury. Biochem. Pharmac. 1988;37,13:2569–2573. doi: 10.1016/0006-2952(88)90248-1. [DOI] [PubMed] [Google Scholar]
  407. Tiegs G., Wolter M., Wendel A. Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem. Pharmac. 1989;38:627–631. doi: 10.1016/0006-2952(89)90208-6. [DOI] [PubMed] [Google Scholar]
  408. Tran Thi T.A., Gyufko K., Haussinger D., Decker K. Net prostaglandin release by perfused rat liver after stimulation with phorbol 12-myristate 13-acetate. J. Hepatol. 1988;6:151–157. doi: 10.1016/s0168-8278(88)80026-6. [DOI] [PubMed] [Google Scholar]
  409. Tran Thi T.A., Gyufko K., Reinke M., Decker K. Output and effects of thromboxane produced by the liver perfused with phorbol myristate acetate. Biol. Chem. Hoppe-Seyler. 1988;369:1179–1184. doi: 10.1515/bchm3.1988.369.2.1179. [DOI] [PubMed] [Google Scholar]
  410. Tran Thi T.A., Haussinger D., Gyufko K., Decker K. Stimulation of prostaglandin release by Ca2-mobilizing agents from the perfused rat liver. Biol. Chem. Hoppe-Seyler. 1988;369:65–68. doi: 10.1515/bchm3.1988.369.1.65. [DOI] [PubMed] [Google Scholar]
  411. Tsukamoto H., Xi X.P. Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis. Hepatology. 1989;9:302–306. doi: 10.1002/hep.1840090223. [DOI] [PubMed] [Google Scholar]
  412. Utili R., Abernathy C.O., Zimmermann H.J. Cholestatic effects of Escherichia coli endotoxin on the isolated perfused rat liver. Gastroenterology. 1976;70:248–253. [PubMed] [Google Scholar]
  413. Utili R., Abernathy C.O., Zimmerman H.J., Gaeta G.B., Adinolfi L., Lukacs L. Endotoxin protects against chlorpromazine-induced cholestasis in the isolated perfused rat liver. Gastroenterology. 1981;80:673–680. [PubMed] [Google Scholar]
  414. Utili R., Adinolfi L.E., Gaeta G.B., Tripodi M.F., Alvaro D. Effect of endotoxin tolerance on drug hepatotoxicity: amelioration of taurolithocholate cholestasis in the perfused rat liver. Digestion. 1987;36:74–80. doi: 10.1159/000199402. [DOI] [PubMed] [Google Scholar]
  415. Van Bossuyt H., Wisse E. Cultured Kupffer cells, isolated from human and rat liver biopsies, ingest endotoxin. J. Hepatol. 1988;7:45–56. doi: 10.1016/s0168-8278(88)80505-1. [DOI] [PubMed] [Google Scholar]
  416. Van Bossuyt H., De Zanger R.B., Wisse E. Cellular and subcellular distribution of injected lipopolysaccharide in rat liver and its activation by bile salts. J. Hepatol. 1988;7:325–337. doi: 10.1016/s0168-8278(88)80005-9. [DOI] [PubMed] [Google Scholar]
  417. Van de Broeck A., Uyttenhove K., Bollen M., Stalmans W. The hepatic glycogenolysis induced by reversible ischaemia or KCN is exclusively catalysed by phosphorylase a. Biochem. J. 1988;2565:685–688. doi: 10.1042/bj2560685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  418. Van Deventer S.J.H., Ten Cate J.W., Tytgat G.N.J. Intestinal endotoxemia. Gastroenterology. 1988;94:825–831. doi: 10.1016/0016-5085(88)90261-2. [DOI] [PubMed] [Google Scholar]
  419. Van Zwieten P.A., Timmermans P.B.W.W.M. Receptor subtypes involved in the action of calcium entry blockers. Ann. N.Y. Acad. Sci. 1988;522:351–360. doi: 10.1111/j.1749-6632.1988.tb33376.x. [DOI] [PubMed] [Google Scholar]
  420. Varin F., Huet P.M. Hepatic microcirculation in the perfused cirrhotic rat liver. J. clin. Invest. 1985;76:1904–1912. doi: 10.1172/JCI112186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  421. Vidins E.I., Britton R.S., Medline A., Blendis L.M., Israel Y., Orrego H. Sinusoidal caliber in alcoholic and non alcoholic liver disease: diagnostic and pathogenic implications. Hepatology. 1985;5:408–414. doi: 10.1002/hep.1840050311. [DOI] [PubMed] [Google Scholar]
  422. Villeneuve J.P., Huet P.M. Microcirculatory abnormalities in liver disease. Hepatology. 1987;7:186–187. doi: 10.1002/hep.1840070135. [DOI] [PubMed] [Google Scholar]
  423. Villeneuve J.P., Wood A.J., Shand D.G. Impaired drug metabolism in experimental cirrhosis in the rat. Biochem. Pharmac. 1978;27:2577–2581. doi: 10.1016/0006-2952(78)90330-1. [DOI] [PubMed] [Google Scholar]
  424. Von Kugelgen I., Haussinger D., Starke K. Evidence for a vasoconstriction mediating receptor for UTP, distinct from the P2 purinoceptor, in rabbit ear artery. Naunyn-Schmiedebergs Arch. Pharmac. 1987;336:556–560. doi: 10.1007/BF00169313. [DOI] [PubMed] [Google Scholar]
  425. Vorobioff J., Bredfeldt J.E., Groszmann R.J. Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am. J. Physiol. 1983;244:G52–G57. doi: 10.1152/ajpgi.1983.244.1.G52. [DOI] [PubMed] [Google Scholar]
  426. Vorobioff J., Bredfeldt J.E., Groszmann R.J. Increased blood flow through the portal system in cirrhotic rats. Gastroenterology. 1984;87:1120–1126. [PubMed] [Google Scholar]
  427. Wendel A., Tiegs G., Werner C. Evidence for the involvement of a reperfusion injury in galactosamine/endotoxin-induced hepatitis in mice. Biochem. Pharmac. 1987;36:2637–2639. doi: 10.1016/0006-2952(87)90544-2. [DOI] [PubMed] [Google Scholar]
  428. Willet I., Esler M., Burke F., Leonard P., Dudley F. Total and renal sympathetic nervous system activity in alcoholic cirrhosis. J. Hepatol. 1985;1:639–648. doi: 10.1016/s0168-8278(85)80007-6. [DOI] [PubMed] [Google Scholar]
  429. Willet I.R., Jennings G., Esler M., Dudley F.J. Sympathetic tone modulates portal pressure in alcoholic cirrhosis. Lancet. 1986;939–942 doi: 10.1016/s0140-6736(86)90599-4. [DOI] [PubMed] [Google Scholar]
  430. Wisse E., DeZanger R.B., Charels K., Van Der Smissen P., McCuskey R.S. The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology. 1985;5:683–692. doi: 10.1002/hep.1840050427. [DOI] [PubMed] [Google Scholar]
  431. Wood A.J., Villeneuve J.P., Branch R.A., Rogers L.W., Shand D.G. Intact hepatocyte theory of impaired drug metabolism in experimental cirrhosis in the rat. Gastroenterology. 1979;76:1358–1362. [PubMed] [Google Scholar]
  432. Woolf P.D., Hamill R.W., Lee L.A., McDonald J.V. Free and total catecholamines in critical illness. Am. J. Physiol. 1988;254:E287–E291. doi: 10.1152/ajpendo.1988.254.3.E287. [DOI] [PubMed] [Google Scholar]
  433. Yamada S., Ogata I., Hirata K., Mochida S., Tomiya T., Fujiwara K. Intravascular coagulation in the development of massive hepatic necrosis induced by Coryne bacterium parvum and endotoxin in rats. Scand. J. Gastroent. 1989;24:293–298. doi: 10.3109/00365528909093049. [DOI] [PubMed] [Google Scholar]
  434. Yamaguchi N., Garceau D. Correlations between hemodynamic parameters of the liver and norepinephrine release upon hepatic nerve stimulation in the dog. Can. J. Physiol. Pharmac. 1980;58:1347–1355. doi: 10.1139/y80-204. [DOI] [PubMed] [Google Scholar]
  435. Yamamoto K., Sherman I., Philipps M.J., Fisher M.M. Three dimensional observations of the hepatic arterial terminations in rat, hamster and human liver by scanning electron microscopy of microvascular casts. Hepatology. 1988;5:452–456. doi: 10.1002/hep.1840050318. [DOI] [PubMed] [Google Scholar]
  436. Zimmerman H.J. Vol. XVI. Springer; Berlin: 1976. Experimental toxicity; pp. 1–99. (Handbook of Experimental Pharmacology). Part 5. [Google Scholar]
  437. Zweier J.L., Kuppusami P., Lutty G.A. Vol. 85. 1988. Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues; pp. 4046–4050. (Proc. natn. Acad. Sci. U.S.A.). [DOI] [PMC free article] [PubMed] [Google Scholar]

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