Abstract
Before the prophylactic effect of human interferon α2 (HuIFN-α2) can be tested against naturally acquired rhinovirus infection in a large-scale field trial, it is desirable to show that self-administration of the drug is practical, and to determine the smallest well-tolerated dose likely to produce a worthwhile effect. Here we report that self-administered intranasal interferon can be effective, and show how prophylaxis against rhinovirus infection is affected by both the quantity of interferon, and the interval between a dose and virus challenge. Finally, the medication regimen suggested for use in field trials (3.85 MU 3 times/day) was tested in a double-blind, placebo-controlled trial in volunteers. Although virus challenge was at a time when those being treated with interferon would be most susceptible, a substantial protective effect was still demonstrated.
Keywords: interferon, prophylatis, rhinoviruses infection, volunteer studies
Footnotes
This work was supported by the Medical Research Council of Great Britain, and the Schering-Plough Corporation.
References
- 1.Aoki F.Y., Crawley J.C.W. Distribution and removal of human serum albumin in technetium 99M instilled intranasally by drops and spray. Br. J. Clin. Pharmacol. 1976;3:869–878. doi: 10.1111/j.1365-2125.1976.tb00640.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Beare A.S., Reed S.E. The study of antiviral compounds in volunteers. In: Oxford J., editor. Chemoprophylaxis and Viral Infection of the Respiratory Tract. CRC Press; Cleveland: 1977. pp. 27–55. [Google Scholar]
- 3.Harmon M.W., Greenberg S.B., Johnson P.E. Vol. 164. 1980. Rapid onset of the interferon-induced antiviral state in human nasal epithelial and foreskin fibroblast cells (40838) pp. 146–152. (Proc. Soc. Exp. Biol. Med.). [DOI] [PubMed] [Google Scholar]
- 4.Horn M.E., Reed S.E., Taylor P. Role of viruses and bacteria in acute wheezy bronchitis in childhood: a study of sputum. Arch. Dis. Child. 1977;54:587–592. doi: 10.1136/adc.54.8.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Larson H.E., Reed S.E., Tyrrell D.A.J. Isolation of rhinoviruses and coronaviruses from 38 colds in adults. J. Med. Virol. 1980;5:221–229. doi: 10.1002/jmv.1890050306. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.McHardy V., Inglis J.M., Calder A., Crofton J.W., Grigg I., Ryland D.A., Taylor P., Chadwick M., Coombs B., Riddell R.W. A study of infective and other factors in exacerbations of chronic bronchitis. Br. J. Dis. Chest. 1980;74:228–238. doi: 10.1016/0007-0971(80)90048-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Phillpotts R.J., Wallace J., Tyrrell D.A.J., Freestone D.S., Shepherd W.M. Failure of 4′,6, dichloroflavan to protect against rhinovirus infection in man. Arch. Virol. 1983;75:115–121. doi: 10.1007/BF01314131. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Scott G.M., Phillpotts R.J., Wallace J., Gauci C.L., Tyrrell D.A.J., Greiner J. Prevention of rhinovirus colds by human interferon alpha 2 from Escherichia coli. Lancet. 1982;ii:186–188. doi: 10.1016/s0140-6736(82)91031-5. [DOI] [PubMed] [Google Scholar]