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. 2002 Nov 13;16(2):215–224. doi: 10.1016/0165-5728(87)90076-2

Induction of class I and class II transplantation antigens in rat brain during fatal and non-fatal measles virus infection

Tomas Olsson 2,∗, Jan Maehlen 1, Arthur Löve 1,3, Lars Klareskog 4, Erling Norrby 3, Krister Kristensson 1
PMCID: PMC7134084  PMID: 3497946

Abstract

Measles virus induced a marked increase in the expression of MHC-coded class I and class II antigens as detected by immunostaining during both fatal and non-fatal brain infections in rats. The distribution of these molecules in the brain was much more widespread than the occurence of viral antigen suggesting a soluble factor for their induction. In 14-day-old rats with a non-fatal infection there was a marked infiltration of T lymphocytes of ‘cytotoxic/suppressor’ phenotype in the brain parenchyma, whereas T ‘helper’ cell phenotypes mainly were located perivascularly. In brains from newborn rats with a fatal infection no or only few lymphocytes were detected.

Keywords: Transplantation antigen, class I and class II; T lymphocyte; Immunohistochemistry; Measles virus infection

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