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. 1998 Apr 27;34(1):31–46. doi: 10.1016/S0167-5877(97)00060-3

Associations between passive immunity and morbidity and mortality in dairy heifers in Florida, USA

GArthur Donovan a,∗, Ian R Dohoo b, David M Montgomery b, Fred L Bennett a
PMCID: PMC7134088  PMID: 9541949

Abstract

A prospective cohort study was undertaken to determine calf-level factors that affected calf health status between birth and 6 months of age. A convenience sample of approximately 3300 female Holstein calves born in 1991 on two large Florida dairy farms was used for the study. Data collected on each calf at birth included farm of origin, weight, height at the pelvis, birth date, and serum total protein (a measure of colostral immunoglobulin absorption). Birth season was dichotomized into summer and winter using meteorological data collected by University of Florida Agricultural Research Stations. Health data including date of initial treatment and number of treatments were collected for the diseases diarrhea, omphalitis, septicemia and pneumonia. All calves were followed for 6 months. Cumulative incidences of mortality and occurrence of diarrhea, omphalitis, septicemia and pneumonia were 0.12, 0.35, 0.11, 0.24 and 0.21, respectively. Serum total protein (TP) was a significant risk factor for mortality. The association of TP and mortality was quadratic and showed a dramatic decrease in mortality as TP increased from 4.0 to 5.0 g/dl, a small improvement from 5.0 to 6.0 g/dl and virtually no improvement in mortality rates as TP increased over 6.0 g/dl. The hazard mortality ratio was constant from birth to six months, indicating that the increased risk of mortality associated with low levels of TP was evident through six months of age. No interactions between TP, farm, season, or birth weight were found in these analyses. Serum total protein concentration was a significant risk factor for the occurrences, age of onset and severity of septicemia and pneumonia. The association between TP and septicemia was linear and an interaction with birth season was found. The association between TP and pneumonia was quadratic, and in contrast to the TP-and-septicemia relationship, the morbidity hazard ratio for pneumonia was not constant over the time measured; that is, colostral immunity protected the calf from developing pneumonia early in life, but this effect disappeared as the calf got older. Total protein was not a significant risk factor for diarrhea or omphalitis.

Keywords: Cattle-morbidity and mortality, Passive immunity, Immunology

References

  1. Archambault D., Morin G., Elazhary Y., Roy R.S., Joncas J.H. Immune response of pregnant heifers and cows to bovine rotavirus inoculation and passive protection to rotavirus infection in newborn calves fed colostral antibodies or colostral lymphocytes. Am. J. Vet. Res. 1989;49:1084–1091. [PubMed] [Google Scholar]
  2. Belknap E.B., Baker J.C., Patterson J.S., Walker R.D., Haines D.M., Clark E.G. The role of passive immunity in bovine respiratory syncytial virus infected calves. J. Infect. Dis. 1991;163:470–476. doi: 10.1093/infdis/163.3.470. [DOI] [PubMed] [Google Scholar]
  3. Boyd J.W. The relationship between serum immune globulin deficiency and disease in calves: a farm survey. Vet. Rec. 1972;90:645–649. doi: 10.1136/vr.90.23.645. [DOI] [PubMed] [Google Scholar]
  4. Boyd J.W., Baker J.R., Leyland A. Neonatal diarrhea in calves. Vet. Rec. 1974;95:310–313. doi: 10.1136/vr.95.14.310. [DOI] [PubMed] [Google Scholar]
  5. Braun R.K., Tennant B.C. The relationship of serum gamma globulin levels of assembled neonatal calves to mortality caused by enteric diseases. Agri-Practice. 1983;4:14–24. [Google Scholar]
  6. Caldow G.L., White D.G., Kelsey M., Peters A.R., Solly H.J. Relationship of calf antibody status to disease and performance. Vet. Rec. 1988;122:63–65. doi: 10.1136/vr.122.3.63. [DOI] [PubMed] [Google Scholar]
  7. Curtis C.R., Shearer J.K., Kelbert D.K. Evaluation of 3 field tests compared to a laboratory test to assess colostrum management in a large dairy herd. J. Dairy Sci. 1986;69(Suppl. 1):244. [Google Scholar]
  8. Davidson J.N., Yancey S.P., Campbell S.G., Warner R.G. Relationship between serum immunoglobulin values and incidence of respiratory disease in calves. J. Am. Vet. Med. Assoc. 1981;179:708–710. [PubMed] [Google Scholar]
  9. Duhamel G.E., Osburn B.I. Neonatal immunity in cattle. Bovine Pract. 1984;19:71–77. [Google Scholar]
  10. Fallon R.J., Harte F.J., Harrington D. The effect of calf purchase weight, serum Ig level and feeding systems on the incidence of diarrhoea, respiratory disease and mortality. Bovine Pract. 1987;22:104–106. [Google Scholar]
  11. Fleenor W.A., Stott G.H. Hydrometer test for estimation of immunoglobulin concentration in bovine colostrum. J. Dairy Sci. 1980;63:973–977. doi: 10.3168/jds.S0022-0302(80)83034-7. [DOI] [PubMed] [Google Scholar]
  12. Gardner I.A., Hird D.W., Utterback W.W., Danaye-Elmi C., Heron B.R., Christiansen K.H., Sischo W.M. Mortality, morbidity, case-fatality, and culling rates for California dairy cattle as evaluated by the National Animal Health Monitoring System, 1986–87. Prev. Vet. Med. 1990;8:157–170. [Google Scholar]
  13. Gay C.C. Proc. 4th Int. Symp. Neonatal Diarrhea. 1983. Failure of passive transfer of colostral immunoglobulins in neonatal disease in calves. A review; pp. 346–364. [Google Scholar]
  14. Glantz S.A., Slinker B.K. McGraw-Hill; Toronto: 1990. Primer of applied regression and analysis of variance; p. 777. [Google Scholar]
  15. Harp J.A., Woodmansee D.B., Moon H.W. Effects of colostral antibody on susceptibility of calves to Cryptosporidium parvum infection. Am. J. Vet. Res. 1989;50:2117–2119. [PubMed] [Google Scholar]
  16. Hartman D.A., Everett R.W., Slack S.T., Warner R.G. Calf mortality. J. Dairy Sci. 1974;57:576–578. [Google Scholar]
  17. Hosmer D.W., Lemeshow S. Wiley; New York: 1989. Applied logistic regression; p. 307. [Google Scholar]
  18. Howard J.C., Clarke M.C., Brownlie J. Protection against respiratory infection by bovine virus diarrhea virus by passively acquired immunity. Vet. Microbiol. 1989;19:195–203. doi: 10.1016/0378-1135(89)90066-7. [DOI] [PubMed] [Google Scholar]
  19. James R.E., McGuilliard M.L., Hartman D.A. Calf mortality in Virginia dairy herd improvement herds. J. Dairy Sci. 1984;67:908–911. doi: 10.3168/jds.S0022-0302(84)81387-9. [DOI] [PubMed] [Google Scholar]
  20. Jenny B.F., Grambling G.E., Glaze T.M. Management factors associated with calf mortality in South Carolina dairy herds. J. Dairy Sci. 1981;64:2284–2289. [Google Scholar]
  21. Logan E.F., Stenhouse A., Ormrod D.J. The role of colostral immunoglobulins in intestinal immunity to enteric colibacillosis in the calf. Res. Vet. Sci. 1974;17:290–301. [PubMed] [Google Scholar]
  22. McDermott J.J., Schukken Y.H. A review of methods used to adjust for cluster effects in explanatory epidemiological studies of animal populations. Prev. Vet. Med. 1994;18:155–173. [Google Scholar]
  23. McEwan A.D., Fisher E.W., Selman I.E. Observations on the immune globulin levels of neonatal calves and their relationship to disease. J. Comp. Path. 1970;80:250–265. doi: 10.1016/0021-9975(70)90093-9. [DOI] [PubMed] [Google Scholar]
  24. McGuire T.C., Pfeiffer N.E., Weikel J.M., Bartsch R.C. Failure of colostral immunoglobulin transfer in calves dying of infectious disease. J. Am. Vet. Med. Assoc. 1976;169:713–718. [PubMed] [Google Scholar]
  25. Naylor J.M., Kronfeld D.S. Refractometry as a measure of the immunoglobulin status of the newborn dairy calf: Comparison with the zinc sulfate turbidity test and single radial immunodiffusion. Am. J. Vet. Res. 1977;38:1331–1334. [PubMed] [Google Scholar]
  26. Naylor J.M., Kronfeld D.S., Bech-Nielsen S., Bartholomew R.C. Plasma total protein measurement for prediction of disease and mortality in calves. J. Am. Vet. Med. Assoc. 1977;171:635–638. [PubMed] [Google Scholar]
  27. Reid J.F.S., Martinez A.A. A modified refractometer method as a practical aid to the epidemiological investigation of disease in the neonatal ruminant. Vet. Rec. 1975;96:177–179. doi: 10.1136/vr.96.8.177. [DOI] [PubMed] [Google Scholar]
  28. Robison J.D., Stott G.H., DeNise S.K. Effects of passive immunity on growth and survival in the dairy heifer. J. Dairy Sci. 1988;71:1283–1287. doi: 10.3168/jds.S0022-0302(88)79684-8. [DOI] [PubMed] [Google Scholar]
  29. SAS Institute . 4th edn. SAS Institute; Cary, NC: 1989. p. 846. (SAS/STAT User's Guide). Version 6. [Google Scholar]
  30. Shearer J.K., Beede D.K. Thermoregulation and physiological responses of dairy cattle in hot weather. Agri-Practice. 1990;11(4):5–17. [Google Scholar]
  31. Smith B.P., Habasha F.B., Reina-Guerram M., Hardy A.J. Immunization of calves against salmonellosis. Am. J. Vet. Res. 1980;12:1947–1951. [PubMed] [Google Scholar]
  32. Snedecor G.W., Cochran W.G. 7th edn. Iowa State Univ. Press; Ames, LA: 1980. Statistical methods; p. 243. [Google Scholar]
  33. Thomas L.H., Swann R.G. Influence of colostrum on the incidence of calf pneumonia. Vet. Rec. 1973;92:454–455. doi: 10.1136/vr.92.17.454. [DOI] [PubMed] [Google Scholar]
  34. Tizard I.R. 5th edn. Saunders; Philadelphia, PA: 1996. Veterinary immunology: An introduction; p. 531. [Google Scholar]
  35. Waltner-Toews D., Martin S.W., Meek A.H. Dairy calf management, morbidity and mortality in Ontario Holstein herds: III. Association of management with morbidity. Prev. Vet. Med. 1986;4:137–158. [Google Scholar]
  36. Wittum T.E., Perino L.J. Passive immune status at postpartum hour 24 and long-term health and performance of calves. Am. J. Vet. Res. 1995;56:1149–1154. [PubMed] [Google Scholar]

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