Abstract
Twelve cattle with body wts ranging from 100 to 250 kg were treated using various doses and routes for four days with an E. coli derived alpha-hybrid interferon. The lowest parenteral doses (104 units per kg body wt) and the orally administered interferon did not lead to any disturbances, whereas the higher dosages led to marked changes in body temperature, pulse and respiration rates. Animals with the highest dose (108 units per kg body wt) became extremely distressed. The blood picture showed distinct changes, with very low leukocyte counts during treatment, which took weeks to recover. It is suggested that the dosages that did not lead to clinical symptoms are best suited for prophylactic or therapeutic purposes.
Keywords: Alpha-hybrid interferon, body weight, body temperature, pulse rate, respiratory rate, WBC, dosage
Résumé
Douze bovins pesant entre 100 et 250 kg ont été traités par des doses et voies d'administration variées pendant quatre jours avec un interféron alpha-hybride dérivée de E. coli. Les doses les plus basses (104 unités par kg du poids vif) administrées par voie orale n'ont engendré aucun trouble, tandis que les doses plus élevées causaient des modifications importantes de la température du corps ainsi du pouls et des mouvements respiratoires. Les animaux ayant reçu les doses les plus élevées (108 unités par kg du poids vif) manifestaient une détresse extrême. La formule leucocytaire subissait des changements importants avec des taux leucocytaires très bas pendant les jours de traitement. Plusieurs semaines étaient nécessaires pour retrouver une formule normale. Il est suggéré que les doses n'engendrant pas des symptomes cliniques sont les mieux appropriés pour les buts prophylactiques ou thérapeutiques.
Mots-clé: Interféron alpha-hybride, poids vif, température du corps, taux du pouls, taux des mouvements respiratoires, taux leucocytaire, dosage
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