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. 2003 Aug 22;318(8252):915–918. doi: 10.1016/S0140-6736(81)91402-1

MULTISITE INTRADERMAL ANTIRABIES VACCINATION

Immune Responses in Man and Protection of Rabbits Against Death from Street Virus by Postexposure Administration of Human Diploid-Cell-Strain Rabies Vaccine

KarlG Nicholson a, Howard Prestage a, PeterJ Cole b, GeorgeS Turner c, SallyP Bauer d
PMCID: PMC7134747  PMID: 6117693

Abstract

Lymphocyte transformation, production of neutralising antibody, and the development of antirabies IgG antibody were studied in ten healthy volunteers in response to 0·8 ml of human diploid-cell strain (HDCS) rabies vaccine administered on one occasion in divided doses in 8 intradermal (i.d.) sites. All ten volunteers rapidly developed substantial titres of rabies antibody, and eight of the ten had T lymphocytes that were immunologically stimulated by HDCS rabies-virus antigen. Postexposure treatment with 0·8 ml of HDCS vaccine given at 4 i.d. sites completely protected fourteen rabbits from death by street virus. The results suggest that in developing countries patients could be protected with small volumes of potent tissue-culture vaccine administered intradermally shortly after exposure.

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