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. 2002 Feb 11;7(4):472–483. doi: 10.1016/0955-0674(95)80003-4

Aquaporin water channels: unanswered questions and unresolved controversies

Peter Agre a,∗, Dennis Brown b, Søren Nielsen c
PMCID: PMC7135066  PMID: 7495566

Abstract

The long-standing biophysical question of how water crosses plasma membranes has been answered by the recent discovery of the aquaporins. Identification of this large family of membrane water-transport proteins has generated new questions about the physiological functions, tissue distributions, and regulatory mechanisms of individual aquaporins. The fast pace of developments in this field has also resulted in major discrepancies in published reports which warrant resolution.

Abbreviations: AQP—aquaporin, cRNA—complementary RNA, MIP—major intrinsinc protein of lens, PCR—polymerase chain reaction

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