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. 2008 Jan 3;35(5):895–902. [Article in French] doi: 10.1016/S0755-4982(06)74709-1

Orientation diagnostique devant une lymphopénie

Diagnosis of lymphocytopenia

Alice Berezné 1, Wafaa Bono 1, Loïc Guillevin 1, Luc Mouthon 1,⁎
PMCID: PMC7135154  PMID: 16710163

Points essentiels

Une lymphopénie est définie par un nombre de lymphocytes circulants < 1 500/mm3 chez l’adulte et 4 500/mm3 chez l’enfant avant 8 mois.

Nous proposons de classer les lymphopénies en fonction de leur mécanisme supposé

  • •

    les insuffisances de production, qui regroupent les déficits immunitaires primitifs ou secondaires à une dénutrition et/ou une carence en zinc

  • •

    les excès de catabolisme comprenant la radiothérapie, la chimiothérapie, les traitements immunosuppresseurs, l’infection VIH et le lupus érythémateux systémique

  • •

    les modifications de la répartition des lymphocytes, qui comprennent principalement l’hypersplénisme, certaines infections virales, le choc septique, les brûlures étendues, les granulomatoses et la corticothérapie

  • •

    les autres causes de lymphopénie, dont le mécanisme est encore mal compris : ethnie (Éthiopiens), insuffisance rénale, lymphome, tumeur solide, lymphopénie CD4 idiopathique.

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Articles from Presse Medicale (Paris, France : 1983) are provided here courtesy of Elsevier

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