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. 2004 Feb 24;5(4):606–612. doi: 10.1016/0955-0674(93)90129-E

Targeting and retention of Golgi membrane proteins

Carolyn E Machamer 1
PMCID: PMC7135176  PMID: 8257601

Abstract

Recent cloning of genes encoding membrane proteins of the Golgi complex has allowed investigation of protein targeting to this organelle. Targeting signals have been identified in three glycosyltransferases, a viral envelope protein and several proteins of the trans-Golgi network. Interestingly, the targeting signals for membrane proteins of the Golgi stacks seem to be contained in transmembrane domains. Information in the cytoplasmic tails is required for the targeting of trans-Golgi network proteins. Mechanisms involving both retention and retrieval have been invoked.

Abbreviations: CGN—cis-Golgi network; DPAP A—dipeptidyl aminopeptidase A; ER-endoplasmic reticulum; IBV—infectious bronchitis virus; GnTI—N-acetylglucosaminyltransferase I; GT—β1,4-galactosyltransferase; IBV—infectious bronchitis virus; ST—α2,6-sialyltransferase; TGN—traps-Golgi network; TMD—transmembrane domain

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