Skip to main content
Elsevier - PMC COVID-19 Collection logoLink to Elsevier - PMC COVID-19 Collection
. 2016 Feb 15;1(3):471–493. doi: 10.1016/S0749-0720(15)31297-4

Rotaviral and Coronaviral Diarrhea

Alfonso Torres-Medina 1,*, Donald H Schlafer 1,, Charles A Mebus 1,
PMCID: PMC7135422  PMID: 3000544

Abstract

Rotaviruses and coronaviruses are very common causes of calfhood diarrhea throughout the world. Rotaviral and coronaviral infections in neonatal calves can produce a severe diarrhea of high morbidity but of variable mortality depending upon secondary bacterial infections and electrolyte imbalances. Laboratory diagnosis of rotaviral and coronaviral diarrhea is mostly done by detection of virus particles or virus antigens in fecal specimens. The sample of choice for these diagnostic tests is a fresh fecal sample collected directly from the calf as close as possible to the onset of diarrhea.

REFERENCES

  • 1.Acres D.S., Radostits O.M. The efficacy of a modified live reo-like virus vaccine and an E. coli bacterin for prevention of acute undifferentiated neonatal diarrhea of beef calves. Can. Vet. J. 1976;17:197–212. [PMC free article] [PubMed] [Google Scholar]
  • 2.Almeida J.D., Hall T. The effect of trypsin on the growth of rotavirus. J. Gen. Virol.1978;40:213–218. doi: 10.1099/0022-1317-40-1-213. [DOI] [PubMed] [Google Scholar]
  • 3.Argenzio R.A. Physiology of diarrhea: Large intestine. J. Am. Vet. Med. Assoc. 1978;173:667–672. [PubMed] [Google Scholar]
  • 4.Babiuk L.A., Acres S.D., Rouse B.T. Solid-phase radioimmunoassay for detecting bovine (neonatal calf diarrhea) rotavirus antibody. J. Clin. Microbiol. 1977;6:10–15. doi: 10.1128/jcm.6.1.10-15.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Bachmann P.A., Hess R.G. Routine isolation and cultivation of bovine rotaviruses in cell culture. Am. J. Vet. Res. 1981;42:2149–2150. [PubMed] [Google Scholar]
  • 6.Baker J.A. A filterable virus causing enteritis and pneumonia in calves. J. Exp. Med. 1943;78:435–446. doi: 10.1084/jem.78.6.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Birch C.J., Lehmenn N.I., Hawker A.J. Comparison of electron microscopy, enzyme-linked immunosorbent assay, solid-phase radioimmunoassay, and indirect immunofluorescence for detection of human rotavirus antigen in faeces. J. Clin. Pathol. 1979;32:700–705. doi: 10.1136/jcp.32.7.700. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Bridger J.C. Location of type-specific antigens in calf rotaviruses. J. Clin. Microbiol. 1978;5:625–628. doi: 10.1128/jcm.8.6.625-628.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Bridger J.C., Caul E.O., Egglestone S.I. Replication of an enteric bovine coronavirus in intestinal organ cultures. Arch. Virol. 1978;57:43–51. doi: 10.1007/BF01315636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Bridger J.C., Woode G.N., Meyling A. Isolation of coronaviruses from neonatal calf diarrhea in Great Britain and Denmark. Vet. Microbiol. 1978;3:101–113. [Google Scholar]
  • 11.Bulgin M.S., Anderson B.C., Ward A.C.S. Infectious agents associated with neonatal calf disease in southwestern Idaho and eastern Oregon. J. Am. Vet. Med. Assoc. 1982;180:1222–1226. [PubMed] [Google Scholar]
  • 12.Carpio M., Bellamy J.E.C., Babiuk L.A. Comparative virulence of different bovine rotavirus isolates. Can. J. Comp. Med. 1981;45:38–42. [PMC free article] [PubMed] [Google Scholar]
  • 13.Dea S., Roy R.S., Begin M.E. Bovine coronavirus isolation and cultivation in continuous cell lines. Am. J. Vet. Res. 1980;41:30–39. [PubMed] [Google Scholar]
  • 14.Dea, S., Roy, R.S., and Begin, M.E.: Counterimmunoelectrophoresis for detection of neonatal calf diarrhea coronavirus: Methodology and comparison with electron microscopy. J. Clin. Microbiol., 10:240-244. [DOI] [PMC free article] [PubMed]
  • 15.Dea S., Roy R.S., Begin M.E. Physicochemical and biological properties of neonatal calf diarrhea coronaviruses isolated in Quebec and comparison with the Nebraska calf coronavirus. Am. J. Vet. Res. 1980;41:23–29. [PubMed] [Google Scholar]
  • 16.Dubourguier H.C., Gouet P.H., Mandard O. Scanning electron microscopy of abomasum and intestine of gnotoxenic calves infected either with rotavirus, coronavirus or enterophathogenic Escherichia coli or with rotavirus and E. coli. Ann. Rech. Vet.1978;9:441–451. [PubMed] [Google Scholar]
  • 17.Ellens D.J., de Leeuw P.W. Enzyme-linked immunosorbent assay for diagnosis of rotavirus infections in calves. J. Clin. Microbiol. 1977;6:530–532. doi: 10.1128/jcm.6.5.530-532.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Ellens D.J., de Leeuw P.W., van Balken J.A.M. Comparison of five diagnostic methods for the detection of rotavirus antigens in calf feces. Med. Microbiol. Immunol. 1978;166:157–163. doi: 10.1007/BF02121145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.England J.J., Frye C.S., Enright E.A. Negative contrast elecron microscopy diagnosis of viruses of neonatal calf diarrhea. Cornell Vet. 1976;66:172–182. [PubMed] [Google Scholar]
  • 20.Eugster A.K., Sneed L. Viral intestinal infections of animals and man. Comp. Immunol. Microbiol. Infect. Dis. 1980;2:417–435. doi: 10.1016/0147-9571(79)90084-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Flewett T.H. Electron microscopy in the diagnosis of infectious diarrhea. J. Am. Vet. Med. Assoc. 1978;173:538–543. [PubMed] [Google Scholar]
  • 22.Flewett T.H., Bryden A.B., Davies H. Relation between viruses of acute gastroenteritis of children and newborn calves. Lancet. 1974;2:61–63. doi: 10.1016/s0140-6736(74)91631-6. [DOI] [PubMed] [Google Scholar]
  • 23.Flewett T.H., Woode G.N. The rotaviruses: Brief review. Arch. Virol. 1978;57:1–23. doi: 10.1007/BF01315633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Gerna G., Battaglia M., Cereda P.M. Reactivity of human coronavirus OC 43 and neonatal calf diarrhea coronavirus membrane-associated antigens. J. Gen. Virol. 1982;60:385–390. doi: 10.1099/0022-1317-60-2-385. [DOI] [PubMed] [Google Scholar]
  • 25.Couet P., Contrepois M., Dubourguier H.C. The experimental production of diarrhoea in colostrum deprived axenic and gnotoxenic calves with enteropathogenic Escherichia coli, rotavirus, coronavirus, and in a combined infection of rotavirus and E. coli. Ann. Rech. Vet.1978;9:433–440. [PubMed] [Google Scholar]
  • 26.Guy J.S., Brian D.A. Proceedings of the International Symposium on Neonatal Diarrhea. Veterinary Infectious Disease Organization; Saskatoon, Saskatchewan, Canada: 1978. Bovine coronavirus RNA; pp. 305–320. [Google Scholar]
  • 27.Hall G.A., Bridger J.C., Chandler L.R. Gnotobiotic piglets experimentally infected with neonatal calf diarrhea reovirus-like agent (rotavirus) Vet. Pathol. 1976;3:197–210. doi: 10.1177/030098587601300304. [DOI] [PubMed] [Google Scholar]
  • 28.Halpin C.G., Caple I.W. Changes in intestinal structure and function of neonatal calves infected with reovirus-like agent and Escherichia coli. Aust. Vet. J. 1976;52:438–441. doi: 10.1111/j.1751-0813.1976.tb05384.x. [DOI] [PubMed] [Google Scholar]
  • 29.Hodes H.L. Gastroenteritis with special reference to rotavirus. Adv. Pediatr. 1980;27:195–245. [PubMed] [Google Scholar]
  • 30.Hoshino Y., Wyatt R.G., Greenberg H.B. Serotypic similarity and diversity of rotavirus of mammalian and avian origin as studied by plaque-reduction neutralization. J. Infect. Dis. 1984;149:694–702. doi: 10.1093/infdis/149.5.694. [DOI] [PubMed] [Google Scholar]
  • 31.House J.A. Economic impact of rotavirus and other neonatal disease agents of animals. J. Am. Vet. Med. Assoc. 1978;173:573–576. [PubMed] [Google Scholar]
  • 32.Ihara T., Samejima T., Kuwahara H. Isolation of new serotypes of bovine rotaviruses. Arch. Virol. 1983;78:145–150. doi: 10.1007/BF01310870. [DOI] [PubMed] [Google Scholar]
  • 33.Kapikian A.Z., Yolken R.H., Greenberg H.B. Gastroenteritis viruses. In: Lennette E.H., Schmidt N.J., editors. Diagnostic Procedures for Viral, Rickettsial, and Chlamydial Infections. D.C., American Public Health Association; Washington: 1979. pp. 927–995. [Google Scholar]
  • 34.King B., Brian D.A. Bovine coronavirus structural proteins. J. Virol. 1982;42:700–707. doi: 10.1128/jvi.42.2.700-707.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Kubo M., Akashi H., Inaba Y. Pathological studies on encephalitis in mice experimentally inoculated with bovine coronavirus. Natl. Inst. Anim. Health. 1982;22:45–53. [PubMed] [Google Scholar]
  • 36.Langpap T.J., Bergeland M.E., Reed D.E. Coronaviral enteritis of young calves: Virologic and pathologic findings in naturally occurring infections. Am. J. Vet. Res. 1979;40:1476–1478. [PubMed] [Google Scholar]
  • 37.Lewis L.D., Phillips R.W. Pathophysiologic changes due to coronavirus-induced diarrhea in the calf. J. Am. Vet. Med. Assoc. 1978;J73:636–642. [PubMed] [Google Scholar]
  • 38.Lewis L.D., Phillips R.W., Elliott C.D. Changes in plasma glucose and lactate concentrations and enzyme activities in the neonatal calf with diarrhea. Am. J. Vet. Res. 1975;36:413–416. [PubMed] [Google Scholar]
  • 39.McDaniels A.E., Cochran K.W., Gannon J.J. Rotavirus and reovirus stability in microorganism-free distilled and wastewaters. Water Res. 1983;17:1349–1353. [Google Scholar]
  • 40.McLean B.S., Holmes I.H. Effects of antibodies, trypsin, and trypsin inhibitors on susceptibility of neonates to rotavirus infection. J. Clin. Microbiol1981;13:22–29. doi: 10.1128/jcm.13.1.22-29.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 41.McNulty M.S. Rotaviruses. J. Gen. Virol. 1978;40:1–18. doi: 10.1099/0022-1317-40-1-1. [DOI] [PubMed] [Google Scholar]
  • 42.McNulty M.S. The etiology, pathology and epidemiology of viral gastroenteritis. Ann. Rech. Vet. 1983;14:427–432. [Google Scholar]
  • 43.McNulty M.S., Logan E.F. Longitudinal survey of rotavirus infection in calves. Vet. Rec. 1983;113:333–335. doi: 10.1136/vr.113.15.333. [DOI] [PubMed] [Google Scholar]
  • 44.Mebus C.A. Calf diarrhea induced by coronavirus and reovirus-like agent. Mod. Vet. Pract. 1976;57:693–698. [PubMed] [Google Scholar]
  • 45.Mebus C.A., Kono M., Underdahl N.R. Cell culture propagation of neonatal calf diarrhea (scours) virus. Can. J. Comp. Med. 1971;12:69–72. [PMC free article] [PubMed] [Google Scholar]
  • 46.Mebus C.A., Newman L.E. Scanning electron, light and immunofluorescent microscopy of intestine of gnotobiotic calf infected with reovirus-like agent. Am. J. Vet. Res.1977;38(5):553–558. [PubMed] [Google Scholar]
  • 47.Mebus C.A., Newman L.E., Stair E.L. Scanning electron, light and immunofluorescent microscopy of intestine of gnotobiotic calf infected with calf diarrheal coronavirus. Am. J. Vet. Res. 1975;36(12):1719–1725. [PubMed] [Google Scholar]
  • 48.Mebus C.A., Rhodes M.B., Underdahl N.R. Neonatal calf diarrhea caused by a virus that induces villous epithelial cell syncytia. Am. J. Vet. Res. 1978;39:1223–1228. [PubMed] [Google Scholar]
  • 49.Mebus C.A., Stair E.L., Rhodes M.B. Neonatal calf diarrhea: Propagation, attenuation, and characteristics of a coronavirus-like agent. Am. J. Vet. Res. 1973;34:145–150. [PubMed] [Google Scholar]
  • 50.Mebus C.A., Stair E.L., Rhodes M.B. Pathology of neonatal calf diarrhea induced by a coronavirus-like agent. Vet. Pathol. 1973;10:45–64. doi: 10.1177/030098587301000105. [DOI] [PubMed] [Google Scholar]
  • 51.Mebus C.A., Stair E.L., Underdahl N.R. Pathology of neonatal calf diarrhea induced by a reo-like virus. Vet. Pathol. 1971;8:490–505. [Google Scholar]
  • 52.Mebus C.A., Underdahl N.R., Rhodes M.B. Calf diarrhea (scours): Reproduced with a virus from a field outbreak. University of Nebraska Research Bulletin no. March, 1969;233 [Google Scholar]
  • 53.Mebus C.A., Wyatt R.G., Kapikian A.Z. Intestinal lesions induced in gnotobiotic calves by the virus of human infantile gastroenteritis. Vet. Pathol. 1977;14:273–282. doi: 10.1177/030098587701400310. [DOI] [PubMed] [Google Scholar]
  • 54.Moon H.W., McClurkin A.W., Isaacson R.E. Pathogenic relationships of rotavirus. Escherichia coli and other agents in mixed infections of calves. J. Am. Vet. Med. Assoc. 1978;173:577–583. [PubMed] [Google Scholar]
  • 55.Morin M., Lariviere S., Lallier R. Proceedings of the International Symposium on Neonatal Diarrhea. Veterinary Infectious Disease Organization; Saskatoon, Saskatchewan, Canada: 1978. Neonatal calf diarrhea: Pathology and microbiology of spontaneous cases in dairy herds and incidence of the enteropathogens implicated as etiological agents; pp. 347–369. [Google Scholar]
  • 56.Morinet F., Ferchal F., Colimon R. Comparison of six methods for detecting human rotavirus in stools. Eur. J. Clin. Microbiol.1984;3:136–140. doi: 10.1007/BF02014331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 57.Murakami Y., Nishioka N., Hashignoki Y. Serotypes of bovine rotaviruses distinguished by serum neutralization. Infect. Immun. 1983;40:851–855. doi: 10.1128/iai.40.3.851-855.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 58.Narang H.K., Codd A.A. Frequency of preclumped virus in routine fecal specimens from patients with acute nonbacterial gastroenteritis. J. Clin. Microbiol. 1981;13:982–988. doi: 10.1128/jcm.13.5.982-988.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 59.Ojeh C.K., Snodgrass D.R., Herring A.J. Evidence for serotypic variation among bovine rotaviruses. Arch. Virol. 1984;79:161–171. doi: 10.1007/BF01310809. [DOI] [PubMed] [Google Scholar]
  • 60.Pearson G.R., Logan E.F., McNulty M.S. Proceedings of the International Symposium on Neonatal Diarrhea. Veterinary Infectious Disease Organization; Saskatoon, Saskatchewan, Canada: 1978. Comparsion of enteropathogenic Escherichia coli and rotavirus infections of neonatal calves. pp. 331–346. [Google Scholar]
  • 61.Pedersen N.C., Ward J., Mengeling W.L. Antigenic relationship of the feline infectious peritonitis virus to coronaviruses of other species. Arch. Virol. 1978;58:45–53. doi: 10.1007/BF01315534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 62.Radostits O.M., Acres S.D. The control of acute undifferentiated diarrhea of newborn beef calves. Vet. Clin. North Am. [Large Animal Pract.]1983;5(1):143–155. doi: 10.1016/S0196-9846(17)30097-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 63.Reynolds D.J. Coronavirus replication in the intestinal and respiratory tracts during infection of calves. Ann. Rech. Vet. 1983;14:445–446. [PubMed] [Google Scholar]
  • 64.Rhodes M.B., Stair E.L., McCullough R.A. Comparison of results using electron microscope, immunodiffusion and fluorescent antibody analyses to detect rotaviruses in diarrheic fecal samples of calves. Can. J. Comp. Med. 1979;43:84–89. [PMC free article] [PubMed] [Google Scholar]
  • 65.Rodak L., Babiuk L.A., Acres S.D. Detection by radioimmunoassay and enzyme-linked immunosorbent assay of coronavirus antibodies in bovine serum and lacteal secretions. J. Clin. Microbiol. 1982;16:34–40. doi: 10.1128/jcm.16.1.34-40.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 66.Runnels P.L., Moon H.W., Whipp S.C. Proceedings of the International Symposium on Neonatal Diarrhea. Veterinary Infectious Disease Organization; Saskatoon, Saskatchewan, Canada: 1980. Interaction of rotavirus and enterotoxigenic Escherichia coli (ETEC) in gnotobiotic calves; pp. 343–360. [Google Scholar]
  • 67.Sato K., Inaba Y., Matumoto M. Serological relation between calf diarrhea coronavirus and hemagglutinating encephalomyelitis virus. Arch. Virol. 1980;66:157–159. doi: 10.1007/BF01314983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 68.Sato K., Inaba Y., Miura Y. Neutralizing antibody to calf diarrhea coronavirus in various animal species in Japan. Microbiol. Immunol. 1981;25:623–625. doi: 10.1111/j.1348-0421.1981.tb00065.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 69.Schlafer D.H., Scott F.W. Prevalence of neutralizing antibody to the calf rotavirus in New York cattle. Cornell Vet. 1979;69:262–271. [PubMed] [Google Scholar]
  • 70.Schwers A., Dangenais L., Chappuis G. Propagation of bovine rotavirus by young dogs. J. Clin. Pathol. 1983;93:135–141. doi: 10.1016/0021-9975(83)90051-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 71.Sharpee R.L., Mebus C.A., Bass E.P. Characterization of a calf diarrheal coronavirus. Am. J. Vet. Res. 1976;37:1031–1041. [PubMed] [Google Scholar]
  • 72.Snodgrass D.R., Herring A.J., Campbell I. Comparison of atypical rotaviruses from calves, piglets, lambs and man. J. Gen. Virol. 1984;65:909–914. doi: 10.1099/0022-1317-65-5-909. [DOI] [PubMed] [Google Scholar]
  • 73.Spence L., Fauvel M., Petro R. Comparison of rotavirus strains by hemagglutination inhibition. Can. J. Microbiol. 1978;24:353–356. doi: 10.1139/m78-059. [DOI] [PubMed] [Google Scholar]
  • 74.Stair E.L., Rhodes M.B., White R.G. Neonatal calf diarrhea: Purification and electron microscopy of a coronavirus-like agent. Am. J. Vet. Res. 1972;33:1147–1156. [PubMed] [Google Scholar]
  • 75.Steel R.B., Torres-Medina A. Effects of environmental and dietary factors on human rotavirus infection in gnotobiotic piglets. Infect. Immun. 1984;43:906–911. doi: 10.1128/iai.43.3.906-911.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 76.Storz J., Leary J.J., Carlson J.H. Parvoviruses associated with diarrhea in calves. J. Am. Vet. Med. Assoc.1978;173:624–627. [PubMed] [Google Scholar]
  • 77.Storz J., Dougri A.M., Hajer I. Coronaviral morphogenesis and ultrastructural changes in intestinal infections of calves. J. Am. Vet. Med. Assoc. 1978;173:633–635. [PubMed] [Google Scholar]
  • 78.Storz J., Rott R., Kaluza G. Enhancement of plaque formation and cell fusion of an enteropathogenic coronavirus by trypsin treatment. Infect. Immun. 1981;31:1214–1222. doi: 10.1128/iai.31.3.1214-1222.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 79.Takahashi, E., Inaba, Y., Sato, K., et al.: Epizootic diarrhea of adult cattle associated with a coronavirus-like agent. Vet. Microbiol., 5:151-154.
  • 80.Theil K.W., Bohl E.H., Saif L.J. Techniques for rotaviral propagation. J. Am. Vet. Med. Assoc. 1978;173:548–551. [PubMed] [Google Scholar]
  • 81.Torres-Medina A. Effect of combined rotavirus and Escherichia coli in neonatal gnotobiotic calves. Am. J. Vet. Res. 1984;45(4):643–651. [PubMed] [Google Scholar]
  • 82.Torres-Medina A. Effect of rotavirus and/or Escherichia coli infection on the aggregated lymphoid follicles in the small intestine of neonatal gnotobiotic calves. Am. J. Vet. Res. 1984;45(4):652–660. [PubMed] [Google Scholar]
  • 83.Toth T.E. Trypsin-enhanced replication of neonatal diarrhea coronavirus in bovine embryonic lung cells. Am. J. Vet. Res. 1982;43:967–972. [PubMed] [Google Scholar]
  • 84.Tzipori S.R., Makin T.J., Smith M.L. Clinical manifestations of diarrhea in calves with rotavirus and enterotoxigenic Escherichia coli. J. Clin. Microbiol. 1981;13:1011–1016. doi: 10.1128/jcm.13.6.1011-1016.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 85.Vesikari, T., Isolauri, E., D'Hont, E., et al.: Protection of infants against rotavirus diarrhea by RIT 4327 attenuated bovine rotavirus stain vaccine. Lancet, J:980-981, 1984. [DOI] [PubMed]
  • 86.Wege H., Siddell S., ter Meulen V. The biology and pathogenesis of coronaviruses. Curr. Topics Microbiol. Immunol. 1982;99:165–200. doi: 10.1007/978-3-642-68528-6_5. [DOI] [PubMed] [Google Scholar]
  • 87.Welch A.B. Purification, morphology, and partial characterization of a reovirus-like agent associated with neonatal calf diarrhea. Can. J. Comp. Med. 1971;35:195–202. [PMC free article] [PubMed] [Google Scholar]
  • 88.Woode G.N. Epizootiology of bovine rotavirus infection. Vet. Rec. 1978;103:44–46. doi: 10.1136/vr.103.3.44. [DOI] [PubMed] [Google Scholar]
  • 89.Woode G.N., Bridger J.C. Isolation of small viruses resembling astrovirus and calciviruses from acute enteritis of calves. J. Med. Microbiol. 1978;11:441–452. doi: 10.1099/00222615-11-4-441. [DOI] [PubMed] [Google Scholar]
  • 90.Woode G.N., Bridger J.C. Viral enteritis of calves. Vet. Rec. 1975;96:85–88. doi: 10.1136/vr.96.4.85. [DOI] [PubMed] [Google Scholar]
  • 91.Woode G.N., Kelso N.E., Simpson T.F. Antigenic relationships among some bovine rotaviruses: Serum neutralization and cross-protection in gnotobiotic calves. J. Clin. Microbiol. 1983;18:358–364. doi: 10.1128/jcm.18.2.358-364.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 92.Woode G.N., Reed D.E., Runnels P.L. Studies of an unclassified virus isolated from diarrheic calves. Vet. Microbiol. 1982;7:221–240. doi: 10.1016/0378-1135(82)90036-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 93.Wyatt R.G., Kalica A.R., Mebus C.A. Reovirus-like agents (rotaviruses) associated with diarrheal illness in animals and man. In: Pollard M., editor. Volume 10. Raven Press; New York: 1978. pp. 121–145. (Perspectives in Virology). [Google Scholar]

Articles from The Veterinary Clinics of North America. Food Animal Practice are provided here courtesy of Elsevier

RESOURCES