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. 2008 Jan 3;33(5):344–351. [Article in French] doi: 10.1016/S0755-4982(04)98581-8

Syndrome respiratoire aigu sévère : une épidémie singulière de pneumonie virale

Severe acute respiratory syndrome: a singular epidemic of viral pneumonia

Amélie Guihot 1, François Bricaire 1, Taisheng Li 2, Philippe Bossi 1,⁎
PMCID: PMC7135803  PMID: 15041887

Résumé

Agent infectieux

Le Syndrome respiratoire aigu sévère (Sras) est une pneumopathie fébrile initialement observée en Chine à la fin de l’année 2002. L’agent infectieux étiologique a rapidement été identifié comme étant un nouveau Coronavirus, baptisé Coronavirus associé au Sras (Sras-CoV). La transmission du virus est interhumaine, par les particules respiratoires principalement.

Clinique et traitement

La gravité clinique est variable, allant de la simple fièvre au syndrome de détresse respiratoire aigu. Il n’existe pas de traitement spécifique. Cependant, la ribavirine combinée à des corticoïdes a été utilisée avec succès dans un certain nombre de cas.

Épidémiologie

Au cours du premier semestre de l’année 2003, la dissémination du virus a été extrêmement rapide, évoluant sur un mode pandémique, contaminant plus de 8000 patients, dont 774 en sont décédés. Le réservoir viral, probablement d’origine animale, reste inconnu à ce jour. L’épidémie semble être actuellement jugulée, mais des ré-émergences sporadiques ou épidémiques sont possibles et ont été décrites en Chine dans la province de Guangdong début janvier 2004.

Références

  • 1.Zhao Z., Zhang F., Xu M. Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China. J Med Microbiol. 2003;52:715–720. doi: 10.1099/jmm.0.05320-0. [DOI] [PubMed] [Google Scholar]
  • 2.Sampathkumar P., Temesgen Z., Smith T.F., Thompson R.L. SARS: epidemiology, clinical presentation, management, and infection control measures. Mayo Clin Proc. 2003;78:882–890. doi: 10.4065/78.7.882. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.http://www.who.int/csr/sars
  • 4.Desenclos J.-C., van der Werf S., Bonmarin I. Introduction of SARS in France, March–April 2003. Emerg Infect Dis. 2004;10:195–200. doi: 10.3201/eid1002.030351. http://www.cdc.gov/ncidod/EID/vol10no2/03-0351.htm [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Drosten C., Gunther S., Preiser W. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003;348:1967–1976. doi: 10.1056/NEJMoa030747. [DOI] [PubMed] [Google Scholar]
  • 6.Fouchier R.A., Kuiken T., Schutten M. Aetiology: Koch's postulates fulfilled for SARS virus. Nature. 2003;423:240. doi: 10.1038/423240a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Ruan Y.J., Wei C.L., Ee A.L. Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection. Lancet. 2003;361:1779–1785. doi: 10.1016/S0140-6736(03)13414-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Leung W.K., To K.F., Chan P.K. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology. 2003;125:1011–1017. doi: 10.1016/j.gastro.2003.08.001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Nicholls J.M., Poon L.L., Lee K.C. Lung pathology of fatal severe acute respiratory syndrome. Lancet. 2003;361:1773–1778. doi: 10.1016/S0140-6736(03)13413-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Li L., Wo J., Shao J. SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients. J Clin Virol. 2003;28:239–244. doi: 10.1016/S1386-6532(03)00195-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Ng S.K. Possible role of an animal vector in the SARS outbreak at Amoy Gardens. Lancet. 2003;362:570–572. doi: 10.1016/S0140-6736(03)14121-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Byron E.E. Virology: SARS virus infection of cats and ferrets. Nature. 2003;425:915. doi: 10.1038/425915a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Peiris J.S., Chu C.M., Cheng V.C. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003;361:1767–1772. doi: 10.1016/S0140-6736(03)13412-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.http://www.cdc.gov/mmwr/preview/mmwrhtml/mm 5241a2.htm
  • 15.Consensus document on the epidemiology of severe acute respiratory syndrome (SARS). http://www.who.int/csr/sars/en/WHOconsensus.pdf
  • 16.Donnelly C.A., Ghani A.C., Leung G.M. Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. Lancet. 2003;361:1761–1766. doi: 10.1016/S0140-6736(03)13410-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Booth C.M., Matukas L.M., Tomlinson G.A. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA. 2003;289:2801–2809. doi: 10.1001/jama.289.21.JOC30885. [DOI] [PubMed] [Google Scholar]
  • 18.Choi K.W., Chau T.N., Tsang O. Outcomes and prognostic factors in 267 patients with severe acute respiratory syndrome in Hong Kong. Ann Intern Med. 2003;139:715–723. doi: 10.7326/0003-4819-139-9-200311040-00005. [DOI] [PubMed] [Google Scholar]
  • 19.Hon K.L., Leung C.W., Cheng W.T. Clinical presentations and outcome of severe acute respiratory syndrome in children. Lancet. 2003;361:1701–1703. doi: 10.1016/S0140-6736(03)13364-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Cui W., Fan Y., Wu W. Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome. Clin Infect Dis. 2003;37:857–859. doi: 10.1086/378587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Tsang K.W., Ho P.L., Ooi G.C. A cluster of cases of severe acute respiratory syndrome in Hong Kong. N- Engl J Med. 2003;348:1977–1985. doi: 10.1056/NEJMoa030666. [DOI] [PubMed] [Google Scholar]
  • 22.Wong K.T., Antonio G.E., Hui D.S. Severe acute respiratory syndrome: radiographic appearances and pattern of progression in 138 patients. Radiology. 2003;228:401–406. doi: 10.1148/radiol.2282030593. [DOI] [PubMed] [Google Scholar]
  • 23.Lee N., Hui D., Wu A. A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med. 2003;348:1986–1994. doi: 10.1056/NEJMoa030685. [DOI] [PubMed] [Google Scholar]
  • 24.Yam W.C., Chan K.H., Poon L.L. Evaluation of reverse transcription-PCR assays for rapid diagnosis of severe acute respiratory syndrome associated with a novel coronavirus. J Clin Microbiol. 2003;41:4521–4524. doi: 10.1128/JCM.41.10.4521-4524.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Franks T.J., Chong P.Y., Chui P. Lung pathology of severe acute respiratory syndrome (Sars): a study of 8 autopsy cases from Singapore. Hum Pathol. 2003;34:743–748. doi: 10.1016/S0046-8177(03)00367-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Conduite à tenir pour la prise en charge des personnes présentant un syndrome ou une suspicion de syndrome respiratoire aigu sévère (SRAS) et des personnes contacts. http://www.sante.gouv.fr/htm/dossiers/pneumapathies/protoc_2005.pdf
  • 27.Zhong N.S., Zeng G.Q. Our strategies for fighting severe acute respiratory syndrome (SARS) Am J Respir Crit Care Med. 2003;168:7–9. doi: 10.1164/rccm.200305-707OE. [DOI] [PubMed] [Google Scholar]
  • 28.Gilbert B.E., Knight V. Biochemistry and clinical applications of ribavirin. Antimicrob Agents Chemother. 1986;30:201–205. doi: 10.1128/aac.30.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29.Tsui P.T., Kwok M.L., Yuen H., Lai S.T. Severe acute respiratory syndrome: clinical outcome and prognostic correlates. Emerg Infect Dis. 2003;9:1064–1069. doi: 10.3201/eid0909.030362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 30.Booth C.M., Matukas L.M., Tomlinson G.A. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA. 2003;289:2801–2809. doi: 10.1001/jama.289.21.JOC30885. [DOI] [PubMed] [Google Scholar]
  • 31.Tsang O.T., Chau T.N., Choi K.W. Coronaviruspositive nasopharyngeal aspirate as predictor for severe acute respiratory syndrome mortality. Emerging Infectious Diseases. 2003;9:1381–1387. doi: 10.3201/eid0911.030400. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Presse Medicale (Paris, France : 1983) are provided here courtesy of Elsevier

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