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. 2019 Jun 25;16(4):615–625. doi: 10.1080/15548627.2019.1632621

Figure 4.

Figure 4.

wdr45b and wdr45 double KO mice. (A and B) wdr45b and wdr45 double KO mice are born smaller than their single KO littermates (A). Mean ± SD (n = 4) is shown in B. (C and D) Accumulation of SQSTM1 in the cerebellum of wdr45b and wdr45 double KO mice, but not in control and single KO mice (C). Quantification of SQSTM1 aggregates is shown as mean ± SD (n = 3) in D. Bar: 10 μm. (E) Costaining of SQSTM1 (red) and RBFOX3 (green) shows that SQSTM1 aggregates accumulate in the neurons of the cortex in wdr45b and wdr45 double KO mice, as indicated by arrows. Bar: 10 μm.