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. 2020 Mar 19;7(2):ENEURO.0320-19.2020. doi: 10.1523/ENEURO.0320-19.2020

Figure 3.

Figure 3.

PERG analysis, rescue of visual function. A, Box and whisker plot showing PERG amplitudes of control-Veh-ttd, EAE-Veh-ttd, and EAE-Klf4fl/fl-Cre-ttd mice at 1 and 4 MPS where EAE sensitization and intravitreal injections were done simultaneously (n = 8 eyes/group). B, Box and whisker plot showing PERG amplitudes of Control, EAE and EAE-Klf4fl/fl mice at 9 MPS versus 18 MPS + 9 MPI of Veh-ttd or Cre-ttd mice. Box-plot elements include, center line, median; box limits, upper 75th and lower 25th percentile of the data; whiskers, lowest and highest data points. C, Representative PERG wave forms of CFA, EAE and EAE Klf4fl/fl mice at 9 MPS versus 18 MPS + 9 MPI of scAAV-CMV-mCherry or ssAAV-CMV-Cre-ires-GFP. PERGs were recorded three times for each mice/time point and mean PERGs with subtracted background was used for final analysis. Statistical analysis was performed by two-way ANOVA followed by Tukey’s multiple comparison test and p values were adjusted for multiple sample comparisons, p < 0.05 was considered to be statistically significant; *p = 0.01–0.05; **p = 0.001–0.009; ***p = 0.0001–0.0009, ****p < 0.0001; (n = 8 eyes for each group).Figure Contributions: Venu Talla acquired the data, analyzed, and generated the figure.