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. 2020 Mar 19;7(2):ENEURO.0320-19.2020. doi: 10.1523/ENEURO.0320-19.2020

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Copyright © 2020 Talla and Koilkonda

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Histopathology and inflammation in EAE mice: A–C, Light microscopic images of the toluidine blue-stained ON sections obtained 18 MPS/9 MPI show normal healthy axons in control-Veh-ttd mice (A), whereas inflammatory infiltration and fibrosis seen in EAE-Veh-ttd (B), and EAE-Klf4^fl/fl-Cre-ttd mice. D–F, Representative transmission electron micrographs show minimal to no cellular infiltration in control-Veh-ttd mice (D), whereas infiltration of astroglial cells was more evident in EAE-Veh-ttd (E) and EAE-Klf4^fl/fl-Cre-ttd (F) mice ONs. Scale bars: 100 μm (light micrographs) and 10 μm (TEM images).Figure Contributions: Venu Talla and Rajeshwari Koilkonda acquired the images. Venu Talla generated the figure.