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Multimeric applications. (A) FN3 domains on the fibronectin chain exhibit binding to multiple partners. Mimicking this beads-on-a-string approach quickly produces (B) bivalent, (C) tetravalent and (D) bispecific monobody constructs. (E) Furthering this fusion approach, tandem monobodies are fused with domains which confer longer circulating half-life or (F) greater avidity.
