Figure 5.
(A) Effect of B10 on the monomeric Aβ1−42 aggregation; (B) TEM images of Aβ1−42 aggregation; (C) effect of B10 on Aβ1−42 aggregates disaggregation; (D) molecular docking of B10 with Aβ1−42 (PDB code: 1IYT); (E) effect of B10 on Cu2+-induced Aβ1−42 aggregation; (F) effect of B10 on Cu2+-Aβ1−42 aggregates disaggregation. In aggregation assay, Aβ1−42/compound (1/1) or Aβ1−42/Cu2+/compound (1/1/2) was in HEPES at 37 °C for 24 h. In disaggregation assay, after Aβ1−42 or Aβ1−42/Cu2+ was incubated for 24 h to form aggregates, compounds were then added and further incubated for 24 h. Values are reported as the mean ± SD of three independent experiments. *** p < 0.001, ** p < 0.01 vs. Aβ1−42 or Aβ1−42/Cu2+ alone.