Figure 1.

Defective aortic contraction in Lmna^G609G/G609G mice. Thoracic aortas from 14-week-old progeroid Lmna^G609G/G609G mice (ubiquitous progerin expression) and wild-type (Lmna^+/+) mice were analyzed by wire myography (n = 12 for each genotype). (A) Strength of contraction induced by phenylephrine (left) and representation of the area under de curve (right; a.u.: arbitrary units). (B) Strength of contraction induced by KCl. Statistical differences were analyzed by two-way ANOVA with Bonferroni’s post-hoc test for phenylephrine data, and by two-tailed t-test for KCl data. * p < 0.05 *** p < 0.001.