Table 2.
Selected hubs with the highest number of interactions with NBR1-interacting proteins (hub degree).
| Hub No | AGI Code | Hub Degree | Gene Name/Description (from TAIR, Modified) |
|---|---|---|---|
| Hub1 | AT5G03240 | 59 | UBQ3/encodes ubiquitin that is attached to proteins destined for degradation. UBQ3 transcript level is modulated by UV-B and light/dark treatments. |
| Hub2 | AT4G30840 | 24 | NUP43/Transducin/WD40 repeat-like superfamily protein |
| Hub3 | AT1G80670 | 20 | RAE1/Encodes a protein with a DWD motif. It can bind to DDB1a in Y2H assays and may be involved in the formation of a CUL4-based E3 ubiquitin ligase |
| Hub4 | AT4G29040 | 16 | RPT2a/Encodes the 26S proteasome subunit. It is required for root meristem maintenance, and it regulates gametogenesis. It is also shown to regulate gene silencing via DNA methylation. |
| Hub5 | AT4G09000 | 12 | GRF1/Encodes a member of 14-3-3 family. The major native forms of 14-3-3s are homo- and hetero-dimers. Serving as adapters, activators, and repressors, they are involved in a vast array of processes such as the response to stress, cell-cycle control, and apoptosis. |
| Hub6 | AT5G46630 | 11 | AP2M/Clathrin adaptor complexes medium subunit family protein, contains Pfam profile: PF00928 adaptor complexes medium subunit family; it is similar to micro-adaptins of clathrin coated vesicle adaptor complexes |
| Hub7 | AT3G14980 | 11 | IDM1/ROS4/Histone H3 acetyltransferase recognizing unmethylated H3K4 through its PHD domain and methylated DNA through its MBD domain; it negatively regulates DNA demethylation |
| Hub8 | RAD23A | 11* | Homo sapiens RAD23A having interactions with many Arabidopsis proteins [34] |
* including NBR1, identified previously as interactor of RAD23A.