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. 2020 Feb 13;39(15):3102–3113. doi: 10.1038/s41388-020-1186-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Box plots of LGALS9 (galectin-9) mRNA expression measured in various human solid tumors (sample size in parentheses) assessed by RNA-seq. Tumors are sorted in order of decreasing median expression of LGALS9 mRNA. Of the pancreatic cancer samples from the TCGA database (n = 179), we analyzed only PDAC (n = 146). All expression values are log2-transformed. b Expression of CD274 (PD-L1) and LGALS9 mRNA was tested in human PDAC tissues using the TCGA database. c Correlation between high and low tertiles of LGALS9 mRNA expression and CD4, CD8A, and TRGC2 expression, d CD163, CD206, and TNF (TNFA) and e FUT4 (CD15) expression. Each point represents data from one patient. Data, median, unpaired t-test. *p < 0.05, ****p < 0.0001.