Figure 3.

Renal function, dose regimen and drug plasma levels of patient 1: A total of 34 samples were analyzed (colisthimethate sodium (CMS) peak n = 16, CMS trough n = 16, Colistin peak n = 16, Colistin trough n = 20). (A) eGFR derived from serum creatinine levels is plotted at indicated treatment days. (B) Dosing regimen for CMS, colored portions indicate the particular doses during the day. (C) Time courses of CMS trough and peak levels along with Colistin levels. Colistin elimination was measured by continuing monitoring after the end of treatment (light blue dots) and the individual fitted elimination is plotted in Figure 1A. Target level for CMS is indicated by dashed line.