Table 3.
Effect of chokeberry juice or silymarin on the level of liver fibrosis, lymphocyte infiltration, and density of vacuolated hepatocytes.
| Parameters | Treatment | |||||
|---|---|---|---|---|---|---|
| Controls | CCl4 | Chokeberry | CCl4 + | Silymarin | CCl4 + | |
| Juice | Chokeberry | Silymarin | ||||
| (T) | (A) | Juice | (S) | (S + T) | ||
| (A + T) | ||||||
| Fibrosis | 0.04 ± 0.01 | 0.18 ± 0.03 | 0.04 ± 0.01 | 0.23 ± 0.05 | 0.04 ± 0.01 | 0.09 ± 0.01 a,b |
| Infiltration | - | 4.6 ± 2.2 | - | 14.3 ± 6.6 c | - | 6.2 ± 2.2 |
| Vacuolization | - | 208 ± 23 | - | 65 ± 14 d | - | 179 ± 39 |
Results are means ± SD, n = 8. Control rats were administered water. Fibrosis = the ratio of the area affected by fibrosis to the total area examined. Infiltration = the ratio of area infiltrated by lymphocytes to the total area examined. Vacuolization = number of vacuolated hepatocytes (density) per 1 mm2. “-” absence of the trait; a S + T group vs. CCl4-treated animals, p < 0.036; b S + T group vs. controls, p < 0.001; c,d A + T group vs. CCl4-treated rats, p = 0.029.