Table 1.
Accuracy and precision of the assay for KD025 in rat plasma.
| Added Concentration (Plasma Sample, ng/mL) |
Intra-day (n = 5) | Inter-day (n = 15) | ||||
|---|---|---|---|---|---|---|
| Measured Concentration |
Precision (CV, %) | Accuracy (%) |
Measured Concentration |
Precision (CV, %) | Accuracy (%) | |
| 1 | 0.8 | 5.1 | 83.3 | 1.0 | 10.7 | 98.3 |
| 3 | 2.9 | 7.1 | 96.6 | 2.9 | 3.4 | 97.5 |
| 40 | 40.9 | 7.0 | 102.3 | 40.8 | 3.9 | 102.0 |
| 400 | 390.2 | 5.8 | 97.5 | 408.1 | 2.4 | 102.0 |
| 800 | 764.2 | 3.2 | 95.5 | 801.1 | 5.6 | 100.1 |
| 800 a | 801.8 | 10.8 | 100.2 | 810.9 | 9.7 | 101.1 |
a The ultra-high quality control (UHQC) (8000 ng/mL) sample was diluted 10 times with blank rat plasma to the concentration of 800 ng/mL for dilution integrity evaluation.