Table 3.
Interaction between alafosfalin and meropenem against carbapenemase-producing Enterobacterales as determined using a chequerboard technique.
| Species | Carbapenemase | Alafosfalin MIC (mg/L) | Meropenem MIC (mg/L) | FICI | Interpretation |
|---|---|---|---|---|---|
| K. oxytoca | KPC-2 | 4 | 0.25 | 0.16 | Synergy |
| K. pneumoniae | KPC-3 | 1 | 1 | 0.25 | Synergy |
| K. pneumoniae | KPC-3 | 1 | 16 | 0.19 | Synergy |
| K. pneumoniae | KPC-4 | 0.5 | 4 | 0.38 | Synergy |
| K. pneumoniae | KPC | 1 | 0.25 | 0.38 | Synergy |
| E. coli | NDM-1 | 0.125 | 8 | 0.75 | No interaction |
| E. coli | NDM-1 | 0.031 | 0.125 | 0.76 | No interaction |
| E. cloacae | NDM-1 | 1 | 4 | 1 | No interaction |
| K. pneumoniae | NDM-1 | 2 | 2 | 0.27 | Synergy |
| E. coli | NDM-1 | 0.125 | 16 | 0.25 | Synergy |
| E. cloacae | VIM-1 | 2 | 4 | 0.19 | Synergy |
| K. pneumoniae | VIM-1 | 2 | 16 | 0.28 | Synergy |
| K. pneumoniae | IMP | 0.25 | 1 | 0.37 | Synergy |
| K. pneumoniae | IMP | 0.25 | 1 | 0.50 | Synergy |
| K. oxytoca | IMP | 1 | 0.5 | 0.13 | Synergy |
| K. pneumoniae | OXA-48 | 1 | 8 | 0.38 | Synergy |
| E. coli | OXA-48 | 0.125 | 0.25 | 0.37 | Synergy |
| K. pneumoniae | OXA-48 | 2 | 1 | 0.5 | Synergy |
| K. pneumoniae | OXA-48 | 2 | 4 | 0.26 | Synergy |
| K. pneumoniae | OXA-48 | 1 | 2 | 0.63 | No interaction |
Abbreviation: FICI; Fractional inhibitory concentration index.