Scheme 1.
Synthesis of 1-amino-alkyltetrazoles. Reagents and conditions: (a) Cs2CO3, MeI, DMF; (b) NH3 (MeOH), 50 °C; (c) TosCl, pyridine, DCM; (d) NaN3, NH4Cl, DMF, 90 °C; (e) H2 (g), 5% Pd/C, EtOH, 3 bar [9].
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