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. 2020 Mar 13;25(6):1315. doi: 10.3390/molecules25061315

Scheme 5.

Scheme 5

Solid phase synthesis of series of N-terminal succinyl-, C-terminal l-1-aminoethyltetrazole oligopeptides 21-LL, 22-LLL, 23-LLLL. Reagents and conditions: (a) piperidine, DMF; (b) Fmoc-L-Alanine, HBTU, DIPEA, DMF; (c) Succinic anhydride, DIPEA, DMF; (d) 95% TFA, 2.5% H2O, 2.5% TIS.